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  • [ X ]
    Öğe
    Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder
    (Korean Neuropsychiatric Assoc, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Karababa, Ibrahim Fatih; Emhan, Ali; Aksoy, Nurten; Bulut, Mahmut; Gunes, Mehmet
    Objective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.
  • Küçük Resim
    Öğe
    Kamu ve özel sektör çalışanlarında işkoliklik ve obsesyon arasındaki ilişkinin incelenmesi
    (Dicle Üniversitesi Tıp Fakültesi, 2012) Emhan, Abdurrahim; Mete, Mehmet; Emhan, Ali
    Amaç: Bu çalışmada özel sektörde faaliyet gösteren serbest muhasebeci-mali müşavirler ve kamuda çalışan memurlardan oluşan bir grupta işkoliklik ve obsesyon düzeylerinin ilişkisi incelenmiştir. Gereç ve yöntem: İşkoliklik ve obsesyon düzeylerini belirlemek için iki ayrı ölçek kullanılmıştır. Araştırma kapsamında toplam 260 çalışana bu ölçekler ve demografik veri formu uygulanmıştır. Toplam 170 kişinin verileri değerlendirmeye tabi tutulmuştur. Verilerin analizinde, parametrik testler ve korelasyon analizi kullanılmıştır. İstatistikî anlamlılık düzeyi p<0.05 olarak kabul edilmiştir. Bulgular: Serbest muhasebeci-mali müşavirlerin işten zevk alma (İZA) puanlarının, devlet dairesinde çalışan memurlar ve kendi yanlarında çalıştırdıkları stajyerlerden daha yüksek olduğu tespit edildi. Üniversite mezunlarının İZA puanlarının lise mezunlarından yüksek olduğu görüldü. Serbest muhasebeci-mali müşavirlerde İZA puanı ile obsesyon alt ölçeklerinden kontrol ve kesinlik puanı arasında pozitif doğrusal ilişki tespit edildi. Ayrıca, işkoliklik ölçeği işe kendini kaptırma puanı ile temizlik, düşüncelere kapılma, kontrol ve kesinlik arasında da pozitif doğrusal ilişkiler olduğu tespit edildi. Sonuç: İşkoliklik alt ölçekleri ile obsesif düşünce şekli arasında pozitif yönde doğrusal bir ilişki olduğu söylenebilir.
  • [ X ]
    Öğe
    Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder
    (Elsevier, 2013) Bulut, Mahmut; Selek, Salih; Bez, Yasin; Karababa, Ibrahim Fatih; Kaya, Mehmet Cemal; Gunes, Mehmet; Emhan, Ali
    In recent years, there has been an increasing focus on generalized anxiety disorder (GAD) which is one of the most prevalent mental disorders in general population. Psychological, genetic, neurobiological, and neurochemical factors are believed to play role in the etiopathogenesis of GAD. The role of oxidative stress, as a neurochemical cause, in various anxiety disorders has been studied in recent years; however, it has not been thoroughly studied in GAD, yet. In this paper, we aimed to evaluate the serum levels of lipid hydroperoxide (LOOH), paraoxonase, and arylesterase in GAD patients without any co-morbid psychiatric disorders and investigate their diagnostic performance. Blood samples were collected from 40 GAD patients and 40 healthy control subjects to measure their serum LOON levels, arylesterase and paraoxonase activities. Obtained results have been compared between groups and receiver operating characteristic (ROC) curve has been drawn for diagnostic performance of measured biochemical markers. Positive and negative predictive values have been estimated where appropriate. Mean LOOH level of the GAD patients was significantly higher than that of control subjects (t=-549, p<0.001), whereas, mean paraoxonase activity was lower in these patients (t=3.056, p=003), GAD could be predicted for LOON level over 7.740 mu mol/l with 92.5% positive predictive value and 92% negative predictive value. Increased LOON level and decreased paraoxonase activity of GAD patients may suggest increased lipid peroxidation and oxidative stress in these patients. LOON levels may be a state marker for diagnosing GAD. (C) 2013 Elsevier B.V. All rights reserved.