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Alt ekstremite amputasyonlu hastalarda uyku kalitesi ve ilişkili faktörlerin değerlendirilmesi
(Türkiye Fiziksel Tıp ve Rehabilitasyon Derneği, 2015) Em, Serda; Batmaz, İbrahim; Karakoç, Mehmet; Aydın, Abdulkadir; Bozkurt, Mehtap; Çağlayan, Mehmet; Nas, Kemal
Amaç: Alt ekstremite amputasyonlu (AEA) hastalarda uyku kalitesini değerlendirmek ve uyku bozukluğu ile ilişkili faktörleri belirlemektir.Gereç ve Yöntemler: Bu çalışmaya AEA'lı 35 hasta ve 35 sağlıklı kontrol alındı. Çalışma grubunun demografik verileri kaydedildi. Uyku kalitesi Pittsburgh Uyku Kalitesi İndeksi (PUKİ) ile değerlendirildi. Amputasyonla ilişkili ağrı, Vizüel Analog Skala kullanılarak ölçüldü. Psikolojik durum Beck Depresyon Ölçeği (BDÖ) ve Beck Anksiyete Ölçeği (BAÖ) ile değerlendirildi.Bulgular: Hastalarda PUKİ'nin uyku süresi alt skoru dışında tüm alt skorları ve total skoru kontrol grubuna göre anlamlı olarak yüksekti. Total PUKİ skoru ile BDÖ (p<0,05) ve BAÖ (p<0,01) skoru korele idi. Multipl regresyon analizi ile yaş ve anksiyetenin uyku kalitesini belirlemede en önemli faktörler olduğu gösterildi (p<0,05). Sonuç: Çalışmamız kontrol grubuna göre AEA'lı hastalarının uyku kalitesinde bozulma olduğunu ve buna ek olarak yaş ve emosyonel durumun uyku kalitesiyle ilişkili olduğunu gösterdi. Bu nedenle ileri yaşta ve emosyonel durumu bozuk olan hastalarda çok yönlü tedavi yaklaşımları uyku bozukluğunu gidermek için gereklidir. Ancak uyku bozukluğunun nedenlerini ve genel sağlık üzerine etkilerini gösteren daha fazla hasta ile yapılmış ileri çalışmalara ihtiyaç vardır.
Ankilozan spondilitli hastalarda komorbit hastalıkların değerlendirmesi
(Dicle Üniversitesi Tıp Fakültesi, 2014) Em, Serda; Bozkurt, Mehtap; Çağlayan, Mehmet; Oktayoğlu, Pelin; Karakoç, Mehmet; Nas, Kemal
Amaç: Bu çalışmanın amacı ankilozan spondilit (AS) hastalarında komorbit hastalıkları ve bulunma oranlarını belirlemektir. Yöntemler: Bu çalışmaya 70 AS’li hasta, 70 romatoid artritli (RA) hasta ve 70 sağlıklı kontrol alındı. Demografik ve klinik özellikler kaydedildi. Tüm gruplar hipertansiyon, Aterosklerotik Kalp Hastalığı (ASKH), kalp yetmezliği, tiroid hastalıkları, akciğer hastalıkları, Tip2 diyabet ve serebrovasküler olay (SVO) açısından sorgulandı ve daha kapsamlı bilgi elde etmek için hasta kayıtları retrospektif olarak incelendi. Bulgular: Hasta ve kontrol grupları yaş, boy ve kilo bakımından benzerdi. AS’li hastalarda hipertansiyon görülme sıklığı, sağlıklı kontrollerden anlamlı olarak yüksekti (p<0.05). Fakat AS ve RA hastaları hipertansiyon açısından karşılaştırıldığında böyle bir farklılık gözlenmedi (p>0.05). AS ve RA’lı hastalarda ASKH ve kalp yetmezliği görülme sıklığı benzerdi ve AS hastaları kontrol grupları ile karşılaştırıldığında anlamlı farklılık yoktu. AS’li hastalarda tiroid hastalıkları %12.8 olarak görülürken, Tip2 diyabet sıklığı %11.4 idi ve sağlıklı kontrollerle AS hastaları karşılaştırıldığında bu iki hastalık açısından iki grup arasındaki fark anlamlıydı (p<0.05). Sonuç: AS’li hastalarda, sağlıklı kontrollere göre hipertansiyon, tiroid hastalıkları ve diyabet görülme sıklığı anlamlı derecede yüksekti. Ancak RA’lı hastalar ve AS’li hastalar arasında komorbit hastalık açısından anlamlı fark tespit edilmedi.
Assessment of Hand Functions in Patients with Chronic Hepatitis B
(Aves, 2014) Oktayoglu, Pelin; Tekin, Recep; Caglayan, Mehmet; Bozkurt, Mehtap; Em, Serda; Yildiz, Mehmet; Ucmak, Feyzullah
Objective: Motor dysfunction is an important clinical finding in patients with liver cirrhosis (LC), but there is no study assessing fine motor coordination in patients with chronic hepatitis B (CHB). We aimed to investigate hand functions and fingertip dexterity in patients with CHB. Materials and Methods: A total of 17 female and 15 male patients diagnosed with CHB without histopathological findings of cirrhosis were enrolled to the study; 21 female and 9 male healthy volunteers were included as a control group. Hand grip strength was assessed by Jamar hand dynamometer. Three kinds of pinch strength of fingers were assessed by Jamar pinchmeter. Functional status was evaluated by using the Stanford Health Assessment Questionnaire (HAQ). Duruoz Hand Index (DHI) was used to assess the hand functions. Fingertip dexterity was evaluated by Purdue pegboard test. Results: Bilateral hand grip strength and pinch strength were not statistically different from controls (p>0.05). There was also no significant difference between the categories of the Purdue pegboard test between the groups. HAQ scores of patients were higher than controls (p< 0.05). Conclusion: Hand functions are not influenced in patients with CHB. Disruptions in the functional status of patients with CHB may be due to fatigue and depression, which are usually seen in chronic liver diseases.
Assessment of Serum S100 Protein Levels in Patients with Fibromyalgia
(Clinical & Exper Rheumatology, 2014) Cavas, Husamettin; Oktayoglu, Pelin; Verim, Sabahattin; Em, Serda; Caglayan, Mehmet; Bozkurt, Mehtap; Yildiz, Ismail
[Abstract Not Available]
Assessment of sexual function and quality of life in patients with lower limb amputations
(Ios Press, 2019) Em, Serda; Karakoc, Mehmet; Sariyildiz, Mustafa Akif; Bozkurt, Mehtap; Aydin, Abdulkadir; Cevik, Remzi; Nas, Kemal
BACKGROUND: Diseases causing disabilities lead to sexual dysfunction. However, studies that evaluate sexual functions in patients with traumatic lower limb amputations (LLA) are limited and controversial. OBJECTIVE: The objective is to evaluate sexual functions in male patients with LLA and to identify factors that might contribute to sexual dysfunction. The hypothesis is that male patients with LLA would experience worse sexual and emotional functioning and consequently emotional impairment that consequently influenced the sexual function. METHODS: Sixty men with traumatic LLA and 60 healthy men were assessed according to the International Index of Erectile Function (IIEF) scoring system. Emotional state was assessed by the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), and the quality of life by the Short Form-36 Health Survey (SF-36). RESULTS: Patients had significantly lower scores in the IIEF total score and subscores in comparison with the controls. Intercourse satisfaction scores were significantly higher (p < 0.05) in patients with trans-tibial amputation than in those with trans-femoral amputation. BDI and BAI scores negatively correlated with erectile function, sexual desire, intercourse satisfaction, overall satisfaction and total IIEF scores. The mental and physical scores of SF-36 significantly correlated with some of the sub scores and IIEF total scores. The power of statistical analysis for study population was 100% according to the given effect size (alpha = 0.01). CONCLUSION: The present study suggests that the LLA leads to impairments in the sexual function and quality of life in male patients. Also, sexual dysfunction in patients is strongly associated with emotional state, pain, level of amputation and quality of life.
Association Between Neuropathic Pain, Pregabalin Treatment, and Erectile Dysfunction
(Wiley-Blackwell, 2014) Bozkurt, Mehtap; Gocmez, Cuneyt; Soylemez, Haluk; Daggulli, Mansur; Em, Serda; Yildiz, Mehmet; Atar, Murat
Introduction. The pathophysiology of erectile dysfunction (ED) may be vasculogenic, hormonal, anatomical, neurogenic, drug-induced and/or psychogenic in origin. Neuropathic pain (NP) may facilitate ED, because it is frequently associated with anxiety, depression, and its drug, pregabalin, may also contribute ED. Aim. The objective of this study was to determine whether pregabalin treatment for patients with neuropathic pain promotes erectile dysfunction. Methods. The study sample consisted of a total of 102 male subjects that were subdivided into three groups. Group 1 patients (n = 31) had a pre-existing diagnosis of NP and was treated with 300 mg/day of pregabalin for at least 3 months. Group 2 patients (n = 34) were diagnosed with NP for at least 3 months; however, neither were they treated with pregabalin nor did they received physical therapy throughout the study. Lastly, healthy age-matched control subjects comprised group 3 (n = 37). Main Outcome Measures. Patients in all groups completed the International Index for Erectile Function (IIEF) questionnaire. Results. Mean age and mean body mass index did not differ significantly between each of the three groups. The cause of NP and the mean duration of having a diagnosis of NP did not differ significantly in groups 1 and 2. However, IIEF scores were significantly lower for group 1 when compared to group 2 in terms of erectile function, orgasmic function, overall satisfaction and total score. Yet groups 1 and 2 did not diverge significantly in the intercourse satisfaction and sexual desire scores. Overall IIEF scores for group 3 were significantly higher than those of group 2 except for mean erectile function scores. Conclusion. Taking pregabalin for the treatment of neuropathic pain poses an increased risk for developing ED in male patients. Thus, clinicians prescribing pregabalin to patients diagnosed with neuropathic pain should assess for ED before and during treatment with this medication.
Association of pain and clinical factors on disability and quality of life in systemic sclerosis: A cross-sectional study from Turkish League Against Rheumatism Network
(Bayçınar Tıbbi Yayıncılık, 2023) Çevik, Remzi; Em, Serda; Nas, Kemal; Toprak, Murat; Cengiz, Gizem; Çalış, Mustafa; Sezer, İlhan; Enginar, Ayşe Ünal; Karslı, Pınar Bora; Sağ, Sinem; Sargın, Betül; Melikoğlu, Meltem Alkan; Aydın, Yıldıray; Duruöz, Mehmet Tuncay; Gezer, Halise Hande; Ecesoy, Hilal
Objectives: In this study, we aimed to evaluate the factors associated with disability and quality of life (QoL) in Turkish patients with systemic sclerosis (SSc). Patients and methods: Between January 2018 and January 2019, a total of 256 SSc patients (20 males, 236 females; mean age: 50.9±12.4 years; range, 19 to 87 years) who were diagnosed with SSc were included in the study. Disability and health-related QoL (HRQoL) were evaluated by the Health Assessment Questionnaire (HAQ), scleroderma HAQ (SHAQ), Duruöz Hand Index (DHI), and Short Form-36 (SF-36). Linear regression analysis methods were used to describe factors associated with disability and QoL of the patients. Results: All disability scores were higher and HRQoL scores were lower in diffuse cutaneous SSc patients compared limited cutaneous SSc, and differentiations were significant (p=0.001 and p=0.007). In multiple regression, pain (VAS) was the strongest predictor for high disability and low QoL scores (p<0.001) as HAQ (β=0.397, 0.386, 0.452), SHAQ (β=0.397, 0.448, 0.372), DHI (β=0.446, 0.536, 0.389), PCS (β=-0.417,-0.499, -0.408) and MCS (β=-0.478, -0.441, -0.370) in combined, lcSSc and dcSSc patients respectively. The factors associated with high disability and low QoL scores were forced vital capacity for HAQ (β=-0.172, p=0.002) and SF-36 PCS (β=0.187, p=0.001); disease duration for HAQ (β=0.208, p<0.001), DHI (β=0.147, p=0.006), and SF-36 PCS (β=-0.134, p=0.014); 6-minute walk test for HAQ (β=-0.161, p=0.005) and SF-36 PCS (β=0.153, p=0.009); and modified Rodnan skin score for SHAQ (β=0.250, p<0.001) and DHI (β=0.233, p<0.001) in SSc patients. Diffusing capacity of the lungs for carbon monoxide for HAQ (β=-0.189, p=0.010) and SHAQ (β=-0.247, p=0.002); erythrocyte sedimentation rate for DHI (β=0.322, p<0.001); age for SF-36 PCS (β=-0.221, p=0.003) and body mass index for SF-36 PCS (β=-0.200, p=0.008) and MCS (β=-0.175, p=0.034) were the other variables associated with high disability or low QoL scores in SSc subsets. Conclusion: Clinicians should consider the management of the pain and its sources as a key to improve better functional state and quality of daily life in SSc.
Benign eklem hipermobilite sendromlu hastalarda emosyonel durum ve ilişkili faktörler
(Dicle Üniversitesi Tıp Fakültesi, 2014) Em, Serda; Çağlayan, Mehmet; Oktayoğlu, Pelin; Bozkurt, Mehtap; Ceylan, Veysi; Nas, Kemal
Amaç: Benign eklem hipermobilite sendromlu (BEHS) hastalarda emosyonel durumu değerlendirmek ve emosyonel durum üzerine etkili hastalıkla ilgili faktörleri belirlemektir. Yöntemler: Beighton tanı kriterlerine göre BEHS tanısı konan 63 kadın hasta ve 60 sağlıklı kontrol bu çalışmaya dahil edildi. Hastalar sorgulandıktan sonra kas-iskelet sistem muayeneleri yapılarak elde edilen bulgular kaydedildi. Hastaların kronik ağrılarını değerlendirmek için Vizüel Analog skala (VAS) kullanıldı. BEHS’li hastalar ve kontrollerin anksiyete ve depresyon durumları Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) ile değerlendirildi. Bulgular: Hasta ve kontrol grubu, yaş ortalaması bakımından benzerdi. Hastaların Beighton toplam skor ortalaması (6.64 ± 1.28) kontrol grubundan (0.65±0.86) anlamlı olarak yüksekti (p<0.001). Ortalama anksiyete ve depresyon oranları açısından hasta ve kontroller arasındaki fark anlamlıydı (sırasıyla, p<0.05; p<0.01). HADÖ anksiyete skoru, hem Beighton skoru ile hem de VAS ağrı skoru ile korele iken, depresyon skoru sadece VAS ağrı skoru ile ilişkiliydi. Sonuç: BEHS’li hastalarda, sağlıklı kontrollere göre anksiyete ve depresyon oranı anlamlı derecede yüksekti. Aynı zamanda hastalardaki hipermobilite derecesi ve ağrı şiddeti ile emosyonel durum arasında bir ilişki vardı. Bu nedenle BEHS’li hastaların takip ve tedavisinde emosyonel durum göz önüne alınmalıdır
Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats
(Canadian Soc Clinical Investigation, 2014) Bozkurt, Mehtap; Em, Serda; Oktayoglu, Pelin; Turkcu, Gul; Yuksel, Hatice; Sariyildiz, Mustafa A.; Caglayan, Mehmet
Purpose: The purpose of this study was to investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced renal damage in rats. Methods: Twenty-four male rats were equally divided into three groups: group I, control treatment; group II, MTX-treated; and group III, MTX+CAR-treated. A single dose of CAR (73 mg/kg) was administered intraperitoneally to group III on the first day of the experiment and a single dose of MTX (20 mg/kg) was administered intraperitoneally to groups II and III on the second day of the experiment. Blood samples and kidney tissue were obtained from each animal on day 8 for the measurement of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). Light microscopy was used for histopathological examination of kidney specimens. Results: MDA, TOS and OSI levels were significantly greater in the group receiving MTX alone relative to the control animals, while the TAS level was significantly reduced in the MTX group compared with the control group. The administration of CAR was associated with signicantly decreased MDA, TOS, and OSI levels and increased TAS levels relative to the rats treated with MTX alone. Animals treated with CAR exhibited decreased tubular degeneration and architectural impairment relative to animals treated with MTX alone; however, the difference in histological scores did not meet the threshold of statistical significance. Conclusions: MTX treatment results in oxidative damage to the rat kidney; damage which is partially abrogated by the administration of CAR.
Clinical and molecular evaluation of MEFV gene variants in the Turkish population: a study by the National Genetics Consortium
(Springer Heidelberg, 2022) Dündar, Munis; Fahrioğlu, Umut; Yıldız, Saliha Handan; Güngör, Burcu Bakır; Temel, Sehime Gülsün; Akın, Haluk; Tekeş, Selahaddin; Üzel, Veysiye Hülya; Em, Serda
Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. loss-of-function), and inheritance. In this study, MEFV gene analysis results and clinical findings of 27,504 patients from 35 universities and institutions in Turkey and Northern Cyprus are combined in an effort to provide a better insight into the genotype-phenotype correlation and how a specific variant contributes to certain clinical findings in FMF patients. Our results may help better understand this complex disease and how the genotype may sometimes contribute to phenotype. Unlike many studies in the literature, our study investigated a broader symptomatic spectrum and the relationship between the genotype and phenotype data. In this sense, we aimed to guide all clinicians and academicians who work in this field to better establish a comprehensive data set for the patients. One of the biggest messages of our study is that lack of uniformity in some clinical and demographic data of participants may become an obstacle in approaching FMF patients and understanding this complex disease.
Comparison of the Efficacy of Phonophoresis and Conventional Ultrasound Therapy in Patients with Primary Knee Osteoarthritis
(Erciyes Univ Sch Medicine, 2014) Oktayoglu, Pelin; Gur, Ali; Yardimeden, Ibrahim; Caglayan, Mehmet; Cevik, Figen; Bozkurt, Mehtap; Em, Serda
Objective: To compare the efficacy of phonophoresis (PH) versus ultrasound (US) in patients with primary knee osteoarthritis (OA). Materials and Methods: Forty patients were divided into two groups as PH and US. Acoustic gel containing no pharmacological agent was applied in the US group, whereas a gel containing 1.16% diclofenac diethylamonium was applied in the PH group for 10 sessions. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale and Visual Analogue Scale (VAS) were used for the assessment of pain. The WOMAC physical function subscale, Lequesne functional index and Stanford Health Assessment Questionnaire (HAQ) were used for the assessment of physical activities. Patients were assessed for a 3 month follow-up period. Results: In the PH group, painless walking duration improved at all follow-up times except for week 2 (p< 0.05). Painless walking distance and VAS scores also improved at all follow-up times (p< 0.05). In the US group, VAS scores during walking and flexion of the knee, WOMAC pain and physical function scores and total WOMAC scores improved significantly at all follow-up times (p< 0.05). Conclusion: Both therapeutic modalities were found effective. We suggest neither therapy is superior to the other but PH can improve painless walking duration more successfully than US.
Determining quality of life and associated factors in patients with stroke
(Turkish Society of Physical Medicine and Rehabilitation, 2015) Em, Serda; Bozkurt, Mehtap; Karakoç, Mehmet; Çağlayan, Mehmet; Akdeniz, Dicle; Oktayoğlu, Pelin; Varol, Sefer; Nas, Kemal
Objective: This study aims to examine the overall and domain-specific quality of life in patients with stroke and to identify variables predicting quality of life after stroke. Material and Methods: A total of 104 patients with sufficient cognitive functions having hemiplegia because of cerebrovascular accident and 108 controls were included in this study. Demographic and clinical features were recorded. The Barthel Index (BI) and Functional Ambulation Category scale were employed to assess the functional state of patients. Quality of life was evaluated by the Short Form 36 (SF-36) health survey, whereas the emotional state of the patients was evaluated by the Hospital Anxiety and Depression Scale (HADS). Functional status, motor impairment, and emotional state were determined as independent variables, and multiple regression analysis was used to predict quality of life. Results: Patients had significantly lower scores in the quality of life subscores and total scores in comparison with the controls (p<0.001). The mean anxiety and depression rates in the patients were significantly higher than those in controls (p<0.001). The sum of subscores and physical composite score of SF-36 were significantly lower in female and illiterate patients than in male and educated patients. Multiple regression analyses indicated that HADS depression was associated with mental health (p<0.001), whereas BI was independently associated with the physical health total score (p<0.05). The power of the statistical analysis for study population was 100% according to the given effect size (α=0.01). Conclusion: Present results demonstrated that patients with stroke have a significantly poor quality of life than the general population. The reduced quality of life after stroke appears to be related the emotional state, physical disability, and demographic properties such as gender and education. Therefore, prevention of disability and early diagnosis and treatment of depression are vital in improving the quality of life of patients with stroke.
Effects of lumbosacral angles on development of low back pain
(Journal Of Musculoskeletal Pain, 2014) Çağlayan, Mehmet; Tacar, Orhan; Demirant, Ayda; Oktayoğlu, Pelin; Karakoç, Mehmet; Çetin, Abdurrahman; Em, Serda; Bozkurt, Mehtap; Uçar, Demet; Nas, Kemal
Objective: Low back pain [LBP] is an important health issue due the diagnosis and treatment expenses and loss of workforce it leads to. Biomechanical changes in the vertebral column caused by changes in the lumbosacral angles [LSAs] may lead to LBP. The purpose of this study was to assess body mass index [BMI] and LSAs in patients with LBP and investigate the association between LBP, LSAs and BMI. Methods: Lumbar lordotic angle [LLA], LSA, sacro-horizontal angle [SHA] and sacral inclination angle [SIA] were measured in 117 patients with chronic LBP and 85 healthy normal controls [HNCs] by means of lumbosacral radiography. In addition, association between LSAs, BMI and LBP was investigated. Results: There were no significant differences between patients and HNCs regarding LSAs and BMI. LLA was lower in male patients with LBP compared to male HNCs without LBP [p = 0.013]. In addition, SIA [p = 0.002] and BMI [p = 0.006] were higher in female patients with LBP compared to male patients with LBP. It was found that an increase in LLA increased the risk of having LPB by approximately 1.04-folds [ranging from 1.01 to 1.08; p = 0.045]. On the other hand, no association was found between LSAs and BMI. Conclusion: Changes in LSAs may cause LBP. An increase in LLA may be influential in increasing the risk of LBP. Therefore, measurement of LSAs may guide the physician who is to make clinical decisions in examination of patients with LBP.
Effects of the use of conventional versus computer-aided design/computer-aided manufacturing sockets on clinical characteristics and quality of life of transfemoral amputees
(Derman Medical Publ, 2019) Aydin, Abdulkadir; Atic, Ramazan; Aydin, Zekiye Sevinc; Alemdar, Celil; Karakoc, Mehmet; Nas, Kemal; Em, Serda
Aim: Amputee mobilisation requires prosthetic device use regardless of the amputation level and type. The socket is the most important part of the prosthesis and is manufactured by conventional methods worldwide. Recently, computer-aided design/computer-aided manufacturing systems have been frequently used in Europe and the United States for socket design. Use of the computer-aided design/computer-aided manufacturing method for socket production is increasing day by day. Are the sockets produced by this method advantageous or disadvantageous for amputees compared to the sockets produced by the conventional method? These results will provide guidance for units and centres that produce both above-knee and below-knee prostheses. For this purpose, we investigated whether there are differences between amputees fitted with conventional sockets and those fitted with computer-aided design/computer-aided manufacturing sockets in terms of their clinical characteristics and quality of life. Material and Method: In total, 56 patients, 28 fitted with a conventional socket (CS group) and 28 fitted with a computer-aided design/computer-aided manufacturing socket (CAD/CAM group), were included in the study. The duration of daily prosthetic use, walking time with the prosthesis, walking distance with the prosthesis, walking time with the prosthesis without pain, time of adaptation to the prosthesis, causes of amputation, and manufacturing and fitting time of the prosthesis were investigated. Quality of life was evaluated using the 36-item Short-Form Health Survey (SF-36) and Turkish version of the Trinity Amputation and Prosthesis Experience Scales (TAPES). Pain was evaluated using the visual analogue scale (VAS). Results: General and mental health statuses were somewhat better in the CAD/CAM group. Results were more favourable in the CAD/CAM group for the other items of the Short-Form 36 (SF-36) questionnaire (p > 0.05). The CAD/CAM group performed better in restriction of activity subscale (p m 0.012). There were no statistically significant differences between the groups regarding other parameters of TAPES (p > 0.05). The daily walking time with the prosthesis was higher in the CAD/CAM group than in the CS group (statistically significant; p = 0.020). The manufacturing and fitting time of the prosthesis was significantly different between the CAD/CAM and CS groups (p = 0.017). The VAS pain score was significantly lower in the CAD/ CAM group (p < 0001). Discussion: Prosthetic sockets manufactured for above-knee amputees using the CAD/CAM method yielded some better outcomes than those manufactured with conventional methods in terms of quality of life.
Efficiency of pulsed electromagnetic fields on pain, disability, anxiety, depression, and quality of life in patients with cervical disc herniation: A randomized controlled study
(Turkiye Klinikleri, 2019) Hattapoğlu, Erkam; Batmaz, İbrahim; Dilek, Banu; Karakoç, Mehmet; Em, Serda; Çevık, Remzi
Background/aim: In this study, it was aimed to investigate the effects of pulsed electromagnetic field (PEMF) therapy on pain, disability, psychological state, and quality of life in cervical disc herniation. Materials and methods: Patients were randomly divided into two groups, including Group 1, which received a therapy consisting of transcutaneous electrical nerve stimulation (TENS), hot pack (HP), and PEMF, and Group 2, which received a magnetic field (sham magnetic field) without current flow in addition to TENS and HP therapy. Pain was assessed by a visual analog scale (VAS, 0–10 cm). The other outcome measures were function (Neck Pain and Disability Scale), anxiety-depressive mood (Hospital Anxiety and Depression Scale), and quality of life (Nottingham Health Profile). All evaluations were performed at baseline, in the 3rd week, and in the 12th week after treatment. Results: A significant improvement was found in the neck pain, disability, depression, anxiety, and quality of life scores of both groups after treatment when compared to those before treatment. However, in the comparison between changes within groups, significant improvements were determined only in the VAS and Nottingham Health Profile sleep subparameter in the 12th week after treatment compared to those before treatment. Conclusion: PEMF therapy in cervical disc herniation can be used safely in routine treatment in addition to conventional physical therapy modalities
Elevated serum levels of calprotectin (MRP8/MRP14) in patients with Behcet's disease and its association with disease activity and quality of life
(Taylor & Francis Ltd, 2015) Oktayoglu, Pelin; Mete, Nuriye; Caglayan, Mehmet; Bozkurt, Mehtap; Bozan, Turgut; Em, Serda; Nas, Kemal
Background. Behcet's disease (BD) is an inflammatory disease with multisystem chronic vasculitis. The disease is characterized by attacks of oral and genital ulcerations, skin lesions, arthritis, uveitis and deep vein thrombosis. The main histopathological feature is known to be vascular inflammatory change. Calprotectin (MRP8/MRP14) has been identified as an important alarmin that is expressed by activated phagocytes, granulocytes, monocytes and vascular endothelial cells, recognized by toll-like receptors, and induces a thrombogenic and inflammatory response in human microvascular endothelial cells. Aim. We aimed to investigate the serum levels of calprotectin in patients with BD and its association with disease activity and quality of life. Materials and methods. Forty-eight patients (25 males and 23 females) and 47 healthy controls (29 males and 18 females) were included to study. BD Current Activity Form (BDCAF) was used to assess the disease activity of patients with BD. Quality of life was assessed by using the Nottingham Health Profile (NHP). Depression and anxiety symptoms were assessed by using the Hospital Anxiety and Depression Scale (HADS). Serum level of calprotectin was determined using an ELISA kit. Results. Serum levels of calprotectin was significantly higher in patients with BD compared to healthy controls (p = 0.001). Serum levels of calprotectin did not correlate with the sores of BDCAF, NHP and HADS. Conclusion. Calprotectin may play a significant role in the pathogenetic mechanisms of BD. Further insight into this area of research might provide opportunities to develop novel treatment strategies.
Elevated Serum Levels of Calprotectin (Myeloid-Related Protein 8/14) in Patients With Ankylosing Spondylitis and Its Association With Disease Activity and Quality of Life
(Lippincott Williams & Wilkins, 2014) Oktayoglu, Pelin; Bozkurt, Mehtap; Mete, Nuriye; Caglayan, Mehmet; Em, Serda; Nas, Kemal
Background: Calprotectin is one of the major leukocyte S100 proteins showing both calcium binding and antimicrobial characteristics. The serum level of calprotectin is markedly elevated in patients with inflammatory bowel disease, rheumatoid arthritis, as well as systemic lupus erythematosus and has been suggested to play a prominent role in both progression and pathogenesis of these diseases. Aim: The purpose of this study was to investigate the serum level of calprotectin in patients with ankylosing spondylitis (AS) and its association with disease activity and other clinical characteristics of AS. Materials and Methods: Thirty-one patients who met the modified New York criteria for AS and 45 healthy controls were included in this study. Both Bath AS disease activity index and AS disease activity score were applied on the patients with AS for the assessment of disease activity; Bath AS functional index, for the assessment of functional activity; Bath AS radiology index, for the assessment of radiological damage; and the AS quality of life questionnaire for the assessment of disease-related life status. Spinal and hip measurements were performed using Bath AS metrology index. The serum level of calprotectin was determined using enzyme-linked immunosorbent assay kit. Results: Mean serum level of calprotectin was significantly higher in the patients with AS compared with healthy controls (P = 0.003). Serum levels of calprotectin did not correlate with Bath AS disease activity index, AS disease activity score, Bath AS functional index, Bath AS radiology index, Bath AS metrology index, modified Schober, chest expansion, AS quality of life questionnaire, erythrocyte sedimentation rate, and C-reactive protein values (P > 0.05). Conclusions: Our results suggest that calprotectin might play an important role in the pathogenetic mechanisms of AS; however, the calprotectin levels did not correlate with the measurements of disease activity, functional abilities, radiological damage, and the quality of life in these patients. Further insight into this area of research might provide opportunities to develop novel treatment strategies, which take into account the role of these peptides in the pathogenetic mechanisms of AS.
Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life
(Springer Heidelberg, 2013) Oktayoglu, Pelin; Em, Serda; Tahtasiz, Mehmet; Bozkurt, Mehtap; Ucar, Demet; Yazmalar, Levent; Nas, Kemal
This study was carried out to determine the serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis (AS) and to evaluate its correlation with disease activity and quality of life. According to our knowledge, it is the first trial evaluating HMGB1 levels in AS. Serum samples of 30 patients (18 males and 12 females) with AS and 29 healthy controls (HC) (15 females and 14 males) were collected. HMGB1 levels were measured by enzyme-linked immunosorbent assay, activity of disease was assessed according to the Bath AS Disease Activity Index (BASDAI), and functional status of patients was evaluated with Bath AS Functional Index (BASFI). Modified Schober, chest expansion values and AS Quality of Life Questionnaire (ASQoL) scores were noted. The serum levels of HMGB1 were obtained significantly increased in AS patients compared to HC (p < 0.05). There was no significant correlation between HMGB1 levels and ESR (p > 0.05), and CRP (p > 0.05) values. BASDAI, BASFI and ASQoL scores were also not correlated with serum levels of HMGB1 (p > 0.05). Our results suggest that HMGB1 might play an important role in the pathogenesis of AS; however, it seems not to be a good candidate for reflecting disease activity, functional abilities and the quality of life in patients with AS; on the other hand, the increased levels of HMGB1 in patients may open a new dimension for targeting this cytokine as a new therapy option in AS.
Evaluation of hearing loss in patients with ankylosing spondylitis
(Aves Yayıncılık, 2014) Bozkurt, Mehtap; Çağlayan, Mehmet; Uçar, Demet; Oktayoğlu, Pelin; Em, Serda; Gün, Ramazan; Gür, Ali; Nas, Kemal
Materials and Methods: A total of 50 AS patients and 34 healthy controls were enrolled into the study. Physical examinations and disease activity score measurements were performed in patients with AS. Results: The mean age was 32.20 years (18-55) in AS patients and 35.58 (20-50) in the control group. The mean disease duration was 5.27 years (0-22) in patients with AS. Hearing loss was detected in seven (14%) of the AS patients and three (8.8%) of the control patients. In terms of hearing loss, a statistically signifcant difference was not found between the two groups. Sensorineural hearing loss was the most commonly detected type of hearing loss in the two groups. Hearing loss was present in two (28.5%) of the seven AS patients in whom the duration of disease was more than 10 years. There was no statistically signifcant correlation between the duration of disease and hearing loss. Conclusion: There was no signifcant difference between the AS and control groups with respect to hearing loss. The rate of hearing loss increased in line with the duration of disease. Objective: The aim of this study was to evaluate the rate of hearing loss in patients with ankylosing spondylitis (AS) and to analyze whether the rates of hearing loss were different from the control group or not.
Evaluation of the incidence of haemorrhoidal disease in patients with ankylosing spondylitis
(Springer London Ltd, 2015) Caglayan, Mehmet; Turkoglu, Ahmet; Oktayoglu, Pelin; Yildiz, Mehmet; Dagli, Abdullah Zubeyir; Boyuk, Abdullah; Em, Serda
Haemorrhoidal disease (HD) is one of the most common diseases encountered by the clinicians of general surgery. Chronic constipation, pushing during defecation and increased abdominal pressure play an important role in development of haemorrhoidal disease. Patients with ankylosing spondylitis (AS) frequently use the Valsalva manoeuvre in their daily lives, which may increase the abdominal pressure, leading to formation of haemorrhoids. The purpose of this study was to evaluate the incidence of haemorrhoidal disease in patients with AS. A total of 221 individuals were included in this study in three groups as follows: 72 patients with ankylosing spondylitis (AS), 75 patients with chronic low back pain (LBP) and 74 healthy control subjects. Patients were examined both physically and anoscopically, and their histories were taken. The incidence of HD was 45.8 % in patients with AS, 16 % in patients with chronic LBP and 9.5 % in healthy control subjects. The incidence of HD was significantly higher in patients with AS compared to the other groups. Patients with AS have a high incidence of HD, which should be taken into consideration by clinicians during routine examination of these patients.

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