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Öğe The effect of educational level on bone mineral density in postmenopausal women(Elsevier Science Inc, 2003) Gur, A; Sarac, AJ; Nas, K; Cevik, R; Ataoglu, S; Em, S[Abstract Not Available]Öğe Hypothalamic-pituitary-gonadal axis and cortisol in young females with fibromyalgia: The potential roles of depression, fatigue and sleep disturbance in the occurrence of hypocortisolism(B M J Publishing Group, 2003) Gur, A; Cevik, R; Nas, K; Acar, S; Sarac, AJ; Em, S[Abstract Not Available]Öğe Hypothalamic-pituitary-gonadal axis and cortisol in young women with primary fibromyalgia: the potential roles of depression, fatigue, and sleep disturbance in the occurrence of hypocortisolism(Bmj Publishing Group, 2004) Gur, A; Cevik, R; Sarac, AJ; Colpan, L; Em, SObjectives: To investigate abnormalities of the hypothalamic-pituitary-gonadal (HPG) axis and cortisol concentrations in young women with primary fibromyalgia ( FM); and to determine whether depression, fatigue, and sleep disturbance affect these hormones. Methods: Follicle stimulating hormone (FSH), luteinising hormone (LH), oestradiol, progesterone, prolactin, and cortisol concentrations in 63 women with FM were compared with those in 38 matched healthy controls; all subjects aged <35 years. The depression rate was assessed by the Beck Depression Inventory (BDI) and patients with high and low BDI scores were compared. Additionally, patients were divided according to sleep disturbance and fatigue and compared both with healthy controls and within the group. Results: No significant differences in FSH, LH, oestradiol, prolactin, and progesterone levels were found between patients with FM and controls, but cortisol levels were significantly lower in patients than in controls (p < 0.05). Cortisol levels in patients with high BDI scores, fatigue, and sleep disturbance were significantly lower than in controls (p < 0.05). Correlation between cortisol levels and number of tender points in all patients was significant (r = -0.32, p < 0.05). Conclusion: Despite low cortisol concentrations in young women with FM, there is no abnormality in HPG axis hormones. Because fatigue, depression rate, sleep disturbance, and mean age of patients affect cortisol levels, these variables should be taken into account in future investigations.Öğe Hypothalamic-pituitary-gonadal axis hormones and cortisol, and effect of depression on these hormones in premenopausal women with chronic fatigue syndrome(B M J Publishing Group, 2003) Cevik, R; Gur, A; Nas, K; Acar, S; Sarac, J; Em, S[Abstract Not Available]Öğe Sex and thyroid hormone status in women with rheumatoid arthritis(Blackwell Publishing Ltd, 2004) Cevik, R; Em, S; Gur, A; Nas, K; Sarac, AJ; Çolpan, LThere has been considerable interest in the role of hormones in the aetiopathogenesis of rheumatoid arthritis (RA). In this study, we aimed to investigate sex and thyroid hormone conditions according to menopausal state and disease activation in RA women. Fifty-four women with RA were included in the study. Age-matched 28 women with low back pain were used as controls. Sex and thyroid hormones were evaluated in all patients, which included the measurement of estractiol (E-2), progesterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, thyroid-stimulating hormone (TSH), total (T) and free (F) triiodothyronine (T3) and (T) and (F) thyroxine (T4). The RA patients were subdivided according to their pre-menopausal and post-menopausal Status and their disease activation conditions. Mean age was 45.68 (+/-12.5) in women (aged 22-70) with RA;and 42.39 (+/-12.45) in controls (aged 22-62). There were no significant differences in sex hormones, but there were statistically significant higher levels of TT3 and TT4 in whole women with RA compared to controls. Lower concentrations of FSH were detected in active RA patients. There were statistically lower concentrations of LH and higher concentrations of TT3 and TT4 in pre-menopausal RA women, while lower concentrations of FSH were detected in post-menopausal RA women. TT3 and FT3 levels of pre-menopausal RA women were significantly higher than post-menopausal RA women. There were no significant differences for all other hormones studied. In conclusion, sex and thyroid hormones have been influenced in women with RA. Reproductive and menopausal conditions should be taken into consideration when sex and thyroid hormones studies are carried out in RA women.