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Öğe Ankilozan spondilitli hastalarda güncel tedavi yaklaşımları(Dicle Üniversitesi, 2015) Elbey, BilalAnkilozan spondilit (AS) başlıca sakroiliak eklemler ve omurgayı etkileyen kronik, inflamatuar bir romatizmal hastalık olarak, daha çok erkeklerde sıklıkla 2. ve 3. On yılda ortaya çıkan bir hastalıktır. AS’li hastalarda tedavinin temelini ağrı ve inflamasyonu azaltan nonsteroid anti-inflamatuar ilaçlar (NSAİİ) almaktadır. Modifiye edici antiromatizmal (DMARD) ilaçlar, AS hastalığın tedavisinde etkinliği kanıtlanamamıştır. DMARD’ların kullanımı semptomların iyileştirilmesinde yeterli bulunmamıştır. Son zamanlarda anti tümör nekrozis faktör (TNF) blokerleri olan Golimumab, Etanersept, Adalimumab, İnfliksimab gibi ajanlar AS tedavisinde umut verici sonuçlar vermektedir. TNF blokerleri AS hastalarının fiziksel işlevlerinde, yaşam kalitesinde ve semptomlarında iyileşme sağlamaktadır. Bu yazı AS’li hastaların güncel farmakolojik tedavisi üzerine odaklanmıştır.Öğe Ankilozan spondilitli hastalarda interlökin 23’ün klinik ve laboratuvar parametreleri ile ilişkisi(Dicle Üniversitesi, 2014) Elbey, BilalÖZET Ankilozan spondilit başlıca Sakroiliak eklemler ve omurgayı etkileyen kronik, inflamatuar bir romatizmal hastalıktır. Günümüzde AS?nin patogenezi ile ilgili araştırmalar; başlatıcı faktörlerin tanımlanması, hastalığın seyrinde gelişen olaylar, inflamasyon mediyatörleri ve hastalığın seyrinin düzenleyicileri üzerine yoğunlaşmıştır. Bu nedenle bu çalışmada; aksiyel iskeleti etkileyen, yapısal ve fonksiyonel yetersizlikle birlikte yaşam kalitesinde azalmaya yol açabilen, karakteristik inflamatuar bel ağrısına sebep olan yaygın romatizmal bir hastalık olan AS?li hastalarda IL-23?ün klinik ve laboratuar parametreleri ile ilişkisini araştırmak ve aynı zamanda AS?li hastalarda BASDAI ve BASFI?nin iki yanıtlama yönteminin performans karakteristiklerini karşılaştırmayı amaçladık. Bu çalışmaya Dicle Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı polikliniğine, 15Aralık2013-30 Mart 2014 tarihleri arasında başvuran, kronik bel ağrısı olan AS tanısı alan hastalar dahil edildi. Hasta ve kontrol grubunda yaş, cinsiyet, eğitim durumu gibi demografik verileri kaydedildi. Laboratuar bulgusu olarak ESH, CRP ve IL-23 değerleri kaydedildi. Hastaların fonksiyonel olarak değerlendirilmeleri için BASDAI, BASFI, VAS ve ASQoL ölçekleri kaydedildi. AS hastalarının IL-23 seviyeleri sağlıklı kontrollerle kıyaslandığında anlamlı olarak yüksek tespit edildi (p<0,05). Korelasyon analizinde IL-23 seviyeleri periferik artrit sayısı ve CRP seviyesi ile pozitif yönde ilişki göstermekteydi. Enteziti olan ve olmayan hastaların klinik ve laboratuar parametreleri karşılaştırıldığında Enteziti olan hastalarda BASDAI, BASFI ve VAS skorları Enteziti olmayanlara kıyasla anlamlı yüksekti (p<0,05). ASQoL skoru yüksek/düşük olan hastalarda AS?nin klinik ve laboratuar parametreleri (IL-23,ESH, CRP) karşılaştırıldığında ASQoL skoru yüksek olan hastalarda BASDAI, BASFI, VAS skorları anlamlı yüksekti (p<0,05). Labaratuar parametrelerindende ESH anlamlı yüksekti. Sonuç olarak Ankilozan Spondilitin progresif bir hastalık olduğunu, hastaların yaşam boyu izlenmesi gerektiğini, CRP ye göre daha pahalı olsa da IL- 23?ün de laboratuar bulgusu olarak kullanabileceğini ve BASDAI, BASFI, VAS ve XIII ASQol?ün bu izlemlerde faydalı olabileceğini söyleyebiliriz. Ayrıca tedavide IL-23 baskılanmasının ne kadar anlamlı olacağı mutlaka araştrılmalıdır. Anahtar Sözcükler: Ankilozan Spondilit, CRP, IL – 23,BASDAI, BASFI, VAS, ASQol XIV ABSTRACT Ankylosing spondylitis is a chronic, inflammatory, rheumatic disease that affects main sacroiliac joints and spine. Nowadays, researches about AS?s pathogenesis focus on defining major factors, incidents that develop during the disease, inflammation mediators and the regulatories of the course of disease. For this reason in this study we aimed to investigate relationship between IL-23 and clinical and laboratory parameters in patients who has a common rheumatic disease called AS, which affects axial skeleton, causes decrease in life quality as well as structural and functional inability and characteristic inflammatory backache. At the same time we aimed to compare performance characteristics of the two answering methods of BASDAI and BASFI in AS patients. In this study, diagnosed AS patients with chronic backache who applied at Dicle University Medical Faculty, Department of Physical Medicine and Rehabilitation, between December 15 2013 and March 2014, were included. The demografic information such as sex and educational status of both patient and control group is recorded. As a laboratory finding, ESH, CRP and IL-23 values are recorded. To evaluate patients functionally BASDAI, BASFI, VAS and ASQol scales are recorded. When AS patients? IL-23 levels are compared with healthy controls, it is reported significantly high (p<0,05). In the analysis of correlation, the IL-23 levels showed positive relationship with the number of peripheral artrit and CRP level. When compared the clinical and laboratory parameters of patients with enthesitis and patients without enthesitis, BASDAI, BASFI and VAS scores were significantly higher in patients with enthesitis than patients without enthesitis (p<0,05). When compared clinical and laboratory parameters of patients with high and low ASQol scores, it is observed that patients with high ASQol score had significantly high scores in BASDAI, BASFI and VAS (p<0,05). As a result, we can say that AS is a progressive disease, these patients need to be monitored throughout their life, although it is more expensive than CRP, IL-23 XV can also be used as a laboratory finding and BASDAI, BASFI, VAS and ASQol can be useful in this monitoring process. Key Words: Ankylosing spondylitis, CRP, IL -23, BASDAI, BASFI, VAS, ASQoLÖğe Anti-Oxidant and Anti-Inflammatory Activity of Nebivolol in L-Arginine-Induced Acute Pancreatitis: An Experimental Study on Rats(Wiley-Blackwell, 2015) Elbey, Bilal; Yazgan, Umit Can; Yilmaz, Ahmet; Ibiloglu, Ibrahim; Kaplan, Ibrahim; Baykal, Burhan; Yalinkilic, Ibrahim[Abstract Not Available]Öğe Caffeic acid phenethyl ester prevents fluoxetine-induced hepatotoxicity in rats(Wiley-Blackwell, 2015) Yilmaz, Ahmet; Elbey, Bilal; Yazgan, Umit Can; Turkoglu, Ahmet[Abstract Not Available]Öğe Comparison of the anti-diabetic effects of resveratrol, gliclazide and losartan in streptozotocin-induced experimental diabetes(Taylor & Francis Ltd, 2015) Yazgan, Umit Can; Tasdemir, Ezel; Bilgin, Hakki Murat; Obay, Basra Deniz; Sermet, Abdurrahman; Elbey, BilalAim: The aim of this study was to compare the effect of the resveratrol with gliclazide and losartan in streptozotocin induced diabetic rats. Materials and methods: Adult male Wistar albino rats were divided into five groups of seven rats each. Diabetes was induced with a single intraperitoneal (i.p.) injection of streptozotocin (55mg/kg). Rats with blood glucose levels above 250mg/dl after 48h of streptozotocin injection were included in the diabetic group. Gliclazide and resveratrol were administered for 3 weeks at 5mg/kg per day and losartan was administered for 3 weeks at 30mg/kg per day in an oral aqueous suspension. At the end of the third week all rats were euthanized and fasting blood glucose, HbA1c and the metabolic activity of the hepatic enzymes hexokinase and glucose-6 phosphate dehydrogenase were measured in tail blood and liver specimens. All parameters were quantified using an ELISA plate reader. Results: Resveratrol and gliclazide significantly reduced both blood glucose levels and HbA1c levels in diabetic rats (p<0.001). However, losartan did not exhibit the same effects (p<0.05). The enzymatic activity of the liver enzymes hexokinase, glucose-6 phosphate dehydrogenase, fructose 1,6-biphosphatase, pyruvate kinase and glucose-6 phosphatase were enhanced by resveratrol and gliclazide, while losartan treatment was not associated with significant changes in liver carbohydrate metabolism. Conclusion: Resveratrol was not effective in improving liver carbohydrate metabolism relative to gliclazide, a drug widely used to treat diabetes. Dose-response profile of resveratrol remains indeterminate and additional studies may be necessary to determine effective dosing in diabetes.Öğe The effects of CAPE on the oxidant status of the liver and the serum in rat model of acute methanol intoxication(Wiley-Blackwell, 2015) Yazgan, Umit Can; Elbey, Bilal; Kus, Seyyit; Baykal, Burhan; Keskin, Idris; Sahin, Alparslan; Yilmaz, Ahmet[Abstract Not Available]Öğe Immune mechanisms and the role of oxidative stress in intrahepatic cholestasis of pregnancy(Termedia Publishing House Ltd, 2014) Ozler, Ali; Ucmak, Derya; Evsen, Mehmet Siddik; Kaplan, Ibrahim; Elbey, Bilal; Arica, Mustafa; Kaya, MuhsinIntroduction: The purpose of this study was to investigate levels of inflammatory cytokines such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and neopterin and oxidative stress status in patients with intrahepatic cholestasis of pregnancy (ICP) as well as their potential role in the pathophysiology. Material and methods: Thirty patients with ICP (Group 1) and 30 healthy pregnant women (Group 2) were included in this prospective case-control study. Levels of IL-6, TNF-alpha and neopterin were determined in both of the groups. Total anti-oxidant status (TAS) and total oxidative stress (TOS) levels were determined by means of a fully automated Erel method. Oxidative stress index (OSI) was calculated as the ratio of TOS to TAS. Results: There was no significant difference between the groups in IL-6 and TNF-alpha levels (p = = 0.105 and p = 0.722, respectively). The mean neopterin level was significantly higher in Group 1 compared to Group 2 (2.34 +/- 0.77 and 1.57 +/- 0.38, respectively, p = 0.001). In addition, TAS, TOS and OSI levels were significantly higher in Group I (p = 0.004, p = 0.001 and p = 0.001, respectively) compared to Group 2. Discussion: Intrahepatic cholestasis of pregnancy is an inflammatory disorder in which maternal immune reaction may play a role. Interleukin 6 and TNF-alpha, which are some of the markers of humoral reaction, act as an indicator of abnormal reaction rather than acute-phase reaction in ICP. Further clinical trials and supportive placental findings are needed on the role of cytokines in cellular and humoral immune reactions during the symptomatic period and delivery to better understand the role of immune mechanisms in the aetiology of ICP.Öğe Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate(Soc Chilena Anatomia, 2016) Sula, Bilal; Deveci, Engin; Ozevren, Huseyin; Ekinci, Cenap; Elbey, BilalLead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were drawn from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. Sections of rat facial skin were examined histopathological and immunohistochemical. In the group treated with lead acetate, minimal to slight multifocal hydropic degeneration of basal cell layer, depending on the thinning of the epidermis, the cellular degeneration in the dermis and a increase in the number of necrotic cells was observed in sebaceous glands of the hair follicle hemorrhage. The immunohistochemical results of the present work demonstrated an increase in Proliferating cell nuclear antigen (PCNA) immunoreactivity in skin specimens from lead acetate treated animals. Vimentin immunoreactivity was very dense in hair follicle of the subepidermal region. It was also strongly stained around the myoepithelial cells surrounding sebaceous and stromal cells.Öğe Mean Platelet Volume in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy(Hindawi Ltd, 2016) Sahin, Muhammed; Sahin, Alparslan; Elbey, Bilal; Yuksel, Harun; Turkcu, Fatih Mehmet; Cingu, Abdullah KursatObjective. We aimed to investigate the mean platelet volume (MPV) of the patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. The medical records of 46 patients with the diagnosis of NAION and 90 control subjects were retrospectively evaluated. All participants underwent complete ocular examination including intraocular pressure (IOP) measurement. Hematocrit, MPV, hemoglobin, and platelet levels of the patients with NAION were compared with those of control subjects. Results. There was no significant difference between the groups in platelet counts (p = 0.76). NAION group had significantly higherMPV values (8.25 +/- 1.26 fL) than that of control subjects (7.64 +/- 1.01 fL) (p < 0.001). Multivariate logistic regression analysis showed that MPV is an independent predictor of NAION (odds ratio = 1.61; 95% confidence interval (CI) = 1.13-2.28; p = 0.007). The mean IOP was significantly higher in NAION group (p < 0.001). IOP was also found as an independent predictor of NAION according to the regression analysis (OR = 1.27; 95% CI = 1.08-1.48; p = 0.003). Conclusion. Our results demonstrated that the MPV values were significantly higher in NAION patients, suggesting that larger platelets may contribute to the pathogenesis of the NAION.Öğe Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in retinal vein occlusion(Wiley, 2020) Sahin, Muhammed; Elbey, Bilal; Sahin, Alparslan; Yuksel, Harun; Turkcu, Fatih Mehmet; Caca, IhsanBackground To evaluate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and the development of retinal vein occlusion. Methods One hundred and eleven patients and 88 control subjects were enrolled. Retinal vein occlusion diagnosis was clinically made with fundus examination. NLR and PLR values were compared between groups. Results Neutrophil levels were found to be comparable between the two groups (p = 0.47). Lymphocyte levels were lower in retinal vein occlusion patients (p = 0.001). NLR was significantly higher in retinal vein occlusion patients (p = 0.001). Platelet counts were found to be comparable in the two groups (p = 0.75). PLR was significantly higher in retinal vein occlusion patients (p = 0.001). According to the receiver operating characteristic curve analysis, the optimal cut-off values of NLR and PLR to predict retinal vein occlusion were > 1.63 and > 98.50, respectively. Conclusions The present study showed that higher NLR and PLR were associated with the development of retinal vein occlusion. Also, NLR and PLR may be used as predictive tools for identifying risk for retinal vein occlusion.Öğe Novel markers of endothelial dysfunction and inflammation in Beh‡et's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio(Springer London Ltd, 2016) Yuksel, Murat; Yildiz, Abdulkadir; Oylumlu, Mustafa; Turkcu, Fatih Mehmet; Bilik, Mehmet Zihni; Ekinci, Aysun; Elbey, BilalThe etiology of Beh double dagger et's disease (BD) has not been fully elucidated. However, immunological and environmental factors, endothelial dysfunction (ED), and genetic susceptibility have been proposed to play a role. In this study, we aimed to evaluate epicardial fat thickness (EFT) together with serum asymmetric dimethylarginine (ADMA), carotid intima media thickness (CIMT), and neutrophil-to-lymphocyte ratio (NLR) in BD patients with ocular involvement. Thirty-six ocular BD patients (17 active and 19 inactive ocular involvement), and 35 age and sex-matched healthy controls were enrolled to this cross-sectional study. All patients underwent examinations with transthoracic echocardiography and carotid Doppler ultrasound. Serum ADMA levels, CIMT, EFT, and NLR were compared between groups, and their association with disease activity was evaluated. Beh double dagger et's disease patients had higher WBC counts, neutrophil counts, NLR, CIMT, EFT values, and serum ADMA levels than do healthy controls. The other biochemical, hematological, and echocardiographic parameters were comparable between the two groups. Beh double dagger et's disease duration was positively correlated with EFT and CIMT. Multivariate logistic regression analysis revealed that increased serum ADMA concentration and CIMT are independently associated with BD. Neutrophil counts, NLR, and serum ADMA level were higher, and lymphocyte count was lower in patients with active ocular BD compared to those of inactive ocular BD group. Carotid intima media thickness, serum ADMA level, EFT, and NLR were increased in ocular BD patients compared to healthy subjects. In addition, both serum ADMA level and NLR were associated with disease activity of ocular involvement. Increase in disease duration was associated with increase in CIMT and EFT which suggests that anatomical changes occur in time during the disease course. Increased CIMT, serum ADMA level, EFT, and NLR may provide new clues about the role of ED and inflammation in the etiopathogenesis of BD.Öğe The prognostic value of the neutrophil/lymphocyte ratio in patients with snake bites for clinical outcomes and complications(Elsevier Science Bv, 2017) Elbey, Bilal; Baykal, Burhan; Yazgan, Umit Can; Zengin, YilmazIntroduction: Snake bites have cardiotoxicity, neurotoxic, myotoxic, nephrotoxic, and hemotoxic features. The neutrophil/lymphocyte ratio (NLR) provides valuable information for the determination of the diagnosis and prognosis of various diseases. In this study, we aimed to investigate the relationship between NLR with the development of complications and duration of hospital stay in snakebite cases. Method: In this study, 107 patients with snakebite complaints that applied to a tertiary care university hospital between 2011 and 2014 were retrospectively reviewed. The control group compromised of 107 age-and gender-matched healthy subjects. These patients were examined using their previous laboratory results, bite areas pictures, geographic location, and analysis of complications that developed during the hospitalization. Results: Patients in our snake bites group (n= 107), included males (64%) and females (36%). When NLR1-NLR2, NLR1-NLR3, and NLR2-NLR3 were compared, a statistically significant difference was found (p< 0.001). No mortality was observed in our patients. In cases of snakebites, 4.67% of the patients underwent finger amputation. Compartment syndrome occurred in 3.73% of patients. In one case that developed compartment syndrome, a finger amputation was made. When 8 patients with a complication were compared with patients having snakebite but no complication, the initial NLR was found to be higher and statistically significant ( p= 0.042). The average length of stay of patients in the hospital was 9 days. In the analysis of the correlation between the duration of hospitalization and NLR, the patients with a high level of NLR were found to have a longer hospital stay compared to lower NLR levels ( p= 0.012). Conclusion: NLR was significantly increased in patients that developed complications and needed a longer stay in the hospital. (c) 2015 The Authors. Production and hosting by Elsevier B. V. on behalf of King Saud University. This is an open access article under the CC BY-NC-NDlicense (http://creativecommons.org/licenses/by-nc-nd/4.0/).Öğe The protective effect of pomegranate extract against cisplatin toxicity in rat liver and kidney tissue(Taylor & Francis Ltd, 2015) Bakir, Salih; Yazgan, Umit Can; Ibiloglu, Ibrahim; Elbey, Bilal; Kizil, Murat; Kelle, MustafaObjectives: The purpose of this study was to perform a histopathological investigation, at the light microscopy level, of the protective effects of pomegranate extract in cisplatin-induced liver and kidney damage in rats. Material and methods: Twenty-eight adult male Wistar albino rats were randomly divided into four groups of seven animals: Group 1: Control; Group 2: Treated for 10 consecutive days by gavage with pomegranate juice (2ml/kg/day); Group 3: Injected intraperitoneally with cisplatin (8mg/kg body weight, single dose) onset of the day 5, and Group 4: Treated by gavage with pomegranate juice 10 days before and after a single injection of cisplatin onset of the day 5. After 10 days, the animals were sacrificed and their kidneys and liver tissue samples were removed from each animal after experimental procedures. Cisplatin-induced renal and hepatic toxicity and the effect of pomegranate juice were evaluated by histopatological examinations. Results: In the kidney tissue, pomegranate juice significantly ameliorated cisplatin-induced structural alterations when compared with the cisplatin alone group. But in the liver tissue, although pomegranate juice attenuated the cisplatin-induced toxicity only in two rats, significant improvement was not observed. Conclusion: In conclusion, these results demonstrate that the anti-oxidant pomegranate juice might have a protective effect against cisplatin-induced toxicity in rat kidney, but not in liver. Pomegranate juice could be beneficial as a dietary supplement in patients receiving chemotherapy medications.Öğe The Protective Effect of Pomegranate Juice against Cisplatin Toxicity in Rat Liver and Kidney Tissue(Wiley-Blackwell, 2015) Bakir, Salih; Yazgan, Umit Can; Ibiloglu, Ibrahim; Elbey, Bilal; Kizil, Murat; Kelle, Mustafa[Abstract Not Available]Öğe Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study(Hindawi Ltd, 2016) Yilmaz, Ahmet; Elbey, Bilal; Yazgan, Umit Can; Donder, Ahmet; Arslan, Necmi; Arslan, Serkan; Alabalik, UlagBackground. The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats. Materials and Methods. Group I served as control. Group II received CAPE intraperitoneally. Group III received fluoxetine per orally. Group IV received fluoxetine and CAPE. The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured. Liver tissues were processed histopathologically for evaluation of liver injury and to validate the serum enzyme levels. Results. An increase in TOS and OSI and a decrease in TAC and PON-1 levels in serum and liver tissues of Group III were observed compared to Groups I and II. After treatment with CAPE, the level of TOS and OSI decreased while TAC and PON-1 increased in serum and liver in Group IV. Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment and reduction of injury with CAPE treatment. Conclusion. Our results suggested that CAPE treatment provided protection against fluoxetine toxicity. Following CAPE treatment with fluoxetine-induced hepatotoxicity, TOS and OSI levels decreased, whereas PON-1 and TAC increased in the serum and liver.Öğe Risk Factors for Health Care-Associated Bloodstream Infections in a Neonatal Intensive Care Unit(Kowsar Corp, 2016) Ertugrul, Sabahattin; Aktar, Fesih; Yolbas, Ilyas; Yilmaz, Ahmet; Elbey, Bilal; Yildirim, Ahmet; Yilmaz, KamilBackground: Healthcare-associated bloodstream infections (HCA-BSI) are a major cause of morbidity and mortality in neonatal intensive care units (NICUs). Objectives: We aimed to determine the causative organisms and risk factors of HCA-BSIs in NICUs. Methods: This study was performed between January 2011 and December 2014 in the neonatal intensive care unit of Dicle university, Turkey. The study consisted of 126 patients (infected group) with positive blood culture and 126 randomly selected patients (uninfected control group) with negative blood culture after four days of hospitalization. Results: We found that the most common causative agents isolated from nosocomial infections (NIs) were 20.7% Staphylococcus epidermidis, 26.7% Klebsiella spp., and 13.3% Acinetobacter spp. Incidences of low gestational age, low birth weight, vaginal birth type, and long length of hospitalization were higher in the infected neonates than in the uninfected neonates. In the univariate analysis, surgical operation, ventriculoperitoneal shunt, use of umbilical catheter, nasogastric or orogastric tube, urinary catheter, mechanical ventilation, surfactant treatment, erythrocyte transfusion, plasma transfusion, thrombocyte transfusion, total parenteral nutrition infusion, intracranial hemorrhage, length of hospital stay, fifth-minute Apgar score, and total parenteral nutrition time were significantly associated with NIs. In the multiple logistic regression analysis, fifth-minute Apgar, use of erythrocyte transfusion and surgical operation were found as the independent risk factors for HCA-BSI. Conclusions: This study determined the causative organisms and risk factors of HCA-BSIs in NICUs.Öğe Vernal keratokonjonktivitli olgularda ortalama trombosit hacmi ve nötrofil/lenfosit oranı(Modestum Publishing Ltd., 2014) Elbey, Bilal; Yazgan, Ümit Can; Yıldırım, Adnan; Karaalp, Ümit; Şahin, AlparslanAmaç: Bu çalışmada vernal keratokonjonktiviti (VKK) olan hastaların nötrofil, eozinofil, lenfosit, trombosit sayısı, nötrofil/lenfosit oranı (NLO), ortalama trombosit hacmi (MPV) değerlendirilmesi amaçlanmıştır.Yöntemler: Bu çalışmada göz hastalıkları polikliniğine başvurmuş ve VKK tanısı almış olguların dosya kayıtları retrospektif olarak incelendi. Şaşılık dışında herhangi bir sistemik ve oküler hastalığı bulunmayan yaş ve cinsiyet uyumlu olgular kontrol grubuna dahil edildi. Tüm katılımcıların yaş ve cinsiyet verileri kaydedildi. Hemogram değerlerinden; MPV nötrofil, eozinofil, lenfosit, trombosit sayımı, NLO otomatik analizörlerle ölçüldü. Elde edilen veriler iki grup arasında karşılaştırıldı.Bulgular: Çalışma kapsamında 30 VKK ve 30 kontrol olgusu değerlendirildi. Gruplar arasında yaş ve cinsiyet açısından anlamlı farklılık saptanmadı. MPV ve NLO, VKK grubunda kontrol grubuna oranla daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi (sırasıyla p=0,19 ve p=0,16).Sonuç: Bu çalışmanın sonucunda MPV ve NLO değerlerinin VKK hastalığıyla ilişkili olmadığını gösterilmiştir. MPV ve NLO değerlerinin VKK'da istatistiksel olarak anlamlı olmamalarına rağmen daha yüksek olması VKK için yardımcı parametre olarak kullanılabilir.
