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    Diagnostic value of neutrophil-to-lymphocyte ratio in allergy patients
    (Univ West Indies Faculty Medical Sciences, 2021) Elbey, B.; Yazgan, U. C.; Zengin, Y.
    Objective: To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the clinical characteristics of the acute allergic reaction patients diagnosed in an emergency clinic. Methods: The medical records of the patients with a diagnosis of acute allergic reactions that were presented to Dicle University Medical Faculty Hospital Emergency Department, Diyarbakir; Turkey, between January 1, 2014 and December 31, 2014 were included in the study. The age, gender; NLR, white blood count, eosinophil, mean platelet volume (MPV), glucose, and the platelet count of all the participants were recorded. The study included 100 allergy patients and 100 healthy control group subjects. The demographic and the clinical characteristics of the groups were compared using statistical analyses. Results: The mean age, gender; lymphocyte count, eosinophil count, platelet count, and MPV were similar in the two groups (p > 0.05 for all). The mean NLR values of the allergy and the control group were 4.36 and 2.12, respectively (p = 0.008). Moreover; the serum glucose levels were significantly higher in the allergy group compared with the control group (p < 0.001). Conclusion: The patients with acute allergic reactions had a significantly higher value of NLR. Thus, NLR may be a useful diagnostic indicator of allergic conditions.
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    Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication
    (Springer London Ltd, 2017) Yazgan, U. C.; Elbey, B.; KuAY, S.; Baykal, B.; Keskin, I.; Yilmaz, A.; Sahin, A.
    Methanol toxicity is one of the major public health problems because it can cause severe morbidity and mortality. Methanol intoxication causes changes in the balance between the production of free radicals and antioxidant capacity. We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on the total oxidant status, total antioxidant status (TAS), and oxidative stress index (OSI) parameters of the liver and the serum in a rat model of acute methanol intoxication. Rats were treated with intraperitoneal (i.p.) Methotrexate (MTX) for 7 days. On the 8th day, i.p. Methanol was administered in the methanol, ethanol and CAPE groups. Four hours after methanol treatment, ethanol was injected i.p. in the ethanol group; CAPE (i.p.) in the CAPE group; serum physiologic i.p. in other groups. After 8 hours, rats were killed and the serum and the liver samples were obtained for biochemical analyses. The OSI value was significantly higher in the methanol group compared to the ethanol and CAPE groups. Serum TAS levels of the methanol group were significantly different compared to the control group, but not compared to the MTX group. The amelioration of oxidative stress was greater in the CAPE group compared to the ethanol group but was not statistically significant. This study demonstrates that CAPE treatment ameliorates oxidative stress in the serum and liver in a rat model of acute methanol intoxication.
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    The Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitis
    (Univ West Indies Faculty Medical Sciences, 2021) Elbey, B.; Ayyıldız, O.; Yazgan, U. C.; Çevik, R.; Kaplan, I.; Sarıyıldız, M. A.
    Objective: In the present study, we aimed to investigate the relationship between interleukin 23 (IL-23) and the clinical and laboratory parameters in patients with ankylosing spondylitis (AS). Ankylosing spondylitis causes structural and functional inability, particularly in the axial skeleton, and results in the inflammatory lower back pain. At the same time, we aimed to investigate the relationship between IL-23 levels and disease related variables in patients with AS. Methods: A total of 38 patients with AS (33 males and 5 females) and 42 healthy controls (32 males and 10 female) were enrolled in the study. The demographic characteristics of the participants were recorded. As laboratory findings, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and IL-23 values were noted. Bath AS Disease Activity Index, Bath AS Functional Index, Visual Analogue Scale, and AS Quality of Life scales of the patients were measured. Results: The mean age of the AS group and the control subjects was 32.4 +/- 7.06 and 30.0 +/- 6.24 years, respectively. The ESR, CRP and IL-23 levels were significantly higher in the AS group compared to those of the healthy controls (p < 0.001, p < 0.013, p < 0.012, respectively). There was a significant correlation between ESR, CRP, and IL-23 levels in patients with AS (r = 0.328, p = 0.030 and r = 0.392, p = 0.008, respectively). While 12 subjects (31.5%) were positive for peripheral arthritis, 26 patients were negative (68.4%). The IL-23 levels were significantly higher in the group that was positive for peripheral arthritis (p < 0.05). Conclusion: Interleukin 23 may play a role in the progression and/or pathogenesis of AS and is most likely involved in the joint problems independent of the classic inflammatory response measures.