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Öğe An Adult Choledochocele Case Presented with Acute Pancreatitis: Treatment by Endoscopic Sphincterotomy and Cyst Unroofing(Korean Soc Gastrointestinal Endoscopy, 2015) Bestas, Remzi; Ekin, Nazim; Ucmak, Feyzullah; Kaya, Muhsin[Abstract Not Available]Öğe Association between IL28B gene polymorphism (rs12979860) and sustained virological response in patients infected with hepatitis C virus Genotype 1(Wiley-Blackwell, 2012) Akkiz, Hikmet; Sezgin, Orhan; Altintas, Engin; Yalcin, Kendal; Ekin, Nazim; Uskudar, Oguz; Sandikci, Macit U.[Abstract Not Available]Öğe Clinicopathological characteristics of patients with oesophageal squamous papilloma in Turkey and comparison with the literature data: The largest case series ever reported from Turkey(Wiley, 2021) Ekin, Nazim; Bestas, Remzi; Cetin, AlpayAim Oesophageal squamous papilloma (ESP) is a rare tumoural lesion of the oesophagus considered to have a benign course. Due to the fact that they are rare lesions, there are not many publications with large case series on ESPs in the literature. In this study, we aimed to investigate the clinical, endoscopic and histopathological characteristics of ESPs. Methods Reports of upper gastrointestinal endoscopies performed in the endoscopy unit within the Division of Gastroenterology of a tertiary care hospital in the Southeastern Anatolia Region of Turkey in the last 8-year period were evaluated retrospectively. Patients who were determined to have oesophageal polypoid lesions during the endoscopic procedure and were then diagnosed with oesophageal squamous cell papilloma in the histopathological examination were included in the study. Results Of 11 541 patients who underwent upper gastrointestinal endoscopy, 51 were diagnosed with a total number of 55 ESPs (0.44%). In addition, 26 of these patients (51%) were female, and the mean age of the patients at the time of diagnosis was 42.2 years. The average size of the ESPs was 3.47 mm, and the most frequent location was the middle oesophagus with 51%. No statistically significant relationship was found between the location of ESPs and gender, endoscopy indication, oesophagitis, lower oesophageal sphincter dysfunction, hiatal hernia, gastroesophageal reflux disease (GERD) and Helicobacter pylori positivity. Conclusion In this study with the largest case series ever reported from Turkey, it was determined that ESPs were seen in younger ages in Turkey and were also smaller in size, which is not in agreement with the literature data. Besides, this study, in which ESPs were most frequently detected in the middle oesophagus, supports the view that GERD may not be the main factor in ESP aetiology.Öğe Development of hepatocellular carcinoma in patients with chronic hepatitis C who had sustained viral response following direct-acting antiviral therapy(Kare Publ, 2022) Ebik, Berat; Aygan, Mustafa; Tuncel, Elif Tugba; Kacmaz, Huseyin; Ekin, Nazim; Arpa, Medeni; Yalcin, KendalBackground and Aim: Several studies have suggested that treatment with direct-acting antivirals (DAAs) in patients with chronic hepatitis C virus (HCV) may be associated with an increased risk of developing hepatocellular carcinoma (HCC). We investigated the incidence and risk factors of HCC in HCV patients who achieved a sustained virologic response (SVR) following DAA therapies. Materials and Methods: The medical data of patients who were diagnosed with HCV and received DAA therapy in two tertiary centers in Turkey were retrospectively collected. Results: Among them, 75 patients (52.4%) were noncirrhotic and 68 patients (47.6%) were cirrhotic. The overall SVR rate was 97.2% (139/143). It was 100% in noncirrhotic and 94.1% in cirrhotic patients. HCC was developed in 5 (7.4%) patients, all of whom had baseline cirrhosis. The annual rate of HCC occurrence was 2.94%, and the 5-year cumulative incidence of HCC was 7.3%. The mean Child-Pugh score (CPS) and Model for End-Stage Liver Disease (MELD) score significantly decreased after DAA treatment (CPS 7.0 vs 5.9, p=0.001; MELD 10.8 vs 9.5, =-0.003). Conclusion: There was no significant increase in the rate of HCC in cirrhotic HCV patients treated with DAAs. This treatment led to a remarkably high SVR rate and lowered CPS and MELD scores in cirrhotic HCV patients.Öğe Effect of fully charged and discharged batteries on esophageal tissue: an experimental study(E-Century Publishing Corp, 2016) Oruc, Menduh; Yilmaz, Ahmet; Ekin, Nazim; Durkan, Atilla; Sahin, Atalay; Nergiz, YusufThe aim of this study was to compare the effect of charged and discharged alkaline batteries on esophageal tissue, and to determine the impact of duration due to the exposure to alkaline batteries. Thirty-five rabbits were divided into 5 groups each containing 7 rabbits. Alkaline batteries were ingested by rabbits [except for the control group [Group 1]]. Rabbits in Group 2 were exposed to discharged alkaline batteries for 180 minutes. In Group 3-5, the fully charged batteries were left in esophagus for 60, 120, and 180 minutes, respectively. Macroscopic appearance of esophageal mucosa as well as histopathologic examination of battery induced esophageal injury and pH of environment were compared. Battery capsules were intact in each group. No color change was observed in the anode pole of batteries for Group 2. Color change was evident in the anode pole of batteries for 3 rabbits in Group 3, in 4 rabbits in Group 4, and in 7 rabbits from Group 5; while no significant change was observed in any rabbit from Group 2. Histopathologically, mucosal erosion was observed in 7 rabbits of Group 3. In Group 4, mucosal erosion extended to the internal muscular layer. Necrosis was exceeding external muscular layer in Group 5. Alkaline batteries may cause erosion as a result of electrical currency without corrosive substrate leakage. Duration of exposure is an important determinant of tissue injury.Öğe Neutrophil-to-Lymphocyte Ratio in the Prediction of Microscopic Colitis(Derman Medical Publ, 2015) Ucmak, Feyzullah; Yilmaz, Ahmet; Ekin, Nazim; Tuncer, Elif Tugba; Firat, Ugur; Palanci, YilmazAim: The aim of this study was to investigate the importance of the neutrophil-to-lymphocyte ratio (NLR) in predicting microscopic colitis (MC) in patients with diarrhea-dominant type irritable bowel syndrome (IBS-D). Material and Method: Between January 1, 2010 and December 31, 2012, 49 patients who fulfilled the Roma III criteria for IBS-D were included in the study. All patients had underwent colonoscopy and colonoscopic biopsy (cecum, ascending, transverse, descending and rectosigmoid sections) to diagnose MC (25 patients with MC). Complete blood count parameters were evaluated in the two groups (IBS-D and MC) using standard methodology. Results: The patients were evaluated in two groups: MC and IBS-D. The groups were similar with respect to age, gender and presence of hypertension. The NLO was significantly higher in the MC group compared to the IBS-D group (2.48 +/- 0.99, 1.92 +/- 0.84; p=0.041, respectively). A cut-off value of 1.86 had a sensitivity of 76% and spesificity of 55% in predicting MC in patients with symptoms of IBS-D. Discussion: A significant association was found between the presence of MC in patients with IBS-D and increased NLR. The NLR may be a useful marker in predicting MC in patients with symptoms of IBS-D.Öğe THE STATUS OF OXIDATIVE STRESS AND ANTIOXIDANT DEFENSE IN PATIENTS WITH CHRONIC HEPATITIS D(Carbone Editore, 2016) Ucmak, Feyzullah; Solmaz, Ihsan; Ekin, Nazim; Kaplan, Ibrahim; Tuncel, Elif Tugba; Senates, Ebubekir; Yalcin, KendalIntroduction: Oxidative stress is increasingly recognized as an important factor in the progression of chronic liver disease of varying etiologies and antioxidants are utilized in the treatment of some of them. Chronic viral hepatitis D continues to be a significant health problem in certain regions of the world. Rates of response to currently proposed treatments are rather low. The aim of this study was to investigate oxidative stress in patients with chronic viral hepatitis D. Materials and methods: A total of 91 patients with chronic hepatitis D virus infection were included in this study (mean age: 42.2 +/- 11.7). In addition, 40 healthy volunteers were included in the study to form the control group. Patients were divided into two main sub-groups as cirrhotic (n=30) and non-cirrhotic (n=61) groups. Blood samples were taken from both patients and control subjects and compared for total oxidant status (TOS), total anti-oxidant status (TAS) and oxidative stress index (OSI). Results: TOS levels were significantly higher in the patients compared to the control sub-jects (p<0.001). Moreover, TOS levels were higher in the cirrhotic patients compared to the non-cirrhotic patients (p=0.006). TAS levels were significantly lower in the patients compared to the control subjects (p=0.003). OSI levels were significantly higher in the patients compared to the control subjects (p<0.001). Moreover, OSI levels were higher in the cirrhotic patients compared to the non-cirrhotic patients (p<0.05). Conclusion: These results are supportive of the role of oxidative stress in the pathogenesis of chronic viral hepatitis D. Antioxidant therapies might be considered in patients with chronic viral hepatitis D considering the presence of oxidative stress in these patients.Öğe An Unusual Case of Cavernous Hemangioma of the Rib in a Young Man with Lung Tuberculosis: A Brief Review and Case Report(Japan Soc Internal Medicine, 2013) Oruc, Memduh; Atay, Ahmet Engin; Karabulut, Pervin; Pasa, Semir; Elbey, Ahmet; Ekin, Nazim; Yildirim, SerdarHemangiomas are benign vascular tumors that usually involve the liver, skin, eyes and central nervous system. Hemangioma of the bone is unusual and is generally observed in the vertebrae or skull while hemangioma of the costae is extremely rare. Hemangioma of the rib and chest wall tuberculosis may be misdiagnosed as chest wall tumors. We herein report a case of hemangioma of the rib with a tuberculosis infection of the pleura.Öğe Unusual presentations of spider angiomas(Wiley-Blackwell, 2013) Yalcin, Kendal; Ekin, Nazim; Atay, Ahmet[Abstract Not Available]Öğe What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?(Termedia Publishing House Ltd, 2024) Ebik, Berat; Ekin, Nazim; Bacaksiz, Ferhat; Uzel, Ali; Akkuzu, Mustafa Zanyar; Ucmak, Feyzullah; Kaya, MuhsinIntroduction: Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other. Aim: To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them. Material and methods: In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021. Results: We detected MC in 102 (9.3%) of 1096 patients investigated for chronic diarrhoea. We detected CD in 1 (1.1%) of 90 patients with MC who participated in the study. Only 10% of the patients were positive for AGA IgA, 3.3% for EMA IgA, and 2.2% for Anti-TG2 IgA. There was no difference in autoantibody titre in treatment-responsive and treatment-resistant MC patients. HLA DQ2 was positive in 32.2% (n = 29) of the MC patients, and HLA DQ8 was found in 5.5% (n = 5). Intraepithelial lymphocyte increase was remarkable in the duodenal biopsies of MC patients who did not respond to treatment (40% vs. 11.4%; p = 0.007). Conclusions: We did not reach the conclusion that CD is more common in MC patients. An increase in IEL may also occur in the small intestine in patients with MC who do not respond to treatment.
