Yazar "Ediz, Levent" seçeneğine göre listele

Listeleniyor 1 - 4 / 4
  • [ X ]
    Öğe
    The frequency and effect of fibromyalgia in patients with Behcet's disease
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2017) Toprak, Murat; Erden, Metin; Alpayci, Mahmut; Ediz, Levent; Yazmalar, Levent; Hiz, Ozcan; Tekeoglu, Ibrahim
    Objectives: This study aims to investigate the scores of depression, anxiety, sleep and quality of life (QoL), to identify the prevalence of fibromyalgia (FM) in Behcet's disease (BD), and to evaluate whether there is a difference between BD patients with and without FM in these scores. Patients and methods: Between March 2008 and January 2009, 97 patients with BD and 95 age- and sex-matched healthy controls were included in the study. The patients with BD were divided into two groups according to the presence or absence of FM. All participants were evaluated by the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), and Medical Outcomes Study Short Form-36 (SF-36). Results: Compared to the controls, FM prevalence was higher (19.6% vs 3.2%) with increased BDI and BAI scores, while the subscores of SF-36 including physical function, physical role, pain, general health, social function, and emotional role decreased in BD patients (for all p<0.001). All BD patients with FM were females (n=19), while only 46% of BD patients without FM were females (n=36) (p<0.001). In BD patients with FM, compared to female BD patients without FM, the mean age (p=0.017), disease duration (p=0.028), and BDI scores (p=0.017) were significantly higher, while the PSQI scores (p=0.001) and SF-36 subscores, except general health (p=0.114), were significantly lower (for all p<0.05). Conclusion: Our study results suggest that patients with BD have an increased severity of depression and anxiety, higher frequency of FM, and worsened QoL than healthy individuals. In addition, the presence of FM seems to be related with female sex, longer disease duration, older age, depression, sleep disturbance, and poor QoL in BD patients.
  • [ X ]
    Öğe
    The frequency and effect of fibromyalgia in patients with Behçet’s disease
    (2017) Ediz, Levent; Erden, Metin; Tekeoğlu, İbrahim; Alpaycı, Mahmut; Yazmalar, Levent; Toprak, Murat; Hız, Özcan
    This study aims to investigate the scores of depression, anxiety, sleep and quality of life (QoL), to identify the prevalence offibromyalgia (FM) in Behçet’s disease (BD), and to evaluate whether there is a difference between BD patients with and without FM in thesescores.Patients and methods: Between March 2008 and January 2009, 97 patients with BD and 95 age- and sex-matched healthy controls wereincluded in the study. The patients with BD were divided into two groups according to the presence or absence of FM. All participants wereevaluated by the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), and MedicalOutcomes Study Short Form-36 (SF-36).Results: Compared to the controls, FM prevalence was higher (19.6% vs 3.2%) with increased BDI and BAI scores, while the subscores of SF-36including physical function, physical role, pain, general health, social function, and emotional role decreased in BD patients (for all p<0.001). AllBD patients with FM were females (n=19), while only 46% of BD patients without FM were females (n=36) (p<0.001). In BD patients with FM,compared to female BD patients without FM, the mean age (p=0.017), disease duration (p=0.028), and BDI scores (p=0.017) were significantlyhigher, while the PSQI scores (p=0.001) and SF-36 subscores, except general health (p=0.114), were significantly lower (for all p<0.05).Conclusion: Our study results suggest that patients with BD have an increased severity of depression and anxiety, higher frequency of FM,and worsened QoL than healthy individuals. In addition, the presence of FM seems to be related with female sex, longer disease duration,older age, depression, sleep disturbance, and poor QoL in BD patients.
  • [ X ]
    Öğe
    The Prevalence of "MEFV" Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
    (2014) Gülcü, Elif; Delen, Veysel; Ediz, Levent; Tülüce, Yasin; Yıldırım, İbrahim Halil; Özkol, Halil
    Amaç: Enflamasyonu inhibe edici bir protein olan pyrin/marenostrin, Ailevi Akdeniz ateşi (AAA) geni tarafından kodlanır. Bu gendeki mutasyonların, AAA hastalığına sebep olduğu bilinir. Akdeniz ateşi geninin mutasyonları ile romatolojik hastalıklar arasında da bir ilişki olduğu ileri sürülmüştür. Bu çalışmanın amacı AAA geninin en sık rastlanan 4 mutasyonunun frekansını, Türkiye'nin doğusunda yaşayan 110 romatoid artrit (RA) hastasında ve 98 sağlıklı kontrol (SK) bireylerinde araştırmaktır.Gereç ve Yöntemler: DNA eldesi, çalışmaya dahil edilen bütün bireylerin periferal lenfositlerinden "salting out" metoduyla gerçekleştirilmiştir. Ekzon 10'un polymerase chain reactions (PCR) amplifikasyonu uygun primerler yardımıyla yapılmış ve tek nükleotid polimorfizimleri (TNP) mutasyonel veya yabanıl tip DNA bölgelerini tanıyan spesifik restriksiyon endonükleazlar yardımıyla belirlenmiştir. Bulgular: Bu çalışmada, romatoid artrit hastalarının mutasyon frekansı, SK bireylerinden daha yüksek bulundu. Ancak, bu sonuç istatistiksel olarak anlamlı değildi (p>0,05). Sonuç: Türkiye'nin doğusunda yaşayan RA hastalarındaki AAA mutasyon oranı, SK bireylerinden anlamlı derecede farklı değildi. Romatoid artrit etyopatogenezinde etkili olabilecek diğer gen mutasyonlarını araştırmak için yeni çalışmalara ihtiyaç bulunmaktadır
  • [ X ]
    Öğe
    The Prevalence of MEFV Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2014) Ozkol, Halil; Yildirim, Ibrahim Halil; Tuluce, Yasin; Ediz, Levent; Delen, Veysel; Gulcu, Elif
    Objective: An inhibitory protein of inflammation pyrin/marenostrin is encoded by the Mediterranean fever (MEFV) gene. Mutations of this gene are known to cause familial Mediterranean fever (FMF) disease. A relation between mutations of the MEFV gene and rheumatic diseases was also suggested. The aim of the present study was to investigate the frequency of four common mutations of the MEFV gene in 110 rheumatoid arthritis (RA) patients and 98 healthy controls (HC) inhabiting a region of eastern Turkey. Material and Methods: DNA extraction was realized by salting out method from peripheral blood lymphocytes of all subjects included in the study. Polymerase chain reactions (PCR) amplification of exon 10 was performed by the appropriate primers, and single-nucleotide polymorphisms (SNPs) were detected by specific restriction endonucleases recognizing the mutational DNA or wild-type DNA regions. Results: Mutation frequency of RA patients was higher than in HC, but this result was not statistically significant (p>0.05). Conclusion: The MEFV mutation rate of RA patients living in eastern Turkey was not significantly different from HC. Further studies are needed to investigate other gene mutations that may affect RA etiopathogenesis.