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Öğe Clinical characteristics and metabolic abnormalities in preschool-age children with urolithiasis in southeast Anatolia(Elsevier Sci Ltd, 2014) Elmaci, A. M.; Ece, A.; Akin, F.Objective: Data on urolithiasis in preschool-age children are limited. The aim of this study was to investigate the metabolic etiology and clinical findings of preschool-age children with urolithiasis. Methods: The medical records of 143 preschool-age children (81 boys, 62 girls, aged 2-6 years) with urolithiasis were retrospectively analyzed. Results of physical examination, serum biochemistry, and urine metabolic evaluation (including urinary citrate, oxalate, calcium, uric acid, cystine, and magnesium) were recorded. Results: The mean age at diagnosis was 3.7 +/- 1.3 years. A family history of stone disease was found in 79.7% of patients, and 37% of parents had consanguineous marriages. The most common presenting symptoms were hematuria (33%) and urinary tract infection (UTI; 29%). Metabolic abnormalities were found in 119 (83.2%) patients, including hyperuricosuria in 24.5%, hypocitraturia in 23.8%, hyperoxaluria in 21.7%, hypercalciuria in 21.0%, cystinuria in 7.7%, and hypomagnesuria in 1.4%. Multiple metabolic abnormalities were found in 24 (16.8%) patients. Results of 28 stone analyses revealed calcium oxalate or phosphate, cystine, and uric acid in 15, nine, and four of the patients, respectively. (99m)Technetium-dimercaptosuccinic acid renal scintigraphy revealed that 27.8% of the children with UTI had renal parenchymal scarring, with only four of them having vesicoureteral reflux. Conclusion: The most frequent metabolic abnormalities in preschool-age children with urolithiasis were hyperuricosuria and hypocitraturia. A comprehensive investigation of stone disease in children presenting with hematuria and UTI is important to prevent the development of renal parenchymal scarring. (C) 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.Öğe Community-acquired urinary tract infections in children: pathogens, antibiotic susceptibility and seasonal changes(Verduci Publisher, 2013) Yolbas, I.; Tekin, R.; Kelekci, S.; Tekin, A.; Okur, M. H.; Ece, A.; Gunes, A.AIM: Urinary tract infections (UTIs) are common infections affecting children. The aim of our study is to determine microorganisms that cause community-acquired urinary tract infections and their antibiotic susceptibility in children. MATERIALS AND METHODS: Our investigation includes 150 cases which has positive urine culture. The cases are detected at Pediatric Polyclinics of Dicle University between June 2010 and June 2011. RESULTS: The study included 118 (78.7%) female and 32 (21.3%) male children. Urinary tract infections were seen in autumn 10.7% (n = 16), summer 35.3% (n = 53), winter 30.7% (n = 46) and spring 23.3% (n = 35). The culture results indicated 75.3% (n = 113) Escherichia coli; 20.7% (n = 31) Klebsiella; 2.7% (n = 4) Proteus and % 1.3 (n = 2) Pseudomonas. The antibiotic resistance against Escherichia coli was found out is amikacin (3%), ertapenem (7%), imipenem (0%), meropenem (0%), nitrofurantoin (9%), trimethoprim/sulfamethoxazole (58%), piperacillin (83%), amoxicillin/clavulanate (50%), ampicillin/sulbactam (65%), cefazolin (54%), cefotaxime (51%), cefuroxime sodium (51%) and tetracycline (68%). The resistance ratios of Klebsiella are amikacin (0%), imipenem (0%), levofloxacin (0%), meropenem (0%), amoxicillin/clavulanate (57%), ampicillin/sulbactam (79%), ceftriaxone (68%), cefuroxime sodium (74%) and trimethoprim/sulfamethoxazole (61%). CONCLUSIONS: The results represent the increasing antibiotic resistance against microorganisms among the community-acquired UTI patients in a developing country such as Turkey. So, the physicians should consider resistance status of the infectious agent and choose effective antibiotics which are nitrofurantoin and cefoxitin for their empirical antibiotic treatment. Furthermore, they should be trained about selection of more effective antibiotics and check the regional studies regularly.Öğe Evaluation of children with juvenile idiopathic arthritis in southeastern Turkey: a single center experience(Lithographia, 2015) Sen, V; Ece, A.; Uluca, U.; Yel, S.; Tan, I; Karabel, D.; Yildirim, B.Background: The aim of this study was to investigate the disease characteristics of children with juvenile idiopathic arthritis (JIA) in southeast Turkey. Methods: The International League of Associations for Rheumatology (ILAR) criteria were used to diagnose JIA. Hospital records of the Pediatric Rheumatology Unit, of the Dicle University Hospital, were reviewed retrospectively and demographic, clinical and laboratory data were recorded. Results: Totally 213 children (103 boys, 110 girls), with an age range of 1.6-18 years were enrolled. The mean age of the disease onset was 8.1 years. Polyarticular type was the most common (42.3%) presentation. The frequencies of other JIA subtypes were as follows: oligoarticular 37.1%, systemic 8.9%, enthesitis-related arthritis (ERA) 10.8% and psoriatic arthritis 0.9%. The knees (74.2%) and ankles (54.0%) were the most commonly affected joints. Uveitis was found in 4.2% of patients. Anti-nuclear antibodies were positive in 11.7% and HLA-B27 in 2.8% of patients. Active disease was seen in 57 (26.7%) patients at the last visit. Conclusion: In the present study, polyarticular JIA was the predominant subtype and there were fewer patients with positive ANA or uveitis compared to previous studies.Öğe Multiple sclerosis: Relationships between cytokines, visual evoked potentials and disability(Blackwell Publishing, 2006) Tasdemir, N.; Karaca, E. E.; Ece, A.; Tasdemir, M. S.[Abstract Not Available]Öğe Neutrophil activation, protein oxidation and ceruloplasmin in children with Henoch-Schonlein purpura(Springer, 2007) Ece, A.; Kelekci, S.; Hekimoglu, A. Tas; Kocamaz, H.; Balik, H.; Yolbas, I.; Erel, O.[Abstract Not Available]Öğe Renal Growth in Children with Growth Hormone Deficiency(Springer, 2010) Ece, A.; Cetinkaya, S.; Eksioglu, S.; Senel, S.; Ozkasap, S.; Ginis, T.; Sen, V.[Abstract Not Available]Öğe URINARY EARLY KIDNEY INJURY MOLECULES IN CHILDREN WITH BETA-THALASSEMIA MAJOR(Pergamon-Elsevier Science Ltd, 2014) Sen, V.; Ece, A.; Uluca, I.; Soker, M.; Gunes, A.; Kaplan, O.; Tan, I.[Abstract Not Available]
