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    Evaluation of hepatic metabolic activity in non-alcoholic fatty livers on 18FDG PET/CT
    (Elsevier Doyma Sl, 2013) Dostbil, Z.; Varoglu, E.; Serdengecti, M.; Kaya, B.; Onder, H.; Sari, O.
    Objective: The liver has been used as a reference organ for the assessment of abnormal F-18-fluoro-2-deoxy-D-glucose ((18)FDG) in the body. Some researchers found that hepatosteatosis significantly changed the hepatic (18)FDG uptake, while others did not. This study investigated whether the liver's (18)FDG uptake was affected by the diffuse fatty infiltration of the liver. Material and methods: A total of 156 cases were included in this study. Different patient groups were defined according to the liver Hounsfield unit (HU). The HU was calculated from an unenhanced CT, for all patients, and we calculated the mean standardized uptake value (STmean) and maximum standardized uptake value (SUNmax) on an (18)FDG PET scan. For this purpose, we placed regions of interest (ROIs) on the liver image. We statistically compared the SUVmean and SUVmax measured in the fatty liver patients and the control group. Results: The average SUVmean and SUVmax values were calculated as 2.58 +/- 0.66 and 3.94 +/- 1, respectively, in the patient group and 2.54 +/- 0.57 and 3.7 +/- 0.88, respectively, in the control group. We found the average SUVmean and SUVmax values in the fatty liver group and its subsets were not significantly different from the values in the control group (p > 0.05). We also did not find any statistically significant correlation between average liver density (HU) and the average SUV values (p > 0.05). Conclusion: Fatty infiltration may not have a significant effect on the liver's (18)FDG uptake. Thus, the liver may be used as a reference or comparator on (18)FDG PET scans in patients with fatty liver disease. (C) 2012 Elsevier Espana, S.L. and SEMNIM. All rights reserved.
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    Is 18F-FDG-PET/CT prognostic factor for survival in patients with small cell lung cancer? Single center experience
    (Elsevier Espana Slu, 2013) Inal, A.; Kucukoner, M.; Kaplan, M. A.; Urakci, Z.; Nas, N.; Guven, M.; Dostbil, Z.
    Background: Although a number of studies in patients with a variety of malignant tumors have shown that metabolic activity on fluorine-18 deoxyglucose positron emission tomography computed tomography (F-18-FDG-PET/CT) is correlated with survival, there are few studies about the impact of F-18-FDG-PET/CT for survival in small cell lung cancer (SCLC) patients. There is still some ambiguity as to whether FDG PET in patients with SCLC will ensure prognostic knowledge for survival. We performed a retrospective analysis of prognostic implication of F-18-FDG-PET/CT in patients with SCLC. Methods: We retrospectively reviewed 54 patients with histologically or cytologically proven SCLC who had undergone pre-treatment F-18-FDG-PET/CT scanning between September 2007 and November 2011 in the Dicle University, School of Medicine, Department of Medical Oncology. SUVmax and other potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. Result: Among the eleven variables of univariate analysis, three variables were identified as having prognostic significance: Performance status (p < 0.001), stage (p = 0.02) and diabetes mellitus (p =0.05). Multivariate analysis showed that performance status and stage were considered independent prognostic factors for survival (p< 0.001 and p- 0.002 respectively). Conclusion: In conclusion, performance status and stage were identified as important prognostic factors, while F-18-FDG-PET/CT uptake of the primary lesions was not associated with prognostic importance for survival in patients with SCLC. (C) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.
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    Is the pepper spray a triggering factor in myocardial infarction? A case report
    (Verduci Publisher, 2012) Cil, H.; Atilgan, Z. A.; Islamoglu, Y.; Tekbas, E. O.; Dostbil, Z.
    Fourthy years old man was admitted to Emergency Department with complains of chest pain and dispnea after exposure the pepper gas that sprayed to environment during a social event. Physical examination and electrocardiogram was revealed acute myocardial infarction.
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    Prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with advanced non-small cell lung cancer: Single center experience
    (Imprimatur Publications, 2012) Inal, A.; Kucukoner, M.; Kaplan, M. A.; Urakci, Z.; Karakus, A.; Komek, H.; Dostbil, Z.
    Purpose: The purpose of this retrospective single-center study was to evaluate the prognostic implication on overall survival (OS) of the F-18 FDG PET scan in locally advanced or metastatic non small cell lung cancer (NSCLC) patients. Methods: We retrospectively reviewed 120 locally advanced or metastatic NSCLC patients (December 2004-November 2011) treated/followed at the Dicle University, School of Medicine, Department of Medical Oncology. SUVmax and other potential prognostic variables (n=18) were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for OS. Results: Among 18 variables of univariate analysis, 6 were identified to bear prognostic significance: sex (p=0.01), performance status (PS) (p=0.03), stage (p=0.04), bone metastases (p=0.002), serum albumin (p=0.01) and blood glucose level (p=0.03). Multivariate analysis showed that PS, bone metastases and serum albumin level were independent prognostic factors for OS (p=0.01, p=0.004, p=0.003, respectively). Conclusion: PS, serum albumin levels and bone metastases were independent prognostic factors, while FDG uptake of the primary lesion was not associated with prognosis of OS in locally advanced or metastatic NSCLC patients.