Yazar "Dogru A.G." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    The effects of pulsed and sinusoidal electromagnetic fields on E-cadherin and type IV collagen in gingiva: A histopathological and immunohistochemical study
    (Wroclaw University of Medicine, 2013) Dogru A.G.; Tunik S.; Akpolat V.; Dogru M.; Saribas E.E.; Kaya F.A.; Nergiz Y.
    Background. The potential beneficial effects of extremely low frequency pulsed and sinusoidal electromagnetic fields have been shown on many tissues. Gingival epithelium plays an important role in immunosurveillance of the periodontal tissues. The epithelium acts as a mechanical barrier through cell junctions such as E-cadherin. Objectives. Investigation of the effects of extremely low frequency magnetic fields on gingiva. Material and Methods. Twenty-seven male Wistar albino rats were used. The rats were divided into three groups: control group (n = 9), SEMF group (n = 9), PEMF group (n = 9). The SEMF and PEMF (pulse time: 25 ?sn, pulse frequency: 50 Hz) groups were subjected to 1.5 mT, 50 Hz, exposure 6 h a day, 5 days a week for 28 days in methacrylate boxes. The gingival tissue pieces processed for routine histological and immunohistochemical examination and tissue sections were stained with H-E and Masson trichrome. In addition, E-cadherin and type IV collagen expressions were examined immunohistochemically. Results. Intraepithelial lymphocytes and proliferation of epithelial cells increased in both electromagnetic field groups. The over-expressions of E-cadherin on gingival epithelium was detected in the PEMF and SEMF groups. The expression level of type IV collagen was not significant between the control and electromagnetic field treated groups, except for a significant increase in the basal cell layer of the PEMF group, as compared to the control and SEMF groups. Conclusions. PEMF and SEMF have a local pro-inflammatory effect on gingiva, leading to an increase in E-cadherin level but not type IV collagen. Both PEMF and SEMF can be used as a supportive device in the treatment of gingival diseases, especially those which lead to defects in the epithelial barrier. © Copyright by Wroclaw Medical University.
  • [ X ]
    Öğe
    Investigation of periodontal parameters, total antioxidant status and ferritin levels in patients with thalassemia major
    (University of Dicle, 2015) Gunay A.; Dogru A.G.; Isik B.; Soker M.; Gunay A.
    Our aim was to investigate periodontal status and total antioxidant status (TAS), ferritin levels of serum and gingival crevicular fluid (GCF) in patients with thalassemia major. This study comprised 73 individuals aged between 11 and 16 years, divided into 3 groups; Group TMS: periodontally healthy 23 patients with thalassemia major, Group TMG: 25 patients with gingivitis and thalassemia major, and Group C: gingival and systemically healthy 25 individuals. Firstly, Plaque Index (PI), Gingival Index (GI) and Probing Depth (PD) data of all individuals in the study were recorded. For serum samples, 5 cc blood was taken from the antecubital region of the forearm of every individual. At the same time 4 samples of GCF were taken from the maxillar incisive of every individual, collected by standard Periopaper strips. In the comparison of total mouth of the TMG group with the C and TMS groups, GI, PI, PD and GCF volume values were higher in the TMG group as expected (p<0.001). In the evaluation of the TMS and TMG groups in comparison with the C group, statistically significant differences were determined in the ferritin and TAS values of both GCF and serum (P<0.05). No correlation was found in the clinical and biochemical parameters investigated in serum and GCF of the TMG and TMS groups (p>0.05). In this study of relatively few patients, the conclusion was reached that thalassemia major was not a direct risk factor in the formation of gingivitis. Further studies are needed to investigate the relationship between more severe periodontal disease and thalassemia major in different age groups.
  • [ X ]
    Öğe
    The oral findings of the gigantic patient with gingival enlargement-(A case)
    (2009) Kaya F.A.; Saribas E.; Dogru A.G.; Dag A.; Gunay A.
    This syndrome results from a chronic exposure to GH (Growth Hormone) leading to the classic clinical features that the diagnosis seems to be easy. The early diagnosis and intervention may prevent irreversible changes associated with chronic overproduction of GH (as well IGF-1) and may also normalise life expectancy. These patients have an increased mortality rate from systemic sequela of hypersomatotrophism in 2-4 times that of the healthy population. The facial scene changes are generally coarsening of features prognathism and diastema (widely spaced teeth). In this case report it is aimed to represent the periodontal surgery findings of a 24 years old male gigantism patient suffering from gingival enlargement in the site of 11 and 12 teeth who applied to Dicle University Faculty of Dentistry Department of Periodontology. After oral hygiene instruction, initial periodontal treatment was performed and after these the patient was operated. The patients periodic follow ups are still lasting by three months intervals.