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    Comparison of the Effect of Periodontal Therapy and Diode Decontamination and Periodontal Therapy Alone on the Amount of TNF-? in Systemically Healthy Chronic Periodontitis Patients A Non-Randomized Clinical Trial
    (Sci Printers & Publ Inc, 2020) Dogru, Arzum Guler; Toprak, Omer; Uner, Devrim Deniz; Izol, Bozan Serhat; Kaplan, Ibrahim; Dogru, Mehmet; Ipek, Fikret
    OBJECTIVE: To evaluate the outcome of initial periodontal therapy and additional diode laser decontamination therapy on clinical parameters and the amount of tumor necrosis factor alpha (TNF-alpha) in gingival crevicular fluid (GCF) in patients with chronic periodontitis. STUDY DESIGN: The study included 22 patients who were diagnosed with chronic periodontitis and who had at least 1 (>= 5 mm) periodontal pocket in the posterior region of each upper left hemi-arcade. The study was designed as a split-mouth study involving mechanical therapy on the right side and nonsurgical periodontal therapy plus diode laser decontamination therapy on the left side. RESULTS: A statistically significant decrease was observed in clinical parameters at 3 months when compared to the values at baseline in both treatment areas. The change in clinical parameters at 3 months after therapy was not significantly different between the groups (p>0.05). The comparison of GCF TNF-alpha levels at baseline and at 3 months in the 2 treatment areas identified significant changes in the TNF-alpha levels in the hemi-arcade treated with laser diode contamination therapy, whereas the changes in the hemi-arcade treated with nonsurgical periodontal therapy were not significant (p>0.05). A between-group comparison revealed no statistically significant difference at 3 months post-therapy, while the difference at 1 month was found to be statistically significant. CONCLUSION: The study found that laser therapy in addition to nonsurgical periodontal therapy has a positive effect on the clinical parameters and proinflammatory TNF-alpha levels in the early period but makes no contribution in the long term.
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    Effects of Extremely Low Frequency Magnetic Fields on Periodontal Tissues and Teeth in Rats
    (Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Dasdag, Suleyman; Yavuz, Izzet; Kilinc, Nihal; Dogru, Arzum Guler
    The aim of this study is to research the effects of ELF magnetic fields on periodontal tissues and teeth in rats histopathologically. The experiments were performed on 27 male Sprague-Dawley rats, aged 4 months at the beginning of the study, weighing (342.4 +/- 38.89) g and fed with standard pelleted food. The rats were divided into three groups; two experimental and one control (sham). Experimental groups were exposed to 100 and 500 mu T ELF magnetic fields during 10 months, 2 h a day, respectively. Third group was sham that were treated like experimental group except ELF magnetic fields exposure in methacrylate boxes. There was no statistical difference between the experimental groups among all tissues (p>0.05). Alveolar bone, pulp and gingiva there were statistically significant differences among the groups of sham and 1st experimental, sham and 2nd experimental (p<0.05). The statistical difference between the experimental and sham groups in the study makes us to think that ELF magnetic fields may have effects on periodontal tissues and teeth.
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    Examination of extremely low frequency electromagnetic fields on orthodontic tooth movement in rats
    (Taylor & Francis Ltd, 2014) Dogru, Mehmet; Akpolat, Veysi; Dogru, Arzum Guler; Karadede, Beyza; Akkurt, Atilim; Karadede, M. Irfan
    The purpose of this study was to evaluate whether 50 Hz extremely low frequency electromagnetic fields (ELF-EMFs) affect the amount of orthodontic tooth movement in rats. The experiments were performed on 18 male Sprague-Dawley rats. The rats were randomly divided into three groups (n = 6): cage-control (Cg-Cnt) group (n = 6); sinusoidal electromagnetic field (SEMF) group (n = 6); and pulsed electromagnetic field (PEMF) group (n = 6). In SEMF and PEMF groups, rats were subjected to 1.5 mT EMF exposure eight hours per day for eight days. In order to obtain tooth movement, holes were drilled on the right and left maxillary central incisors of the rats at a distance 1.5-2 mm away from the gingiva and 20 g of orthodontic forces were applied to the teeth. Generated linear model for repeated measures and Bonferroni tests were used to evaluate the differences between the groups. Interactions among groups by days were found by using Pillai's trace multivariate test. The results showed that significant differences were present among the groups (F = 5.035; p = 0.03) according to the extent of tooth movement. Significant differences between the amount of tooth movements were determined especially after the fifth day and the following days six, seven and eight (p < 0.001). Within the limitations, according to the results of the present study, the application of ELF-EMF accelerated the orthodontic tooth movement in rats.