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Öğe Changes in blood antioxidant status and lipid peroxidation following distance running(1998) Atmaca, Mukadder; Koçyiğit, Yüksel; Şermet, Abdurrahman; Diken, Hüda; Kelle, MustafaTo examine the effects of increased O2 utilization on blood antioxidant status and lipid peroxidation, ten trained male athletes took part in a 20 km distance race. Venous blood samples were removed before and immediately after completion of the half-marathon. Plasma creatine kinase (CK) activity, an index of muscle damage, increased (p<0.05) after the race but this was not accompanied by changes in thiobarbutiric acid reactive substance (TBARS), which is an index of lipid peroxidation. Plasma cholesterol and uric acid concentrations significantly increased (p<0.01 and p<0.05 respectively) but plasma $alpha$-topocherol, triglyceride, and the total protein levels did not change (p>0.05) after the race. The erythrocyte and leucocyte counts, hematocrit, and hemoglobin levels rose after the race (p<0.05, p<0.001, p<0.05, and p<0.01, respectively). However,the mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC) did not change. Erythrocyte superoxide dismutase (SOD) and catalase activities were unaffected by the exercise but total glutathione (GSH) and reduced GSH decreased (p<0.05) after the race. In the post-race samples, a rise in oxidized glutathione (GSSG) was not statistically significant (p>0.05). The result indicate that, when trained athletes run a comparatively short distance sufficient to cause some degree of muscle damage but insufficient to cause increases in the plasma indices of lipid peroxidation, changes in erythrocyte antioxidant status do occur.Öğe Effect of exercise on blood antioxidant status and erythrocyte lipid peroxidation: Role of dietary supplementation of vitamin E(1999) Atmaca, Mukadder; Kelle, Mustafa; Diken, Hüda; Şermet, Abdurrahman; Tümer, CemilWe tested the effects of moderate physical exercise on the blood antioxidant capacity and erythrocyte lipid peroxidation in 21 Wistar albino rats. Erythrocyte superoxide dismutase (SOD) activity increased significantly (p<0.05) in control exercised animals (C-Ex), but catalase activity did not change. SOD activity was decreased by dietary supplementation of vitamin E (p<0.05). In vitamin E supplemented group (E-Ex), catalase activity was reduced in comparision to C-Ex group. Total glutathione (total GSH) level was unaffected by the exercise. However, significant reduction was observed in reduced glutathione (GSH), whereas oxidized glutathione (GSSG) increased (p<0.01 and p<0.001, respectively). In E-Ex animals, total GSH and GSH were increased in comparison to C-Ex group. GSH/GSSG ratio decreased abnormally in both exercised groups (p<0.001). Serum cholesterol and uric acid levels increased significantly after exercise (p<0.05). The susceptibility of eryhrocytes to in vitro peroxidation increased in C-Ex and E-Ex animals (p<0.001 and p<0.01, respectively). Elevated malondialdehyde (MDA) concentrtaion in serum attained statistical significance after exercise. However, this elevation was prevented by vitamin E supplementation. Our results indicated that moderate intensive treadmill running exercise was sufficient to result in muscle damage and increases in the susceptibility of erythrocytes to in vitro peroxidation. In addition, dietary supplementation of vitamin E is able to minimize oxidative damage caused by exercise.Öğe Effects of cigarette smoking on blood antioxidant status in short-term and long-term smokers(2001) Şermet, Abdurrahman; Kelle, Mustafa; Deniz, Basra; Tümer, Cemil; Baylan, Yüksel; Diken, HüdaEffects of cigarette smoking on blood antioxidant status in short-term and long-term smokersÖğe Macrorhage phagocytic activity at acute cold-restraint stress exposed rats: Possible role of nitric oxide(2005) Turner, C.; Bilgin, Hakkı Murat; Obay, Basra Deniz; Diken, Hüda; Taşdemir, Ezel; Atmaca, MukadderIn this study, the effect of acute cold-restraint stress (ACRS) on macrophage phagocytic activity and the possible role of inducible nitric oxide synthase (iNOS) was investigated. The phagocytic activity and plasma total nitrate levels were increased by administration of ACRS. These effects were blocked by injection of a specific iNOS inhibitor aminogua- nidine (AG) (100 mg/kg, i.p.). Taken together, these findings indicate that the increase of phagocytic activity at ACRS exposed rats is related to the iNOS originated nitric oxide (NO).Öğe Sepsiste hemopoetik büyüme faktörlerinin etkinliği(2001) Yılmaz, Gülşen; Akgün, Yılmaz; Yılmaz, Ruşen; Diken, Hüda; Aldemir, Mustafa; Büyükbayram, Hüseyin[Abstract Not Available]
