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    The effect of pyridoxine supplementation on plasma lipoproteins and its relationship with atherogenic risk
    (Faculty Press, 1999) Sermet, A; Atmaca, M; Diken, H; Kelle, M; Deniz, B
    The effect of pyridoxine-HCl on cholesterol in plasma lipoprotein fractions and its relationship with atherogenic risk were investigated in mate Sprague-Dawley rats and healthy human volunteers. Plasma cholesterol, very low and low density lipoprotein cholesterol (VLDL-C and LDL-C) decreased, and high density lipoprotein cholesterol (HDL-C) increased, in rats treated with pyridoxine. Although the cholesterol content of the liver did not change, it decreased significantly in the aorta. Atherogenic risk decreased in rats treated with pyridoxine because of a decrease in the plasma/HDL or LDL/HDL cholesterol ratio and the aorta cholesterol. Plasma cholesterol and cholesterol in the lipoprotein fractions of healthy volunteers given a placebo did not change significantly at the end of the experimental period. Pyridoxine affected the plasma cholesterol and cholesterol in lipoproteins in healthy persons as well as in the rats. Plasma cholesterol, VLDL-C and LDL-C decreased while HDL-C increased. Thus, the atherogenic risk decreased significantly. These findings; indicate that pyridoxine may be an antiatherogenic agent.
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    Öğe
    Platelet aggregation in type two diabetes mellitus and its relationship with lipoprotein levels
    (Faculty Press, 1998) Sermet, A; Kocyigit, Y; Atmaca, M; Kelle, M; Diken, H
    The relationship between in vitro platelet aggregation and plasma lipoprotein concentrations, in 32 type hive non-insulin dependent diabetes mellitus (NIDDM) patients and 32 healthy subjects, was studied. An increase in the fasting plasma glucose and serum fructosamine concentrations in NIDDM patients was determined. No significant difference was found between platelet counts of the diabetic and control groups, but platelet aggregation induced by adenosine diphosphate (ADP), epinephrine and collagen were significantly higher than in healthy controls. Plasma total cholesterol, low density lipoprotein cholesterol (LDL-C) and triglyceride levels were significantly higher, and the plasma high density lipoprotein cholesterol (HDL-C) level was significantly lower than the controls. In vitro platelet aggregation induced by ADP, epinephrine and collagen correlated positively with LDL-C levels and the LDL-C/HDL-C ratio in both groups, and negatively with HDL-C levels in the diabetic group.