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Öğe Activation of toxoplasma retinochoroiditis during pregnancy and evaluation of ocular findings in newborns(Springer, 2017) Turkcu, Fatih Mehmet; Sahin, Alparslan; Yuksel, Harun; Cinar, Yasin; Cingu, Kursat; Altindag, Suat; Deveci, OzcanThe purpose of this study was to evaluate patients with activation of toxoplasma retinochoroiditis during pregnancy and ocular findings in newborns. A total of 17 pregnant patients who were clinically and serologically diagnosed with ocular toxoplasmosis were retrospectively reviewed. After birth, ocular findings for all infants were recorded. The mean age of the patients was 29.08 +/- 5.71 years. In all cases, activation was present in only one eye. In 13 cases, anterior uveitis was associated with posterior uveitis. Visual acuity in all cases prior to treatment was 0.3 +/- 0.21 and increased to 0.55 +/- 0.29 after treatment. The mean gestational age of the patients was 19.76 +/- 8.71 weeks at the time of hospital admission. No case of toxoplasmic ocular involvement was identified in the infants on postnatal examination. In the case of toxoplasma retinochoroiditis during pregnancy, appropriate treatment and follow-up is very important to protect the newborns and to prevent impaired vision in mothers.Öğe Analysis of antimicrobial consumption and cost in a teaching hospital(Elsevier Science London, 2014) Bozkurt, Fatma; Kaya, Safak; Tekin, Recep; Gulsun, Serda; Deveci, Ozcan; Dayan, Saim; Hosoglu, SalihBackground: The aim of this study is to compare the periods before and after the intervention applied using the ATC/DDD method in order to ascertain the rational use of antibiotics in a newly established hospital. Method: The appropriateness of the hospital's antibiotic use, consumption rates and the costs were calculated and compared with other hospitals. Based on these data, an intervention has been planned in order to raise the quality of antibiotic use. The periods before and after the intervention were compared. Between 16 May 2011 and 23 May 2012, data were collected from all hospital units by the infectious diseases specialists and a point prevalence survey was conducted. Anatomical therapeutic chemical classification and the defined daily dose (DDD) methodology were used to calculate the antibiotic consumption. Results: On two specific days in 2011 and 2012, 194 out of 307 patients (63.2%) and 224 out of 412 patients (54.4%) received antibiotic treatment, respectively. In 2011 and 2012, the percentage of appropriate antibiotic use was 51% and 64.3%, respectively. Both in 2011 and 2012, inappropriate antibiotic use was found to be significantly higher in surgical clinics in comparison to the internal diseases clinics and the ICU. This was caused by the high rates of inappropriate perioperative antimicrobial prophylaxis observed in surgical clinics. During both years, approximately one-third of the antibiotics were prescribed for the purposes of perioperative prophylaxis, while 88.5% and 43.7% of these, respectively, were inappropriate and unnecessary. Cephalosporins, fluoroquinolones, combinations of penicillins (including ii-lactamase inhibitors) and carbapenems were the most frequently prescribed antibiotics during the study periods. The mean total antibiotic consumption was 93.6 DDD/100 bed-days and 63.1 DDD/100 bed-days, respectively. The cost of total antibacterial consumption was (sic) 7901.33 for all the patients ((sic) 40.72 per infected patient) and sic 6500.26 ((sic) 29.01 per infected patient), respectively. Conclusion: Each hospital should follow and assess their antibiotic use expressed in DDD in order to compare their antibiotic use with national and international hospitals (WHO, 2009 [14]). (C) 2013 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.Öğe ASSESSMENT OF THE LABORATORY TRANSMISSION OF BRUCELLOSIS IN AN ENDEMIC REGION(Carbone Editore, 2014) Deveci, Ozcan; Tekin, Recep; Aslan, Emel; Hosoglu, Salih; Bozkurt, Fatma; Dayan, Saim; Demirpence, OzlemObjectives: Laboratory-acquired brucellosis (LB) has been one of the most commonly reported laboratory-associated bacterial infections in both endemic and non-endemic countries. Brucellosis is endemic in Turkey. The aim of this study is to describe the risk factors of LB among laboratory healthcare workers. Material and method: A regional survey study was conducted by face-to-face interview in 7 hospitals from Diyarbakir, Mardin and Batman province, in southeaster Anatolia in Turkey. A structured survey questionnaire was administered to the Laboratory healthcare workers, employed in infectious diseases clinics and microbiology departments, who were at risk of Brucella infection. Result: Of the 136 laboratory workers, 13 (9.5%) had a history of laboratory-acquired brucellosis. Logistic regression analysis identified factors independently associated with an increased risk of LB including lack of biosafety cabinet (P<0.005) and a lack of compliance in the use of the same (P<0.005). Using a biosafety cabinet (P<0.005), existence of biosafety cabinet (P<0.005), full adherence to glove use (P<0.005) and male gender(P<0.005) were found to be protective factors. Conclusion: Increased adherence to personal protective equipment and use of biosafety cabinets should be priority targets to prevent LB.Öğe Comparison of Laboratory Values of Prisoner and Civil Patients with Chronic Hepatitis B(Galenos Yayincilik, 2014) Deveci, Ozcan; Uysal, Cem; Korkmaz, Mustafa; Tekin, Recep; Celen, Mustafa Kemal; Dayan, SaimObjective: Since immune processes play a role in the pathogenesis of HBV infection, the immune system of the host is an important factor in the healing of the infection. The aim of the present study is to compare the laboratory findings related to hepatitis B in inmates with chronic hepatitis B, who live in a confined space and whose immune system is affected by various stress factors, and civilian chronic hepatitis B patients. Materials and Methods: The approval of the Dicle University Medical School, Non-Invasive Clinical Studies Ethics Committee was obtained for the study. Inmates and civilians with hepatitis B who presented to the infectious diseases outpatient clinic between December 2010 and June 2013 were enrolled in the study. Both groups were statistically compared in terms of HBV DNA, ALT, AST and HBeAg. Results: A total of 34 inmates and 34 civilian patients were evaluated. While no difference was observed in terms of the liver enzymes, HBeAg positivity was significantly higher among the inmates. Also, a HBV DNA > 104 copies/ml was more frequently observe din the group of inmates, although the difference was statistically insignificant. Conclusion: Studies comparing chronic hepatitis B patients who are leading different lifestyles will help select the patients with priority for treatment.Öğe Cutaneous anthrax in Southeast Anatolia of Turkey(Taylor & Francis Ltd, 2015) Tekin, Recep; Sula, Bilal; Deveci, Ozcan; Tekin, Alicem; Bozkurt, Fatma; Ucmak, Derya; Kaya, SafakContext: Anthrax is a rare disease cause by Bacillus anthracis, a Gram-positive, rod-shaped endospore-forming capsuled bacterium. Anthrax is manifest in three primary forms: cutaneous, respiratory, and gastrointestinal. Cutaneous anthrax accounts for approximately 95% of all cases of anthrax in humans. Objective: In the present study, we evaluated the clinical diagnosis and treatment of cutaneous anthrax, a rare disease that nonetheless remains a serious healthcare problem in developing countries. Methods: The complete medical records of patients diagnosed with cutaneous anthrax between January 2001 and December 2012 were examined in a retrospective manner. Cutaneous anthrax was diagnosed by the identification of typical antrax lesions and/or the presence of Gram-positive-capsuled bacillus after staining with Gram stain and methylen blue in pathology samples obtained from these lesions and the presence of characteristic scarring with a history of severe swelling, black eschar, and positive response to treatment form the basis of diagnosis in cases where cultures were negative for the presence of bacillus. Results: A total of 58 patients were admitted to the hospital with cutaneous anthrax between January 2001 and December 2012. This included 32 (55.2%) males and 26 (44.8%) females, with an age range of 15-82 years and a mean age of 38 +/- 13.8 years. The incubation period for the infection ranged between 1 and 20 d (mean 3.7 +/- 1.4 d). The most common symptoms at the time of hospital referral were swelling, redness, and black eschar of the skin. The most common lesion site was the hand and fingers (41.3%). Isolated of bacteria was used to diagnose the disease in six cases (23.8%), detection of Gram-positive bacillus in samples of characteristic lesion material was used in seven (28.5%) cases, and the presence of a characteristic lesion was the sole diagnositc criteria in 45 (77.6%) cases. Treatment consisted of penicillin G (12 cases), ampicillin-sulbactam (30 cases), Cefazolin (12 cases), or ciprofloxacin (4 cases). Conclusion: Although the prevalence of anthrax is a decreasing worldwide, it remains a significant problem in developing countries. Rapid identification of the signs and symptoms of cutaneous anthrax is essential for effective treatment. Early supportive treatment and appropriate antimicrobial measures are necessary to address this potentially life-threatening disease.Öğe Cytopenia in adult brucellosis patients(Medknow Publications & Media Pvt Ltd, 2018) Kaya, Safak; Elaldi, Nazif; Deveci, Ozcan; Eskazan, Ahmet Emre; Bekcibasi, Muhammed; Hosoglu, SalihBackground & objectives: Brucellosis can lead to haematological abnormalities including cytopenia confusing with haematological malignancies. The aim of this study was to compare the main characteristics of brucellosis patients without cytopenia (Group 1) and with cytopenia (Group 2). Methods: This five-year period study which was performed in two referral hospitals in Turkey, included all adult brucellosis patients. Abnormally, low counts of leucocyte or haemoglobin or platelets in a patient were considered as cytopenia. The demographics, clinical, laboratory, treatment and outcome data were analyzed. Results: A total of 484 brucellosis patients were enrolled. Among the cases, 162 (33.5%) of them had cytopenia. One hundred and four (21.5%) had anaemia, 88 (18.8%) had thrombocytopenia, 71 (14.6%) had leucopenia and 28 (5.8%) had pancytopenia. The mean age of group 2 was 35.01 +/- 16.05 yr and it was 33.31 +/- 14.39 yr in group 1. While there was no difference between the groups in terms of duration of treatment, the median length of hospital stay (LOS) was significantly longer in group 2 (9 vs 10 days; P<0.001). The most frequently applied combination therapy consisted of doxycycline plus rifampicin and doxycycline plus streptomycin regimens. No significant difference was observed in terms of duration of treatment, LOS and restoration time of cytopenia between the patients who received either of these combinations. Interpretation & conclusions: Our findings suggested that the patients with cytopenia should be investigated for brucellosis, especially if living in, or with a history of travel to, endemic areas, in view of the increase in world travel.Öğe Evaluation of posttraumatic recurrent bacterial meningitis in adults(Turkish Assoc Trauma Emergency Surgery, 2015) Deveci, Ozcan; Uysal, Cem; Varol, Sefer; Tekin, Recep; Bozkurt, Fatma; Bekcibasi, Muhammed; Hosoglu, SalihBACKGROUND: Acute bacterial meningitis may develop as a complication after head trauma. The aim of this study was to present the demographic, clinical, microbiological and radiological characteristics of adult patients who presented with recurrent bacterial meningitis attacks after trauma. METHODS: Using a retrospective approach, the medical records of patients with acute recurrent bacterial meningitis (RBM) were reviewed, and those who had a history of trauma were included into the study. RBM was diagnosed based on clinical, bacteriologic and laboratory results. Demographic characteristics, clinical course, laboratory test results including cerebrospinal fluid analysis (CSF), radiological images, and the applied treatments were evaluated. RESULTS: A total of two hundred and twelve patients with acute bacterial meningitis were included into the study. RBM was diagnosed in twenty-five patients (11.8%), and in 18 of these patients (8.5%), the attacks had occurred subsequent to a trauma. In the CSF cultures of four patients, S. pneumoniae growth was observed. CT cisternography indicated CSF leaks in eleven patients. Moreover, bone fractures were observed in the CT images of ten patients. Ceftriaxone therapy was prescribed to 83% of the patients. Eight patients had a history of a fall in childhood, and five were involved in traffic accidents before acute bacterial meningitis. Four of the patients developed epilepsy and one developed deafness as sequelae. CONCLUSION: Since RBM attacks are frequently observed following trauma, in patients with a history of trauma who present with meningitis, the risk of recurrence should be considered.Öğe Fibromyalgia incidence among patients with hepatitis B infection(Wiley, 2016) Yazmalar, Levent; Deveci, Ozcan; Batmaz, Ibrahim; Ipek, Davut; Celepkolu, Tahsin; Alpayci, Mahmut; Hattapoglu, ErkamAim: The purpose of our investigation was to evaluate the incidence of fibromyalgia syndrome (FMS) and identify FMS-related clinical symptoms in hepatitis B virus (HBV) patients. Methods: One hundred and eighteen HBV surface antigen (HbsAg)-positive patients (40 with chronic active hepatitis B, 40 hepatitis B carriers and 38, all of whom had been antiretroviral-treated for at least 3 months) were included in this study. In addition, 60 age- and gender-matched HbsAg-negative healthy controls were included in the study. Results: There was no significant difference in age, gender or body mass index (BMI) between the two groups (P > 0.05). Serum aspartate aminotransferase and alanine aminotransferase levels were significantly higher in HBV patients relative to the control group (P < 0.05). The incidence of FMS, widespread body pain, fatigue, sleep disturbance, anxiety, morning stiffness, arthralgia was significantly greater among HBV patients relative to the control group. Additionally, the mean tender point counts and the visual analog scale values were significantly higher among the HBV patients (P < 0.05). Conclusions: The results of the present study demonstrate that FMS incidence is greater among HBV patients relative to control subjects. However, there were no differences in FMS incidence among the subgroups of HBV diagnoses.Öğe FOUR-YEAR STUDY OF ENTECAVIR EFFICACY AND SAFETY IN NUCLEOS(T)IDE-NAIVE HBeAg POSITIVE CHRONIC HEPATITIS B PATIENTS(Sestre Milosrdnice Univ Hospital, 2014) Celen, Mustafa Kemal; Dal, Tuba; Ayaz, Celal; Bayan, Kadim; Mert, Duygu; Deveci, Ozcan; Oruc, Ebru KursunEntecavir is a guanosine analogue with activity against hepatitis B virus. The aim of this 4-year trial was to evaluate entecavir treatment in nucleos(t)ide-naive HBeAg-positive chronic hepatitis B patients. Forty-nine patients received entecavir and nine of them withdrew from the trial at the end of week 96. The initial mean value of alanine aminotransferase was 79.4 +/- 41.5 IU/L, and at the end of the 4-year study period, 90% of patients had alanine aminotransferase values within the normal range. At week 96, 91.7% of patients had HBV DNA <300 copies; at month 48, 90% of patients had HBV DNA <50 IU/mL. HBeAg loss was recorded in 7.1% of patients at week 96 and in 12.5% at month 48. The rate of HBeAg seroconversion was 4.8% at week 96 and 7.5% at month 48. The rate of HBsAg seroconversion was 2.1% at week 96 and 2.5% at month 48. Entecavir as a potent and safe agent leading to continuous viral suppression proved to be safe and well tolerated therapy.Öğe IN VITRO ACTIVITY OF QUINUPRISTIN-DALFOPRISTIN, METHICILLIN AND VANCOMYCIN AGAINST STAPHYLOCOCCUS STRAINS ISOLATED FROM CLINICAL SAMPLES(Erciyes Üniversitesi, 2012) Yula, Erkan; Özer, Turkan TOKA; Deveci, Ozcan; Tekin, Alicem; Yanık, Keramettin; Durmaz, SuleymanBu çalışmada, çeşitli klinik örneklerden izole edilen stafilokok suşlarında kinupristin-dalfopristin duyarlılık oranlarının araştırılması amaçlanmıştır. Çalışmaya, mikrobiyoloji laboratuvarına gönderilen çeşitli klinik örneklerden izole edilen 98 stafilokok suşu [74'ü koagülaz negatif stafilokok (KNS) ve 24'ü S. aureus] dahil edildi. Stafilokok suşları konvansiyonel yöntemler ile tanımlandı. Stafilokok suşlarının metisilin ve kinupristin-dalfopristin duyarlılığı Clinical and Laboratory Standards Institute (CLSI) önerileri doğrultusunda Kirby-Bauer disk difüzyon yöntemiyle çalışıldı. Ayrıca suşların vankomisin duyarlılığı E-test yöntemi ile araştırıldı. Çalışmada kalite kontrol suşu olarak S. aureus ATCC 25923 kullanıldı. İzole edilen KNS’lerin 53(% 72)’ü metisiline dirençli KNS (MR-KNS) ve S. aureus’ların ise 3(%13)’ü metisiline dirençli (MRSA) olarak tanımlandı. MRKNS’lerin 8(% 15)’i kinupristin-dalfopristine dirençli iken, metisiline duyarlı KNS'lerde (MS-KNS) kinupristindalfopristin direnci 1(%5) suşta tespit edildi. MSSA ve MRSA suşlarının hiçbirinde kinupristin-dalfopristin direnci tespit edilmedi. Suşların tamamının vankomisine duyarlı olduğu bulundu. Stafilokok suşlarının kinupristindalfopristine yüksek oranda duyarlı oldukları bulundu. Sonuç olarak vankomisin gibi kinupristin-dalfopristin kombinasyonun da özellikle dirençli Gram-pozitif kok enfeksiyonlarının tedavisinde alternatif olabileceğini düşünmekteyizÖğe Investigation of the Effects of Total Oxidative Stress and Total Antioxidant Capacity on the Prognosis in Patients with Chronic Viral Hepatitis B(Galenos Publ House, 2022) Mermutluoglu, Cigdem; Bekcibasi, Muhammed; Deveci, Ozcan; Cerrah, Serkan; Kaplan, Ibrahim; Bozkurt, Fatma; Celen, Mustafa KemalObjectives: Experimental studies showed the role of oxidative stress in cell destruction and DNA damage in chronic viral hepatitis, In this study, oxidative stress was measured in various clinical forms of chronic hepatitis B (CHB) and the role of oxidative stress was investigated in the development of hepatitis clinic.Materials and Methods: In total, 33 patients with inactive hepatitis B carrier (IHBC), 33 patients with active CHB infection, and 33 healthy adults were included in the study. Serum transaminases [alanine aminotransferase (ALT), aspartate aminotransferase, total antioxidant capacity, and total oxidative stress (TOS)] were measured and compared in the patient groups.Results: In 99 patients were included in the study (56 men, 43 women). The mean age of patients in CHB was 33.21 +/- 10.20, in IHBC 36.73 +/- 11.54, and the control group 33 +/- 11.71. The mean ALT value was 40.93 +/- 28.28 U/L in the patients with CHB and 36.33 +/- 28.99 U/L in the patients with IHBC. The TOS value115.46 +/- 139.64 pm H2O2 equivalent/L in the CHB and 52.67 +/- 40.36-pm H2O2 equivalent/L in IHBC.Conclusion: ALT and TOS levels were significantly higher in the CHB than in the other groups. The increased TOS levels in the CHB may be related to the activity of cell destruction in active cases.Öğe The levels of copper, zinc and magnesium in type II diabetic patients complicated with foot infections(Springer India, 2013) Bozkurt, Fatma; Tekin, Recep; Gulsun, Serda; Satici, Omer; Deveci, Ozcan; Hosoglu, SalihChanges in levels of trace elements and magnesium (Mg) may contribute to progression of diabetes mellitus (DM) and development of the complications. The aim of this study was to measure the levels of Copper (Cu), Zinc ( Zn), Mg and Cu/Zn ratios in diabetic foot infected patients (DFI) compared to controlled diabetic patients and healthy controls. 50 patients complicated with DFI, 50 controlled diabetic patients without any complications and 100 age and sex matched healthy subjects were enrolled in the study. Fasting plasma glucose, HbA1c, Cu, Zn and Mg were measured. One-Way ANOVA test was used to compare three different groups. Correlations between different variables were analysed using Pearson's correlation coefficients(r). The mean values of Cu and Zn were higher in patients with DFI and DM compared to controls (P < 0.001). Cu/Zn ratios were higher in DM compared to DFI and control groups (P < 0.001). Serum Mg levels were lower in all diabetic patients. Elevation of Cu in DFI and DM groups was positively correlated with Cu/Zn ratios and elevation of Zn is negatively correlated. Our findings indicate an association between increased Zn concentrations and DFI.Öğe Non-invasive parameters in the assessment of liver fibrosis.(Allied Acad, 2017) Dayan, Saim; Dal, Tuba; Tekin, Recep; Deveci, Ozcan; Ipek, Davut; Ozcan, Nida; Bozkurt, FatmaLiver biopsy and histopathological evaluation are the main methods to assess liver pathology. However, liver biopsy is not widely used due to implementation challenge. We aimed to investigate non-invasive parameters for evaluation of liver fibrosis in chronic Hepatitis B patients. A total of 65 patients who admitted to outpatient clinic and diagnosed as chronic hepatitis were included in this study. Liver puncture biopsy was performed for all patients and was evaluated according to the Modified Ishak Fibrosis Score. The patients without fibrosis or with mild and moderate fibrosis were evaluated as Group I (Stage O, I, II), the patients with advanced fibrosis were evaluated as Group II (stage III, IV, V, VI). Among 65 patients, 42 were male and 23 were female; 48 of the patients were in group I while 17 patients belonged to group II. Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Aspartat Transaminaz (AST) and Alanin Aminotransferaz (ALT) levels were significantly higher in Group II patients. In the assessment of liver fibrosis, liver biopsy remains the gold standard diagnostic method but AST, ALT, GGT, ALP parameters have contribution to this evaluation. Non-invasive testing may be useful in cases which biopsy cannot be performed or repeat biopsy required.Öğe Nosocomial infections in a district hospital in Turkey.(Allied Acad, 2015) Ozer, Turkan Toka; Deveci, Ozcan; Yula, Erkan; Tekin, Alicem; Yanik, Keramettin; Durmaz, SuleymanNosocomial infections are significantly important health problems for both hospitals and patients. No data are available on nosocomial infections in South-East Anatolian region of Turkey region. This study was performed to determine the nosocomial infection rate and type in Kiziltepe State Hospital, Mardin within one year. The surveillance data of nosocomial infections in Kiziltepe State Hospital between January 1st and December 31th, 2010, was evaluated retrospectively. The epidemiological data was collected by laboratory and hospital-based active surveillance method between January and December 2010. 10,410 patients were hospitalized during this period. 27 (0.26%) hospital-acquired infections were detected. Incidence density was calculated to be 1.46. The highest rate of hospital infections (0.50%) was seen in the intensive care unit. The highest rate of infection was observed in the Thoracic Surgery Clinic (4.1%). In total, 55.5% of detected hospital-acquired infections were surgical site infections, 25.9% urinary tract infections and 11.1% were pneumonia. The frequency of nosocomial infections was found to be low in this hospital compared to other hospital infection rates reports from Turkey. The low infection rate was related with rapid patient circulation. The rate of nosocomial infection is high in intensive care unit patients, especially for surgical site infections. The results provide epidemiological information that will help to implement infection control policies in this hospital.Öğe Orthophenylphenol in healthcare environments: a trial related to a new administration method and a review of the literature(Tubitak Scientific & Technological Research Council Turkey, 2013) Tekin, Alicem; Dal, Tuba; Selcuk, Caferi Tayyar; Deveci, Ozcan; Tekin, Recep; Mete, Mahmut; Dayan, SaimAim: To investigate antibacterial and antifungal effectiveness of orthophenylphenol (Fumispore, LCB, La Salle, France) with a new administration method in healthcare environments. Materials and methods: This study was performed in 3 units of the Dicle University Hospital. Surface swab and ambient air samples were collected just before the application of Fumispore and 6 h later. All samples were inoculated onto plate count agar and Sabouraud dextrose agar. The total aerobic colony count (ACC) was determined by using the standard method based on quantitative bacterial measurement. Results: In total, 30 surface swabs and 6 ambient air samples were collected. The mean values of the total ACC were determined on surface swabs: 12.1 colony CFU/cm2 for total microorganisms and 2.9 CFU/cm2 for fungi before application, and 1.6 CFU/cm2 for total microorganisms and 0.4 CFU/cm2 for fungi after application. The mean values of the total ACC were detected in ambient air samples: 258 CFU/m3 for total microorganisms and 208 CFU/m3 for fungi before application, and 20 CFU/m3 for total microorganisms and 15 CFU/m3 for fungi after application. Conclusion: The total ACC values obtained before and after applications have shown that orthophenylphenol (Fumispore) is suitable for adequate disinfection in healthcare environments.Öğe Prognostic significance of transforming growth factor-beta-1 in chronic hepatitis C virus infection(Academic Journals, 2012) Deveci, Ozcan; Agalar, Canan; Demirdal, Tuna; Demirturk, Nese; Yula, Erkan; Tekin, Alicem; Kaygusuz, SedatInterferon treatment in hepatitis C virus (HCV) infection is expensive and has various adverse effects. Some markers may help in making decision to stop or maintain the treatment. The aim of this study was to evaluate the effectiveness of serum transforming growth factor beta-1 (TGF-beta 1) in assessing outcome of interferon treatment in patients with HCV infection. Twelve patients with chronic HCV infections included in the study as treatment group [Treatment group: anti-HCV (+), HCV RNA (+)] and 12 patients with anti-HCV positive, HCV-RNA negative and normal liver function tests included as control group. All patients in the treatment group were administered with peginterferon and ribavirin for 24 weeks. HCV-RNA levels were determined by realtime-PCR and TGF-beta 1 levels were measured with ELISA methods, at the beginning and 24th week of the treatment. Mann-Whitney U Test and Wilcoxon Test were used to compare variables within and between groups. Median age and male/female ratios were 46 years and 5/7, and 45 years and 3/9 for treatment groups and control group, respectively. Although no difference was found in TGF-beta 1 levels at the beginning of the treatment between groups (p>0.05), significantly decreased TGF-beta 1 levels were observed following 24 weeks of interferon treatment in treatment group (p=0.015). Despite limited number of patients, our data suggested that, TGF-beta 1 levels may be used as a prognostic marker for effectiveness of interferon treatment in patients with hepatitis C virus infection.Öğe Risk Factors for Colistin-Associated Acute Kidney Injury: A Multicenter Study from Turkey(Natl Inst Infectious Diseases, 2016) Gul, Serdar; Kuscu, Ferit; Aydemir, Hande; Ozturk, Dogan Baris; Deveci, Ozcan; Duygu, Fazilet; Kacmaz, BirgulThe aim of this study was to investigate the incidence of acute kidney injury (AKI) and risk factors due to colistin use in patients infected with multidrug-resistant pathogens. This multicenter, retrospective, observational study was conducted in Turkey, at 5 different research and university hospitals. Cox regression analyses were performed, to determine independent predictors of AKI. From April 2012 to July 2014, a total of 216 patients aged between 18-94 years, treated with colistimethate sodium (CMS) were included in the study. The mean age of the patients was 60.3 +/- 20.1 years. The overall incidence of AKI was 34.3% (74/216) at any time during treatment. Concomitant use of loop diuretics, baseline creatinine level, and CMS dosage were independently associated with AKI. According to our results, patients with higher baseline creatinine levels, or patients who had to use concomitant loop diuretics may need to be monitored more closely, and dose adjustment should be done promptly. More comprehensive studies are, however, still needed to evaluate the efficacy of low-dose colistin since higher doses tend to increase the risk of AKI.Öğe Risk Factors for Nosocomial Burn Wound Infection Caused by Multidrug Resistant Acinetobacter baumannii(Lippincott Williams & Wilkins, 2014) Tekin, Recep; Dal, Tuba; Bozkurt, Fatma; Deveci, Ozcan; Palanci, Yilmaz; Arslan, Eyup; Selcuk, Caferi TayyarAcinetobacter baumannii infections in burn patients may lead to delays in wound healing, graft losses, and development of sepsis. Determining the risk factors for multidrug resistant A. baumannii (MDR-AB) infections is essential for infection control. In the present study, the authors aimed to evaluate risk factors for wound infections caused by A. baumannii in burn patients. The study was conducted at Dicle University Hospital Burn Center, from April 2011 to July 2012, to investigate the risk factors for MDR-AB infections. The data of both the case and control group patients and the result of wound cultures were recorded on a daily basis, on individual forms given for each patient, and analyzed. A total of 30 cases infected with MDR-AB, and 60 uninfected control patients, were included in the study. The mean age (+/- SD) was 7.7 +/- 15.4 years in infected patients and 11.4 +/- 16.5 years in uninfected patients. The mean total burn surface area was 13.5 +/- 10.9% in uninfected patients and 34.7 +/- 16.2% in infected patients. The mean total burn surface area, the abbreviated burn severity index, acute physiological and chronic health evaluation II score, day of admission to hospital, length of hospital stay, first excision day, prior usage of third-generation cephalosporins, and stay in intensive care unit of the infected patients were significantly higher (P < .001) than those of patients without infection. Univariate analysis found that high acute physiological and chronic health evaluation II score, first excision time of wound, invasive device usage, admission day to hospital, and prior usage of broad-spectrum antibiotics were risk factors for nosocomial infections. This study showed that multiple factors contribute to multidrug resistance in A. baumannii. A combination of an early diagnosis of wound infections, appropriate antimicrobial treatments, surgical debridement, and early wound closure may be effective in the management.Öğe Soft Tissue Abscess Caused by Aspergillus Fumigatus in an Immunosuppressive Patient(Modestum Ltd, 2013) Dal, Tuba; Tekin, Alicem; Tekin, Recep; Deveci, Ozcan; Firat, Ugur; Mete, Mahmut; Dayan, SaimAspergillosis is a definition including a wide variety of diseases caused by fungi in the genus Aspergillus. Aspergillosis that occurs especially in neutropenic and immunosuppressive patient is an opportunistic infection with a very high mortality rate. In this study, we presented a case of primary cutaneous aspergillosis that caused in a heart transplant recipient. Thirty-nine-years-old male patient with the complaints of high fever lasting for ten days, redness of the right thigh, swelling, and pain, was admitted to our hospital. By the tissue ultrasonography of right thigh, 3x12 cm in size of septated intensive fluid collection (abscess?) in muscle tissue at a depth of 1.5 cm to the skin surface was reported. The biopsy specimens that were taken from the lesion sent to microbiology and pathology laboratories. The branching septate hyphae were observed in Hematoxylin-Eosin and Gram stained preparations. Aspergillus fumigatus was isolated and identified from the biopsy specimen. The patient's symptoms were regressed rapidly and the lesion was improved by surgical debridement and antifungal agent (amphotericin B) therapy. In the light of this case report, we were emphasized that microbiologic examination and culture have an important role for diagnosis of cutaneous aspergillosis.Öğe Therapy for wound infections after earthquakes requires inclusion of drugs targeting Gram-negative bacteria(Taylor & Francis Ltd, 2017) Bekcibasi, Muhammed; Hosoglu, Salih; Deveci, Ozcan; Dayan, Saim[Abstract Not Available]
