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Öğe Changes in serum desnutrin levels in patients with acne vulgaris(John Libbey Eurotext Ltd, 2014) Demir, Betul; Ucak, Haydar; Cicek, Demet; Aydin, Suleyman; Erden, Filter; Dertlioglu, Selma BakarBackground: Androgens and insulin may contribute to increased sebum production in the pathogenesis of acne vulgaris. Objective: We investigated the association between serum desnutrin levels and acne vulgaris in the pathogenesis of insulin resistance. Material and methods: 25 patients presenting with acne vulgaris and 25 control subjects participated in this study. Fasting blood glucose, triglycerides, LDL, VLDL, HDL, total cholesterol, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Desnutrin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Results: Patients with acne vulgaris had a mean serum desnutrin level of (8.83 +/- 1.13 mu IU/mL), which was statistically significantly lower in the control group (10:58 +/- 3.43 mu IU/mL). In patients with acne vulgaris the serum glucose levels, insulin levels and HOMA-IR values (87.92 +/- 7:46 mg/dL, 11.33 +/- 5.93 mu IU/mL, 2.49 +/- 1.40, respectively) were significantly higher than the control group (77.36 +/- 9.83 mg/dL, 5.82 +/- 2.68 mu IU/mL, 1.11 +/- 0.51, respectively) (p = 0.01, p<0.001, p<0.001, p<0.001, respectively). Conclusion: Full cohort (patients and controls) evaluation revealed a negative correlation between the serum glucose and desnutrin levels (r = -0.31, p<0.05). A positive correlation was found between insulin and desnutrin levels (r = 0.42, p<0.001). In patients with acne vulgaris, as a result of increased levels of serum glucose and insulin, the function of desnutrin was suppressed, perhaps contributing to insulin resistance.Öğe Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis(Taylor & Francis Ltd, 2013) Ucak, Haydar; Demir, Betul; Cicek, Demet; Dertlioglu, Selma Bakar; Akkurt, Zeynep Meltem; Ucmak, Derya; Halisdemir, NurhanBackground: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.Öğe Quality of life in lepromatous leprosy patients(Deri Zuhrevi Hastaliklar Dernegi, 2014) Demir, Betul; Ucak, Haydar; Dertlioglu, Selma Bakar; Demir, Sukru; Guler, Kubilay; Cicek, Demet; Halisdemir, NurhanBackground and Design: Leprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus affecting the skin and peripheral nervous system. Leprosy can lead to severe deformities depending on the extent of the disease. In this study, we aimed to investigate the quality of life of patients with lepromatous leprosy. Materials and Methods: Thirty-five patients with lepromatous leprosy and 35 healthy controls were included in the study. The patients were evaluated with the Turkish version of the Dermatology Life Quaky Index (DLQI) and the 36-Item Short Form Health Survey (SF-36). The relationship of quality of life with age, gender, marital status, and the grade of the visual impairment was studied and compared with the healthy controls. Results: Total and all the subgroup DLQI scores were higher in the leprosy group than in the control group (p<0.05). The patients with grade 2 visual impairment were more severely affected by the disease with regard to symptoms/feelings and school/work life as compared to the patients with grade 1 visual impairment (p=0.04, p=0.03, respectively). SF-36 physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, and emotional role functioning scores were statistically lower in the patient group than in the control group (p<0.05). Conclusion: We observed that DLQI scores were lower in patients with lepromatous leprosy than in the control group, while increasing impairment in eyes was found to have a negative impact on quality of life. The SF-36 revealed that physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, emotional role functioning, and mental health were negatively influenced in patients with lepromatous leprosy.Öğe Serum ghrelin levels in patients with Behcet's disease(Termedia Publishing House Ltd, 2016) Erden, Ilker; Ucak, Haydar; Demir, Betul; Cicek, Demet; Dertlioglu, Selma Bakar; Aydin, Suleyman; Ozturk, SavasIntroduction: Behcet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. Aim: To measure serum ghrelin levels in BD patients and healthy controls and to investigate its association with metabolic syndrome (MetS). Material and methods: Thirty BD patients and 30 healthy individuals were enrolled in the study. Ghrelin levels were measured in blood samples using ELISA. Results: The mean serum ghrelin level in BD patients (28.57 +/- 14.04) was significantly lower compared to healthy controls (40.72 +/- 23.21) (p = 0.01). The mean serum ghrelin level in BD patients who had MetS (24.18 +/- 12.73) was lower compared to BD patients who did not have MetS (30.77 +/- 14.45), but this difference was not significant (p > 0.05). Conclusions: Ghrelin levels were lower in BD patients compared to healthy controls. There was no association between reduced ghrelin levels and MetS; however, there was a negative correlation between ghrelin levels and disease activity.Öğe Serum salusin-? and salusin-? levels in patients with Behcet's disease(John Libbey Eurotext Ltd, 2014) Erden, Ilker; Demir, Betul; Ucak, Haydar; Cicek, Demet; Dertlioglu, Selma Bakar; Aydin, SuleymanBackground: Behcet' s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. There is an increased predisposition to insulin resistance and metabolic syndrome (MetS) in BD patients. Objective: The aim of this study was to determine serum salusin-alpha and salusin-beta levels in BD patients and healthy controls and to investigate their association with MetS. Patients and Methods: Twenty-five BD patients and 25 healthy controls were included in the study. Salusin-alpha and salusin-beta levels were measured in blood samples using ELISA. In addition, BD patients and healthy controls were evaluated in terms of MetS. Results: The mean serum salusin-alpha level in BD patients was significantly lower compared to healthy controls (p = 0.03), whereas the mean serum salusin-beta level in BD patients was significantly higher compared to healthy controls (p = 0.03). The mean serum salusin-alpha level was significantly lower in BD patients with MetS compared to BD patients without MetS (p = 0.04). Conclusions: Serum salusin-a level (an anti-atherogenic molecule) was lower, while serum salusin-beta level (a pro-atherogenic molecule) was higher in BD patients. We consider that the decrease in salusin-alpha and the increase in salusin-beta levels contribute to the development of MetS.
