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    Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study
    (Pergamon-Elsevier Science Ltd, 2011) Demirin, Hilmi; Ozhan, Hakan; Ucgun, Taner; Celer, Ahmet; Bulur, Sule; Cil, Habip; Gunes, Cemalettin
    Aim: Mean platelet volume (MPV) in the healthy population has not been studied before. Therefore, the aim of the study was to measure MPV in normal subjects in a large cohort of Turkish adults. Methods: A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. Subjects who had smoking habit, diabetes, hypertension, coronary artery disease, dyslipidemia, chronic obstructive pulmonary disease, cancer, chronic use of any drugs including antiplatelets, heavy drinkers, metabolic syndrome, ejection fraction < 55%, creatinine > 1.4 in men and > 1.1 in women, abnormal liver function tests and an abnormal TSH were excluded in a in a stepwise manner. Complete blood counts were done on the same day within 6 hours by a CELL-DYN 3700 SL analyzer (Abbott Diagnostics). Results: Three hundred twenty-six participants (204 females (63%) and 122 males (37%) with a mean age of 41 +/- 16) constituted the final healthy cohort. Mean MPV of the cohort was 8.9 +/- 1.4 fL. There was no significant difference among age groups regarding MPV. Conclusion: Ninety-five percent of the individuals had a MPV between 7.2 and 11.7 fL. A patient having a MPV beyond this range should be evaluated carefully especially for occlusive arterial diseases. (C) 2011 Elsevier Ltd. All rights reserved.
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    Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C
    (Asian Journal Of Chemistry, 2013) Demirin, Hilmi; Gokalp, Osman; Kaya, Ertugrul; Buyukvanli, Bora; Cesur, Gokhan; Ozkan, Aybars; Kaya, Murat
    Phosalone (6-chloro-3-[diethoxyphosphinothioylsulfanylmethyl]-1,3-benzoxazol-2-one) is one of the most commonly used organophosphorus pesticides in the peat control of crops. Subchronic phosalone exposure was evaluated for its effects on the serum activities of some enzymes concerning hepatic and pancreatic damage including aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), cholinesterase (ChE); and finally protective effects of combination of vitamins E and C in 24 wistar-albino rats. Experimental groups were as follows: control group (n = 8); a group treated with 120 mg/kg body weight phosalone (P group, n = 8); and a group treated with 120 mg/kg body weight phosalone + vitamin E + vitamin C (P+V group, n = 8). The P and P+V groups were treated orally with phosalone on 5 days a week for 4 weeks. The serum activities of the above mentioned enzymes were analyzed. In the samples phosalone significantly increased the activities of ALT, LDH and decreased ChE (p < 0.05). However no significant change was detected for the remainder enzymes (p > 0.05). In the P+V group, ALT and LDH activities were significantly increased and ChE decreased (p < 0.05). It is concluded that subchronic phosalone causes rat liver damage to an extent, which is somewhat reflected on the liver enzymes. Furthermore, a combination of vitamins E and C can reduce the toxic effects of phosalone on liver tissue of rats.