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Öğe Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study(Elsevier, 2019) Duman, Taskin; Demirci, Seden; Uluduz, Derya; Kozak, Hasan Huseyin; Demir, Serkan; Misirli, Cemile Handan; Kucukoglu, HayriyeAim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics. Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded. Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 +/- 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up. Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings.Öğe Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study(Hindawi Limited, 2020) Uludüz, Derya Uğurlu; Sahin, Sevki; Duman, Taskin; Öztürk, Şerefnur; Yayla, Vildan Ayşe; Afşar, Nazire; Nevzat, Uzuner; Midi, İpek; Çınar, Nilgün; Sungur, Mehmet Ali; Domaç, Füsun Mayda; İnce, Birsen; Göksan, Baki; Mısırlı, Cemile Handan; Bakar, Mustafa; Kozak, Hasan Hüseyin; Çolakoǧlu, Sena; Karahan, Ali Yavuz; Göksu, Eylem Özaydın; Özdağ, Fatih Mehmet; Şenol, Mehmet Güney; Yürekli, Vedat Ali; Aluçlu, Ufuk; Demir, Serkan; Küçükoğlu, Hayriye; Oruç, Serdar; Yesilot, Nilufer; Küsbeci, Özge Yılmaz; Nazlıel, Bijen; Tokuç, Firdevs Ezgi Ucan; Bektaş, Hesna; Taşçılar, Fatma Nida; Aytaç, Emrah; Gökçe, Mustafa; Çaǧlayan, Hale Zeynep Batur; Tüfekçi, Ahmet; Uzuner, Gülnur Tekgöl; Örken, Dilek Necioǧlu; Yalın, Özgür Osman; Utku, Uygar; Yılmaz, Arda; Genc, Hamit; Çabalar, Murat; Milanlıoğlu, Aysel; Ekmekçi, Hakan Ahmet; Zeydan, Burcu; Baybaş, Sevim; Kablan, Yüksel; Göksel, Başak Karakurum; Açıkgöz, Mustafa; Kurucu, Hatice; Demirci, Seden; Güneş, Taşkınackground. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group. Methods. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF. Results. The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34±9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38±9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%). Conclusion. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.Öğe Clinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein(Galenos Publ House, 2024) Koc, Sumeyye; Sen, Sedat; Terzi, Yuksel; Kizilay, Ferah; Demir, Serkan; Aksoy, Durdane Bekar; Kurtulus, FatmaBackground: Optic neuritis, myelitis, and neuromyelitis optica spectrum disorder (NMOSD) have been associated with antibodies against myelin oligodendrocyte glycoprotein-immunoglobulin G (anti-MOG-IgG). Furthermore, patients with radiological and demographic features atypical for multiple sclerosis (MS) with optic neuritis and myelitis also demonstrate antibodies against aquaporin-4 and anti-MOG-IgG. However, data on the diagnosis, treatment, follow-up, and prognosis in patients with anti-MOG-IgG are limited. Aims: To evaluate the clinical, radiological, and demographic characteristics of patients with anti-MOG-IgG. Study Design: Multicenter, retrospective, observational study. Methods: Patients with blood samples demonstrating anti-MOG-IgG that had been evaluated at the Neuroimmunology laboratory at Ondokuz May & imath;s University's Faculty of Medicine were included in the study. Results: Of the 104 patients with anti-MOG-IgG, 56.7% were women and43.3% were men. Approximately 2.4% of the patients were diagnosed with MS, 15.8% with acute disseminated encephalomyelitis (ADEM), 39.4% with NMOSD, 31.3% with isolated optic neuritis, and 11.1% with isolated myelitis. Approximately 53.1% of patients with spinal involvement at clinical onset demonstrated a clinical course of NMOSD. Thereafter, 8.8% of these patients demonstrated a clinical course similar to MS and ADEM, and 28.1% demonstrated a clinical course of isolated myelitis. The response to acute attack treatment was lower and the disability was higher in patients aged > 40 years than patients aged < 40 years at clinical onset. Oligoclonal band was detected in 15.5% of the patients. Conclusion: For patients with NMOSD and without anti-NMO antibodies, the diagnosis is supported by the presence of anti-MOG-IgG. Furthermore, advanced age at clinical onset, Expanded Disability Status Scale (EDSS) score at clinical onset, spinal cord involvement, and number of attacks may be negative prognostic factors in patients with anti-MOG-IgG.Öğe Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study(Kare Publ., 2021) Duman, Taşkın; Çınar, Nilgün; Uludüz, Derya; Domaç, Füsun Mayda; Öztürk, Şerefnur; Yayla, Vildan; Karahan, Ali Yavuz; Afşar, Nazire; Sungur, Mehmet Ali; Göksu, Eylem Özaydın; Yürekli, Vedat Ali; Genç, Hamit; Utku, Uygar; Şahin, Şevki; Tekeli, Hakan; Tokuç, Firdevs Ezgi; Uzuner, Nevzat; Şenol, Mehmet Güney; Yılmaz, Arda; Gökçe, Mustafa; Demirci, Seden; Küsbeci, Özge Yılmaz; Uzuner, Gülnur Tekgöl; Çağlayan, Hale Zeynep Batur; Açıkgöz, Mustafa; Kurucu, Hatice; Özdağ, Mehmet Fatih; Baybas, Sevim; Ekmekçi, Hakan; Çabalar, Murat; Yaman, Mehmet; Bektaş, Hesna; Kaplan, Yüksel; Göksel, Başak Karakurum; Milanlıoğlu, Aysel; Örken, Dilek Necioğlu; Aluçlu, Mehmet Ufuk; Çolakoğlu, Sena; Tüfekçi, Ahmet; Bakar, Mustafa; Nazliel, Bijen; Taşçılar, Nida; Göksan, Baki; Kozak, Hasan Hüseyin; Mısırlı, Cemile Handan; Küçükoğlu, Hayriye; Midi, Ipek; Mengüllüoğlu, Necdet; Aytaç, Emrah; Yeşilot, Nilüfer; İnce, Birsen; Yalın, Osman Özgür; Güneş, Taşkın; Oruç, Serdar; Demir, SerkanObjectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache [NIH]). Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis ( VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared. Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group. Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.Öğe Revize Edilmiş Okul İklimi Öğretmen Ölçeğinin Türkçe Formunun Geçerlik ve Güvenirlik Çalışması(2016) Yılmaz, Ferat; Demir, SerkanBu çalışmada, karakter eğitimi bakış açısıyla geliştirilmiş olan Revize Edilmiş Okul İklimi Öğretmen Ölçeğinin (REOİÖÖ) Türkçeye uyarlanması hedeflenmiştir. Bu çalışma bir ölçek uyarlama çalışmasıdır. Araştırmada üç farklı çalışma grubu bulunmaktadır. Birinci grup, dilsel eşdeğerliğin belirlenmesi için çalışılan 56 İngilizce öğretmeninden oluşan gruptur. Araştırmanın ikinci ve üçüncü grubunu, İstanbul'un Beşiktaş, Kâğıthane, Beyoğlu, Esenyurt ve Küçükçekmece ilçelerinde çalışan öğretmenler oluşturmaktadır. İkinci grup, uyum geçerliğini belirlemek için çalışılan 58 öğretmeni içermektedir. Üçüncü grup ise yapı geçerliği ile ölçüm güvenilirliğini belirlemek ve madde analizlerini gerçekleştirmek için çalışılan 240 öğretmenden oluşan gruptur. Bu çalışmada kullanılan veri toplama araçları, Türkçeye uyarlanması hedeflenen REOİÖÖ ve bu ölçeğin uyum geçerliğini belirlemek amacıyla kullanılan Örgütsel İklim Ölçeğidir (ÖİÖ). Bu çalışmanın sonuçlarına göre, geliştirilmiş olan Türkçe form, dilsel açıdan orijinal formla yüksek düzeyde eşdeğerlik göstermektedir. REOİÖÖ'nün bazı alt ölçeklerinin uyum geçerliğine sahip olduğu söylenebilir. REOİÖÖ Türkçe formunun yapı geçerliği doğrulayıcı faktör analizi ile doğrulanmıştır. Yapılan madde analizlerine göre ölçekte yer alan maddeler, ölçeği puanlayanları iyi derecede ayırt edebilmektedir. Alt ölçeklerle yapılan ölçümlerin ölçüm güvenirlikleri ve çalışma grubunun özellikleri de dikkate alınınca, Revize Edilmiş Okul İklimi Öğretmen Ölçeğinin Türkçe formunun, Türkiye'deki tüm okul kademelerinde geçerli ve güvenilir bir ölçme aracı olarak kullanılabileceğini söylemek mümkündür.Öğe The Turkish experience of COVID-19 infection in people with NMOSD and MOGAD: A milder course?(Elsevier Sci Ltd, 2022) Sen, Sedat; Tuncer, Asli; Ozakbas, Serkan; Uzunkopru, Cihat; Baba, Cavid; Demir, Serkan; Beckmann, YesimBackground: COVID-19 is a multisystemic infection with variables consequences depending on individual and comorbid conditions. The course and outcomes of COVID-19 during neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are not clearly known. Objective/methods: The aim of this study was to examine the features and outcomes of COVID-19 infection in NMOSD and MOGAD patients. The patients' demographic and clinical factors, disease modifying treatment (DMT) used and disease information of COVID-19 infection were recorded. Conditions leading to hospitalization and severe exposure to COVID-19 infection were also analyzed. Results: The study included 63 patients from 25 centers. Thirty-two patients (50.8%) belong to AQP-4 seropositive group, 13 (20.6%) and 18 (28.6%) were in MOG-positive and double-seronegative groups, respectively. Risk factors for severe COVID-19 infection and hospitalization were advanced age, high disability level and the presence of comorbid disease. Disease severity was found to be high in double-seronegative NMOSD and low in MOGAD patients. No statistically significant effect of DMTs on disease severity and hospitalization was found. Conclusion: In NMOSD and MOGAD patients, advanced age, high disability and presence of comorbid disease pose risks for severe COVID-19 infection. There was no direct significant effect of DMTs for COVID-19 infection.Öğe The Validity and Reliability Study of Revised School Climate Teacher Survey's Turkish Version(Izzet Kara, 2016) Yilmaz, Ferat; Demir, SerkanIt is aimed to adapt Revised School Climate Teacher Survey (RSCTS) which is developed with a character education perspective to Turkish and assess its psychometrics properties in this study. This study is an instrument adaptation study. There are three different study groups in this study. First group consists of 56 English teachers studied with to determine the linguistic equivalence. Second group consists of 58 teachers studied with to determine the concurrent validity. Third group consisting of 240 elementary and secondary teachers was studied with to reveal the construct validity, measurement reliability and to analyze the items. Data collection tools of this study are RSCTS aimed to adapt and Organizational Climate Scale (OCS) used to determine the concurrent validity of RSCTS. Based on the results of this study, it can be concluded that Turkish and English versions of RSCTS are equivalent at a high level with regard to linguistic equivalence. Furthermore, some sub-scales of RSCTS have concurrent validity. Construct validity of Turkish version of RSCTS was confirmed by Confirmatory Factor Analysis. According to item analysis, items in RSCTS can discriminate the participants remarkably. Considering measurement reliability coefficients and characteristics of the study group, it is possible to state that RSCTS can be used as a valid and reliable instrument to measure teacher's perceptions about school climate in all of the school stages in Turkey.
