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    A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats
    (Assoc Bras Divulg Cientifica, 2014) Demir, F.; Guzel, A.; Kati, C.; Karadeniz, C.; Akdemir, U.; Okuyucu, A.; Gacar, A.
    Cardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n = 7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg.kg(-1).day(-1)), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-alpha) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-alpha levels were elevated after contusion (P = 0.001 and P = 0.001). Seven days later, Tn-I and TNF-alpha levels decreased in the rats treated with methylprednisolone, quercetin, and the combination of methylprednisolone and quercetin compared to the rats without therapy, but a statistical significance was found only with the combination therapy (P = 0.001 and P = 0.011, respectively). Histopathological degeneration and necrosis scores were statistically lower in the methylprednisolone and quercetin combination group compared to the group treated only with methylprednisolone (P = 0.017 and P = 0.007, respectively). However, only degeneration scores were lower in the combination therapy group compared to the group treated only with quercetin (P = 0.017). Inducible nitric oxide synthase positivity scores were decreased in all treatment groups compared to the untreated groups (P = 0.097, P = 0.026, and P = 0.004, respectively). We conclude that a combination of quercetin and methylprednisolone can be used for the specific treatment of cardiac contusion.
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    Echocardiography screening for rheumatic heart disease among schoolchildren in southeastern anatolia region of Turkey
    (Oxford Univ Press, 2016) Yildiz, A.; Tuncez, A.; Yuksel, M.; Demir, F.; Toprak, N.; Karabel, D.; Oylumlu, M.
    [Abstract Not Available]
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    Evaluation of adolescent pregnancies: 10-year experience of a hospital in rural Turkey
    (I R O G Canada, Inc, 2011) Demir, B.; Guzel, A. I.; Celik, Y.; Demir, S.; Demir, F.
    Purpose: To evaluate the characteristics of adolescent pregnancies admitted to our clinic. Materials and Methods: This retrospective and descriptive study was performed at Ergani State Hospital from January 2000 to December 2010. This is an outpatient gynecology and obstetrics at government hospital in Southern Eastern Region of Turkey. A total of 15,210 pregnancies were delivered during the study period, of whom 711 of them were adolescent pregnancies. Statistical analyses were carried out using the statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: During the study period, of the total of 15,210 deliveries 711(4.6%) were adolescent pregnancies (age range 14-19 years). The mean age (95% CI) of the patients was 17.90 +/- 1.12 (17.82-17.98) years old. Most of the patients were nulliparous (n = 559, 78.60%). Mean gestational weeks, fetal birth weight and fetal birth length and 95% Cl values were as follows: 37.11 +/- 2.53 (36.93-37.30), 3045.73 +/- 51.70 (3007.65-3083.79) and 48.68 +/- 2.31 (48.51-48.85), respectively. Six hundred and twenty (87.20%) of the patients delivered spontaneously by the vaginal route, while 91 (12.80%) were delivered by cesarean section. Although the age range of the patients was not wide, there was a significant correlation between maternal age, gestational age, fetal birth weight and fetal birth length (p < .01). Conclusion: According to this study, the ratio of adolescent pregnancies was found to be 4.6% which was lower than other regions of Turkey. The majority of the patients were nulliparous and most delivered spontaneously by the vaginal route. There was a significant correlation between maternal age, gestational age, fetal birth weight and fetal birth length.
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    Hypertrophic Cardiomyopathy as a Clinical Component of Congenital Cytomegalovirus Infection
    (Univ West Indies Faculty Medical Sciences, 2016) Demir, F.; Yilmazer, M. M.; Dalli, S.; Yolbas, I.; Uluca, U.; Bilici, M.; Turan, M. I.
    We report hypertrophic cardiomyopathy in a newborn with congenital cytomegalovirus infection. The neonate had distinct signs of congenital cytomegalovirus infection including petechiae, jaundice, intracranial calcifications, cerebral ventriculomegaly and chorioretinitis together with hypertrophic cardiomyopathy. Following determination of anti-cytomegalovirus IgM, viral DNA was also isolated from the plasma of the patient by polymerase chain reaction. Although cytomegalovirus is a relatively frequent cause of myocarditis in childhood, it was rarely reported to be associated with cardiac abnormalities such as structural heart disease, atrioventricular block, or dilated cardiomyopathy. To our knowledge, this is the first case with congenital cytomegalovirus infection and hypertrophic cardiomyopathy.
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    Outcomes of pregnancies in women with parity ten or more: a case control study
    (I R O G Canada, Inc, 2012) Demir, B.; Guzel, A. I.; Demir, S.; Demir, F.; Celik, Y.
    Purpose: To determine the outcomes of pregnancies in women with parity ten and more. Materials and Methods: We designed this study in a government hospital in rural Turkey. Pregnant women with parity of ten or more (n = 126) were evaluated and compared with pregnant women with parity lower than ten (n = 90). The risk factors recorded were maternal age, parity, gestational age (weeks), delivery mode, fetal birth weight and Apgar scores. Statistical analyses were carried out using the statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: During the study period, a total of 12,551 deliveries were delivered at the current clinic. One hundred and twenty-six mothers were delivered with parity ten or more with a ratio of 1.01%. There was a statistically significant difference between the study and control group by means of maternal age, parity, fetal birth weight and 1- and 5-min Apgar scores (p < 0.05). There was no difference in delivery mode between the groups. Conclusion: According to this study, pregnant women with parity ten or more showed no adverse clinical characteristics when compared with pregnant women with parity lower than ten.
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    Prognostic importance of nutritional assessment in patients with acute ischemic stroke undergoing endovascular thrombectomy
    (Verduci Publisher, 2023) Ozbek, M.; Akil, M. A.; Demir, M.; Arik, B.; Demir, F.; Akil, E.
    - OBJECTIVE: The prevalence of malnutrition in patients with acute isch-emic stroke (AIS) can range from 8% to 34%. It has been shown that prognostic nutritional in-dex (PNI) and control nutritional status (CO -NUT) scores can provide an opportunity to make prognostic predictions in some disease groups. Previous studies have shown a close relationship between malnutrition scores and stroke prognosis. We evaluated the effect of nutritional scores on in-hospital and long-term mortality in AIS patients undergoing endovas-cular therapy (EVT).PATIENTS AND METHODS: 219 patients who underwent EVT for the AIS were included in this retrospective design and cross-sectional study. The primary endpoint of the study was accepted as all-cause death including in-hospital death, 1-year death, and 3-years death. RESULTS: A total of 57 patients died in the hospital. In-hospital mortality rate was higher in the high CONUT group [36 (49.3%), 10 (13.7%), 11 (15.1%), p<0.001]. A total of 78 patients died within one year, and 1-year mortality was higher in the high CONUT group [43 (58.9%), 21 (28.8), 14 (19.2), p<0.001]. At the end of the 3-year fol-low-up, 90 patients had died, and the 3-year mortality rate was significantly higher in groups with a high CONUT score than in those with a low CONUT score (p<0.001).CONCLUSIONS: A higher CONUT score, cal-culated easily by simple scoring with parame-ters studied from peripheral blood before the EVT procedure, is an independent predictor of in-hospital, 1-year, and 3-years all-cause mor-tality.
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