Yazar "Demir, Caner F." seçeneğine göre listele

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    Arnold Chiari-I Malformasyonu ile Muhtemel İlişkili İnternükleer Oftalmopleji
    (Gümüşhane Üniversitesi, 2014) Özdemir, Hasan H.; Demir, Caner F.; Berilgen, M. Said; Taşcı, İrem; Balduz, Metin
    Arnold Chiari-I malformasyonu (ACM) serebellar tonsillerin spinal kanala doğru herniasyonu ile karakterize bir konjenital anomalidir. Farklı klinik ve zamanlarda çeşitli semptomlar görülebilir. 40 yaşında bir kadın hasta akut başlangıçlı yürüme güçlüğü, bulanık ve çift görme ile kliniğimize başvurdu. Nörolojik muayenesinde internükleer oftalmopleji saptandı. Bu yazıda; ACM bulgusu olarak bulanık görme, baş ağrısı ataksi ve sağ INO ile başvuran, dekompresyon cerrahisinden sonra, sadece kısmen sola bakışta sağ gözde içe bakış kısıtlılığı devam eden nadir bir vakayı sunduk.
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    Auditory P300 event-related potentials in children with Sydenham's chorea
    (Assoc Arquivos Neuro- Psiquiatria, 2014) Ozdemir, Hasan Huseyin; Demiroren, Kaan; Demir, Caner F.; Serin, Mine Hapsen
    P300 event-related potentials (ERPs), objective measures related to cognitive processing, have not been studied in Sydenham's chorea (SC) patients. Purpose: To assess cognitive impairment with P300 ERPs. Method: Seventeen patients with SC and 20 unaffected healthy children were included. Stanford-Binet test was used for psychometric assessment, and odd-ball paradigm was used for auditory ERPs. Results: There was no significant difference in P300 latencies between the SC-pretreatment group, SC-posttreatment group and control group (p>0.05). Mean interpeak latencies in SC-pretreatment group and SC-posttreatment group showed significant prolongation compared with the control group (p<0.05). Mean interpeak latencies in SC-posttreatment group were significantly decreased compared with SC-pretreatment group (p<0.05). Compared to controls, patients did not show significant difference in Stanford-Binet intelligence examination. Conclusion: This report suggests that interpeak latencies and amplitudes of P300 ERPs could be useful for detecting and monitoring cognitive impairment in SC patients.
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    A case of Ross syndrome presented with Horner and chronic cough
    (Wolters Kluwer Medknow Publications, 2014) Baran, Aslıhan; Balbaba, Mehmet; Demir, Caner F.; Özdemir, Hasan H.
    Ross syndrome is a rare sweating disorder associated with Adie's tonic pupil, decreased or diminished tendon reflex and unknown etiology. Although autonomic disturbances affecting sudomotor and vasomotor functions are seen commonly, they are rarely symptomatic. While Ross syndrome is typically characterized with dilated tonic pupil, it may be rarely manifested with miotic pupils (little old Adie's pupil), which can make diagnosis difficult. In this article, we aim to specify the atypical clinical manifestations of syndrome by means of Ross syndrome manifested by autonomic symptoms, Horner syndrome, chronic cough together with bilateral little old Adie's pupil.
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    Determination of the effects on learning and memory performance and related gene expressions of clothianidin in rat models
    (SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS, 2014) Özdemir, Hasan Hüseyin; Kara, Murat; Yumrutaş, Önder; Üçkardeş, Fatih; Eraslan, Ersin; Demir, Caner F.; Bal, Ramazan
    Clothianidin (CLO) is one of the pesticides used to protect against insects, and its potential toxic effects on cognitive functions are not clearly known. This study aims to evaluate the possible effects of dose-dependent CLO on learning and memory in infant and adult male rats and the expression of related genes in the hippocampus. Doses of 2, 8 and 24 mg/kg of CLO were administered to newborn infant and adult albino Winstar rats in the form of gavage and dissolved in vehicle matter. Their cognitive and learning functions were evaluated by the Morris water maze and probe tests. Expression levels of N-methyl D-aspartate 1 (GRIN1), muscuranic receptor M1, synoptophysin (SYP) and growth-associated protein 43 (GAP-43) of tissues isolated from the hippocampus were determined using the real-time PCR method. In the Morris water maze test, no change (p > 0.05) was exhibited in the adult and infant rats after CLO was applied, although there was a significant difference (p < 0.05) in performance between infants and the control group after 24 mg/kg was applied in the probe test. Also, expression levels GRIN1, M1, SYP, GAP-43 did not change when compared to the control (p > 0.05). Our study shows that exposure to high doses of CLO causes deterioration of cognitive functions in infant rats.
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    The effects of needle deformation during lumbar puncture
    (Wolters Kluwer Medknow Publications, 2015) Ozdemir, Hasan Huseyin; Demir, Caner F.; Varol, Sefer; Arslan, Demet; Yildiz, Mustafa; Akil, Esref
    Objective: The aim of this study is to assess deformation of the tip and deflection from the axis of 22-gauge Quincke needles when they are used for diagnostic lumbar puncture (LP). Thus, it can be determined whether constructional alterations of needles are important for predicting clinical problems after diagnostic LP. Materials and Methods: The 22-gauge Quincke needles used for diagnostic LP were evaluated. A specially designed protractor was used for measurement and evaluation. Waist circumference was measured in each patient. Patients were questioned about headaches occurring after LP. Results: A total of 115 Quincke-type spinal needles used in 113 patients were evaluated. No deflection was detected in 38 (33.1%) of the needles. Deflection between 0.1 degrees and 5 degrees occurred in 43 (37.3%) of the needles and deflection >= 5.1 degrees occurred in 34 patients (29.6%). Forty-seven (41.5%) patients experienced post lumbar puncture headache (PLPH) and 13 (11.5%) patients experienced intracranial hypotension (IH). No statistically significant correlation between the degree of deflection and headache was found (P > 0.05). Epidural blood patch was performed for three patients. Deformity in the form of bending like a hook occurred in seven needles and IH occurred in six patients using these needles. Two of the needles used in three patients requiring blood patch were found to be bent. Conclusion: Deformation of needles may increase complications after LP. Needle deformation may lead to IH. In case of deterioration in the structure of the needle, termination of the puncture procedure and the use of a new needle could reduce undesirable clinical consequences, especially IH.
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    Evaluation of cerebral venous thrombosis secondary to oral contraceptive use in adolescents
    (Springer-Verlag Italia Srl, 2015) Ozdemir, Hasan H.; Varol, Sefer; Akil, Esref; Acar, Abdullah; Demir, Caner F.
    Our goal was to evaluate the clinical patterns, additional risk factors, treatment and outcome of cerebral venous thrombosis (CVT) related to adolescent oral contraceptive pill (OCP) usage. We evaluated 22 patients with CVT related to OCPs admitted to Firat and Dicle University Hospitals from January 2008 to January 2013. We assessed the clinical features, risk factors, imaging results and prognosis. Magnetic resonance imaging (MRI) and magnetic resonance were the preferred procedures for the diagnosis of CVT. MRI revealed parenchymal lesions in 11 (50 %) patients, and the remaining patients had normal MRIs. The sinuses most frequently affected by thrombosis were the superior sagittal sinus and the transverse sinus. The additional risk factors identified for CVT were antiphospholipid syndrome, protein C deficiency, protein C and S deficiency, factor V Leiden associated with heterozygous antithrombin III deficiency, methylenetetrahydrofolate reductase and prothrombin gene mutations. CVT may be overlooked in adolescents because it is more common among middle-aged and elderly adults. CVT should be suspected in the presence of neurological symptoms in adolescents, especially in those using OCPs.
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    Facial diplegia: etiology, clinical manifestations, and diagnostic evaluation
    (Assoc Arquivos Neuro- Psiquiatria, 2015) Varol, Sefer; Ozdemir, Hasan Huseyin; Akil, Esref; Arslan, Demet; Aluclu, M. Ufuk; Demir, Caner F.; Yucel, Yavuz
    Objective: Facial diplegia (FD) is a rare neurological manifestation with diverse causes. This article aims to systematically evaluate the etiology, diagnostic evaluation and treatment of FD. Method: The study was performed retrospectively and included 17 patients with a diagnosis of FD. Results: Patients were diagnosed with Guillain-Barre syndrome (GBS) (11), Bickerstaff's brainstem encephalitis (1), neurosarcoidosis (1), non-Hodgkin's Lymphoma (1), tuberculous meningitis (1) herpes simplex reactivation (1) and idiopathic (1). In addition, two patients had developed FD during pregnancy. Conclusion: Facial diplegia is an ominous symptom with widely varying causes that requires careful investigation.
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    Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model
    (Wiley, 2015) Kara, Murat; Yumrutas, Onder; Demir, Caner F.; Ozdemir, Hasan Huseyin; Bozgeyik, Ibrahim; Coskun, Salih; Eraslan, Ersen
    The potential toxic effects of several pesticides, including imidacloprid on non-target organisms have not been clearly established. Also, the chronic effects of non-toxic doses on cognitive function in mammals are unknown. In this study, the effects of different doses of imidacloprid on learning and memory of infant and adult rats were evaluated, and the expressions of genes synthesizing proteins known to be associated with learning in brain tissues were also documented. 0.5, 2 and 8 mg/kg doses of imidacloprid were administered to newborn infant and adult Wistar albino rats by gavage. Their learning activities were evaluated, and the expression levels of the inotropic glutamate receptor GRIN1, synoptophysin, growth-associated protein 43 and the muscarinic receptor M1 in hippocampus were determined by real-time PCR method. Learning activities were diminished significantly at 2 and 8 mg/kg doses in the infant model groups and at 8 mg/kg dose in adult rats. Also, expression levels of GRIN1, SYP and GAP-43 were found to be insignificantly altered. Only the expression of M1 were significantly changed in high doses of adult group. Thus imidacloprid in high doses causes deterioration in cognitive functions particularly in infant rats, and this deterioration may be associated with changes in the expressions of related genes.