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Öğe Assessment of nasal carriage of staphylococcus aureus in patients with acne vulgaris(Turkish Soc Dermatology Venerology, 2015) Demir, Betul; Denk, Affan; Erden, Ilker; Cicek, Demet; Ucak, HaydarBackground and Design: Systemic antibiotics, such as tetracycline and doxycycline are used in the treatment of inflammatory forms of moderate acne, or acne that is resistant to topical treatment. Oral isotretinoin treatment is the most effective treatment option in severe papulopustular and nodular forms of acne. Dose-related nasal carrier state of Staphylococcus aureus (S. aureus), has been reported in 90% of patients using isotretinoin. Long-term oral and/or topical antibiotic use in the treatment of acne causes changes in antibiotic susceptibility and emergence of methicillin-resistant S. aureus (MRSA) pathogens. The present retrospective study examined the colonization rates of S. aureus in patients who had an increase in acneiform lesions while taking medications for the treatment of acne and whose nasal swap samples were obtained and also investigated their relationship with treatment options. Materials and Methods: A total of 86 patients with moderate acne who attended our dermatology outpatient clinic with the complaints of acne and in whom nasal swap samples were obtained due to increased pustules during acne therapy. The patients were divided into three groups according to the treatment methods as patients receiving topical treatment, patients treated with oral doxycycline, and patients treated with oral isotretinoin. The results of the cultures were evaluated in three groups: no growth, methicillin-sensitive S. aureus (MSSA), and MRSA-isolated. Results: 39.5% culture positivity (S. aureus) were determined in 34 patients. Thirty two (94.1%) culture positivity were MSSA, and 2 (5.9%) culture positivity were MRSA. Twenty nine (58%) culture positivity were found in the patients using the oral isotretinoin. There was statistically significant culture positivity in the patients using oral isotretinoin compared to patients receiving other treatments (p<0.001). Conclusion: We observed that S. aureus colonization increased in patients using systemic isotretinoin independent from the drug dose and duration of drug use. There was no significant change in patients using systemic doxycycline and the colonization decreased in patients using topical antibiotic treatment.Öğe Changes in serum desnutrin levels in patients with acne vulgaris(John Libbey Eurotext Ltd, 2014) Demir, Betul; Ucak, Haydar; Cicek, Demet; Aydin, Suleyman; Erden, Filter; Dertlioglu, Selma BakarBackground: Androgens and insulin may contribute to increased sebum production in the pathogenesis of acne vulgaris. Objective: We investigated the association between serum desnutrin levels and acne vulgaris in the pathogenesis of insulin resistance. Material and methods: 25 patients presenting with acne vulgaris and 25 control subjects participated in this study. Fasting blood glucose, triglycerides, LDL, VLDL, HDL, total cholesterol, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Desnutrin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. Results: Patients with acne vulgaris had a mean serum desnutrin level of (8.83 +/- 1.13 mu IU/mL), which was statistically significantly lower in the control group (10:58 +/- 3.43 mu IU/mL). In patients with acne vulgaris the serum glucose levels, insulin levels and HOMA-IR values (87.92 +/- 7:46 mg/dL, 11.33 +/- 5.93 mu IU/mL, 2.49 +/- 1.40, respectively) were significantly higher than the control group (77.36 +/- 9.83 mg/dL, 5.82 +/- 2.68 mu IU/mL, 1.11 +/- 0.51, respectively) (p = 0.01, p<0.001, p<0.001, p<0.001, respectively). Conclusion: Full cohort (patients and controls) evaluation revealed a negative correlation between the serum glucose and desnutrin levels (r = -0.31, p<0.05). A positive correlation was found between insulin and desnutrin levels (r = 0.42, p<0.001). In patients with acne vulgaris, as a result of increased levels of serum glucose and insulin, the function of desnutrin was suppressed, perhaps contributing to insulin resistance.Öğe Effect of Oral Isotretinoin Treatment on Retinal Nerve Fiber Layer Thickness(B C Decker Inc, 2014) Ucak, Haydar; Aykut, Veysel; Ozturk, Savas; Cicek, Demet; Erden, Ilker; Demir, BetulBackground: Oral isotretinoin treatment can cause ocular side effects. Objective: This study was performed to detect possible toxic effects of oral isotretinoin treatment on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL). Methods: The study population consisted of 54 eyes of 27 patients with nodulocystic acne who used oral isotretinoin (Roaccutane) treatment. Macular GCL and peripapillary RNFL thickness measurements were performed using spectral domain optical coherence tomography (OCT) before and after therapy. Results: Before and after treatment, a complete ophthalmologic examination was normal in all eyes. However, posttreatment lower temporal (TL) values were significantly lower (76.80 +/- 16.31) than pretreatment TL values (84.96 +/- 24.83) (p = .02). There was no statistically significant difference in the other OCT values, upper temporal, superotemporal, superonasal, upper nasal, lower nasal, inferonasal, and inferotemporal (p = .35, p = .40, p = .56, p = .95, p = .94, p = .93, p = .61, respectively). Also, there was no statistically significant difference between the right and left eyes and between genders for all parameters (p > .05). Conclusion: The use of oral isotretinoin treatment has increased in recent years. In addition, oral isotretinoin treatment has a broad adverse effect potential on the ocular system. The measurement of RNFL thickness, especially TL thickness, by OCT may be useful for detecting the possible toxic effect of oral isotretinoin therapy on RNFL.Öğe Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis(Taylor & Francis Ltd, 2013) Ucak, Haydar; Demir, Betul; Cicek, Demet; Dertlioglu, Selma Bakar; Akkurt, Zeynep Meltem; Ucmak, Derya; Halisdemir, NurhanBackground: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.Öğe Ghrelin in the pilosebaceous unit: alteration of ghrelin in patients with acne vulgaris(John Libbey Eurotext Ltd, 2015) Cicek, Demet; Demir, Betul; Erden, Ilker; Kuloglu, Tuncay; Ucer, Ozlem; Aydin, Suleyman; Ucak, HaydarBackground: Ghrelin in the pilosebaceous tissues of human skin and ghrelin levels in patients with acne vulgaris have not yet been investigated. Objective: The purpose of this study was to screen ghrelin immunoreactivity by immunohistochemistry in human pilosebaceous tissues of human skin and also to determine the quantities of ghrelin in the serum of the patients with acne vulgaris. Methods: 30 patients presenting with acne vulgaris and 30 control subjects participated in this study. Ghrelin levels were determined by enzyme linked immunosorbent assay (ELISA). Human hair follicles and sebaceous glands were immunohistochemically examined. Results: Immunohistochemistry results showed that there is a strong ghrelin immunoreactivity in the hair follicles and sebaceous glands in sections of human skin. The mean serum ghrelin levels (27.58 +/- 15.44 pg/mL) in patients with acne vulgaris was significantly lower than those of controls (35.62 +/- 20.46 pg/mL). Conclusions: Ghrelin produced in hair follicles and sebaceous glands of the skin might participate in the pathogenesis of acne vulgaris and also acne vulgaris in humans might be associated with decreased serum ghrelin.Öğe Quality of life in lepromatous leprosy patients(Deri Zuhrevi Hastaliklar Dernegi, 2014) Demir, Betul; Ucak, Haydar; Dertlioglu, Selma Bakar; Demir, Sukru; Guler, Kubilay; Cicek, Demet; Halisdemir, NurhanBackground and Design: Leprosy is a chronic infectious disease caused by Mycobacterium leprae bacillus affecting the skin and peripheral nervous system. Leprosy can lead to severe deformities depending on the extent of the disease. In this study, we aimed to investigate the quality of life of patients with lepromatous leprosy. Materials and Methods: Thirty-five patients with lepromatous leprosy and 35 healthy controls were included in the study. The patients were evaluated with the Turkish version of the Dermatology Life Quaky Index (DLQI) and the 36-Item Short Form Health Survey (SF-36). The relationship of quality of life with age, gender, marital status, and the grade of the visual impairment was studied and compared with the healthy controls. Results: Total and all the subgroup DLQI scores were higher in the leprosy group than in the control group (p<0.05). The patients with grade 2 visual impairment were more severely affected by the disease with regard to symptoms/feelings and school/work life as compared to the patients with grade 1 visual impairment (p=0.04, p=0.03, respectively). SF-36 physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, and emotional role functioning scores were statistically lower in the patient group than in the control group (p<0.05). Conclusion: We observed that DLQI scores were lower in patients with lepromatous leprosy than in the control group, while increasing impairment in eyes was found to have a negative impact on quality of life. The SF-36 revealed that physical functioning, physical role functioning, general health perceptions, vitality, social role functioning, emotional role functioning, and mental health were negatively influenced in patients with lepromatous leprosy.Öğe Quality of life in patients with calluses(Wiley-Blackwell, 2016) Demir, Betul; Cicek, Demet; Erden, Ilker; Ucak, Haydar; Demir, Sukru; Ozturk, Savas[Abstract Not Available]Öğe Serum ghrelin levels in patients with Behcet's disease(Termedia Publishing House Ltd, 2016) Erden, Ilker; Ucak, Haydar; Demir, Betul; Cicek, Demet; Dertlioglu, Selma Bakar; Aydin, Suleyman; Ozturk, SavasIntroduction: Behcet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. Aim: To measure serum ghrelin levels in BD patients and healthy controls and to investigate its association with metabolic syndrome (MetS). Material and methods: Thirty BD patients and 30 healthy individuals were enrolled in the study. Ghrelin levels were measured in blood samples using ELISA. Results: The mean serum ghrelin level in BD patients (28.57 +/- 14.04) was significantly lower compared to healthy controls (40.72 +/- 23.21) (p = 0.01). The mean serum ghrelin level in BD patients who had MetS (24.18 +/- 12.73) was lower compared to BD patients who did not have MetS (30.77 +/- 14.45), but this difference was not significant (p > 0.05). Conclusions: Ghrelin levels were lower in BD patients compared to healthy controls. There was no association between reduced ghrelin levels and MetS; however, there was a negative correlation between ghrelin levels and disease activity.Öğe Serum salusin-? and salusin-? levels in patients with Behcet's disease(John Libbey Eurotext Ltd, 2014) Erden, Ilker; Demir, Betul; Ucak, Haydar; Cicek, Demet; Dertlioglu, Selma Bakar; Aydin, SuleymanBackground: Behcet' s disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology. There is an increased predisposition to insulin resistance and metabolic syndrome (MetS) in BD patients. Objective: The aim of this study was to determine serum salusin-alpha and salusin-beta levels in BD patients and healthy controls and to investigate their association with MetS. Patients and Methods: Twenty-five BD patients and 25 healthy controls were included in the study. Salusin-alpha and salusin-beta levels were measured in blood samples using ELISA. In addition, BD patients and healthy controls were evaluated in terms of MetS. Results: The mean serum salusin-alpha level in BD patients was significantly lower compared to healthy controls (p = 0.03), whereas the mean serum salusin-beta level in BD patients was significantly higher compared to healthy controls (p = 0.03). The mean serum salusin-alpha level was significantly lower in BD patients with MetS compared to BD patients without MetS (p = 0.04). Conclusions: Serum salusin-a level (an anti-atherogenic molecule) was lower, while serum salusin-beta level (a pro-atherogenic molecule) was higher in BD patients. We consider that the decrease in salusin-alpha and the increase in salusin-beta levels contribute to the development of MetS.Öğe Serum salusin-? and salusin-? levels in patients with psoriasis(John Libbey Eurotext Ltd, 2015) Erden, Ilker; Ucak, Haydar; Demir, Betul; Cicek, Demet; Bakar Dertlioglu, Selma; Ozturk, Savas; Aydin, Suleyman[Abstract Not Available]
