Yazar "Delen, Veysel" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    Decreased neck muscle strength in patients with the loss of cervical lordosis
    (Elsevier Sci Ltd, 2016) Alpayci, Mahmut; Senkoy, Emre; Delen, Veysel; Sah, Volkan; Yazmalar, Levent; Erden, Metin; Toprak, Murat
    Background: The loss of cervical lordosis is associated with some negative clinical outcomes. No previous study has examined cervical muscle strength, specifically in patients with the loss of cervical lordosis. This study aims to investigate whether there is weakness of the cervical muscles or an imbalance between cervical flexor and extensor muscle strength in patients with the loss of cervical lordosis compared with healthy controls matched by age, gender, body mass index (BMI), and employment status. Methods: Thirty-two patients with the loss of cervical lordosis (23 F, 9 M) and 31 healthy volunteers (23 F, 8 M) were included in the study. Maximal isometric neck extension and flexion strength, and the strength ratio between extension and flexion were used as evaluation parameters. All measurements were conducted by a blinded assessor using a digital force gauge. The participants were positioned on a chair in a neutral cervical position and without the trunk inclined during measurements. Findings: Maximal isometric neck extension and flexion strength values were significantly lower in the patients versus healthy controls (P<0.001 and P = 0.040, respectively). The mean (SD) values of the extension/flexion ratio were 1.21 (0.34) in the patients and 1.46 +/- 0.33 in the controls (P = 0.004). Interpretation: According to our results, patients with the loss of cervical lordosis have reduced neck muscle strength, especially in the extensors. These findings may be beneficial for optimizing cervical exercise prescriptions. (C) 2016 Elsevier Ltd. All rights reserved.
  • [ X ]
    Öğe
    The Prevalence of "MEFV" Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
    (2014) Gülcü, Elif; Delen, Veysel; Ediz, Levent; Tülüce, Yasin; Yıldırım, İbrahim Halil; Özkol, Halil
    Amaç: Enflamasyonu inhibe edici bir protein olan pyrin/marenostrin, Ailevi Akdeniz ateşi (AAA) geni tarafından kodlanır. Bu gendeki mutasyonların, AAA hastalığına sebep olduğu bilinir. Akdeniz ateşi geninin mutasyonları ile romatolojik hastalıklar arasında da bir ilişki olduğu ileri sürülmüştür. Bu çalışmanın amacı AAA geninin en sık rastlanan 4 mutasyonunun frekansını, Türkiye'nin doğusunda yaşayan 110 romatoid artrit (RA) hastasında ve 98 sağlıklı kontrol (SK) bireylerinde araştırmaktır.Gereç ve Yöntemler: DNA eldesi, çalışmaya dahil edilen bütün bireylerin periferal lenfositlerinden "salting out" metoduyla gerçekleştirilmiştir. Ekzon 10'un polymerase chain reactions (PCR) amplifikasyonu uygun primerler yardımıyla yapılmış ve tek nükleotid polimorfizimleri (TNP) mutasyonel veya yabanıl tip DNA bölgelerini tanıyan spesifik restriksiyon endonükleazlar yardımıyla belirlenmiştir. Bulgular: Bu çalışmada, romatoid artrit hastalarının mutasyon frekansı, SK bireylerinden daha yüksek bulundu. Ancak, bu sonuç istatistiksel olarak anlamlı değildi (p>0,05). Sonuç: Türkiye'nin doğusunda yaşayan RA hastalarındaki AAA mutasyon oranı, SK bireylerinden anlamlı derecede farklı değildi. Romatoid artrit etyopatogenezinde etkili olabilecek diğer gen mutasyonlarını araştırmak için yeni çalışmalara ihtiyaç bulunmaktadır
  • [ X ]
    Öğe
    The Prevalence of MEFV Gene Mutations in Rheumatoid Arthritis Patients Inhabiting the Van Province and Surroundings
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2014) Ozkol, Halil; Yildirim, Ibrahim Halil; Tuluce, Yasin; Ediz, Levent; Delen, Veysel; Gulcu, Elif
    Objective: An inhibitory protein of inflammation pyrin/marenostrin is encoded by the Mediterranean fever (MEFV) gene. Mutations of this gene are known to cause familial Mediterranean fever (FMF) disease. A relation between mutations of the MEFV gene and rheumatic diseases was also suggested. The aim of the present study was to investigate the frequency of four common mutations of the MEFV gene in 110 rheumatoid arthritis (RA) patients and 98 healthy controls (HC) inhabiting a region of eastern Turkey. Material and Methods: DNA extraction was realized by salting out method from peripheral blood lymphocytes of all subjects included in the study. Polymerase chain reactions (PCR) amplification of exon 10 was performed by the appropriate primers, and single-nucleotide polymorphisms (SNPs) were detected by specific restriction endonucleases recognizing the mutational DNA or wild-type DNA regions. Results: Mutation frequency of RA patients was higher than in HC, but this result was not statistically significant (p>0.05). Conclusion: The MEFV mutation rate of RA patients living in eastern Turkey was not significantly different from HC. Further studies are needed to investigate other gene mutations that may affect RA etiopathogenesis.