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    Activity, acute and sub-acute toxicity and safety assesment of the hydroalcholic root extract of Diplotaenia turcica
    (Agricultural Research Communication Centre, 2018) Ozdek, U.; Basbugan, Y.; Yildirim, S.; Boga, M.; Firat, M.; Deger, Y.
    Diplotaenia turcica is widely utilized in conventional treatment in the east of Turkey. Due to the insufficient data on the safety profile, the acute and sub acute toxicity of Diplotaenia turcica was determined. Furthermore, total phenolic content, flavonoid content and antioxidant activity of the extract were determined. The acute toxicity of hydroalcoholic root extract of Diplotaenia turcica (HREDT) was evaluated in mice after administration of single oral dose at the 5000 mg/kg (acute model) and rat after 28 days orally administration at the dose range of 250, 500 and 1000 mg/kg (subacute model). According to result, the LD50 value of HREDT was found to be greater than 5000 ing/kg. In sub acute toxicity study, no statistically significant differences were observed in the values of hematological and pathological parameters in comparison with control group. It was determined that the glucose, triglyceride, cholesterol and LDL levels exerted a significant effect depending on the HREDT doses. The results from the present study found out that HREDT did not produce any toxic effects or deaths in animals for both single and chronic administration. Additionally, HREDT showed moderate antioxidant activities and exhibited relatively notable total phenolic content.
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    Evaluation of the Use of PEEK Material in Implant-Supported Fixed Restorations by Finite Element Analysis
    (Wolters Kluwer Medknow Publications, 2019) Tekin, S.; Deger, Y.; Demirci, F.
    Aims: The purpose of this study is to compare the stresses occurring in the peri-implant bones, implants, crowns, abutments, and screws after loading through finite element analysis by using the poly-ether-ether-ketone (PEEK) materials, which are alternative to titanium abutment and metal supported restorations and to try to reduce the level of neck resorption. Materials and Methods: In our study, three-dimensional modeling of 2 PEEK and titanium abutments, metal-ceramic, and monolithic PEEK upper central dental restorations were made on four titanium implants (Biohorizons (R) Implant Systems Ins., Birmingham, AL, USA) with diameters of 3.8 mm and 10.5 mm and four groups were obtained. Then, a stress analysis of the finite element was performed by applying a 178 N oblique force of 45 degrees to the long axis of the tooth 2 mm below the incisal edge of the model's palatal surface. Results: It has been observed that the PEEK material reduces the stresses caused by the force applied on itself during all tests. In all groups, PEEK abutments and PEEK crowns have reduced stress on the abutment. The most significant difference is observed in the stresses on the crowns and screws. When the stresses on the crown are examined, the use of PEEK crown reduces the stresses on itself and the use of PEEK abutment increases the stresses on the crown. Conclusions: The stress on the implant system can be changed through the usage of different prosthetic materials.
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    Tooth wears and dentoalveolar compensation of vertical height
    (Taylor & Francis Ltd, 2007) Zengingul, A. I.; Eskimez, S.; Deger, Y.; Kama, J.
    The present study aims to determine differences in vertical facial dimensions as a result of dental wear The study consisted of 20 subjects with vertical tooth wear. The mean age of sample was 52.4 years. The control group consisted of 20 dental school students. The mean age of control group was 22 years (subjects with severe malocclusion or tooth wear were not included). All subjects cephalometric and panoramic radiographs were taken from natural head posture. Dentoalveolar height was recorded as in the maxilla and in the mandible on the both cephalometric and panoramic radiograph. Result of the cephalometric measurements showed that significant differences lower face height (ANS-Me), lower dentoalveolar height (Ii-MP) between the groups (p< 0, 001). Upper dentoalveolar height (Is-PP) and total face height (N-Me) was greater than control group (P<0,01). According to the result of panoramic measurement dentoalveolar compensatory, of samples was greater than control group in mandibuler premolar area (p < 0, 05). We found out that dentoalveolar structure is compensating the loss of vertical height when there is the severe occlusal tooth wears.