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Öğe Ani işitme kayıplı hastalarda immunolojik ve viral faktörlerin etyolojideki önemi(2016) Dedeoğlu, Serkan; Topçu, İsmailBu çalışma ani işitme kaybı etiyolojisinde viral ve immunolojik faktörlerin rolünü araştırmak için yapıldı. Prospektif, plasebo kontrollu bir çalışmadır. Çalışmaya Ocak 2010 ile Kasım 2011 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi KBB polikliniğine ani işitme kaybı şikayeti ile başvuran 40 hasta (32 si erkek 8 i bayan; En büyük yaş 72, en küçük yaş 9 idi ve ortalama yaş 36,4 ) ile sağlıklı 40 kontrol vakası (28 i erkek 12 si bayan, büyük yaş 81, en küçük yaş 6 ve ortalama yaş 36 ) dahil edildi. her iki grubun kan örnekleri birbiri ile karşılaştırıldı. Ani işitme kayıplı (AİK) hastalarda ve kontrol grubunda viral (Hbs Ag, Anti-Hbs, CMV İgM, CMV İgG, Rubella İgM, Rubella İgG, Ebstein-Barr Virüs-İgM, EBV-İgG, Herpes Simplex Virüs 1 İgM, HSV 1 İgG, HSV 2 İgM, HSV 2 İgG, Mumps İgG, Mumps İgM, anti-HİV) ve immünolojik (Antinükleer antikor, Anti ds-DNA, Antikardiolipin İgM, Antikardiolipin İgG, ASO, CRP, RF, İgG, İgM, C3, C4) markerler incelendi. Sonuçlar: Ani işitme kayıplı hastaların 26 sı sağ kulak 14 ü sol kulak etkilenmişti. Her iki grup kendi arasında karşılaştırıldı. Ani işitme kayıplı hastaların işitme kaybı ortalaması 69,82 idi (42db ile 113db arasında). Kesikli değişkenler çarpraz tablolar haline dönüştürülerek Yates düzeltmeli Ki-Kare testi ile analiz edildi. Yapılan istatistiksel analizler sonucunda, viral etkenler gözününe alındığında, her iki grupta da anlamlı bir fark saptanmadı. İmmünolojik markerlerden C4 ortalama değerleri her iki grupta da normal sınırlar içerisinde seyretmesine rağmen; hasta grubunun ortalama değerleri, kontrol grubu ile karşılaştırıldığında daha düşük bulunmuş ve bu fark istatistiksel olarak anlamlı çıkmıştır. Elde edilen bu veriler ve analizler doğrultusunda hasta grubunda düşük C4 değerleri AİK etyopatogenezinde inflamatuar ve immün mekanizmaların rol alabileceğini düşündürmüştür. Bununla beraber ani işitme kayıplı hastalarla sağlıklı bireyler arasında yaptığımız viral ve immunolojik faktörlerin serum değerlerin de önemli bir fark bulunmamıştır. ANAHTAR SÖZCÜKLER: Ani işitme kaybı, sensorinöral işitme kaybı, etyoloji, viral enfeksiyon, immunolojik faktörlerÖğe Astaxanthin protects against hearing impairment in diabetic rats(Elsevier Editora Ltda, 2022) Toprak, Serdar Ferit; Dedeoğlu, SerkanObjective: Diabetes Mellitus (DM) causes an increase in oxidative stress that leads to deterioration in auditory functions. Astaxanthine (AST) is known to have strong antioxidant effects. In this study, the aim is to investigate the effect of AST against hearing loss that is due to DM. Methods: This study is an experimental animal study. The study was designed in four groups with 8 animals (n = 8) in each group. The groups were as follows; Control Group (CNT), Diabetic Group (DM), AST applied diabetic group (DM+AST), and AST applied non-diabetic group (AST). Streptozotocin was applied in rats to induce DM. AST was administered by oral gavage. Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests were performed on several days of the study. At the end of the study, pro-inflammatory cytokine levels were analyzed in cochlear tissue samples, and Glutathione Peroxidase (GPx), Superoxide Dismutase (SOD), Catalase (CAT) and Malondialdehyde (MDA) levels were measured. Results: When the findings obtained in the ABR and DPOAE tests in the DM group, it was observed that there was a significant deterioration in the hearing sense. This deterioration was not observed in the DM+AST group. In the DM group, GPx, SOD and CAT levels decreased and MDA levels increased in blood and cochlear tissue. Compared to the DM group, it was noted that antioxidant enzyme levels increased and MDA levels decreased in the DM+AST group. Cochlear tissue pro-inflammatory cytokine levels, which increased with DM, were significantly decreased in the DM+AST group. Conclusion: Even though the effects of AST were investigated in a diabetic experimental animal model, if this molecule is proven to be effective in diabetic humans, it can be considered an adjunct therapeutic option with its antioxidant effects. Level of evidence: The level of evidence of this article is 5. This article is an experimental animal and laboratory study.Öğe The diagnostic value of fine needle aspiration biopsy in parotid tumors(Springer India, 2021) Ayral, Muhammed; Akıl, Ferit; Yılmaz, Ümit; Toprak, Serdar Ferit; Dedeoğlu, Serkan; Akdağ, MehmetThe aim of this study was to investigate the diagnostic accuracy rates of the patients who underwent an operation for parotid mass, by comparing their fine needle aspiration biopsy (FNAB) cytology results with the final pathology. A total of 136 patient files of those who applied to Otorhinolaryngology clinic due to parotid mass and underwent parotidectomy procedure between 2010 and 2020 at a tertiary center were scanned retrospectively. Database on patient age, gender, preoperative FNAB results, and final surgical histopathology results was created. The mean age of the patients was 48.26 +/- 17.37 Superficial parotidectomy was performed to 108 (79.4%) and total parotidectomy to 28 (20.6%) of the patients. The sensitivity of FNAB was found as 85.2%, specificity as 96.2%, positive predictive value as 85.2%, negative predictive value as 96.2% and accuracy as 94.0%. It is found that FNAB has the high specificity and high negative predictive value with high diagnostic accuracy on detecting preoperative malignancy in parotid gland. We think that FNAB is a significant, necessary and safe method in the diagnosis of parotid lesions in preoperative sense.Öğe Protective effect of ethyl pyruvate on amikacin-induced ototoxicity in rats(Verduci Publisher, 2022) Dedeoğlu, Serkan; Ayral, MuhammedOBJECTIVE: Amikacin (AMK) is a widely used antibiotic, but its ototoxic side effects limit its use. This study investigated the effects of ethyl pyruvate (EP). known for its antioxidant and anti-inflammatory effects, against AMK ototoxicity. MATERIALS AND METHODS: 32 Wistar albino rats (n: 8) were used in this study. To cause ototoxicity, AMK 600 mg/kg/day dose was applied intramuscularly for 14 days. EP was administered via ip at a dose of 50 mg/kg/day for 14 days. RESULTS: The Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests were performed on the study's 0, 7, and 14 days. The results have shown that the hearing functions were significantly impaired with the AMK application. A significant improvement was observed in the AM-K+EP group. While total oxidant status (TOS), oxidative stress index (OSI), and malondialdehyde (MDA) levels were found to be significantly higher in the AMK group compared to the control group. total antioxidant status (TAS) level was found to be significantly lower. In the AM-K+EP group, on the other hand, deterioration in TOS, OSI, and MDA levels detected in the AMK group was not observed. No elevated pro-inflammatory cytokines, such as TNF-alpha, IL-1 beta, and IL-6 were present in the EP+AMK group, which were detected in the AMK group. CONCLUSIONS: Hearing tests and biochemical results show that ethyl pyruvate has protective effects against amikacin ototoxicity due to its antioxidant and anti-inflammatory effects.Öğe Seroprevalence of francisella tularensis in patients with neck mass complaints(İzzet Baysal Eğitim Araştırma Hastanesi, 2023) Toprak, Serdar Ferit; Ayral, Muhammed; Dedeoğlu, Serkan; Özbek, Erdal; Temiz, HakanBackground: Tularemia is a zoonotic disease endemic in the northern hemisphere. The causative agent of the disease is Francisella tularensis. F.tularensis is endemic in Turkey, predominantly in the Marmara and Black Sea regions, and causes small outbreaks. This study aimed to investigate the seroprevalence of F.tularensis in patients admitted to the Otorhinolaryngology outpatient clinic with the complaint of neck mass by using two different methods. Methods: Serum samples were collected from patients who were admitted to the Otorhinolaryngology outpatient clinic of Dicle University Faculty of Medicine Hospitals between January 2021 and December 2021 with the complaint of neck mass. A commercially available immunochromatographic lateral flow test (ICT) and a single-assay chemiluminescence test (CHT) were used to detect F.tularensis antibodies. Rose-Bengal test was performed on all sera to determine cross-reactions with antibodies produced in brucellosis. Brucella immunocapture agglutination tests (BCT) were performed on the sera of patients with positive screening tests. Results: The ages of patients diagnosed with neck mass ranged between 14–70 years, with a mean age of 44.5±12.1 years. Sixty two (62%) of the patients were male, and 38 (38%) were female. When the test results were evaluated, two sera were positive for F.tularensis by both ICT and CHT methods. The first serum tests were negative for Brucella. The titer of the second serum in the chemiluminescence test was low positive. Conclusion: Tularemia should be considered in the differential diagnosis of patients presenting with neck mass complaints, especially in patients living in rural areas, and specific diagnostic tests should be performed. In addition, a more comprehensive seroprevalence study supported by molecular testing techniques to be conducted in Diyarbakır will provide clearer data on the extent to which tularemia affects our region and which subspecies is the causative agent.Öğe Şiddetli obstrüktif uyku apnesi sendromunda servikal vestibüler uyarılmış miyojenik potansiyellerde oluşan değişimler(Türkiye Klinikleri Yayınevi, 2022) Dedeoğlu, Serkan; Ayral, Muhammed; Toprak, Serdar FeritAmaç: Obstrüktif uyku apnesi sendromu (OUAS), uyku sırasında solunum yolunun kısmen tıkanması ile karakterize bir hastalıktır ve şiddetli vakalarda hipooksijenasyona bağlı olarak beyin sapı hasarı gözlenebilir. Servikal vestibüler uyarılmış miyojenik potansiyeller [vestibular evoked myogenic potentials (sVEMP)] testi beyin sapı hasarının tespitinde kullanılan kolay, noninvaziv bir testtir. Bu çalışmanın amacı, şiddetli OUAS hastalarında gelişebilecek beyin sapı hasarının tespitinde sVEMP testinin geçerliliğini ortaya koymaktır. Gereç ve Yöntemler: Bu çalışma, Eylül 2021-Ocak 2022 tarihleri arasında uyku merkezine başvuran 40 hasta (80 kulak) üzerinde gerçekleştirildi. Çalışma, kontrol ve şiddetli OUAS olmak üzere 2 grup üzerinden planlandı. Apne-Hipoapne İndeks (AHİ) değeri 5’in altında olan 20 hasta kontrol grubuna, AHİ değeri 30’un üzerinde ve oksijen saturasyonu %65’in altında olan 20 hasta OUAS grubuna dâhil edildi. Hastalara rutin odiyometrik muayeneye ilave olarak sVEMP testi uygulandı. Bulgular: İstatistiksel olarak karşılaştırıldığında yaş, cinsiyet ve beden kitle indeksi değerleri açısından kontrol ve OUAS grubu arasında anlamlı bir farklılık gözlenmedi (p>0,05). sVEMP sonuçlarına bakıldığında p1, n1, p2, n2, p1n1 amplitüd ve p1n1 interval değerleri açısından 2 grup arasında anlamlı farklılık gözlenirken, n2p2 amplitüd ve interval değerleri açısından anlamlı farklılık gözlenmedi. Sonuç: Yapılan çalışmalarda sVEMP testinin başta Parkinson, multipl skleroz ve inme gibi hastalıklarda gelişen beyin sapı hasarını değerlendirmede kullanışlı bir yöntem olduğu gösterilmiştir. Bu sonuçlar ucuz ve noninvaziv bir yöntem olan sVEMP testinin şiddetli OUAS hastalarında beyin sapı hasarını ortaya koymak amacıyla kullanılabileceğini göstermektedir.
