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Öğe Do cellular phones alter blood parameters and birth weight of rats?(Marcel Dekker Inc, 2000) Dasdag, S; Akdag, MZ; Ayyildiz, O; Demirtas, ÖC; Yayla, M; Sert, CThe present study aimed to investigate the effects of microwaves (MW) emitted by cellular phones (CPs) on peripheral blood parameters and birth weights of rats. Thirty-six albino rats were divided into four groups, male (n = 6) and female sham-exposed groups (n = 12) and male (n = 6) and female experimental groups (n = 12). No blood parameters differed following exposure (p > 0.05). The birth weight of offspring in the experimental group was significantly lower than in the sham-exposed group (p < 0.001). No significant differences were observed between rectal temperatures of rats in the sham and experimental groups (p > 0.05). The specific absorption rate (SAR) was found to be 0.155 W/kg for the experimental groups. All parameters investigated were normal in the next generation of rats (p > 0.05).Öğe Do microwave ovens affect eyes?(Elsevier Science Inc, 1997) Inaloz, SS; Aksunger, A; Sari, F; Dasdag, S; Deveci, EThe cataractogenic effects of the microwave oven on rat eyes were investigated histologically. Twenty-one adult Wistar-Albino rats (2-2.5 months old) were divided into three groups (n = 7): a control group (sham-exposed) and two experimental groups. The experimental rats were confined in special cages and placed next to the closed door of a microwave oven. The first experimental group was given 15 minutes of daily exposure and the second. 30 minutes, for 1 month. Biomicroscopic examination detected no pathological damage to the lens in the experimental rats. Histologically, there was a lens of single-layered epithelium in the control group. Tn the first experimental group. there was slight pleomorphism in the superficial epithelial cell contours and vacuolizations in the lens fibers: the second experimental group, had pronounced pleomorphism and pyknosis of the nuclei in the superficial epithelium. Some of the superficial epithelial cells had disappeared and were histologically observed as acellular areas, Single-layered epithelium became disorganized and formed multilayered epithelial groups in the superficial epithelium. Vacuolization was more prominent in this group. Personal exposure from microwave ovens is generally minimal because of the rapid decrease in power density with distance. Microwave oven users do not normally stand as close to the oven as the rats in our study were placed: therefore, it is difficult to suggest that microwave ovens always have cataractogenic effects on human eyes. (C) 1997 Japanese Ophthalmological Society.Öğe Does 900 MHZ GSM mobile phone exposure affect rat brain?(Taylor & Francis Inc, 2004) Dasdag, S; Akdag, MZ; Aksen, F; Bashan, M; Buyukbayram, HThis study investigated the effects of cell phone exposure on the fatty acid composition in phospholipids, malondialdehyde concentration, p53 immune reactivity and histological structure of the rat brain. Sixteen Sprague-Dawley rats were divided into two groups of eight, sham and experimental (speech conditions). The rats were confined to Plexiglas cages, and cellular phone were placed 0.5 cm under the cages. For the experimental group, cellular phones were activated 20 minutes per day, 7 days a week, for 1 month. For the sham group, the cellular phones were placed beneath the cages with the phones turned off. The Whole Body Average SAR (rms) was 0.52 W/kg and 1 g averaged peak SAR (rms), 3.13 W/kg. The Mann-Whitney U-test was used for statistical. comparisons of groups.. Histological alteration and changes in brain phospholipid fatty acids composition were not observed in rat brains. Immunohistochemical staining of brain tissue shown that p53 immunoreactivity was not affected by cell phone exposure. Malondialdehyde concentration in exposed brains was significantly higher than sham (p < 0.05).Öğe Effect of chronic low-intensity microwave radiation on sperm count, sperm morphology, and testicular and epididymal tissues of rats(Marcel Dekker Inc, 1999) Akdag, MZ; Çelik, MS; Ketani, A; Nergiz, Y; Deniz, M; Dasdag, SThe aim of this study was to investigate the effect of chronic microwave exposure on sperm count, sperm morphology, and the morphology of rat testis and epididymes. Continuous wave microwave radiation (9450 MHz) specific absorption rate 1.80 W/kg and power density 2.65 mW/cm(2), was administered for 1 h a day for 13, 26, 39, and 52 days, which corresponded to 1, 2, 3, and 4 cycles of seminiferous epithelium, in mature male Sprague-Dawley rats. The rats were sacrificed under Ketalar anesthesia the day after exposure. Then epididymal sperm count, sperm morphology, and the weights of testis, epididymes, seminal vesicles, and prostate were determined. Histologic examinations of testis and epididymes were performed. The parameters were compared with sham groups. Epididymal sperm count decreased significantly only in the 52-day exposure group (p < 0.05). The percentage of abnormal sperm count changed significantly in the 26-, 39-, and 52-day exposure groups (p < 0.05, p < 0.05, and p < 0.001, respectively). The weights of testis and epididymes also changed significantly in the 26-, 39-, and 52-day exposure groups (p < 0.05, p < 0.05, and p < 0.05, respectively). Necrotic tubules, interstitial edema, perforated and necrotic tubules, decrease of spermatogenesis, and absent germinal epithelium in some tubules were observed in the exposed rat testes. In addition, we observed atrophy, interstitial edema, mononuclear cell infiltration, and increased fibroblastic activity in the exposed rat epididymes. We concluded that epididymal sperm count and morphology and weight and morphology of testis and epididymes were affected by chronic prolonged microwave exposure. The incidence of symptoms mentioned here depended on exposure duration.Öğe The effect of chronic microwave irradiation on the rat sperm count and morphology(Pergamon-Elsevier Science Ltd, 1996) Akdag, Z; Celik, MS; Ketani, MA; Deniz, M; Dasdag, S[Abstract Not Available]Öğe The effect of microwave on experimental orthodontic tooth movement(Pergamon-Elsevier Science Ltd, 1996) Karadede, I; Ketani, MA; Akdag, Z; Celik, S; Dasdag, S[Abstract Not Available]Öğe The effect of microwave radiation on morphology of rat epididymidis(Pergamon-Elsevier Science Ltd, 1996) Akdag, Z; Celik, S; Nergiz, Y; Ketani, MA; Dasdag, S[Abstract Not Available]Öğe The effect of microwave radiation on morphology of rat testis(Pergamon-Elsevier Science Ltd, 1996) Nergiz, Y; Akdag, Z; Celik, S; Ketani, MA; Dasdag, S[Abstract Not Available]Öğe Effect of nonionizing radiation on plasmid DNA of E.coli puc9(Mbr Press Inc, 1999) Dasdag, S; Celik, MS; Uyar, F; Akdag, MZ; Sert, C; Ensari, YThe present experiment was carried out to investigate whether 9450 MHz and 2450 MHz microwave exposure (MW) affect to the plasmid DNA of Escherichia coli puc 9 or not. Suspensions of E.coli puc 9 were exposed to microwave radiation at 2450 MHz (55,110,165,220 and 275 W for 30 and 60 second) and 9450 MHz (2.65mW/cm(2) for 10,20,40 and 60 minutes). However, plasmid DNA of E.coli puc 9 were also exposed to 9450 MHz (10,20,40 and 60 minutes) and 2450 MHz (55,110,165,220 and 275 W for 30 and 60 second) Microwave. After exposures of E.coli puc 9, the plasmid DNA were isolated and evaluated by AGE assay. We found that amount of plasmid DNA was not changed in 9450 MHz and 2450 MHz MW exposure. The difference of temperatures between before and after 2450 MHz MW exposures were found to be significant (P<0.01). It was concluded that E.coli puc 9 plasmid DNA was not affected by 9450 MHz and 2450 MHz Microwave radiation.Öğe Effects of extremely low frequency electromagnetic fields on hematologic and immunologic parameters in welders(Elsevier Science Inc, 2002) Dasdag, S; Sert, C; Akdag, Z; Batun, SBackground. Electric are welding is known to cause considerable exposure to extremely low frequency magnetic fields. Although some studies of exposure to magnetic fields and epidemiologic studies have included groups of welders, typically little information is available concerning the hematologic and immunologic effects of ELF electromagnetic fields on welders. Therefore, the aim of the present study is to investigate whether or not extremely low frequency electromagnetic fields (ELF EMF) emitted from electric arc welding affect sonic hematologic and immunologic parameters of welders. Methods. The study was carried out on 16 male welders and 14 healthy males between 20 and 40 years of age from the same geographic area and with similar life styles. The following hematologic and immunologic parameters were measured in both groups: red blood cells (RBC); hemoglobin (Hgb); hematocrit (Hct); platelets (Plt); total white blood cells (WBC); neutrophils; lymphocytes; eosinophils; and CD3, CD4, CD8, and CD4/CD8. Results. Some of the hematologic and immunologic parameters under investigation were similar in both groups. Although T lymphocyte surface antigens, such as levels of CD4 and CD8 were found to be lower in the welders than in the control subjects (p<0.001, p<0.05), the hematocrit levels of the welders were found to be higher than those of the control subjects(p<0.05). However, the differences observed were not clinically significant. ELF electromagnetic field intensities in the welding areas varied between 0.10 and 0.25 mT. Conclusions. These results suggest that ELF electromagnetic fields do not affect the hematologic and immunologic parameters of welders. (C) 2002 IMSS. Published by Elsevier Science Inc.Öğe Effects of intensive and moderate cellular phone use on hearing function(Taylor & Francis Inc, 2006) Oktay, MF; Dasdag, Spurpose of this stud), is to investigate the effects of radiation emitted by mobile phones on the hearing of users. The study was carried out oil three groups: 1) 20 men who have used a cellular phone frequently and spoken approximately 2 h per day for four years; 2) 20 men who have used a cellular phone for 10-20 min per day for four years; and 3) 20 healthy men who have never used a cellular phone (the control group). Brainstem evoked response audiometric (BERA) and pare tone audiometric (PTA) methods were used to measure the effects of exposure on hearing function of the subjects. In BERA measurements, I-III, III-V, and I-V interpeak latencies were evaluated. Interpeak latency of subjects in two experimental groups was compared to that of subjects in the control group. The BEPA results showed no differences among the groups (p > 0.05). In PTA measurements, detection thresholds at 250 Hz, 500 Hz, 1000 Hz, 2000 Hz, 4000 Hz, and 8000 Hz frequencies were measured in all three groups. No differences were observed between moderate mobile phone users (10-20 min. per day) and control subjects. However, detection thresholds in those who talked approximately 2h per day were found to be higher than those in either moderate users or control subjects. Differences at 4000 Hz for both bone and air conduction for right ears, and 500 Hz, and 4000 Hz bone and air conduction for left ears were significant for mean hearing threshold. This study shows that a higher degree of hearing loss is associated with long-term exposure to electromagnetic (EM) field generated by cellular phones.Öğe Effects of microwaves and elf magnetic field on the phagocytic activity of variously treated rat macrophages(Marcel Dekker Inc, 2001) Dasdag, S; Sert, C; Akdag, MZ; Oflazoglu, HDThe purpose of this study was to investigate the effects of 9450-MHz microwaves and extremely low frequency magnetic fields (ELFMF) on the phagocytic activity of rat macrophages in control rats and those treated with vitamins C and E. In the microwave group, 24 albino Wistar rats were exposed to microwaves (2.65 mW/cm(2), specific absorption rate [SAR]: 1.80 W/kg) for 1 h/day for 21 days. Thirty-two albino Wistar rats were divided into four groups (one control, three experimental) (n = 8). The rats in the first exposure group were only exposed to microwaves for 1 h per day for 21 days. In addition to exposure with microwaves as in the first experimental group, vitamins E and C (150 mg/kg/day) were injected intraperitoneally into the rats in the second and third exposure groups, respectively. In the magnetic field exposure group, 26 albino Wistar rats were divided into two groups: the sham (n = 12) and exposed groups (n = 14). The rats in the experimental group were exposed to ELFMF (50 Hz, 0.75 mT) for 3 h/day for 3 weeks. After completing the exposure period, the rats were sacrificed under ketalar anesthesia. The viability of isolated alveolar macrophages of rats in the microwave and ELF groups was determined and compared to sham groups. The results were analyzed with the Mann-Whitney U test. In the microwave group, the phagocytic activity in the experimental groups was found to be higher than the sham groups. However, with phagocytic activity in rats treated with both microwaves and vitamins, only the vitamin C group was significant (p < 0.05). In the magnetic field group, the phagocytic activity of rats exposed to ELFMF was lower than that of the sham group, but the results were not significant (p > 0.05). Rectal temperatures of microwave-exposed groups were found to be significantly higher compared to the control group (p < 0.05).Öğe Effects of microwaves on the phagocytic activity of variously treated rat macrophages(Marcel Dekker Inc, 1998) Dasdag, S; Oflazoglu, H; Kelle, M; Akdag, ZThe purpose of this study was to investigate the effects of 2450 MHz and 9450 MHz microwaves an the phagocytic activity of rat macrophages in rats without treatment and treated with exercise, vitamins C and E, dexamethasone, and both dexamethasone and vitamin C. Alveolar and peritoneal exudates from Swiss albino rats were exposed to microwaves for 1, 5, and 10 secs. The results were analyzed with the Mann-Whitney U test. In the group exposed to 2450-MHz microwaves, altered phagocytic activity of macrophages was found to be significant for each exosure period (p <.05). In the groups that were additionally subjected to vitamin C, vitamin E, and combined treatment with vitamin C and dexamethasone, phagocytic activities were found to be changed for only 10 s (p <.05), 1 and 5 s (p <.05), and 1 s (p <.05), exposure, respectively. In the groups exposed to 9450-MHz microwaves alone and microwaves plus vitamin E, altered phagocytic activities were found to be significant for each exposure period (p <.05) and for only 1 s exposure (p <.05), respectively. The differences between pre- and postexposure temperatures were also found to be significant (p < .05).Öğe The effects of whole body cell phone exposure on the T1 relaxation times and trace elements in the serum of rats(Taylor & Francis Inc, 2004) Aksen, F; Dasdag, S; Akdag, MZ; Askin, M; Dasdag, MMThe. objective of this study was to investigate the effects of radiofrequency radiation emitted from cellular phones on: (1) trace elements such as manganese, iron, copper, zinc, (2) T1 relaxation times in serum, and (3) rectal temperature of rats. exposed to microwave radiation emitted. from cellular phones. Sixteen Sprague-Dawley rats were separated into two groups of eight, one sham-exposed (control) and one expo sed (experimental). The rats were confined in Plexiglas cages and a cellular phone was placed 0.5 cm under the cage. For the experimental group, cellular phones were activated 20 min per day, 7 days a week, for I month. For the control group, a cellular phone placed beneath the cage for 20 min a day was turned off. Rectal temperatures were measured weekly. For 250-mW-radiated powers, the whole body average specified absorption rate (SA R) (rms) is 0.52 W/ kg and 1-g-averaged peak SAR (rms) is 3.13 W/kg. The Mann-Whitney U test was used for statistical comparisons of groups. T1 relaxation time and the values of iron and copper in the serum of the experimental group were not changed compared to the control group (p > 0.05). However, manganese and zinc values in the serum of the experimental group were significantly different from the control group (p < 0.05). The difference in rectal temperature measured before and after exposure in the experimental groups was not statistically different from control (p > 0.05).Öğe Effects of whole body chronic 50 Hz sinusoidal weak magnetic field exposure on the rat pituitary hormones(Mbr Press Inc, 1999) Sert, C; Akdag, MZ; Çelik, MS; Dasdag, SWe have investigated whether functions of pituitary gland change when the rats are exposed to sinusoidal magnetic fields at dark. In this study, 26 Wistar Albino rats were divided into two groups as experimental (n=14) and sham group (n=12). Experimental was exposed to 0.75 mT sinusoidal magnetic field procuded by Helmholtz coils and sham group was housed between inactivated Helmholtz coils, for one month. After one month Animals were sacrificed and their blood were taken. Serum hormone levels were determined by Radioimmunassay method. In exposed group, serum cortisol TSH, FSH and prolactin concentration did not statistically changed according to sham exposed group (p>0.05), but Growth Hormone and testesterone levels statistically changed (p<0.05).Öğe Effects of whole-body chronic microwave exposure on some hormones of variously treated rats(Mbr Press Inc, 1999) Akdag, MZ; Sert, C; Kaya, H; Dasdag, S; Çelik, MSTo investigate the effects of chronic whole-body microwave exposure, on serum Thyroid Stimulating Hormone (TSH), thyroxin (T-4), triiodothyronine (T-3), Cortisol, Growth Hormone (GH), Follicular Stimulating Hormone (FSH) and Estradiol concentrations, Wistar-albino female rats without treated and treated Vitamin C and Vitamin E were exposed to Microwave (MW) with a frequency of 9.450 MHz at the power density of 2.65 mW/cm(2) with corresponding specific absorption rate of 1.80 W/kg for 1h/day during 21 days. Vitamin C (150 mg/kg/day) and Vitamin E (150 mg/kg/day) were administrated during last seven exposure days to MW+Vit.C (n=8) and MW+Vit.E (n=8) groups respectively. Rectal temperatures were measured in all female rats. Serum levels of GH and FSH decreased (p<0.05, p<0.01 respectively) while estradiol levels increased in MW exposure group (p<0.05). But other hormones did not change in MW group (n=8). All hormone levels of rats treated with Vitamin C did not change (p>0.05). T-3 and T-4 hormones of exposed rats were found to be significant at MW +Vit.E group according to MW group (p<0.05). Rectal temperature differences were found to be significant in experimental groups according to sham group (n=8) (p<0.05). It was concluded that the changes of hormone concentrations under study was consistent with MW-induced thermal stimulation of Hypothalamic-Hypophysial-Adrenal (HHA) and Hypothalamic-Hypophysial-Thyroid (HHT) activity and Vitamin E might play role in changing T-3 and T-4 hormones.Öğe Elf magnetic field effects on fatty-acid composition of phospholipid fraction and reproduction of rats' testes(Taylor & Francis Inc, 2002) Sert, C; Akdag, MZ; Bashan, M; Buyukbayram, H; Dasdag, SIn this study, we investigated how rat reproductive cells, testosterone, and the fatty acid composition of the phospholipid fraction of rats' testis cells are affected by extremely low frequency magnetic field (ELFMF). The change in fatty acid composition of the membrane phospholipid fraction can be the mechanism for this effect. We used a total of 26 male Wistar Albino rats, 14 experimental, and 12 controls. The experimental group rats were exposed to a magnetic field (0.8 mT) for 5 weeks, 3 hr per day. The control group rats were kept between inactive coils. After 5 weeks, the testis tissues and sperm cells of all rats were histopathologically investigated and sperm counts determined. Epididymal sperm count did not change compared to the control group (p>.05). Besides this, amorphous head, banana-like head, hammer head, coiled tail, abnormal mid-piece and tail, multiple, and cytoplasmic-droplet type cell numbers did not change in either group (p>.05). However, a statistical difference was found between the control and experimental groups with respect to head with lack of hook and isolated head type sperm (p<.05). In addition, testosterone levels were also found to be altered (p<.05). In the histopathologic investigation of testis tissue, decreased spermatogenesis in some seminiferous tubules, congestion in blood vessels of the interstitium, and increases in interstitial edema and Sertoli cells were observed. Leydig cells were found to be normal in appearance. The fatty acid of the testis cell membrane phospholipids was decreased in the experimental group with respect to the control group.Öğe The evaluation of the role of microwave and vitamins on rat eyes related to lipid peroxidation and tissue damage(Taylor & Francis Ltd, 2002) Akdag, MZ; Sert, C; Erdinc, L; Dasdag, S; Buyukbayram, H; Celik, MS; Cakmak, SSIn the present study, the effect of low-intensity microwave radiation on rat eyes and the protective effect of some vitamins against the damage induced by microwave was investigated. 32 Wistar-albino female rats were divided into four groups (1 Control, 3 Experimental) (n=8). The rats of first experimental group were exposed to 9450 MHz microwave (2.65 mW/cm(2)) for one hour a day during 21 days. In addition to exposure with MW as first experimental group, Vitamin E and Vitamin C (150 mg/kg/day) were injected intraperitoneally to second and third experimental groups respectively during last seven days of exposure. The eyes of rats were examined daily after MW and sham exposure by an ophthalmologist biomicroscopically. After completed 21 days exposure period the rats were sacrificed under ketalar anesthesia. The rat eyes were enucleated for histopathological examination and Malondialdehyde (MDA) assay. Sero hemoragic dark brown secretion was observed in rats' conjunctiva of fist and second experimental groups after biomicroscopic examination. However, no damage was detected in the third group. Vacuolization, pleomorphism between cells and increasing of cell layers in lens fibers of all experimental groups were observed histopathologically. In the cornea of experimental groups, cellular loss, shape and size differences among cells and lack of polarity were noticed. Slight edema, congestion, desquamation in epithelial cells, separation between layers in some areas and alteration in pigment cells of retina were also determined in experimental group rats. The MDA (Malondialdehyde) levels of all experimental groups increased significantly compared to control group (P<0.05). However, no significant differences among experimental groups were observed at MDA levels (P>0.05). The temperature differences of all experimental groups were found to be significant compared to control group (P<0.05). Finally, it was determined that low-intensity long-term microwave exposure caused histopathologic alternations and lipid peroxidations on rat eyes.Öğe Hormone levels of people occupationally exposed to radiofrequencies.(Mbr Press Inc, 1999) Dasdag, S; Balci, K; Kaya, H; Çelik, MSThe present article intended to investigate some hormone levels of technicians in the radio-broadcasting, television (TV) and radio - link stations. The study was carried out on 43 technicians from 20 to 59 years age occupationally exposed to radiofrequency (RF) and microwave (MW) radiation. 20 unexposed and voluntary persons from 20 to 59 years age were accepted as a control group. We determined the levels of some hormones as triiodothyronine (T-3), tetraiodothyronine (T-4), thyroid stimulant hormone (TSH), free T-4, estradiol, dehydroepiondrosterone sulfate (DHEA), testosterone, cortisol and progesterone in the technicians under investigation. The hormone levels of exposure groups were statistically compared with the unexposed control group. T-3, T-4, estradiol, testosterone and progesterone levels of technicians in the radio-link and TV transmitter stations were found to be significant (p<0.05, p<0.001). T-3, T-4, TSH, estradiol and progesterone levels of technicians in the broadcasting station were also found to be significant (p<0.001). In conclusion some hormone levels of technicians under investigation were altered by RF/MW.Öğe The investigation of the effect of microwave on rat TMJ(Pergamon-Elsevier Science Ltd, 1996) Karadede, I; Akdag, Z; Ketani, MA; Dasdag, S; Celik, S[Abstract Not Available]
