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    A general approach and management in complications of hemodialysis catheters: Review
    (Turkiye Klinikleri, 2007) Daniş R.; Özmen Ç.; Akin D.; Yazanel O.
    Central venous catheters are commonly used vascular access for hemodialysis in renal failure. Semi-rigid double-lumen polyurethane catheters may be considered for short-time use (up to 2-3 weeks). Soft silicone double-lumen or twin-catheters, preferably with subcutaneous tunneling, are highly desirable for prolonged usage. The complications related with catheters may be evaluated under three topics: insertion complications, thrombosis, and infection. Infections is the most common cause of the nosocomial sepsis and the most serious complication in dialysis centers. Catheter dysfunction is one of the common complications. The internal jugular route should be considered for mid-term use in order to facilitate the patient's mobilization and to reduce the risk of infection. The subclavian route should be avoided because of the risk of stenosis and/or thrombosis of the outflow vein. Catheter insertion must be performed by a trained physician with ultrasound guidance. Complications associated with insertion, infection, and thrombosis are a major source of morbidity and mortality in end stage renal disease patients. Diagnosis and management of these complications are discussed in details. Copyright © 2007 by Türkiye Klinikleri.
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    Hepatitis B virus infection in patient with Hodgkin's and non-Hodgkin's lymphoma and clinical significance
    (2007) Altintaş A.; Kaplan M.A.; Çil T.; Yilmaz Ş.; Bayan K.; Daniş R.; Ayyildiz O.
    Hepatitis B virus (HBV) is a hepatotrophic virus that have also a potential to replicate in lymphoid cells. This has led to evaluation of potential association between HBV infection and lymphomas. In this study, we retrospectively determined the HBV surface antigen and anti-HBs antibody in Southeastern region of Turkey where the prevalence of this infection is relatively high. A total of 276 patients were recruited, 203 (73.6%) with non-Hodgkin's lymphoma (NHL) and 73 (26.4%) with Hodgkin's lymphoma (HL), in the period of January 1995 and December 2005. In total, 40 (14.5%) patients were positive for HBsAg. Of them, 12 (16.4%) were in HL group and 28 (13.7%) were in NHL group. Anti-HBs antibody was positive in total of 123 patients [29 (39.7%) in HL and 94 (46.3%) in NHL]. Eleven patients were taken lamivudine prophylaxis (100 mg po / day) in the last two years. Ten were not developed a reactivation, while one with diffuse large-cell NHL reactivated. Besides, one patients with HL who was not taking prophylaxis developed anti-HBcIgM positive with aminotransferase elevations compatible with acute hepatitis. Although HBsAg positivity was higher in lymphoma patients than in general population in our study, for a possible casual association there is need for prospective studies with wider populations. In conclusion, prophylaxis with lamivudine of HBV carriers is important and treatment should be continued until one year after termination of chemotherapy.
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    Microchimerism, a dilemma in current medicine
    (2006) Özmen Ş.; Daniş R.; Altintaş A.; Bayan K.; Yilmaz Ş.
    Microchimerism refers to presence of a small number of cells, or DNA of one individual harbored in another individual. Many studies indicate that cell trafficking occurs between the fetus and mother during pregnancy and between others after organ transplantation or blood transfusions. These cells or DHA can persist in recipient's blood or tissues for decades, creating a state of physiologic microchimetism. In several recent studies, microchimerism has been shown to have potential roles in pathogenesis of different diseases. However, due to the fact that microchimerism has also been found in healthy individuals and in organs affected by non-autoimmune conditions, an alternative hypothesis has been suggested in which microchimeiic cells are associated with the healing process of a tissue injury as opposed to causing disease. As a conclusion of this review of recent studies, we can say that microchimerism studies yielded more questions than answers.