Yazar "Dal, Mehmet Sinan" seçeneğine göre listele
Listeleniyor 1 - 20 / 36
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of the underlying causes of the immune thrombocytopenia: Ten years experience(Pakistan Medical Assoc, 2017) Dal, Mehmet Sinan; Karakus, Abdullah; Dal, Tuba; Aydin, Berrin Balik; Hattapoglu, Elif; Ekmen, Mehmet Onder; Ulas, TurgayObjective: Immune thrombocytopenia (ITP) is an immune haematologic disorder causing platelet destruction mediated by anti-platelet antibodies. In this study we aimed to evaluate the clinical and laboratory variables of ITP patients in southeast of Turkey. Methods: In this retrospective study 167 ITP patients between 2005 and 2015 were evaluated. All patients were screened for immunological parameters including ANA (antinuclear antibodies), anti dsDNA (anti-double-strandedDNA), ACA(anti-cardiolipin) IgM and IgG, LA (lupus anticoagulants). All patients were screened for Helicobacter pylori, HBsAg (Hepatitis B surface antigen), anti-HCV (hepatitis C virus antibody), and anti-HIV 1/2 (HIV antibody) and brucellosis. Results: Among the patients, 50 (29.9%) patients were male, 117 (70.1%) were female. The age range of patients was 18-86 (mean 38.16+/-14). In 56 patients (33.5%) splenectomy was performed. 36 patients (21.6%) were positive for ANA, 5 (3%) were positive for anti dsDNA, 14 (8.4%) for ACA Ig G, and 14 (8.4%) patients for ACA IgM. LA was tested in 165 patients and 30 (18%) patients were positive for LA. Microbiologic evaluation was as follows: 16 patients (9.6%) were positive for HbsAg, 109 (65.3%) positive for Anti-HBs, 5 positive for anti-HCV (3%), 56 (33.5%) patients were positive for Helicobacter pylori antigen, 5 (2.9%) for Brucella and one patient was positive for anti-HIV 1/2. Conclusion: Immune thrombocytopenia patients have to be evaluated according to their demographic characteristics and laboratory results. Secondary causes of ITP were HIV, HCV, Helicobacter pylori, brucellosis, tuberculosis, and autoimmune diseases in our region. Management of ITP patients can change in different regions.Öğe BRUCELLOSIS IS A MAJOR PROBLEM: A FIVE YEARS EXPERIENCE(Carbone Editore, 2013) Dal, Tuba; Celen, Mustafa Kemal; Ayaz, Celal; Dal, Mehmet Sinan; Kalkanli, Sevgi; Mert, Duygu; Yildirim, NecmettinBrucellosis is a chronic granulomatous infection which is endemic in Mediterranean countries and Turkey. The aim of this study is to analyze the clinical, laboratory findings and therapeutic features in patients with brucellosis. A retrospective study was conducted with 91 patients who developed brucellosis between 2005 to 2009. The diagnosis was based on clinical findings compatible with brucellosis, serological tests positive, and/or isolation of Brucella species from blood, or other tissues. The mean age was 33 years (16-67 years). Sixty-threes of patients (69.2%) were male. Forty (44%) cases had an occupational history relevant for Brucella exposure and 85 (93%) cases consumption with contaminated animal product. The mean diagnostic delay was 15 days, much longer in focal brucellosis. A total of 77 (85 %) cases had acute brucellosis. The focal brucellosis complications were observed in 39 (42.8%) cases: osteoarticular involvement 32 (82%), epididymo-orchitis 4 (10%), and central nervous system involvement 3 (8%). Chronic brucellosis occurs in 3 (3.3%) cases. Clinical manifestations included non-specific symptoms such as fever (95%). sweats (90%), arthralgia and lower back pain (63%). Of the patients 84 (92%) had serological titre =1/160 and 28 (31%) blood cultures were positive. All of the patients were cured by antibiotic therapy (Doxycycline+rifampicin/streptomycine, streptomycine+rifampicin/Doxycycline, ceftiraxone/rifampicin). Relapse was observed in 5 (5.4%) patients. Brucellosis is an infection with multiple presentations. Its early diagnosis was mandatory to avoid severe complications.Öğe Classification of non-hodgkin lymphoma in Southeast Turkey: A review of 550 cases(Harran Üniversitesi Tıp Fakültesi, 2019) Ekmen, Mehmet Önder; Dal, Mehmet Sinan; Karakuş, Abdullah; Büyükbayram, Hüseyin; Ayyıldız, Mehmet OrhanBackground: The distribution of non-Hodgkin lymphoma (NHL) subtypes differs around the world. In this study we aimed to evaluate the gender, age, subtypes, biopsy sites, nodal and extranodal residential area, and stage of disease in the patients with NHL admitted to our hospital between January 2005 and December 2014. Materials and Methods: The records of NHL patients admitted to our hospital between January 2005 and December 2014 were retrospectively reviewed Results: Among 550 patients, 335 patients (60.9%) were male, 215 patients (39.1%) were female. The average age of over all the patients was 56 years (15-95). The average age of women was 57 (15-88), the average age of men was 54 years (15-95). The histological subtypes of NHL patients were as follows: 447 patients (81.3%) B-cell lymphoma, 84 patients (15.2%) T / NK cell lymphoma, 19 patients (3.5%) unclassified subtype. NHL patients divided into subtypes according to 2001 and 2008 WHO (World Health Organization) Classification and histopathologic subtypes were as follow: Diffuse Large B Cell Lymphoma (DLBCL) 295 patients (53,63%), small lymphocytic lymphoma (SLL) 37 patients (6.7%), Extranodal marginal zone lymphoma (MALT type) 37 patients (6,75%), peripheral T-cell Lymphoma 27 patients (4.9%), mantle cell lymphoma 26 patients (4.72%), Nodal Marginal Zone B-Cell Lymphoma 7 patients (1,3%), follicular lymphoma in 12 patients (2.1%), Burkitt's lymphoma 7 patients (1.3%), Splenic marginal zone B-cell lymphoma 4 patients (0,7). The most common subtype of NHL was DLBCL 295 patients (53,63%). Follicular lymphomas are less common in our center. Extranodal involvement rate was 38,5% of patients. According to the distribution of the sites of extranodal NHLs, the vast majority of patients 43% had GI tract involvement. The most commonly affected GI sites were stomach (27,8%). In this study 22.9% of the patients were in Stage 1, 26.7% in Stage 2, 19.5% in Stage 3, 30.9% in Stage 4 according to Ann- Arbor classification. In conclusion, the characteristics of NHLs in our region show some differences from other sites of the world. Conclusions: The characteristics of NHL patients vary according to geographical differences. Present study has revealed the importance of geriatric assessment. NHL was observed frequently in men. Environmental risk factors have to research, epidemiologically. The most common subtype of NHL was DLBL. Follicular lymphomas are less common in our center. Improvement of national cancer registration system and multicenter large-scale studies reviewing the treatment protocols are needed to ensure the early diagnosis and therapy of NHL.Öğe Clinical characteristics and therapeutic outcomes of elderly patients with chronic myeloid leukemia: A retrospective multicenter study(Wiley, 2015) Korkmaz, Serdal; Dal, Mehmet Sinan; Berber, Ilhami; Sahin, Deniz Goren; Dogu, Mehmet Hilmi; Ayyildiz, Orhan; Nizam, IlknurAimsWe aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (TKI) therapy. MethodsData including the clinical characteristics, therapeutic outcomes and compliance with TKI therapy of elderly patients with chronic myeloid leukemia aged >65years were collected from 13 institutions in Turkey, retrospectively. ResultsA total of 69 patients (27 [39%] men, 42 [61%] women) were evaluated retrospectively. The median age of the patients was 71years (range 66-85years). Of the patients, 66 (96%) were in the chronic phase and three (4.3%) were in the accelerated phase when diagnosed. A total of 63 (91.3%) patients were receiving imatinib as the first-line therapy. The initial dose of imatinib was 400mg/day in 59 patients (93.6%). Imatinib treatment induced 57 (90.5%) complete hematological responses at 3months, 29 (46%) complete cytogenetic responses at 6months and 49 (77.7%) major molecular responses at 12months. As a result, nilotinib and dasatinib were used in 14 patients as second-line therapy. Second-line TKI induced nine complete hematological responses (64.3%) at 3months, four complete cytogenetic responses (28.6%) at 12months and seven major molecular responses (50%) at 18months. A total of 56 of the patients (81.2%) are still alive. The median overall survival and progression-free survival rates were 35months (range 1-95months) and 17months (range 0.8-95months), respectively. ConclusionElderly patients should receive TKI according to the same guidelines that apply to younger patients. Geriatr Gerontol Int 2015; 15: 729-735.Öğe The clinical characteristics and therapeutic outcomes of elderly patients with chronic myeloid leukemia: A retrospective multicenter study.(Lippincott Williams & Wilkins, 2014) Korkmaz, Serdal; Dal, Mehmet Sinan; Berber, Ilhami; Sahin, Deniz Goren; Dogu, Mehmet Hilmi; Ayyildiz, Orhan; Nizam, Ilknur[Abstract Not Available]Öğe Clinical characteristics and therapeutic outcomes of paroxysmal nocturnal hemoglobinuria patients in Turkey: a multicenter experience(Springer, 2021) Şahin, Deniz Gören; Akay, Olga Meltem; Keklik, Muzaffer; Okan, Vahap; Karakuş, Abdullah; Demir, Cengiz; Erkurt, Mehmet Ali; İlkkılıç, Kadir; Yıldırım, Rahşan; Çağlıyan, Gülsüm Akgün; Aksu, Salih; Doğu, Mehmet Hilmi; Dal, Mehmet Sinan; Karakuş, Volkan; Gemici, Ali İhsan; Terzi, Hatice; Kelkitli, Engin; Şıvgn, Serdar; Ünal, Ali; Yılmaz, Mehmet; Ayyıldız, Orhan; Korkmaz, Serdal; Eser, Bülent; Altuntaş, FevziThe aim of this study is to collect paroxysmal nocturnal hemoglobinuria (PNH) patient data from hematology centers all over Turkey in order to identify clinical features and management of PNH patients. Patients with PNH were evaluated by a retrospective review of medical records from 19 different institutions around Turkey. Patient demographics, medical history, laboratory findings, and PNH-specific information, including symptoms at the diagnosis, complications, erythrocyte, and granulocyte clone size, treatment, and causes of death were recorded. Sixty patients (28 males, 32 females) were identified. The median age was 33 (range; 17-77) years. Forty-six patients were diagnosed as classic PNH and 14 as secondary PNH. Fatigue and abdominal pain were the most frequent presenting symptoms. After eculizumab became available in Turkey, most of the patients (n = 31/46, 67.4%) were switched to eculizumab. Three patients with classic PNH underwent stem cell transplantation. The median survival time was 42 (range; 7-183 months) months. This study is the first and most comprehensive review of PNH cases in Turkey. It provided us useful information to find out the differences between our patients and literature, which may help us understand the disease.Öğe Comment on "Rosiglitazone treatment in nondiabetic subjects with nonalcoholic fatty liver disease"(Medycyna Praktyczna, 2012) Ulaş, Turgay; Dal, Mehmet Sinan; Demir, Mehmet Emin; Büyükhatipoǧlu, Hakan[No abstract available]Öğe Comment on: acute and chronic fluctuations in blood glucose levels can increase oxidative stress in type 2 diabetes mellitus(Springer-Verlag Italia Srl, 2013) Ulas, Turgay; Dal, Mehmet Sinan; Tursun, Irfan; Demir, Mehmet Emin; Buyukhatipoglu, Hakan[Abstract Not Available]Öğe Comment on: Infusion of lin-/sca-1+ and endothelial progenitor cells improves proinflammatory and oxidative stress markers in atherosclerotic mice(Elsevier Ireland Ltd, 2013) Ulas, Turgay; Tursun, Irfan; Demir, Mehmet Emin; Dal, Mehmet Sinan; Buyukhatipoglu, Hakan[Abstract Not Available]Öğe Comment on: Oxidative stress in erythrocytes from patients with rheumatoid arthritis(Springer Heidelberg, 2014) Ulas, Turgay; Dal, Mehmet Sinan; Demir, Mehmet Emin; Buyukhatipoglu, Hakan[Abstract Not Available]Öğe Comment on: oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity(Wiley-Blackwell, 2013) Ulas, Turgay; Tursun, Irfan; Dal, Mehmet Sinan; Buyukhatipoglu, Hakan[Abstract Not Available]Öğe Comment on: Study of Oxidative Stress in Vitiligo(Springer India, 2012) Ulas, Turgay; Dal, Mehmet Sinan; Demir, Mehmet Emin; Buyukhatipoglu, Hakan[Abstract Not Available]Öğe Does the eltrompobag treatment safe or effective for refractory chronic immune thrombocytopenia patients?(E-Century Publishing Corp, 2016) Dal, Mehmet Sinan; Karakus, Abdullah; Cakar, Merih Kizil; Ulu, Bahar Uncu; Hattapoglu, Elif; Ekmen, Mehmet Onder; Ulas, TurgayBackground: Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by immune-mediated platelet destruction and reduced platelet production. As the pathophysiology of the disease got clear, thrombopoietin receptor (TPO-R) agonists have been preferred in recent years, which seems to be an effective option in the treatment of resistant cases. Eltrombopag, a TPO-R agonist, is a second or third line medical treatment option for adults with chronic ITP. Objective: To determine the efficacy and safety of long-term eltrombopag treatment in treatment-refractory patients with primary ITP was the aim of this study. Materials and Methods: Retrospective data of 34 patients with refractory ITP who were treated with eltrombopag were examined. Efficacy and safety of the eltrombopag treatment was evaluated. Results: The total rate of response was 82%, and the median duration of response defined as the number of the platelets being over 50x10(9)/L was 14 (interquartile range: 7-28) days. In two patients, thrombosis was observed with no other additional risk factors due to or related to thrombosis. Conclusion: In spite of the fact that the responses to eltrombopag were satisfactory, patients need to be monitored closely for increasing platelet counts as well as thromboembolic events.Öğe Efficacy of CLARA in recurrent/refractory acute myeloid leukaemia patients unresponsive to FLAG chemotherapy(Taylor & Francis Ltd, 2018) Kaya, Ali Hakan; Tekgunduz, Emre; Ilkkilic, Kadir; Dal, Mehmet Sinan; Merdin, Alparslan; Karakus, Abdullah; Hacioglu, Sibel KabukcuWe hereby report our multicentre, retrospective experience with CLARA in patients with fludarabine/cytarabine/GCSF (FLAG) refractory AML. The study included all consecutive R/R AML patients, who received CLARA salvage during October 2010-October 2015 period. All patients were unresponsive to FLAG salvage chemotherapy regimen and did not undergo previous allo-HCT. A total of 40 patients were included. Following CLARA 5 (12.5%) patients experienced induction mortality and 10 (25%) patients achieved CR. 25 (62.5%) patients were unresponsive to CLARA. 7 (17.5%) out of 10 patients in CR received allo-HCT. Median overall survival of patients who achieved CR after CLARA was 24.5 months (8.5-54.5) and 3 months (2.5-5), in patients who underwent and didn't allo-HCT, respectively. Our results indicate that CLARA may be good alternative even in FLAG refractory AML patients and can be used as a bridge to allo-HCT, who have a suitable donor and able to tolerate the procedure.Öğe Evaluation of febrile neutropenic patients hospitalized in a hematology clinic(Hainan Medical University, 2015) Görük, Mücahit; Dal, Mehmet Sinan; Dal, Tuba; Karakuş, Abdullah; Tekin, Recep; Özcan, Nida; Ayyıldız, Orhan; 0000-0003-2090-4392Objective: To evaluate the febrile neutropenic patients with hematological malignancies hospitalized in hematology clinic with poor hygiene standards. Methods: A total of 124 patients with hematological malignancies (69 male, 55 female) hospitalized in hematology clinic with poor hygiene conditions depending on hospital conditions, between January 2007 and December 2010, were evaluated, retrospectively. Results: In this study, 250 febrile neutropenia episodes developing in 124 hospitalized patients were evaluated. Of the patients, 69 were men (56%) and 55 women (44%). A total of 40 patients (32%) had acute myeloid leukemia, 25 (20%) acute lymphoblastic leukemia, 19 (15%) non-Hodgkin's lymphoma, 10 (8%) multiple myeloma, and 8 (8%) chronic myeloid leukemia. In our study, 56 patients (22%) were diagnosed as pneumonia, 38 (15%) invasive aspergillosis, 38 (15%) sepsis, 16 (6%) typhlitis, 9 (4%) mucormycosis, and 4 (2%) urinary tract infection. Gram-positive cocci were isolated from 52% (n = 20), while Gram-negative bacilli 42% (n = 16) and yeasts from 6% (n = 2) of the sepsis patients, respectively. The most frequently isolated Gram-positive bacteria were methicillin-resistant coagulase-negative staphylococci (n = 18), while the most frequently isolated Gram-negative bacteria was Escherichia coli (n = 10). Conclusions: Febrile neutropenia is still a problem in patients with hematological malignancies. The documentation of the flora and detection of causative agents of infections in each unit would help to decide appropriate empirical therapy. Infection control procedures should be applied for preventing infections and transmissions.Öğe Evaluation of oxidative stress parameters and metabolic activities of nurses working day and night shifts(Univ Sao Paolo, 2013) Ulas, Turgay; Buyukhatipoglu, Hakan; Kirhan, Idris; Dal, Mehmet Sinan; Ulas, Sevilay; Demir, Mehmet Emin; Eren, Mehmet AliThe aim of this study was to evaluate the oxidative stress and metabolic activities of nurses working day and night shifts. Intensive care unit (ICU) (n=70) and ordinary service (OS) nurses (n=70) were enrolled in the study. Just before and the end of the shifts, blood samples were obtained to measure the participants' oxidative stress parameters. Metabolic activities were analyzed using the SenseWear Armband. Oxidative stress parameters were increased at the end of the shifts for all OS and ICU nurses compared to the beginning of the shifts. Compared to the OS nurses, the ICU nurses' TAS, TOS, and OSI levels were not significantly different at the end of the day and night shifts. The metabolic activities of the OS and ICU nurses were found to be similar. As a result, the OS and ICU nurses' oxidative stress parameters and metabolic activities were not different, and all of the nurses experienced similar effects from both the day and night shifts.Öğe A forgotten vasoconstrictive peptide in the pathogenesis of contrast induced nephropathy: Urotensin-II(Elsevier Ireland Ltd, 2013) Ulas, Turgay; Tursun, Irfan; Dal, Mehmet Sinan; Demir, Mehmet Emin; Kaya, Zekeriya[Abstract Not Available]Öğe Hearing impairment in middle-aged patients with diabetes(Taylor and Francis Ltd., 2016) Özkurt, Fazıl Emre; Akdağ, Mehmet; Tuna, Mazhar Müslüm; Yılmaz, Beyhan; Şengül, Engin; Dal, Mehmet SinanMost studies focus on elderly patients with type 2 diabetes mellitus (T2DM). There is little known about the hearing of middle-aged subjects with T2DM. The objective of this study is to evaluate hearing impairment in patients aged 40–50 years with T2DM using pure-tone audiometry and high-frequency audiometry. Forty patients with T2DM (19 males, 21 females) and 40 (20 males, 20 females) age and sex similar controls were included. All subjects completed clinical, laboratory and auditory assessments. Pure-tone audiometry auditory tests and high-frequency audiometry tests were performed in a soundproof room for each ear using the AC-40 audiometer from Interacoustics with a special earphone appropriate for high frequency. In the T2DM group, the duration of T2DM was between 5 and 15 years (7.7 ± 2.4 years). At all frequencies, the thresholds of the T2DM group were higher than the control group for both right and left ears and also significant. However, the thresholds at standard frequencies (125–8000 Hz) for both group's average were lower than 20 dB-HL and were considered to be normal, and at high frequencies (9000–16,000 Hz) the T2DM group's average thresholds were higher than 20 dB-HL and considered to be a hearing loss. A Spearman's correlation test was done between the duration of T2DM and hearing thresholds. There was a mild correlation between the duration of T2DM and hearing thresholds in all frequencies. In conclusion, patients with type 2 diabetes have a high prevalence of subclinical sensorineural hearing loss. High-frequency audiometry can be used in hearing assessment screening of diabetic patients.Öğe Helicobacter pylori in primary gastric lymphoma and gastric cancer: A clinicopathologic and prognostic assessment(2013) Dal, Mehmet Sinan; Urakçı, Zuhat; Yıldız, Yılmaz; Alabalık, Ulaş; Küçüköner, Mehmet; İnal, Ali; Balakan, OzanAmaç: Helicobacter pylori mide lenfoması ve adenokarsinom için risk faktörüdür. Bu çalışmada H. pylori'nin primer mide lenfoma ve mide kanserinde prognostik faktör olup olmadığı incelendi.Yöntemler: Primer mide lenfoma ve mide kanserli 255 hastanın rezeksiyon veya biyopsi materyalleri H. pylori açısından incelendi. Patoloji spesmenlerinde H. pylori varlığını değerlendirmek için hematoksilen ve eozin boyası kullanıldı.Bulgular: Primer mide lenfomalı 140 hastanın 34'ünde (%24,3) H. pylori saptanırken mide kanserli 115 hastanın 62'sinde (%53,9) H. pylori saptandı. H. pylori varlığı mide kanserli hastalarda, mide lenfomalardan daha sık görüldü (p< 0.001). H. pylori pozitifliği, mide lenfoma içinde mukoza ilişkili lenfoid doku tip lenfomada (MALT) %53,5 oranında, diffüz büyük B hücreli lenfomadan farklı olarak %18,7 oranında görüldü (p< 0,001). Primer mide lenfoma da H. pylori'nin varlığı hastalıksız sağkalım ve genel sağkalım açısından anlamlılık oluşturmuyordu (p=0,833, p= 0,503). Bununla beraber mide kanserli hastalarda da H. pylori varlığı ile hastalıksız sağkalım ve genel sağkalımda da anlamlılık oluşturmuyordu (p=0,392, p= 0,357). Sonuç: Çalışmamızda mide kanserli ve primer mide lenfoma arasında H. pylori varlığı bakımından anlamlı farklılık vardı. Ancak H. pylori varlığı, hem hastalıksız sağkalım hem de genel sağkalım açısından prognostik anlamlılık oluşturmuyordu.Öğe In which HOMA-IR value acceptable for sampling the patients with insulin resistance?(Elsevier Ireland Ltd, 2013) Ulas, Turgay; Tursun, Irfan; Dal, Mehmet Sinan; Demir, Mehmet Emin; Buyukhatipoglu, Hakan[Abstract Not Available]
