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Öğe BRAF GENE MUTATIONS AND PROGNOSTIC SIGNIFICANCE OF CLINICAL FINDINGS IN CASTLEMAN DISEASE(Ferrata Storti Foundation, 2016) Turker, M.; Subari, S.; Keklik, M.; Dal, M. S.; Sahin, N.; Comert, M.; Alanoglu, G.[Abstract Not Available]Öğe The clinicopathological features and survival of Castleman disease: a multicenter Turkish study(Verduci Publisher, 2022) Yildiz, J.; Bagci, M.; Sayin, S.; Kaya, A.; Yilmaz, F.; Ekinci, O.; Dal, M. S.OBJECTIVE: In this study, we aimed to investigate the clinicopathological features and survival of CD, which is quite rare and has many unknowns. PATIENTS AND METHODS: This study was conducted by retrospectively evaluating patients diagnosed with CD in six different centers in Turkey. RESULTS: The median age of 33 patients included in the study was 49 and 51.5% (n = 17) of these patients were women. 18 (54.5%) patients were in the hyaline vascular subtype and most of the patients were UCD (n = 20, 60.6%). The most common involvement region was head and neck (n = 19, 57.5%). The UCD group was younger than the MCD group (p=0.027). Visceral lymph node involvement was higher in MCD than in UCD (p=0.001). Similarly, it was observed that there was more hepatomegaly (p=0.035) and splenomegaly (p=0.013) in the MCD group. During the median 19.5 months follow-up period, there were no patients who died. CONCLUSIONS: It was observed that UCD and MCD are different clinical entities. Promising survival times can be achieved with surgical and systemic treatments in both subtypes of this extremely rare disease. However, this re- suit should be supported by well-designed prospective comprehensive studies.Öğe The effect of day and night shifts on oxidative stress and anxiety symptoms of the nurses(Verduci Publisher, 2012) Ulas, T.; Buyukhatipoglu, H.; Kirhan, I.; Dal, M. S.; Eren, M. A.; Hazar, A.; Demir, M. E.Background: Oxidative stress is believed to have a role in the development of chronic diseases. It is also known that long-term night and shift work in nurses might be associated with many health-related problems like fatigue, sleep problems, anxiety and difficulties in maintaining regular lifestyles. Aim: In this study, we aimed to evaluate the changes of oxidative stress parameters and anxiety indexes of the nurses on day and night shifts. Materials and Methods: One hundred and twenty nurses in ordinary service and intensive care unit (ICU) were enrolled to the study. Subjects were divided into 2 groups; group 1 (n=60) consisted of nurses working in a day shift and group 2 (n=60) as working in the night shift. Further, both groups were divided in to 2 groups again; group la and 2a (both n=30) who working in the ICU, group 1b and 2b (both n=30) in the ordinary service. Just before and the end of the shifts, blood samples were obtained to measure total antioxidant status (TAS) and total oxidant status (TOS). Oxidative stress index (OSI) was calculated. Anxiety index were determined at the end of the shift using State-Trait Anxiety Inventory index. Results: Oxidative stress parameters were increased in all nurses at the end of the day and night shifts (p < 0.05). However, both in service and ICU nurses TAS, TOS, and OSI levels were not significantly different at the beginning and the end of the shifts (p > 0.05). Anxiety indexes of each ordinary service and ICU nurses were found to be similar (p > 0.05). Conclusions: Ordinary service and ICU nurses' oxidative stress parameters and anxiety indexes were not different and all nurses suffer the similar effects of the shifts both in day and night.Öğe Familial Mediterranean fever without cardinal symptoms and role of genetic screening(Pagepress Publ, 2012) Ulas, T.; Buyukhatipoglu, H.; Bes, C.; Dal, M. S.; Hacibekiroglu, I.; Apucu, H. G.; Borlu, F.Familial Mediterranean fever is an autosomal recessive disorder characterized by paroxysmal episodes of fever and serosal inflammation. The classical presentation is fever and severe recurrent abdominal pain due to serositis that lasts for one to three days and the resolves spontaneously. Between the episodes patients are asymptomatic. Ninety-five percent of patients with familial mediterranean fever have painful episodes localized to the abdomen, which is usually the dominant manifestation of the disease. Herein, we present a case of a 34-year-old man with incomplete abdominal pain episode of familial mediterranean fever limited to the epigastrum and had no cardinals symptoms of this disease. The diagnosis was made by genetic screening. Successful treatment response was achieved by colchicine.Öğe FASCIOLA HEPATICA ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE(Pergamon-Elsevier Science Ltd, 2014) Karakus, A.; Dal, M. S.; Ekmen, M. O.; Yildirim, R.; Dal, T.; Ayyildiz, O.[Abstract Not Available]Öğe A HEREDITARY HEMORAGIC TELANGIECTASIA (OSLER-WEBER-RENDU DISEASE) PRESENTING WITH SEVERE ANEMIA(Pergamon-Elsevier Science Ltd, 2014) Ekmen, M. O.; Dal, M. S.; Karakus, A.; Ayyildiz, O.[Abstract Not Available]Öğe Oxidative stress parameters and ceruloplasmin levels in patients with severe preeclampsia(Soc Editrice Univ, 2013) Demir, M. E.; Ulas, T.; Dal, M. S.; Eren, M. A.; Aydogan, H.; Yalcin, S.; Camuzcuoglu, A.Background. Oxidative stress is believed to have a role in the development of preeclampsia (PE). It is known that an increased ceruloplasmin (CP) level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and CP levels in patients with severe PE. Patients and Methods. Sixty patients with severe PE and 60 healthy pregnant women were recruited to the study. All study subjects were divided into 2 groups; group 1(n=60) consisted of patients with severe PE, and group 2 (n=60) consisted of healthy pregnant subjects. Blood samples were obtained to measure CP, total antioxidant status and total oxidant status from all subjects. Oxidative stress index was calculated. Results. Compared to group 2; group 1 had significantly higher CP, total oxidant status, oxidative stress index and lower total antioxidant status levels (p<0.001, p<0.001, p=0.001, p=0.008, respectively). Serum CP levels were significantly correlated with oxidative stress index levels (r=0.385, p=0.002). Conclusion. The present study demonstrated that both oxidative stress and CP levels increased in patients with PE, and increased CP levels seem to be a consequence of oxidative stress.Öğe RETROSPECTIVE ANALYSIS OF ELTROMBOPAG FOR THE TREATMENT OF REFRACTORY PRIMARY IMMUNE THROMBOCYTOPENIA IN THE SOUTH OF TURKEY(Pergamon-Elsevier Science Ltd, 2014) Dal, M. S.; Hattaboglu, E.; Karakus, A.; Ekmen, M. O.; Ayyildiz, O.[Abstract Not Available]Öğe Seroprevalence of IgG anti-Toxocara canis antibodies and anti-Fasciola sp antibodies in patients with urticaria(Soc Editrice Univ, 2013) Dal, T.; Cicek, M.; Ucmak, D.; Akkurt, M.; Tekin, A.; Dal, M. S.; Tekin, R.Aims. Chronic urticaria (CU) is defined by recurrent episodes occurring at least twice a week for 6 weeks and generally characterized by the rapid appearance of wheals and/or angioedema and may be associated with parasitic infections. We aimed to investigate the seroprevalance of Toxocara canis and Fasciola species in patients with CU. Materials and Methods. We included 55 patients (in age 16-55) with urticaria admitted in study. As a control group we recruited 30 healthy volunteers they had no history of urticaria, rhinitis, asthma, atopic eczema/dermatitis syndrome (AEDS), or other relevant diseases. IgG antibodies to Toxocara canis and Fasciola species were investigated by ELISA method. Results. In a total of 55 patients (mean age: 31.85 +/- 8.92), 8 patients (14.5%) were positive for IgG antibodies to Toxocara canis. Among seropositive patients (mean age: 38.62 +/- 12.46) 6 patients were female. No patient was positive for Fasciola by ELISA. Six of Toxocara canis seropositive cases were frequently visited or lived in rural areas and had contact with pets. Conclusions. Patients with urticaria, should be tested for Toxocara canis and treated with anthelminthic drugs in endemics areas for toxocariasis.Öğe Serum uric acid and inflammation in patients with immune thrombocytopenic purpura: preliminary results(Verduci Publisher, 2015) Dal, M. S.; Karakus, A.; Aydin, B. B.; Ekmen, M. O.; Ulas, T.; Ayyildiz, O.OBJECTIVE: The purpose of this study was to evaluate the uric acid (UA) and Creactive protein (CRP) levels in patients with immune thrombocytopenic purpura (ITP). PATIENTS AND METHODS: Forty patients with newly diagnosed ITP and 40 healthy individuals were enrolled in the study. The patients were divided into two groups; group 1 (n = 40) consisted of patients with ITP, and group 2 (n = 40) consisted of healthy subjects. UA and CRP levels were measured in the blood samples from them. RESULTS: There were no statistical differences in gender, age and body mass index between two groups (p > 0.05 for all). Compared to group 2, group 1 had significantly higher UA levels (p = 0.002), whereas CRP levels were not significantly different (p > 0.05). In ITP patients, serum UA and CRP levels significantly correlated with low platelet count (r = -0.362, p = 0.022; r = -0.383, p = 0.015, respectively); and UA levels significantly correlated with CRP levels (r = 0.436, p = 0.005). CONCLUSIONS: The present study showed that UA levels increased in patients with ITP and negatively correlated with platelet counts. UA levels might be a mediator of inflammation via enhanced production of inflammatory cytokines; they might also be a potential mediator of low platelet count, and could play a pathophysiological role in the development of ITP.
