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    THE EVALUATION OF RELATIONSHIP BETWEEN PLASMA ASYMMETRIC DIMETHYLARGININE (ADMA) AND AORTIC STIFFNESS IN PATIENTS 'WITH SYSTEMIC SCLEROSIS
    (Nobel Ilac, 2013) Ariturk, Zuhal; Dag, Sevin; Elbey, M. Ali; Kaya, Hasan; Ertas, Faruk; Bozkurt, Mehtap; Cevik, Remzi
    Objective: Endothelial dysfunction and vasculopathy are crucial pathogenic factors in systemic sclerosis. Increased concentrations of plasma asymmetric dimethylarginine (ADMA) may also contribute to endothelial dysfunction in patients with systemic sclerosis. We evaluated the relationship between ADMA and aortic elastic properties in patients with systemic sclerosis. Material and Method: Plasma ADMA levels were measured in 30 patients with systemic sclerosis (28females, mean age 40.7 +/- 11.6) and 30 healthy subjects (27 females, mean age 40.6 +/- 13). Aortic stiffness was determined with echocardiography Results: In patients with systemic sclerosis, the mean value of ADMA was 0.53 +/- 0.13ymolficompared with 0.46 +/- 0.15 mu mol/l for control group. Systolic blood pressure, pulse pressure and aortic 'strain' were found to be higher in patients with systemic sclerosis (p=0.027, p=0.048, p=0.037, respectively), diyastolic blood pressure and aortic distensibility was found lower in systemic sclerosis (p=0.039, p=0.045, respectively). There was no significant correlations between ADMA and aortic 'strain'. Conclusion: ADMA serum levels were increased in patients with systemic sclerosis, but no significant correlation was found between ADMA and aort's elastic structure (aortic 'strain', distensibility, and aortic stiffness index).
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    Öğe
    Relation of asymmetric dimethylarginine and cardiac involvement in systemic sclerosis
    (Publisaude-Edicoes Medicas Lda, 2014) Dag, Sevin; Budulgan, M.; Dilek, B.; Batmaz, I; Ariturk, Z.; Nas, K.; Cevik, R.
    Objectives: The heart is a commonly involved organ in systemic sclerosis (SSc) and pulmonary hypertension is a commonly observed complication that is associated with poor prognosis in this disease. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases. In this study, we aimed to contribute to an early diagnosis of cardiac involvement by evaluating ADMA and tissue Doppler echocardiographic findings in patients with SSc. Methods: 30 SSc patients without clinical cardiac symptoms and 30 controls were included. Plasma ADMA levels were measured and tissue Doppler echocardiography examination was carried out for all participants. Systolic and diastolic functions were assessed; pulmonary arterial systolic pressure and mean pulmonary arterial pressure were measured. Results: The patient and control groups demonstrated a significant difference with regard to right ventricular free wall tissue Doppler late diastolic wave, pulmonary arterial systolic pressure, right ventricular ejection fraction, and right ventricular diastolic dysfunction values. ADMA levels were significantly higher in SSc patients and also in active patients compared to inactive patients. No significant relationship between ADMA and echocardiographic parameters was found. Conclusion: Tissue Doppler echocardiography is capable of revealing impaired right ventricular functions and increased pulmonary arterial systolic pressure before the occurrence of any cardiac clinical symptoms in patients with SSc. Serum ADMA levels were increased in SSc and in patients with active disease.