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Öğe Catecholamine levels in a Ramadan fasting model in rats: a case control study(Taylor and Francis Ltd., 2016) Bucaktepe, Pakize Gamze Erten; Akdaǧ, Mehmet; Daşdağ, Süleyman; Çelepkolu, Tahsin; Yılmaz, Mustafa Abdullah; Demir, Vasfiye; Haris, ParvezEating habits as well as physical exercise are very important for a healthy lifespan. Ramadan-type fasting, which is food and water avoidance during the daylight period for four weeks, has drawn attention due to its positive impacts on metabolism and health. The aim of this study was to compare the blood and urine catecholamine (CA) levels in fasting and non-fasting rats, in terms of stress response. A total of 20 male rats were randomly divided into a fasting group and a control group. Four weeks later, blood and urine samples were taken after decapitation. Analysis of CAs was done using high-performance liquid chromatography with florescence detection (HPLC-FLD). The dopamine (DA), adrenaline (ADR) and noradrenaline (NA) blood and urine concentrations were found to be higher in the fasting group compared to the control group, but the difference was statistically significant only for the blood DA levels (p < 0.05). In the fasting group, the blood values of ADR and NA correlated with each other but not with the DA levels, whereas there was correlation among the urine levels of DA, ADR and NA. In the control group, the blood and urine values of DA, ADR and NA correlated with each other. The differences observed in the blood and urine CAs indicate a specific regulation of CAs in Ramadan-type fasting, which needs to be investigated thoroughly in future studies.Öğe Do radiofrequency radiation affect the auditory system of people with occupational exposure?(Springer Tokyo, 1998) Meriç, Faruk; Daşdağ, Süleyman; Vergili, Kemal; 0000-0003-1211-9677The present study intended to investigate whether radiofrequency (RF) affects auditory system of people who are occupationally exposed to RF in terms of noise-induced hearing loss (NIHL) or not. The study was carried out on 31 men from 26 to 53 years of age. All of them have been working in the Diyarbakir Radio Broadcasting Station. On the other hand, the control group was based on 30 unexposed voluntary and healthy men. The range of age for control group was the same as in the exposed group (experimental group). The results of the present study showed that the incidence of NIHL in the exposed group is more and more than that of the unexposed (control) group. The incidence of NIHL was approximately found 70% for exposed group and 6% for unexposed group. The difference of the incidence of NIHL between exposed and unexposed groups were statistically found significant for right and left ears at '4 kHz notch' (p < 0.001). Hearing loss was not observed below 1 kHz. The percentage difference in the incidence of hearing loss (decibel) between control and experimental group was found insignificant for frequency below 1 kHz (p > 0.05). The experimental group was also divided to three subgroups of technicians, officers and men staying in the quarters of radio broadcasting station. Three subgroups were compared with one another statistically. The incidence of NIHL for the right ears of technicians was found higher than the officer (p < 0.05). The incidence of NIHL for the left ears of men staying in quarters was found higher than officers (p < 0.05). The other results of comparison were found insignificant (p > 0.05). In conclusion, the incidence of NIHL at '4 kHz Notch' in the experimental group was found more common than the control group.Öğe Does all-day and long-term exposure to radiofrequency radiation emitted from Wi-Fi affect hearing?(Taylor and Francis Ltd., 2017) Yorgancılar, Ediz; Daşdağ, Süleyman; Akdağ, Mehmet Zülküf; Akkuş, Zeki; Akdağ, Mehmet; Topçu, İsmailWe investigated the long-term effects of radiofrequency radiation (RFR) emitted from Wi-Fi systems on hearing. Sixteen Wistar albino rats were divided equally into two groups: sham control and exposure groups. The rats in the experimental group were exposed to 2.4 GHz RFR emitted from a Wi-Fi generator for 24 h/day for one year. The same procedure was applied to the rats in the sham group, except that the Wi-Fi generator was turned off. All groups were kept in Faraday cages during the 12 months to eliminate external electromagnetic fields. The distance between the Wi-Fi generator antenna and the exposure cages was 50 cm. Pre-exposure distortion product otoacoustic emissions (DPOAE) of all rats were measured at the beginning, 6th and 12th months of the study. The DPOAE values of the sham, baseline and exposure groups were compared statistically. For the 6000 Hz hearing frequency, the DPOAE values in the exposure group were lower than those in the sham group (p < 0.05). Similarly, the 6000 Hz hearing frequency values obtained at the end of the 12th month were also lower than the baseline and 6-month values in the exposure group (p < 0.05). In contrast, the DPOAE values at the 6th and 12th months of exposure for the 2000 Hz hearing frequency were higher than the baseline value (p < 0.05). These results indicated that 12 months of RFR (24 h/day) at 50 cm from a 2.4 GHz Wi-Fi source can affect hearing. However, further studies are necessary.Öğe The effect of microwave irradiation on the E.coli strains K12 and valine(1996) Akdağ, Zülküf; Özerdem, Nezahat; Akşen, Feyzan; Çelik, Salih; Sert, Cemil; Daşdağ, Süleyman; Kaya, Abdurrahman[Abstract Not Available]Öğe Effects of 3.5 GHz radiofrequency radiation on ghrelin, nesfatin-1, and irisin level in diabetic and healthy brains(Elsevier B.V., 2022) Bektaş, Hava; Algül, Şermin; Altındağ, Fikret; Yeğin, Korkut; Akdağ, Mehmet Zülküf; Daşdağ, SüleymanDiabetes, mobile phone use, and obesity have increased simultaneously in recent years. The radiofrequency radiation (RFR) emitted from mobile phones is largely absorbed in the heads of users. With 5 G, which has started to be used in some countries without the necessary precautions being taken, the amount of RFR to which living things are exposed will increase. In this study, the changes in energy homeostasis and redox balance caused by 5 G (3.5 GHz, GSM-modulated) were explored. The effects of RFR on the brains of diabetic and healthy rats were investigated and histopathological analysis was performed. Twenty-eight Wistar albino rats weighing 200–250 g were divided into 4 groups as sham, RFR, diabetes, and RFR+diabetes groups (n = 7). The rats in each group were kept in a plexiglass carousel for 2 h a day for 30 days. While the rats in the experimental groups were exposed to RFR for 2 h a day, the rats in the sham group were kept under the same experimental conditions but with the radiofrequency generator turned off. At the end of the experiment, brain tissues were collected from euthanized rats. Total antioxidant (TAS), total oxidant (TOS), hydrogen peroxide (H2O2), ghrelin, nesfatin-1, and irisin levels were determined. In addition, histopathological analyses of the brain tissues were performed. The specific absorption rate in the gray matter of the brain was calculated as 323 mW/kg and 195 mW/kg for 1 g and 10 g averaging, respectively. After RFR exposure among diabetic and healthy rats, decreased TAS levels and increased TOS and H2O2 levels were observed in brain tissues. RFR caused increases in ghrelin and irisin and a decrease in nesfatin-1 in the brain. It was also observed that RFR increased the number of degenerated neurons in the hippocampus. Our results indicate that 3.5 GHz RFR causes changes in the energy metabolism and appetite of both healthy and diabetic rats. Thus, 5 G may not be innocent in terms of its biological effects, especially in the presence of diabetes.Öğe Effects of 3.5-GHz radiofrequency radiation on energy-regulatory hormone levels in the blood and adipose tissue(Wiley, 2024) Bektaş, Hava; Daşdağ, Süleyman; Altındağ, Fikret; Akdağ, Mehmet Zülküf; Yeğin, Korkut; Algül, Sermin; 0000-0003-1211-9677; 0000-0002-0546-2832In recent years exposure of living beings to radiofrequency radiation (RFR) emitted from wireless equipment has increased. In this study, we investigated the effects of 3.5-GHz RFR on hormones that regulate energy metabolism in the body. Twenty-eight rats were divided into four groups: healthy sham (n = 7), healthy RFR (n = 7), diabetic sham (n = 7), and diabetic RFR (n = 7). Over a month, each group spent 2 h/day in a Plexiglas carousel. The rats in the experimental group were exposed to RFR, but the sham groups were not. At the end of the experiment, blood and adipose tissues were collected from euthanized rats. Total antioxidant, total oxidant, hydrogen peroxide, ghrelin, nesfatin-1, and irisin were determined. Insulin expression in pancreatic tissues was examined by immunohistochemical analysis. Whole body specific absorption rate was 37 mW/kg. For the parameters analyzed in blood and fat, the estimated effect size varied within the ranges of 0.215-0.929 and 0.503-0.839, respectively. The blood and adipose nesfatin-1 (p = 0.002), blood and pancreatic insulin are decreased, (p = 0.001), gherelin (p = 0.020), irisin (p = 0.020), and blood glucose (p = 0.040) are increased in healthy and diabetic rats exposed to RFR. While nesfatin-1 are negatively correlated with oxidative stress, hyperglycemia and insulin, ghrelin and irisin are positively correlated with oxidative stress and hyperglycemia. Thus, RFR may have deleterious effects on energy metabolism, particularly in the presence of diabetes. 3.5 GHz radiofrequency radiation (RFR) may induce alterations in hormones regulating energy metabolism. 3.5 GHz RFR may lead to alterations in total antioxidant, total oxidant, and hydrogen peroxide levels. Particularly in conjunction with diabetes, 3.5 GHz RFR may result in adverse effects on energy metabolism. Although there were changes of the hormone levels in the exposed group, the actual values remained for both sham and exposed groups within the normal range.Öğe Effects of low-intensity microwave radiation on oxidant-antioxidant parameters and DNA damage in the liver of rats(Wiley, 2021) Alkış, Mehmet Eşref; Akdaǧ, Mehmet Zülküf; Daşdağ, Süleyman; 0000-0002-3321-2873; 0000-0003-2826-2734; 0000-0003-1211-9677The continuously increasing usage of cell phones has raised concerns about the adverse effects of microwave radiation (MWR) emitted by cell phones on health. Several in vitro and in vivo studies have claimed that MWR may cause various kinds of damage in tissues. The aim of this study is to examine the possible effects of exposure to low-intensity MWR on DNA and oxidative damage in the livers of rats. Eighteen Sprague-Dawley male rats were divided into three equal groups randomly (n = 6). Group 1 (Sham-control): rats were kept under conditions the same as those of other groups, except for MWR exposure. Group 2: rats exposed to 1800 MHz (SAR: 0.62 W/kg) at 0.127 +/- 0.04 mW/cm(2) power density, and Group 3: rats exposed to 2,100 MHz (SAR: 0.2 W/kg) at 0.038 +/- 0.03 mW/cm(2) power density. Microwave application groups were exposed to MWR 2 h/day for 7 months. At the end of the exposure period, the rats were sacrificed and DNA damage, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), and total oxidant-antioxidant parameter analyses were conducted in their liver tissue samples. It was found that 1800 and 2100 MHz low-intensity MWR caused a significant increase in MDA, 8-OHdG, total oxidant status, oxidative stress index, and comet assay tail intensity (P < 0.05), while total antioxidant status levels (P < 0.05) decreased. The results of our study showed that whole-body exposure to 1800 and 2100 MHz low-intensity MWR emitted by cell phones can induce oxidative stress by altering oxidant-antioxidant parameters and lead to DNA strand breaks and oxidative DNA damage in the liver of rats. Bioelectromagnetics. (c) 2020 Bioelectromagnetics SocietyÖğe Interstitial space between cells in the left and right lobes of rat brains exposed to 900, 1800 and 2100 MHz radiofrequency radiation(Taylor and Francis Ltd., 2023) Daşdağ, Süleyman; Akdağ, Mehmet Zülküf; Er, Hakan; Akpolat, Veysi; Deveci, EnginThe head is the body part that is most exposed to radiofrequency radiation (RFR) during a mobile phone conversation. Therefore, it can be expected that brain cells will be positively or negatively affected by this physical agent. The purpose of this study was to investigate the effects of 900, 1800 and 2100 MHz on the interstitial space between cells in the right and left lobes of the brain. The study was carried out on 28 Wistar Albino rats, which were divided randomly into four groups (n: 7): sham control, 900 MHz, 1800 MHz and 2100 MHz exposure groups. The rats in the exposure groups were subjected to RFR for 3 h/day for one month. At the end of the last exposure, brains were immediately removed and prepared for electron microscopic examination. We determined the interstitial space (μm) between brain cells in the left and right lobes separately and compared them statistically. The results indicated that all three frequencies used in this study increased the interstitial space between cells in both brain lobes. The maximum effective frequencies were 1800 MHz for the right lobe and 2100 MHz for the left lobe. In conclusion, we observed that the RFR used in this study enhanced the interstitial space between cells in both lobes of the brain. Further studies are needed to confirm the results of this study, which we think will open different horizons.Öğe İyonlaştırıcı radyasyonlar ve kanser(Dicle Üniversitesi Tıp Fakültesi, 2010) Daşdağ, SüleymanBu makalenin amacı hastanelerde sıklıkla karşılaşılan gizli bir tehlike olan radyasyon uygulamalarına dikkat çekmektir. Bu amaçla bu makalede tıbbi amaçlarla kullanılan iyonlaştırıcı radyasyonlar ve kanser riski arasındaki ilişki irdelendi. Teşhis amaçlı radyasyon uygulamaları ile kanser risk artışı arasında ilişkiden söz eden araştırmaların sayısı son yıllarda artış göstermektedir. Radyasyonların stokastik etkileri dikkate alındığında bu çalışmalarda sözü edilen düşük dozlu radyasyonlar ile kanser arasında ilişkinin önemi ortaya çıkmaktadır. Sonuç olarak, teşhis veya tedavi amaçlı yapılan iyonlaştırıcı radyasyonlar ile kanser risk artışına ilişkin endişeleri yersiz olmadığı görülmüştür. Ayrıca, hekimlerin bu tür uygulamalarda hastaları için mutlaka kar-zarar hesabı yapmaları gerekirÖğe Öğe Oxidative and antioxidative responses in submandibular and parotid glands of rats exposed to long-term extremely low frequency magnetic field(Modestum Publishing Ltd., 2014) Akdağ, Mehmet; Akdağ, Mehmet Zülküf; Daşdağ, Süleyman; Erel, ÖzcanObjective: Some epidemiologic and laboratory studies have suggested a possible associations between exposure to extremely low frequency magnetic field (ELF-MF) and cancer. However, it is not known underlying mechanisms of this interaction. The aim of the study was to investigate the possible oxidative damage induced by longterm ELF-MF exposure on submandibular and parotid glands of rats.Methods: Rats in the experimental group were exposed to 100 and 500 µT ELF-MF (2 h/day, 7 days/week, for 10 months) corresponding to exposure levels that are considered safe for humans. The same experimental procedures were applied to the sham group, but the ELF generator was turned off. The levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in rat submandibular and parotid gland.Results: Although some oxidative and antioxidative parameters of submandibular gland were altered by ELF100 and ELF-500 exposure groups, these changes were not statistically significant (p >0.05). However, a decrease observed in CAT levels of parotid gland in both the ELF100 and ELF-500 exposure groups (p<0.05, p<0.01). No significant alterations was found in other endpoints related to parotid gland (p>0.05).Conclusion: Our results showed that long-term ELF-MF exposure did not alter oxidative, antioxidative processes and lipid peroxidation in submandibular gland of rats. However, 100 µT and 500 µT ELF-MF exposure decreased CAT activity in parotid gland.Öğe Role of 2.4 GHz radiofrequency radiation emitted from Wi-Fi on some miRNA and faty acids composition in brain(Taylor & Francis, 2022) Daşdağ, Süleyman; Akdağ, Mehmet Zülküf; Başhan, Mehmet; Kızmaz, Veysi; Erdal, Nurten; Erdal, Mehmet EminThe purpose of this study is to investigate the effects of 2.4 GHz Wi-Fi exposure, which is continuously used in the internet connection by mobile phones, computers and other wireless equipment, on microRNA and membrane and depot fatty acid composition of brain cells. Sixteen Wistar Albino rats were divided equally into two groups such as sham and exposure. The rats in the experimental group (n = 8) were exposed to 2.4 GHz RFR emitted from a Wi-Fi generator for 24 h/day for one year. The animals in the control group (n = 8) were kept under the same conditions as the experimental group, but the Wi-Fi generator was turned off. At the end of the study, rats were sacrificed and brains were removed to analyze miRNA expression and membrane and depot fatty acids of brain cells. We analyzed the situation of ten different miRNA expressions and nineteen fatty acid patterns in this study. We observed that long-term and excessive exposure of 2.4 GHz Wi-Fi radiation increased rno-miR-181a-5p, phosphatidylserine (PS) and triacylglycerol (TAG) in the brain. In conclusion, 2.4 GHz Wi-Fi exposure has the potential to alter rno-miR-181a-5p expression and the fatty acid percentage of some membrane lipids such as phospholipid (PL), phosphatidylserine (PS) and triacylglycerol (TAG), which are depot fats in the brain. However, the uncontrolled use of RFRs, whose use and diversity have reached incredible levels with each passing day and which are increasing in the future, may be paving the way for many diseases that we cannot connect with today.Öğe Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones(Taylor and Francis Ltd., 2019) Alkış, Mehmet Eşref; Akdağ, Memet Zülküf; Daşdağ, Süleyman; Yeǧin, Korkut; Akpolat, VeysiThe testes are a sensitive organ to electromagnetic pollution and people are concerned about the harmful effects of the radiofrequency radiation (RFR) emitted from cellular phones. Therefore, the purpose of this study was to investigate the effects of long-term exposure to different RFR frequencies on single-strand DNA breaks and oxidative changes in rat testicular tissue. Twenty-eight male Sprague–Dawley rats were divided randomly into four groups. Three groups were exposed to radiation emitted from 900, 1800 and 2100 MHz RF generators, 2 h/day for 6 months. The sham-control group was kept under the same experimental conditions but the RFR generator was turned off. Immediately after the last exposure, testes were removed and DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were analyzed. The results of this study indicated that RFR increased TOS, OSI, MDA and 8-OHdG (p < 0.05). TAS levels in the exposed group were lower than in the sham group (p < 0.05). In terms of DNA damage, the tail intensities in the comet assay were higher in the exposure groups (p < 0.05). This study demonstrated that long-term exposure to RFR emitted by cellular phones may cause oxidative stress and oxidative DNA damage in rat testicular tissue and may generate DNA single-strand breaks at high frequencies (1800 and 2100 MHz). Our results showed that some RFR emitted from cellular phones has potential to lead to cell damage in the testes.Öğe Tedavi amacıyla kullanılan mikrodalga enerjisinin kan (total protein,serum proteinleri ve T3-T4 hormonları) üzerine etkilerinin in vitro incelenmesi(2017) Daşdağ, Süleyman; Çelik, SalihAldığımız kan örneklerine 5,10, 20 ve 4-0 dakika orta doz (60 watt çıkış gücü) mikro dalga ve 20 dakika yüksek doz (180 watt çıkış gücü) mikrodalga uyguladık. Örnek kanların serumlarını santrifüjle ayırdık. Serumdaki 2L ve QL hormon düzeyini EIA metodu ile, total protein düzeyini spektrofo tometrik yöntem ile, serum proteinleri (AlbumintGrup spesi fik komponent, Ceruloplazmin, Post albumin, Transferrin, He mopexin, Post transferrin) ve Albumin/Globulin düzeylerini Poliakrilamid jel disk elektroforezi ile tespit ettik. 5,10,20 ve 40 dakika orta doz mikrodalga uygulamasın da T3-T4, hormonları, total proteinler, serum proteinleri ve Albumin/Globulin oranlarını kontrol grubu ile karşılaştır dık ve istatistiksel olarak anlamsız bulduk( P> 0,05,NS). 20 dakika yüksek doz mikrodalga uygulamasında ise, diğer parametreler istatistiksel olarak önemsiz( P> 0,05, KS ) bulunurken, total protein ve Albumin/Globulin oranını kontrol grubu ile karşılaştırdığımızda istatistiksel ola rak önemli bulduk( P < 0,05, S ).Öğe Whole body exposure of rats to microwaves emitted from cell phone does not affect the testes(Wiley, 2003) Daşdağ, Süleyman; Akdaǧ, Mehmet Zülküf; Akşen, Feyzan; Yılmaz, Fahri; Başhan, Mehmet; Daşdağ, M. Mutlu; Çelik, Mustafa Salih; 0000-0003-1211-9677; 0000-0001-7965-6229; 0000-0002-1228-9548The objective of this study was to investigate the effects of radiofrequency radiation emitted from cellular phones on the lipid composition, malondialdehyde concentration, p53 immune reactivity, sperm count, morphology, histological structure of testes, and on rectal temperature of rats exposed to microwave radiation emitted from cellular phones. Sixteen Spraque-Dawley rats were separated into two groups of eight, sham exposed (control) and experimental. The rats were confined in plexiglas cages specially designed for this study, and cellular phones were placed 0.5 cm under the cages. For the experimental group, cellular phones were activated 20 min per day (7 days a week) for 1 month. For the control group, the cellular phones were placed beneath the cages for 20 min a day, but the phones were turned off. Rectal temperatures were measured weekly. For 250 mW radiated power, the whole body average SAR (rms) is 0.52 W/kg and 1 g averaged peak SAR (rms) is 3.13 W/kg. The Mann-Whitney U-test was used for statistical comparisons of groups. No statistically significant alteration in any of the endpoints was noted. This study found no evidence suggesting an adverse effect of cell phone exposure on measures of testicular function or structure. (C) 2003 Wiley-Liss, Inc.
