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  • Küçük Resim
    Öğe
    Comparison of healthcare workers and non-healthcare workers in terms of obsessive-compulsive and depressive symptoms during COVID-19 pandemic: a longitudinal case-controlled study
    (Frontiers Media SA, 2023) Uyar, Betül; Dönmezdil, Süleyman
    Objective: The aim of this study was to investigate the obsessive-compulsive and depressive symptoms of healthcare workers in a case-control setting as longitudinal. Method: In this study included 49 healthcare workers and 47 non-health workers. A sociodemographic data form, the Maudsley Obsessive-Compulsive Inventory (MOCI), the Symptom Checklist-90 (SCL-90), and the Hamilton Depression Rating Scale (HAM-D) were used to assess individuals between June 1, 2020 and June 30, 2021. We assessed the same healthcare workers after 12 months on June 30, 2021 using MOCI, HAM-D, and SCL-90. Results: MOCI and SCL-90 obsessive-compulsive subscale scores were significantly higher in the healthcare workers than in the non-health workers. When we assessed MOCI, HAM-D, and SCL-90 obsessive-compulsive subscale scores after 12 months, there was a statistically significant decrease in the scores of all three scales among the healthcare workers. Conclusion: The results of the study showed that healthcare workers were more likely to have obsessive-compulsive symptoms than non-health workers in the early part of the pandemic on June 1, 2020, as shown by their scores on MOCI and the obsessive-compulsive subscale of SCL-90. When we assessed the same participants after 12 months (June 30, 2021), both MOCI and SCL-90 obsessive-compulsive subscale scores had decreased significantly. In contrast to these results, HAM-D scores significantly increased.
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    Öğe
    The Effects of Ethyl Pyruvate on Behavioral and BiochemicalParameters in Immobilization Stress-Induced Mice
    (2021) Akkoc, Hasan; Uyar, Emre; Abul, Mihrab; Dönmezdil, Süleyman
    Objective: Ethyl pyruvate (EP) is a molecule with antioxidant, anti-inflammatory, and anti-apoptotic features. The present study investigates EP's effects on behavioral and biochemical alterations induced by immobilization (IM) stress. Methods: In this outcome, 45 male BALB/c mice were separated into five groups [CONT (control), IM, IM+EP, EP, IM+F (fluoxetine)]. IM applied groups had 6 hours of immobilization stress procedure a day for a week. EP (50 mg/day) and fluoxetine (5 mg/day) were applied to the mice intraperitoneally. After the stress induction protocol, passive avoidance, open field (OF), and forced swimming tests (FST) were executed. After behavioral tests, brain tissues were obtained for biochemical investigations. Results: Immobilization application increased immobility times in the FST and decreased the total distance moved and the center time in the OF test. Immobile times were reduced with fluoxetine and EP applied groups compared with the IM group due to decreased learned helplessness. The IM group had decreased brain-derived neurotrophic factor (BDNF), superoxide dismutase, and glutathione peroxidase levels, which were increased with EP applications.Conclusion: These results show that EP generates antidepressant-like effects with decreasing oxidation and increasing BDNF levels.
  • Küçük Resim
    Öğe
    Ötimik iki uçlu bozukluk hastalarında oksidatif stresle kognitif fonksiyonlar arasındaki ilişki
    (2015) Dönmezdil, Süleyman
    İki uçlu bozukluk (İUB) manik, hipomanik, depresif ataklar ve bu ataklar arasındaki ötimik dönemlerle seyreden kronik bir hastalıktır. Hastalık ortaya çıktıktan sonra kognitif bozulma ortaya çıkmaktadır. Hastalığın hem atak hem de ötimik dönemlerinde oksidatif stresin yükseldiği çalışmalarla ortaya konulmuştur; ancak oksidatif stresle kognitif fonksiyonlar arasındaki ilişkiyi inceleyen herhangi bir çalışma bulunmamaktadır. Bu çalışmadaki amacımız İUB ötimik dönemde oksidatif stresle kognitif fonksiyonlar arasındaki ilişkiyi incelemektir. Dicle Üniversitesi Psikiyatri Anabilim Dalı duygudurum polikliniğine ayaktan başvuran 50 İUB hastası ile 50 sağlıklı gönüllü çalışmaya alındı. Serum Total Antioksidan Seviyesi (TAS), Total Oksidan Seviyesi (TOS) ölçümü ve Oksidatif Stres İndeksi (OSI) hesaplanması Dicle Üniversitesi Biyokimya laboratuvarlarında yapıldı. İUB ötimik dönem hastalarında TOS ve OSI düzeyleri kontrol grubundan anlamlı derecede daha düşüktü (p<0.01). Hasta ve kontrol gruplarına uygulanan Stroop testi, frontal değerlendirme bataryası (FDB), sayı dizisi öğrenme testi sonuçlarında hasta grubunun sonuçları kontrol grubuna göre anlamlı derecede düşüktü (p<0.05). Ölçülen oksidatif stres parametreleri ile uygulanan nöropsikiyatrik testler arasındaki ilişkiye baktığımızda hastalara uygulanan FDB ile TOS (r: -0.353 p:0.012 ) ve OSI (r:-0.346 p:0.014) arasında istatistiksel olarak anlamlı ilişki mevcuttu. Sonuç olarak kontrollerle karşılaştırıldığında hasta grubunda kognitif fonksiyon testlerinde bozulma mevcuttu ve bu bozulma azalmış oksidan düzeyleri ile ilişkiliydi. Daha kapsamlı ve fazla sayıda çalışma yapılması bozulmanın nedeninin anlaşılması için yol gösterici olacaktır. Anahtar Kelimeler: İki Uçlu Bozukluk, Kognitif Fonksiyonlar, Oksidatif Parametreler
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    Öğe
    Piriformis Syndrome and Sleep Quality Relationship between Sexual Life
    (Harran Üniversitesi, 2022) Yükselmiş, Özkan; Dönmezdil, Süleyman
    Background: In this study, it was aimed to emphasize the importance of Piriformis Syndrome which is often overlooked in the differential diagnosis of sciatica in clinical practice and also investigated how it affects sleep quality and sexual life in individuals.Materials and Methods: Fifty patients aged 25-55 completed the study. Fifty healthy individuals had similar demographic characteristics who applied on the same dates were taken as the control group. PMS diagnostic criteria, Pittsburgh Sleep Quality Index and Arizona Sexual Experience Scale were applied to the participants. Participants were examined after signing the informed consent form performed by medical specialists to confirm the presence of pain related to Piriformis Syndrome. Electromyographic and radiological examinations were used during the examination. Demographic characteristics of the participants such as age, gender, marital status, occupation, education level, height and weight were recorded.Results: PSQI score of sleep quality in patients with Piriformis Syndrome was significantly higher than the control group. It was observed that there was no significant difference between the groups regardless of gender, level of education and marital status.There was a weak correlation between sexual satisfaction and sleep quality.Conclusions: ep quality deteriorates in patients with Piriformis Syndrome. There is a weak relationship between sleep quality and sexual satisfaction.Keywords: Piriformis Syndrome, Sleep quality, Sexual life
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    Öğe
    Psikiyatri Hastaları ve Geleneksel Tedaviler
    (Mersin University, 2013) Oto, Remzi; Yüksel, M. Emin; Dönmezdil, Süleyman
    Bu çalışmada Diyarbakır çevresinde hem psikiyatrik hastalara iyi geldiğine inanılan hem de en çok ziyaret edilen yerlere, (türbe, ziyaret, makam) en çok ziyaret edilen gün olan Perşembe günleri gidilerek gözlemde bulunulmuş ve orada çare arayanlarla odak grup görüşmeleri yapılmıştır.Bu çalışmamızda psikiyatrik hastalıkları olan hasta ve yakınları ile yapılan görüşmeler tartışılmıştır