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Öğe Expression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentas(Universidad de la Frontera, 2018) Ekinci, Aysun; Aktaş, Ayfer; Dönder, Ahmet; Ekinci, Cenap; Turgut, Abdulkadir; Deveci, Şenay; Deveci, EnginSevere preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Severe preeclampsia and obstetric characteristics and biochemical and hematological characteristics of healthy subjects were compared. Placenta sections were stained with hematoxylin-eosin for histopathological examination. In the histopathological examination of severe preeclamptic placenta, degeneration in synaptic and cytotrophoblastic cells, increase in insidious knots, fibrinoid necrosis, degeneration in endothelial cells, calcification and hyaline villous stains were observed. In the severe preeclampsia group, Ki-67 expression increased in decidua cells and inflammatory cells, while endothelial cells in the vessel wall and inflammatory cells in the villus and intervillous spaces increased. It is thought that angiogenetic and cellular proliferation is induced in a co-ordinated manner and significantly influences fetal development.Öğe Ganoderma lucidum alleviates ischemia- reperfusion-induced renal injury in wistar rats(SCI Printers & Publication INC, 2021) Dönder, Ahmet; Aşır, FıratOBJECTIVE: To investigate effects of Ganoderma lucidum (G. lucidum) kidney sections of rats induced by ischemia-reperfusion (I/R) injury. STUDY DESIGN: A total of 40 rats were assigned to 4 groups: control (Sham), I/R, G. lucidum, and I/R+ G. lucidum groups. Prior to animal experiments, 20 mL/kg G. lucidum was administered to the G. lucidum-treated groups for 7 days. The control and 1/R groups received only saline solution. The kidney was exposed to hypoxia for 1 hour by clamping renal vessels and was then allowed to reoxygenate for 6 hours. Blood was taken to measure for serum MDA, MPO, and GSH. Kidney tissues were resected for histological paraffin tissue protocol. Hematoxylin-eosin and immunohistochemical staining were performed. RESULTS: MDA and MPO levels were highest in the I/R group but were close to the levels of the control group in the I/R+G. lucidum group. Unlike MDA and MPO values, GSH values were the lowest in the I/R group, but after G. lucidum treatment, GSH levels increased in the I/R+ G. lucidum group. In kidney sections of hematoxylin-eosin staining, the control group showed no pathology. In the I/R group, atrophic glomeruli, degenerated tubular cells, and mononuclear cell infiltration with dilated and congested vessels were observed. In the I/R+ G. lucidum group, I/R pathology was mostly recovered. In the G. lucidum group, ADAMTS-4 expression was moderately expressed in glomerular and tubular cells. The I/R group showed positive ADAMTS-4 expression in mostly inflammatory cells. In the I/R+ G. lucidun: group, ADAMTS-4 was positively expressed only in glomerular structures. In the G. lucidum group, caspase-3 expression was observed in glomerular and tubular cells. The I/R group showed strong caspase-3 activity in glomerular and tubular cells, in vascular cells, and inflammatory cells. The I/R +G. lucidum group showed weak caspase-3 expression. CONCLUSION: Ischemia-reperfusion injury caused histopathological and biochemical alterations in renal tissue; G. lucidum protected tissue structure and integrity by its antioxidant and anti-inflammatory properties.Öğe Investigation of serum vaspin, visfatin, chemerin and IL-18 levels in migraine patients(Assos Arquivos de Neuro-Psiquiatria, 2021) Dönder, Ahmet; Cafer, Vugar; Yılmaz, Ahmet; Aslanhan, Hamza; Arıkanoğlu, AdaletBackground: Migraines are headaches caused by changes in the trigeminovascular metabolic pathway. Migraine headache attacks are associated with neurovascular inflammation, but their pathophysiological mechanisms have not been fully explained. Objective: To investigate the relationship between serum vaspin, visfatin, chemerin and interleukin-18 (IL-18) levels and the frequency of attacks in migraine headache. Methods: Three groups were established: migraine with aura (n = 50), migraine without aura (n = 50) and control group (n = 50). The migraine diagnosis was made in accordance with the International Classification of Headache Disorders-III beta diagnostic criteria. The analyses on serum vaspin, visfatin, chemerin and IL-18 levels were performed using the enzyme-linked immunosorbent assay method. Results: The serum vaspin, visfatin, chemerin and IL-18 levels were found to be significantly higher in the migraine patients than in the control group (p 0.01). No statistically significant differences in serum vaspin, visfatin, chemerin and IL-18 levels were found among the migraine patients during attacks or in the interictal period (p 0.05). The serum visfatin and chemerin levels of the migraine patients were positively correlated with their serum IL-18 levels (p < 0.01), while their serum chemerin and visfatin levels were positively correlated with their serum vaspin levels (p < 0.05). Conclusions: This study showed that these biomarkers may be related to migraine pathogenesis. Nonetheless, we believe that more comprehensive studies are needed in order to further understand the role of vaspin, visfatin, chemerin and IL-18 levels in the pathophysiology of migraine headaches.Öğe Öğrencilerde iş sağlığı ve güvenliği dersinin etkinliğinin belirlenmesi(Van Yüzüncü Yıl Üniversitesi, 2023) Şen, Mehmet Ali; Kurt, Mehmet Emin; Dönder, AhmetÖz Çalışmamız sağlık bölümlerinde öğrenim görmekte olan öğrencilerin iş sağlığı ve güvenliği (İSG) konusunda yeterli bilgiye sahip olup olmadıklarını belirlemek amacıyla gerçekleştirildi. Çalışmamız bir devlet üniversitesindeki sağlık hizmetleri meslek yüksekokulunda öğrenim gören öğrencilere uygulandı. Araştırmamız tanımlayıcı ve kesitsel tipte olup evrenin bilindiği durumlarda örneklem belirleme formülünden yararlanılıp basit rastgele örnekleme yöntemi ile 150 öğrenciye ulaşılmıştır. Araştırmamıza katılan öğrencilerin % 68’i 18-20 yaş arasındaydı. Öğrencilerin %83,3’ü İSG konusunda bir toplantı, konferansa katılmamıştı. Katılımcıların İSG ile ilgili bilgiyi en yüksek oranda okuldan (%30) ve internetten (%20) edindiklerini belirttiler. Öğrenciler, hastanelerdeki İSG kurallarının ihlaliyle oluşacak en büyük riskin (%50,8) bulaşıcı hastalıkların yayılımı olduğunu ve daha sonra (%15,1) yetersiz personel sayısı olduğunu bildirdiler. İSG derslerinin sağlık okullarının müfredatına dâhil olmasını isteyenler %87, okudukları programda ders içeriği olarak bu dersi almak isteyenler ise %82,7’idi. İSG kurallarını bilmenin iş bilincini artıracağını düşünenler %82 oranında en yüksekti. Öğrencilerin %48 meslekleri ile ilgili güncel iş kazalarını biliyordu. Öğrencilerin %89,4’ü ilk yardım derslerini can güvenliğinin sağlanması için faydalı buluyordu. Katılımcıların %68’i İSG kurallarının güvenli çalışma için gerekli olduğunu, % 79,3’ü üretimin İSG’ den daha önemli olmadığını ve %54’ü iş yerinde riskli davranış sergilememenin önemine katılıyordu. İSG konusunda çıkabilecek sorunları daha çok yöneticilerin sorunu olduğunu bildirenler % 69 oranındaydı. Yangın, elektrik ve doğal afet gibi durumlarda öğrencilerin sadece %38’i ne yapacağını biliyordu. İSG’ nin sadece çalışma ortamında değil tüm yaşamda etkili olduğunu düşünenler %90 ve güvenlik kurallarının bazen bile göz ardı edilmemesini düşünenlerin oranı %80,7’idi. Araştırmaya katılan öğrencilerin anket sonuçlarına bakılarak iş sağlığı ve güvenliğinin önemi konusunda farkındalığı yüksek olduğu söylenebilir. Farkındalığın yanı sıra öğrencilerin bilgi ve deneyimlerini artıracak çalışmalara ihtiyaç bulunmaktadır. Anahtar Kelimeler: Sağlık bölümleri, eğitim, iş sağlığı ve güvenliğiÖğe Protective effects of melatonin on spinal cord injury(Universidad de la Frontera, 2018) Baran, Özlem; Çiçekçi, Esra; Dönder, Ahmet; Atiç, Ramazan; Deveci, Engin; Tuncer, Cudi MehmetSpinal cord injury causes neuron nerve fiber loss. The aim of this study was to investigate the neuroprotective, inflammatory and angiogenetic effects of melatonin on rat spinal cord injury (SCI). For spinal cord injury, a standard weight reduction method was used that caused moderate severity of injury (100 g/cm force) T10at Melatonin (10 mg/kg intraperitoneally) was administered for 10 days after trauma. Each group consisted of 10 animals. of these, six were used for biochemical and four were used for th e evaluation of histological analysis. Spinal cord samples were taken for histological examination or determination of malondiald ehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity. Spinal cord injury and melatonin treated group were compared. Melatonin administration in spinal cord injury increased the activity of glial cells in the radial and funicular cells and epen dymal cells and increased the activity of glial cells and also showed a positive ef fect on inflammation and vascular endothelial cells in s ynaptic connections in the nerve fibers undergoing spinal injury endothelial degeneration It is thought that it can regulate the degenerative effect which is caused by both the inflammatory effect and the angiogenic effect which will have a positive effect on the neural connection.
