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Öğe Castleman's disease (giant lymph node hyperplasia) of the neck(Springer, 2001) Osma, Ü; Cureoglu, S; Yaldiz, M; Topcu, ICastleman's disease (giant lymph node hyperplasia) is an uncommon cause of neck mass. Its cause and pathogenesis ale still unknown. Giant lymph node hyperplasia (GLH) usually presents as all asymptomatic solitary mass and can occur anywhere in the head and neck. Diagnostic test results are always inconclusive. Excision and histopathological evaluation are the only ways to make a definitive diagnosis. The disease is curable by surgical excision. A case of GLH presenting as a solitary neck mass in a 68-year-old man is reported. There has been no recurrence during about 7 months.Öğe The complications of chronic otitis media: report of 93 cases(Headley Brothers Ltd, 2000) Osma, U; Cureoglu, S; Hosoglu, SThe aim of this study was to investigate the incidence, mortality and morbidity of complications due to chronic otitis media (COM). During the nine-year period 1990-1999, 2890 cases of COM were reviewed, 93 (3.22 per cent) having 57 (1.97 per cent) intracranial complications (IC) and 39 (1.35 per cent) extracranial complications (EC). In three patients more than one complication was observed. Meningitis and brain abscess were common in the IC group. Subperiosteal abscess (mastoid and Bezold's abscess) was a common complication in the EC group. Cholesteatoma and granulation/polyp in the middle ear/mastoid were the major findings in both groups. Fifteen patients died from IC. Overall, the mortality rate was 16.1 per cent in all patients having complications, and in patients with IC it was 26.3 per cent. In all of the patients with complications, the morbidity rate was 11.8 per cent. Our study supports the finding that meningitis and brain abscess are the common complications of COM and the main reason for mortality.Öğe The effects of extremely. low. frequency magnetic field on inner ear, parotis and submandibular gland(Taylor & Francis Ltd, 2002) Aksen, F; Akdag, MZ; Meric, F; Cureoglu, S; Yilmaz, F; Kaya, AExperiments using sixteen male Spraque-Dawley rats were carried out to determine possible effects of Extremely Low Frequency Magnetic Field (ELF MF) on inner ear, parotis and submandibular glands. The rats were seperated into two. groups of 8, one control and one experimental group, The rats in the experimental groups were exposed to ELF MF (1.35 mT) 2 hour/a day during two months. Eight rats of sham group were treated like experimental group except ELF MF exposure. The rats were sacrificed under ketalar anesthesia immediately after last exposure. Then parotis, submandibular gland and total ear of rats were removed for. histopathological examination. The histopathological results obtained indicate that ELF magnetic field didn't affect parotis, submandibular glands and inner ear.Öğe Examination of the distribution of mast cells in the nasal mucosa of patients with seasonal allergic rhinitis(Saudi Med J, 2004) Kilinc, N; Cureoglu, S; Oktay, FObjective: It is known that mast cells play an important role in pathogenesis of allergic rhinitis. In this study, we investigated the distribution of mast cells in the nasal mucosa of patients with seasonal allergic rhinitis during the pollen-season. Methods: This study was carried out at the Faculty of Medicine, Dicle University, Turkey, during the grass-pollen season between, March and July in 2002. Twenty patients with seasonal allergic rhinitis (12 females and 8 males) and 20 healthy (10 females and 10 males) non-allergic controls were examined for the distribution and abundance of mast cells in nasal biopsies. Biopsies were performed in all patients and controls, once during natural provocation in the spring and were taken from the lower edge of the inferior turbinate using a forceps. The samples of nasal mucosa were fixed in 10% neutral buffered formaline, stained with 0.5% aqueous toluidine blue and hematoxylin and eosin were examined under a light microscope. Results: Mast cells were observed in the nasal mucosa obtained from 12 patients (60%) and 5 patients (25%) controls cases (p=0.025). It was found out that intrapitelial mast cells are present in nasal mucosa samples of patients with SAR (seasonal allergic rhinitis) but not in the epithelium of non-allergic controls. Conclusion: The number of submucosal mast cells has considerably increased in the nasal mucosa samples of patients with SAR. Besides this, these cells are determined in great amounts in non-allergic individuals.Öğe Follow-up results in tuberculous cervical lymphadenitis(Cambridge Univ Press, 2006) Oktay, MF; Topcu, I; Senyigit, A; Bilici, A; Arslan, A; Cureoglu, S; Yildirim, MObjective: To investigate the efficacy of medical antituberculous treatment in patients with tuberculous cervical lymphadenitis (TCL). Methods: In the period 1996-2002, 73 TCL patients were reviewed and the results of clinical and laboratory testing were documented. The efficacy of a four-drug chemotherapy regimen was investigated. Results: Purified protein derivatives (PPD) skin test results were positive in 58 (79 per cent) patients. Chest X-rays revealed changes consistent with tuberculosis in nine (12.3 per cent) patients. The mean duration of medical treatment was 10.04 months. In follow-up evaluation, 14 (20 per cent) patients were considered suspicious for resistant TCL and total excision of all nodes was performed. Histopathology confirmed TB in only 10 of these cases. Conclusion: The high incidence of residual disease in our study indicates that medical treatment (at least nine months of four combined antituberculous drugs) did not seem to be effective. If lymphadenopathy persists, total surgical excision of lymph nodes should be the treatment of choice.Öğe Occupational safety: Effects of workplace radiofrequencies on hearing function(Elsevier Science Inc, 2004) Oktay, MF; Dasdag, S; Akdere, M; Cureoglu, S; Cebe, M; Yazicioglu, M; Topcu, IBackground. The effects of radio frequency (RF) and microwave radiation on humans have been the subject of continuous investigation. Clinical investigations related to occupational RF/microwave exposure have been reported by investigators (1). Since one of the major groups occupationally exposed to RF and microwave radiation includes those working, in radio broadcasting and TV transmitter stations. this study investigates whether RF affects auditory systems of people exposed to RF. Methods. The study is carried out with people working in radio broadcasting stations and living in employee residential houses close to the broadcasting stations. All subjects in the control group were similar in age, work regime, socioeconomic status, and lack of experience in working with RF sources. Brainstem Evoked Response Audiometer (BERA) and Pure Tone Audiometry (PTA) were used to measure the effects of RF under investigation on hearing functions of the subjects. In BERA measurements, I-III, III-IV and I-V interpeak latencies were evaluated. In pure tone audiometric measurements, 250 Hz, 500 Hz, 1000 Hz, 2000 Hz, 4000 Hz and 8000 Hz frequencies of hearing threshold were measured in subjects of experimental and control groups. Interpeak latencies and bone conduction hearing thresholds of subjects in the experimental group were compared with those of the control group. Results. BERA results showed that I-III, I-V and III-V interpeak latencies of people occupationally exposed to RF were not higher than subjects in control groups (p >0.05). Results of BERA indicated no statistically significant differences between exposure and control subjects. In audiometric evaluation, hearing threshold of people occupationally exposed to R-F were found higher than the control group subjects for frequencies of 4000 Hz and 8000 Hz in terms of bone and air conduction of right and left car (p <0.01). Conclusions. The results of traditional audiometer indicated that RF promotes sensorineural hearing loss and affects cochlea parts related to 4000 Hz and 8000 Hz. These findings may have immediate implications and considerations for work-place safety in order to provide an occupationally safe environment to employees working in such settings. (C) 2004 IMSS. Published by Elsevier Inc.Öğe Prognostic value of PCNA and mutant p53 expression in laryngeal squamous cell carcinoma(Taylor & Francis Inc, 2004) Buyukbayram, H; Cureoglu, S; Arslan, A; Isikakdogan, ARThe objective of this study was to investigate the prognostic significance of p53, and proliferative cell nuclear antigen (PCNA) in laryngeal squamous cell carcinoma (LSCC). Sixty pathologic specimens from the patients with LSCC were examined for the expression of the p53 and PCNA, with complete follow-up data. Sixty-three percent of the cases displayed nuclear p53 overexpression. There was a correlation between p53 overexpression and histological grades (p=0.03), and localization site (p=0.05). Median of PCNA index was 42.2 (range 5.9 to 85.2). There was no difference between the p53 overexpression group and the normal group in proliferative activity determined by PCNA (p=0.73). In univariate analyses, localization site, grade, stage, invasion pattern, lymph node status, were significant factors in estimating disease free survival (DFS). Grade was the most important factor affecting recurrence (p=0.002). In multivariate analyses, grade was the only significant predictor for DFS (p=0.001). Grade (p=0.001) and invasion pattern (p=0.03) were found to be significant predictors of overall survival. In conclusion, the histological grade was the most reliable important prognostic factor. Further studies are necessary to facilitate understanding of the mechanisms of laryngeal carcinogenesis.
