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Öğe The effect of diazepam and fentanyl premedication to intraocular pressure during general anesthesia induction(1994) Karakas N.; Mordeniz C.; Saltik A.; Unlu K.; Coskunseven E.; Ozyurek L.; Atasever J.Some agent used for general anesthesia induction can cause unwanted increase in intraocular pressure (IOP). But this increase can be controlled by using some other premedication agents. For this purpose, 90 patients have randomly been allocated into 3 subgroups and diazepam, fentanyl and a placebo (% 0.9 NaCl) were administered to each subgroup and IOP values were compared within and among groups at pre-medical on, pre-induction and post-intubation phases. In diazepam subgroup; the average IOP was raised from 16.0 mm Hg to 22.6 (40 %) between pre and post induction phases. This increase was 50 % in placebo subgroup from 16.6 to 24.5 mm Hg while only 4.3 mm Hg average increase (from 16.7 up to 21.0 and only 20 %) assessed in fentanyl group. The average IOP elevations in diazepam and placebo subgroups carry the patients to the upper normal/critical values but not in fentanyl subgroup. With these findings, fentanyl as a narcotic having dose-dependent IOP decreasing effect have been qualified significantly high performing premedication agent in suxamethonium induction when compared to diazepam and placebo.
