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    Comparison of lamivudine and alpha-interferon combination with alpha-interferon alone in the treatment of HBeAg-positive chronic hepatitis B
    (2006) Ayaz C.; Celen M.K.; Colak H.; Hosoglu S.; Geyik M.F.
    Aim: To compare the efficacy of a combination of a-interferon (IFN-a) and lamivudine with IFN-a alone in the treatment of patients with HBeAg-positive chronic hepatitis B (CHB). Methods: Sixty-eight treatment-naove patients with HBeAg-positive CHB were randomized to receive either 9 MU of IFN-a2a three times a week and lamivudine 100 mg daily (Group 1), or IFN-a2a alone in the same dosage (Group 2), for 12 months. Serum ALT, HBeAg, anti-HBe and HBV DNA were tested at the end of treatment and 6 months later. Complete response was defined as normal ALT, negative HBeAg and negative HBV DNA, six months after stopping treatment. Results: Of the 68 patients, 64 completed the study. In Group 1 (n=31), mean (SD) ALT levels decreased from 124 (59) IU/L to 39 (18) IU/L at 12 months; corresponding values in Group 2 (n=33) were 128 (57) and 56 (11) IU/L (p<0.05). Absence of HBV DNA at the end of treatment was more common in Group 1 (28/31) than in Group 2 (22/33; p<0.022). The number of patients with seroconversion to anti-HBe (4/31 [13%] vs. 4/33 [12%], respectively; p>0.05), as also those with complete response (4/31 [13%] and 4/33 [12%], respectively; p>0.05) six months after completion of treatment was similar in Group 1 and Group 2 . Conclusion: Combination treatment with IFN-a and lamivudine was better than IFN-a monotherapy in normalization of ALT and clearance of HBV DNA; however, it did not have a better sustained response rate than IFN-a alone. © 2004 Indian Journal of Gastroenterology.
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    The evaluation of reasons for replacement of amalgam and composite
    (2013) Bahsi E.; Ince B.; Dalli M.; Sahbaz C.; Colak H.; Acikan I.; Aslan N.
    Amalgam and composite restorations take prime place in restorative dental practices. Over time, restorations are replaced for various reasons. This study aimed to evaluate the reasons for restoration replacement of patients presenting at Dicle University, Dental Faculty, Restorative Dentistry Clinic. The study comprised 705 patients (402 female, 303 male) who presented at the dental clinic for routine dental treatment. Without taking gender into consideration, patients aged 15-80 who were determined to have amalgam and composite filling problems were included in the study. The patients were allocated to 5 groups according to age: Group 1, 16-25 years, Group 2, 26-35 years, Group 3, 36-45 years, Group 4, 46-55 years, Group 5, 56 years and over. The failure of the fillings was diagnosed from clinical and radiological evaluation results. The age, gender and reason for the replacement of the restoration were recorded for all patients. The obtained data was evaluated with Student's t test and a difference was determined between the age groups. Of 705 restorations, 378 (53.62%) were amalgam and 327 were composite (46.38%). When the reasons for replacement of restorations were examined the primary reason was secondary caries (30.78%), followed by fracture of the restoration (17.6%) and overflowing filling (15.46%). A significant difference was found between the age groups in terms of the parameter of reason for restoration replacement (p<0.05). To determine between which age groups this difference was more significant, the Tukey HSD test was applied as a multiple comparison test. The most significant reason for replacement of amalgams and composites was found to be secondary caries. The factor of gender had no effect on the reasons for replacement of the restoration. Failure of the restoration was seen to be greater in the 16-25 age group.