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    Asymptomatic and isolated accessory mitral valve tissue in adult population: three case reports and review of the literature.
    (2012) Cil H.; Atilgan Z.A.; Islamoglu Y.; Yavuz C.; Tekbas E.O.
    Accessory mitral valve tissue is a rare congenital cardiac anomaly and commonly it may cause left ventricular outflow tract obstruction (LVOTO). This anomaly occurs as a part of other congenital cardiac anomalies. However, it may be seen isolated. Structures in LVOT such as tumor, vegetation, cysts may have attention for differential diagnosis. The number of cases is increasing with the routinely using of two-dimensional echocardiography. Accessory mitral valve tissue is detected first early in children with symptoms of LVOT and is very rarely diagnosed in adults. One third of cases may asymptomatic, but commonly significant left ventricular outflow tract gradient can be detected in these cases, especially adult period. Optimal treatment of this anomaly is surgery if there is a significant LVOTO. In this report, we presented the three asymptomatic adult cases with accessory mitral valve tissue, without increased gradient in LVOT. Surgical excision was recommended to the first case in another hospital with diagnosis of cardiac cyst. Two cases are presented.
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    Predictors of subclinical atherosclerosis in premenopausal women
    (Acta Medica Mediterranea, 2014) Alemdar R.; Cil H.; Besir F.H.; Ozhan H.; Aydin Y.; Bulur S.; Yazgan O.
    Aims: We aimed to investigate the predictors of Carotid intima media thickness (CIMT) in premenopausal women. Background: CIMT was shown to be a strong coronary artery disease predictor in both pre- and postmenopausal women. Materials and methods: The study was conducted on 2298 participants. The final cohort included 783 pre-menopausal women (with a mean age of 39 ± 11). Carotid intima media thickness was measured in all of the participants. Results: Mean CIMT of premenopausal women was 0.51 ± 0.14 mm. Age- adjusted correlates of CIMT was SBP (r = 0.138; p=<0.001), DBP (r=0.095; p=0.012) and LDL/HDL (r =0.077; p=0.041) ratio. Linear regression analysis was done in order to find independent covariates of carotid intima media thickness in two different models. Only age and systolic blood pressure were independently associated with CIMT. Logistic regression analysis revealed that only age was an independent predictor of subclinical atherosclerosis . Hypertension had the highest Odds ratio with borderline significance. Conclusion: The age and systolic blood pressure were independently associated with CIMT in premenopausal healthy Turkish women. Hypertension might be the best target for a modifiable risk factor for CIMT and future cardiovascular risk in this population.
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    The relationship between coenzyme Q10 and severity of coronary artery disease
    (2013) Büyükkaya E.; Evliyaoğlu O.; Islamoğlu Y.; Cil H.; Karakaş M.F.; Akçay A.B.; Bilen P.
    Aim To evaluate the relationship between the levels of plasma coenzyme Q10 (CoQ10), a known antioxidant, and severity of the coronary atherosclerosis (AS) measured by Gensini score. Methods Patients with coronary artery disease (CAD) were enrolled to the study between 2010 and 2011 in cardiology outpatient clinics. They were admitted for diagnostic coronary angiography or angioplasty for typical indications. The Gensini scoring system was used to calculate CAD severity. Serum CoQ10, total cholesterol (TC), HDL cholesterol, LDL cholesterol, and triglyceride levels were assessed. Results One hundred thirteen subjects (83 CAD, 30 controls) were included. The patients with CAD were separated into three groups according to Gensini score. The serum levels of CoQ10, CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates in the subjects of mild and severe AS groups were significantly lower than the control group (p<0.016 for all control vs. AS group comparisons). There were no significant differences in serum levels of CoQ10 and CoQ10/ TC, CoQ10/LDL-C, CoQ10/TG rates between the mild and severe AS groups. Conclusion This study revealed that although the serum CoQ10 levels were lower in stable CAD, there was no relationship between the severity of CAD and serum CoQ10 levels in patients with stable angina pectoris.