Yazar "Ceylan, Ramazan" seçeneğine göre listele
Listeleniyor 1 - 6 / 6
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of the Relationship Between Humic Acid Contents and Trace Elements of Some Agricultural Soils in Diyarbakır Region by Multivariate Statistical Methods(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2024) Duzgun, Mehmet; Eren, Abdullah; Bilge, Ugur; Ceylan, Ramazan; Selcuk, Ramazan; Duz, M. ZahirThere are important relationships between humic acid (HA) and the bioavailability, reactions and mobility of trace elements in the soil. For this reason, soils are tried to be improved chemically, biologically and physically with HA applications. In this study, the relationship of humic acid contents of 118 agricultural soil samples from Diyarbakir region with some trace elements (Al, As, Ba, Be, Cd, Fe, Mn, Pb, Sb, Sn, Se, V and P) was evaluated by multivariate statistical analysis. After the soil samples were solubilized by the microwave wet digestion method, the element contents were determined with the ICP OES (Inductively Coupled Plasma Optical Emission Spectrometer) device. SRM NIST 2586 was used as SRM (Standard Reference Material) for the accuracy of the method. Recovery values were found between 91.6% and 105.9% as a result of the analysis. Humic acid was extracted from soils by the International Society for Humic Substances (IHSS) method and determined using a shaker and centrifuge device. For the accuracy of the method, it was tested with Humic Acid Sodium Salt (HA-Na). Pearson correlation and partial correlation analysis were applied to the obtained data set. In addition, multivariate statistical analyses such as multiple regression HCA (Hierarchical Cluster Analysis) and PCA (Principal Component Analysis) were applied. Multiple regression analysis was performed according to the Step-wise method. Manganese and P (p< 0.01) were significant when HA was taken as the dependent variable. According to the Pearson correlation coefficient, the correlation between HA and As (r = -0.282**) in soil was negative and significant, while Fe (r = 0.185*), Mn (r = 0.273**)), Sn (r = 0.242*), Se (r = 0.325**) and P (r = 0.315**) were determined as positive and significant. In clustering and PCA analysis, HA, P Mn and Fe were found to be in the same group. The analyses have shown that HA has a positive effect on the plant nutrients in the soil.Öğe Chemical and biological fingerprints of two Fabaceae species (Cytisopsis dorycniifolia and Ebenus hirsuta): Are they novel sources of natural agents for pharmaceutical and food formulations?(Elsevier Science Bv, 2016) Ceylan, Ramazan; Katanic, Jelena; Zengin, Gokhan; Matic, Sanja; Aktumsek, Abdurrahman; Boroja, Tatjana; Stanic, SnezanaIn the present study, the methanolic extracts of Cytisopsis dorycniifolia and Ebenus hirsuta were analyzed for antioxidant, enzyme inhibitory, antimicrobial and antigenotoxic activities. The identification and quantification of phenolic compounds in these extracts were performed using liquid chromatography coupled with mass spectrometry (LC-MS/MS) technique, and the main components were hyperoside, rutin, hesperidin, tannic acid and p-coumaric acid. The extracts had remarkable biological effects. Generally, C. dorycniifolia had higher level of bioactive components and exhibited stronger in vitro antioxidant effects than E. hirsuta. E. hirsuta was active especially against bacteria Pseudomonas fluorescens and Agrobacterium tumefaciens and fungi Puncturella fastigiata, while C dorycniifolia was active against bacteria E. faecalis and had moderate activity against Trichoderma species. The extracts displayed strong antigenotoxic effects (98.6% for E. hirsuta and 76.3% for C dorycniifolia). Our findings suggested that C dorycniifolia and E. hirsuta could be beneficial for the preparation of high-value pharmaceuticals and functional food ingredients. (C) 2016 Elsevier B.V. All rights reserved.Öğe Combining in vitro, in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea(Pergamon-Elsevier Science Ltd, 2017) Zengin, Gokhan; Ceylan, Ramazan; Katanic, Jelena; Mollica, Adriano; Aktumsek, Abdurrahman; Boroja, Tatjana; Matic, SanjaMethanolic extracts of Moltkia aurea Boiss. (MA) and Moltkia coerulea (Wild.) Lehm. (MC) were investigated for their antioxidant capacity and enzymatic inhibitory potential against acetylcholinesterase, butyrylcholinesterase, alpha-amylase, alpha-glucosidase, and tyrosinase in vitro. MA and MC were also explored for their antimicrobial effect, as well as for their possible genotoxic/antigenotoxic potential on Drosophila melanogaster in vivo. The total bioactive components (phenolic (TPC) and flavonoid contents (TFC)) were determined and liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolite profiling of MA and MC appraised. The plausible docking poses of bioactive compounds to key enzymes were further studied using molecular modelling approach. MA proved to be a better antioxidant with higher TPC and TFC compared to MC. Protocatechuic acid, rutin, hesperidin and malic acid were the most abundant in these extracts. Both MA and MC exhibited antigenotoxic potential with a %R in DNA damage of 60.90 and 53.14% respectively. The docking studies revealed that rutin, hesperidin, and rosmarinic acid have the best scores for all the enzymes tested. MA and MC were found to be rich in phytochemicals with potent antioxidant, antimicrobial, and antigenotoxic activities that can be further studied for the management of neurodegenerative complications, diabetes, and hyperpigmentation. (C) 2017 Elsevier Ltd. All rights reserved.Öğe Enzyme inhibition and antioxidant functionality of eleven Inula species based on chemical components and chemometric insights(Pergamon-Elsevier Science LTD, 2021) Ceylan, Ramazan; Zengin, Gökhan; Mahomoodally, Mohamad Fawzi; Sinan, Kouadio Ibrahime; Ak, Güneş; Jugreet, Sharmeen; Çakır, Oğuz; Ouelbani, Rayene; Paksoy, Mehmet Yavuz; Yılmaz, Mustafa AbdullahThe members of the genus Inula have been widely used in traditional medicinal. In the present study, 11 Inula species were investigated for their phytochemical composition, antioxidant and enzyme inhibitory effects. While quinic acid was the principal compound in I. anatolica, I. britannica, I. inuloides, I. oculus-christi, I. peacockiana, I. sechmenii, I. thapsoides and I. viscidula extracts (22.43?42.02 mg/g dry extract (DE)), I. aucheriana and I. discoidea extracts contained rutin as their most abundant compound (23.28 and 79.10 mg/g extract, respectively). Interestingly, all the Inula extracts were active inhibitors of the five key clinical enzymes (acetylcholinesterase (3.56?5.13 mg galantamine equivalent (GALAE)/g), butyrylcholinesterase (1.49?7.34 mg GALAE/g), tyrosinase (112.31?122.13 mg kojic acid equivalent (KAE)/g), ?-glucosidase (0.77?2.08 mmol acarbose equivalent (ACAE)/ g) and ?-amylase (0.73?0.90 mmol ACAE/g)). Furthermore, the extracts were observed to exhibit substantial antioxidant capacity (1,1-diphenyl-2-picrylhydrazyl (DPPH): 58.99?188.22 mg trolox equivalent (TE)/g); 2,2-azino-bis(3-ethylbenzo-thiazoline-6-sulfonic acid) (ABTS): 90.51?220.97 mg TE/g; cupric reducing antioxidant capacity (CUPRAC): 169.88?460.53 mg TE/g; ferric reducing antioxidant power (FRAP): 81.57?237.99 mg TE/g; metal chelating activity: 8.31?25.39 mg ethylenediamine tetraacetate equivalent (EDTAE)/g; phosphomo-lybdenum: 1.55?2.49 mmol TE/g). In conclusion, the Inula species studied herein showed promising pharma-cological potentials justified by the presence of a panoply of bioactive compounds.Öğe Essential Oil Composition of an Uninvestigated Centaurea Species from Turkey: Centaurea patula DC.(Taylor & Francis Ltd, 2016) Zengin, Gokhan; Aktumsek, Abdurrahman; Boga, Mehmet; Ceylan, Ramazan; Uysal, SengulCentaurea patula is widely distributed in the Central Anatolia Region of Turkey. The essential oil of C. patula was obtained by hydrodistillation and analyzed by GC-FID and GC-MS techniques. Twenty-one components were identified representing 86.4% of the oil. Spathulenol (14.6%), n-hexadecanoic acid (13.4%), 1-pentadecene (13.1%) and phytol (12.4%) were found to be the major components in this oil. This work is the first report on the chemical composition of the essential oil of C. patula. The results could be valuable for the Centaurea genus in terms of essential oil information's.Öğe Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties(Elsevier Science Bv, 2018) Zengin, Gokhan; Mahomoodally, M. Fawzi; Aktumsek, Abdurrahman; Ceylan, Ramazan; Uysal, Sengul; Mocan, Andrei; Yilmaz, Mustafa AbdullahSix wild species (S. alba, S. conoidea, S. dichotoma, S. italica, S. supina, and S. vulgaris) from the Silene genera were tested for potential anti-enzymatic (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE), tyrosinase, alpha-amylase, and alpha-glucosidase), antimicrobial (16 microbial strains), and antioxidant activity. An ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry method was used for phytochemical determination. Quinic acid, malic acid, protocatechuic acid, p-coumaric acid, and hesperidin were common in the six Silene species. All extracts showed higher antibacterial effects compared to streptomycin and ampicillin (except S. dichotoma). Antifungal agents, bifonazole (MIC 0.10-0.20 mg/mL and MFC 0.20-0.30 mg/mL) and ketoconazole (MIC 0.15-2.30 mg/mL and MFC 0.20-3.50 mg/mL) showed lower activity than the investigated Silene species extracts. S. alba inhibited AChE (2.00 mg GALAE/g extract) and BChE (1.0 mg GALAE/g extract). The results showed metal chelating potential ranging from 12 to 19 mg EDTAE/g extract, with S. conoidea being the most active, and S. supina the least. S. dichotoma showed the highest reducing potential against both cupric (154 mg TE/g extract for CUPRAC) and ferric (102 mg TE/g extract for FRAP) ions. Overall, Silene species could be considered as emerging interesting functional foods and sources of nutraceuticals with applications in the management of different diseases.
