Yazar "Cevher, Erdal" seçeneğine göre listele

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    Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine
    (Elsevier Sci Ltd, 2016) Gok, Mehmet Koray; Ozgumus, Saadet; Demir, Kamber; Cirit, Umut; Pabuccuoglu, Serhat; Cevher, Erdal; Ozsoy, Yildiz
    The aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly( acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)(gc) indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine. (C) 2015 Elsevier Ltd. All rights reserved.
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    Öğe
    The effects of the thiolation with thioglycolic acid and L-cysteine on the mucoadhesion properties of the starch-graft-poly(acrylic acid)
    (Elsevier Sci Ltd, 2017) Gok, M. Koray; Demir, Kamber; Cevher, Erdal; Ozsoy, Yildiz; Cirit, Umut; Bacinoglu, Suleyman; Ozgumus, Saadet
    The aim of this study is to investigate the effects of the thiolation on the mucoadhesion characteristics of the gelatinized and crosslinked wheat starch-graft-poly(acrylic acid) [(WS-g-PAA)(gc)] for potential use in drug delivery via vaginal route. Thiolation of (WS-g-PAA)(gc) was first time realized using L-cysteine hydrochloride monohydrate (CyS) and thioglycolic acid (TGA). These conjugates [(WS-g-PAA)(gcth)] were characterized using FTIR. The free SH group, mucoadhesion, cytotoxicity characteristics and the mechanism of the thiolation were also evaluated. To obtain fundamental data for possible application such as drug carrier, in vitro and in vivo progesterone release profiles from the mucoadhesive tablet formulations were also determined. The results showed that, vaginal tablet containing (WS-g-PAA)(gc)-TGA, which has not contain free SH groups in its structure, displays higher mucoadhesion than (WS-g-PAA)(gc) and (WS-g-PAA)(gc)-CyS. This tablet formulation can also be used as a drug carrier in vaginal applications. (C) 2017 Elsevier Ltd. All rights reserved.