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Öğe Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study(Assoc Bras Divulg Cientifica, 2011) Erdemoglu, M.; Kuyumcuoglu, U.; Guzel, A. I.; Celik, Y.; Kale, E.In a prospective case-control study, we compared the amniotic fluid amino acid levels in non-immune hydrops fetalis (NIHF) and normal fetuses. Eighty fetuses underwent amniocentesis for different reasons at the prenatal diagnosis unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University. Forty of these fetuses were diagnosed with NIHF. The study included 40 women each in the NIHF (mean age: 27.69 +/- 4.56 years) and control (27.52 +/- 5.49 years) groups, who had abnormal double-or triple-screening test values with normal fetuses with gestational ages of 23.26 +/- 1.98 and 23.68 +/- 1.49 weeks at the time of sample collection, respectively. Amniotic fluid amino acid concentrations (intra-assay variation: 2.26-7.85%; interassay variation: 3.45-8.22%) were measured using EZ: faast kits (EZ: faast GC/FID free (physiological) amino acid kit; Phenomenex, USA) by gas chromatography. The standard for quantitation was a mixture of free amino acids from Phenomenex. The levels of 21 amino acids were measured. The mean phosphoserine and serine levels were significantly lower in the NIHF group, while the taurine, a-aminoadipic acid (aaa), glycine, cysteine, NH(4), and arginine (Arg) levels were significantly higher compared to control. Significant risk variables for the NIHF group and odds coefficients were obtained using a binary logistic regression method. The respective odds ratios and 95% confidence intervals for the risk variables phosphoserine, taurine, aaa, Arg, and NH(4) were 3.31 (1.84-5.97), 2.45 (1.56-3.86), 1.78 (1.18-2.68), 2.18 (1.56-3.04), and 2.41 (1.66-3.49), respectively. The significant difference between NIHF and control fetuses suggests that the amniotic fluid levels of some amino acids may be useful for the diagnosis of NIHF.Öğe The association of preoperative thrombocytosis with prognostic factors in malign ovarian tumor(I R O G Canada, Inc, 2010) Kuyumcuoglu, U.; Guzel, A. I.; Celik, Y.; Erdemoglu, M.Purpose We assessed the association of preoperative thrombocytosis with prognostic factors in malign ovarian tumor Methods Over a five-year period, cases treated for ovarian cancer were randomly assigned The data were collected from gynecological oncology. radiation oncology, medical oncology and pathology departments Statistical analyses were carried out by using the statistical packages for SPSS 12 0 for Windows (Chicago, IL. USA) Survival was analyzed by the method of Kaplan and Meier. using log-rank (Mantel-Cox) analysis Results 51 cases with ovarian cancer were evaluated Cases with thrombocytosis were found to have greater CA-125 levels, more advanced stage disease, more ascites and shorter periods of survival Conclusion Thrombocytosis is a poor prognostic factor in ovarian cancer As reported previously, it is associated with aggressive tumor biology Thus, preoperative thrombocytosis can be a used as a marker of poor outcomesÖğe Bone mineral density of children with celiac disease: efficacy of gluten free diet(Blackwell Publishing, 2008) Ertekin, V.; Selimoglu, M. A.; Orbak, Z.; Celik, Y.[Abstract Not Available]Öğe The clinical significance of HPV screening in premalignant cervical lesions(7847050 Canada Inc, 2010) Kuyumcuoglu, U.; Hocaoglu, S.; Guzel, A. I.; Celik, Y.Purpose We evaluated the clinical significance of human papilloma virus (HPV) screening in premalignant cervical lesions Methods This prospective study was performed at Dicle University, School of Medicine, Department of Obstetrics and Gynecology. from January 2009 to June 2009 A total of 60 cases were evaluated Thirty cases had premalignant cervical lesions The prevalence of HPV was analyzed by polymerase chain reaction and types determined by Hybrid Capture II The cases that had premalignant cervical lesions were evaluated with colposcopy Statistical analyses were carried out by using the statistical packages for SPSS version 12 0 for Windows (Chicago. IL, USA) Results Of all the cases. those with premalignant cervical lesions had higher prevalence of HPV DNA The cases that had high oncogenic HPV type had more abnormal colposcopic findings Conclusion Premalignant cervical lesions should be evaluated by cervical cytology. colposcopy, HPV DNA screening and cervical tissue sampling In this way, development of cervical cancer can be preventedÖğe Clinical significance of procalcitonin in cervico-vaginal secretions of women with preterm rupture of membranes(I R O G Canada, Inc, 2010) Kuyumcuoglu, U.; Kangal, K.; Guzel, A. I.; Celik, Y.Purpose: To compare vaginal fluid procalcitonin (PCT) concentrations in cases of preterm premature rupture of membranes (PPROM) and healthy pregnant women, and to determine whether the PCT concentrations are of value in the diagnosis of PPROM cases and clinical amnionitis. Methods: 50 cases with PPROM and 50 healthy pregnant women were enrolled in the study. In the PPROM group, analysis was conducted on PCT concentrations with reference to serum leucocytosis, serum C-reactive protein level and urine analysis, as well as to presence/absence of clinical amnionitis. Statistical analyses were carried out by using the statistical packages for SPSS 12.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: Procalcitonin levels in the PPROM group were significantly higher than in cases of healthy pregnant women (1.17 vs 0.05 ng/ml; p < 0.001). In the PPROM group PCT concentrations between the patients with and without clinical amnionitis were comparable. Also, a significant correlation was observed between PCT and leucocytosis (r = 0.64; p < 0.001) and C-reactive protein (r = 0.90; p < 0.001). Conclusion: These findings suggest that the value of vaginal fluid PCT determinations can be useful for diagnostics of PPROM cases suspected of intrauterine infection.Öğe Clinico-epidemiological Study of Caustic Substance Ingestion Accidents in Children in Anatolia: The DROOL Score as a New Prognostic Tool(Acta Medical Belgica, 2012) Uygun, I.; Aydogdu, B.; Okur, M. H.; Arayici, Y.; Celik, Y.; Ozturk, H.; Otcu, S.Background : To examine the clinico-epidemiological details of paediatric caustic substance ingestion (CSI) accidents in Turkey. To present the new DROOL Score (DS), which the authors developed based on the severity and duration of initial signs and symptoms (ISSs) to predict oesophageal stricture (OS) without endoscopy, and to present our management protocol based on immediate feeding, early detection, and oesophageal balloon dilatation (OBD) of OS with no barium study. Methods : We prospectively reviewed the records of 202 children admitted with a history of CSI within 48 hours. Patient, parent, caustic substance, and accident characteristics were noted in detail. Patients were fed as soon as they could swallow saliva. Diagnoses of OS were made earlier via timely endoscopy (mean, 10-14 days after CSI) for patients with persistent dysphagia and OBD was started earlier. ISSs and DSs were analyzed. OS treatment results were compared between early (10-14 days) and late (>= 21 days) dilatation patients who were referred for OBD by other hospitals. Results : In total, 144 (71%) incidents occurred within the parents' home and 44 (22%) occurred at another individual's home. The caustic substances were frequently sold in non-original containers (68.8%). Most patients' parents had low incomes and were poorly educated. Ninety-six children had no ISSs, whereas 106 patients had ISSs. Seventeen symptomatic patients had persistent dysphagia after 10-14 days. Timely endoscopy was performed within 10-14 days for these patients only, and OS was diagnosed and successfully treated. DSs were significantly lower in patients with OS than those without (p < 0.001). A DS <= 4 was a significant predictor of OS (100% sensitivity, 96% specificity, 85% positive and 100% negative predictive values). Results were significantly more satisfactory in early (n = 17) than in late (n = 6) dilatation patients. Conclusions : Paediatric CSI accidents might decrease if caustic substances were sold in the original child-proof containers. OS can be highly predicted by a simple DS instead of endoscopic grading, and can be diagnosed earlier (10-14 days) via endoscopy only in patients with persistent dysphagia, instead of a late barium study (>= 21 days). OBD can then also be started earlier in these patients.Öğe Comparison of inflammatory mediators, cardiac risk factors and functional-structural changes of left ventricle(Blackwell Publishing, 2006) Toprak, G.; Alan, S.; Cevik, K.; Yokus, B.; Celik, Y.[Abstract Not Available]Öğe Comparison of inflammatory mediators, cardiac risk factors and functional-structural changes of left ventricle(Blackwell Publishing, 2006) Toprak, G.; Alan, S.; Cevik, K.; Celik, Y.[Abstract Not Available]Öğe Comparison of tuberculin skin test and a specific T-cell-based test, T-Spot™.TB, for the diagnosis of latent tuberculosis infection(Sage Publications Ltd, 2007) Ozekinci, T.; Ozbek, E.; Celik, Y.There is substantial evidence that the detection of T cells specific for the proteins ESAT-6 and CFP-10 using the ex vivo enzyme-linked immunospot technique is a marked improvement on the existing tuberculin skin test (TST). This new technique, which detects,gamma-interferon-producing T cells, is now available as the commercial assay, T-Spot (TM).TB. We compared the T-Spot (TM).TB test with the TST for the diagnosis of latent tuberculosis infection (LTBI) in different groups of subjects. Significant accordance (85.7%) between the tests was found in subjects with active lung tuberculosis and in tuberculosis clinic and laboratory personnel (63.6%) but accordance was lowest and not significant amongst house contacts of tuberculosis patients (53.6%). We conclude that, in countries where vaccination is routinely performed, the T-Spot (TM).TB test is a useful diagnostic test for LTBI in highrisk groups when carried out either together with the TST and/or to confirm the TST result.Öğe Correlation of Tumour Markers in Ascitic Fluid and Serum: Are Measurements of Ascitic Tumour Markers a Futile Attempt?(Field House Publishing Llp, 2009) Tuzun, Y.; Celik, Y.; Bayan, K.; Yilmaz, S.; Dursun, M.; Canoruc, F.Correlations between tumour markers in ascitic fluid and serum were investigated to determine whether ascitic fluid analysis had any diagnostic advantage over serum in 91 adults with ascites (55 malign; 36 benign). Serum and ascitic fluid were analysed for carcinoembryonic antigen (CEA), cancer antigen (CA) 125, CA19.9, CA72.4, CA15.3, alpha-fetoprotein (AFP) and cytokeratin-19 fragment (CYFRA). The tumour markers were skewed between the groups so were logarithmically transformed. Correlations between serum and ascitic fluid were tested using Pearson's correlation coefficient. Serum and ascitic fluid levels of CEA, CA125, CYFRA and AFP in the malign group were statistically different and CEA, CA19.9, CA5.3, CYFRA and AFP were statistically different in the benign group. For both groups, all tumour markers were highly correlated in serum and ascitic fluid, with the exception of CYFRA in the malign group. These results indicate that, where malignant ascites is suspected, analysing tumour markers in ascitic fluid does not have any advantage over serum analysis.Öğe Evaluation of adolescent pregnancies: 10-year experience of a hospital in rural Turkey(I R O G Canada, Inc, 2011) Demir, B.; Guzel, A. I.; Celik, Y.; Demir, S.; Demir, F.Purpose: To evaluate the characteristics of adolescent pregnancies admitted to our clinic. Materials and Methods: This retrospective and descriptive study was performed at Ergani State Hospital from January 2000 to December 2010. This is an outpatient gynecology and obstetrics at government hospital in Southern Eastern Region of Turkey. A total of 15,210 pregnancies were delivered during the study period, of whom 711 of them were adolescent pregnancies. Statistical analyses were carried out using the statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: During the study period, of the total of 15,210 deliveries 711(4.6%) were adolescent pregnancies (age range 14-19 years). The mean age (95% CI) of the patients was 17.90 +/- 1.12 (17.82-17.98) years old. Most of the patients were nulliparous (n = 559, 78.60%). Mean gestational weeks, fetal birth weight and fetal birth length and 95% Cl values were as follows: 37.11 +/- 2.53 (36.93-37.30), 3045.73 +/- 51.70 (3007.65-3083.79) and 48.68 +/- 2.31 (48.51-48.85), respectively. Six hundred and twenty (87.20%) of the patients delivered spontaneously by the vaginal route, while 91 (12.80%) were delivered by cesarean section. Although the age range of the patients was not wide, there was a significant correlation between maternal age, gestational age, fetal birth weight and fetal birth length (p < .01). Conclusion: According to this study, the ratio of adolescent pregnancies was found to be 4.6% which was lower than other regions of Turkey. The majority of the patients were nulliparous and most delivered spontaneously by the vaginal route. There was a significant correlation between maternal age, gestational age, fetal birth weight and fetal birth length.Öğe Explaining the growth of craniofacial skeleton under protein restriction and ligation of the uterine artery by principal component analysis (PCA)(Wiley-Blackwell, 2007) Kavak, V.; Babacan, F.; Celik, F.; Celik, Y.; Bilici, A.; Kara, I. H.[Abstract Not Available]Öğe How to Increase the Diagnostic Value of Malignancy-related Ascites: Discriminative Ability of the Ascitic Tumour Markers(Field House Publishing Llp, 2009) Tuzun, Y.; Yilmaz, M.; Dursun, M.; Canoruc, F.; Celik, Y.; Cil, T.; Boyraz, T.Making a differential diagnosis between malignant and non-malignant ascites is an important clinical issue, but cytological examination has a relatively low diagnostic sensitivity. This study aimed to find a discriminative model that distinguished between malignancy-related and non-malignant ascites. The study included 107 patients: 50 with nonmalignant and 57 with malignant ascites. Ascites was analysed using a range of tumour markers and standard cytology. Standardized canonical discriminant function coefficients were used to distinguish between ascites types. The combination of carbohydrate antigen (CA) 15-3, carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA-21.1) discriminated between malignancy-related ascites and non-malignant ascites with an accuracy of 98.8% compared with an accuracy of 77.8% for cytological examination. In conclusion, the use of a discriminant function constructed from a combination of CA15-3, CEA and CYFRA-21.1 could distinguish malignant from non-malignant ascites with greater accuracy than cytological examination. Further studies in larger population groups are warranted.Öğe Increased platelet count in severe peritoneal endometriosis(I R O G Canada, Inc, 2014) Evsen, M. S.; Soydinc, H. E.; Sak, M. E.; Ozler, A.; Turgut, A.; Celik, Y.; Tunc, S. Y.Objective: Platelet count (PC) is higher in chronic inflammatory diseases. The aim of this study was to evaluate the PC in patients with severe pelvic endometriosis. Materials and Methods: Patients with advanced stage pelvic endometriosis were retrospectively evaluated in a tertiary center between January 2009 and December 2011. Patients with pelvic endometriosis were divided into two groups; advanced stage peritoneal endometriosis were classified as Group 1 (n = 28). Group 2 consisted of 29 patients which had ovarian endometrioma without clinically apparent peritoneal endometriosis foci. Group 3 included 51 women as control subjects. PC between the groups was tested by Student's t test. The mean values of three groups were analyzed by using one way ANOVA test followed post-hoc test Bonferroni. Results: PC in patients with pelvic endometriosis were found to be higher from the control group (290 +/- 67 10(9)/1; 264 63 +/- 109/1, respectively; p = 0.038). Patients with peritoneal endometriosis (Group 1) had significantly higher PCs compared with the healthy controls (309 +/- 65 109/1; 264 +/- 63 10(9)/1; respectively; p = 0.011). Conclusion: Increased PC in advanced stage pelvic endometriosis may be a sign of increased systemic inflammation. The systemic inflammation may be more apparent in advanced stage peritoneal endometriosis.Öğe Management of non-traumatic acute limb ischemia and predictors of outcome in 270 thrombembolectomy cases(Edizioni Minerva Medica, 2011) Topal, A. Ender; Eren, M. Nesimi; Celik, Y.Aim. Acute limb ischemia (ALI) is one of the most potentially devastating but treatable diseases, resulting from a sudden obstruction in the arterial flow. The aim of this study was to examine the outcome of thromboembolectomy, and to determine the risk factors associated with limb loss and mortality in ALI. Methods. A retrospective chart review of 270 patients on whom thromboembolectomy was performed between September 2002 and December 2009 due to ALI. Of these, 146 (54.1%) were men and mean age was 64.3. Results. Etiology was embolic in 63.3% of cases. Late thromboembolectomy after 72 hours was performed in 57.8% of patients. On admission 38.9% of patients had grade IIb ischemia; grade III ischemia was present in 9.6% of patients. Failure of first thromboembolectomy developed in 21.1% of patients and bypass surgery was performed on 25.2% of patients. Amputation and mortality rates were 7.4% and 8.5% respectively. Binary logistic regression analysis revealed that risk factors of limb loss were thromboembolectomy failure, high ischemic stage, high level of plasma creatinine kinase and compartment syndrome on admission and predictors of mortality were congestive heart failure, ischemic heart disease, reperfusion injury and longer ischemic time. Conclusion. In ALI, thromboembolectomy is highly protective against amputation, as well as mortality, even in delayed cases with more than one week in the clinical absence of tissue necrosis. At least, it provides partial limb salvage. In addition, patients must be given a chance for limb salvage in the case of stage 3 ischemia, too. [Int Angiol 2011;30:172-80]Öğe Outcomes of pregnancies in women with parity ten or more: a case control study(I R O G Canada, Inc, 2012) Demir, B.; Guzel, A. I.; Demir, S.; Demir, F.; Celik, Y.Purpose: To determine the outcomes of pregnancies in women with parity ten and more. Materials and Methods: We designed this study in a government hospital in rural Turkey. Pregnant women with parity of ten or more (n = 126) were evaluated and compared with pregnant women with parity lower than ten (n = 90). The risk factors recorded were maternal age, parity, gestational age (weeks), delivery mode, fetal birth weight and Apgar scores. Statistical analyses were carried out using the statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: During the study period, a total of 12,551 deliveries were delivered at the current clinic. One hundred and twenty-six mothers were delivered with parity ten or more with a ratio of 1.01%. There was a statistically significant difference between the study and control group by means of maternal age, parity, fetal birth weight and 1- and 5-min Apgar scores (p < 0.05). There was no difference in delivery mode between the groups. Conclusion: According to this study, pregnant women with parity ten or more showed no adverse clinical characteristics when compared with pregnant women with parity lower than ten.Öğe Risk factors for maternal mortality in eclampsia: analysis of 167 eclamptic cases(Verduci Publisher, 2012) Sak, M. E.; Evsen, M. S.; Soydinc, H. E.; Turgut, A.; Ozler, A.; Sak, S.; Celik, Y.BACKGROUND: The aim of this study was to evaluate risk factors associated with maternal mortality in patients with eclampsia. METHODS: The probable risk factors of maternal mortality including maternal age, length of hospital stay, gestational age, systolic and diastolic blood pressures; hematocrit, hemoglobin, platelet count, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase were determined from patients' charts and Odds ratios (OR) of these factors were detected using by logistic regression analysis. RESULTS: According to logistic regression model, AST [OR, (95% Confidence Interval, CI): 7.39 (2.71-20.13)]; ALT [6.45 (2.42-17.16)]; postpartum diastolic blood pressure [4.58 (1.80-11.62)]; hematocrit [3.52 (1.86-6.65)]; hemoglobin [2.67 (2.01-3.55)] were found to be significant risk factors for maternal mortality. CONCLUSIONS: In eclamptic patients, close monitoring of particular laboratory values and blood pressure, and early intervention to alterations of certain variables will provide possibility for prevention against potential complications and subsequently decreasing mortality.Öğe The role of asymmetric dimethylarginine (ADMA) and leptin in hypertensive patients(Elsevier Ireland Ltd, 2007) Atamer, A.; Ilan, N.; Kocyigit, Y.; Toprak, G.; Ozbay, M.; Celik, Y.[Abstract Not Available]Öğe The role of asymmetric dimethylarginine (ADMA) and leptin in hypertensive patients(Sage Publications Ltd, 2008) Atamer, A.; Ilhan, N.; Kocylgit, Y.; Toprak, G.; Ozbay, M.; Celik, Y.We investigated the role of leptin and asymmetric dimethylarginine (ADMA) in uncomplicated hypertension. We also investigated their relationship with insulin resistance and serum levels of several metabolic parameters, including homocysteine, lipoprotein(a) and malondialdehyde (MDA). A total of 34 untreated newly-diagnosed hypertensive patients (seven men and 27 women; mean age, 57.4 +/- 10.1 years) and 38 normotensive healthy subjects (20 men and 18 women; mean age, 55.9 +/- 8.7 years) were studied prospectively. Serum leptin, homocysteine, lipoprotein(a), MDA and insulin resistance (HOMA-IR) were significantly higher in hypertensive patients compared with normotensive subjects. There were no significant differences in ADMA, insulin-like growth factor-1 and insulin-like growth factor binding protein-3 between the two groups. No correlation was found between serum ADMA and leptin levels. Our findings suggest that high serum leptin and homocysteine levels, oxidative stress and insulin resistance may be important risk factors for atherosclerosis among patients with uncomplicated hypertension.Öğe THE ROLE of IGF-1 and IGF-BP3 in THYROID NODULE DEVELOPMENT(Springer, 2009) Kaya, H.; Aguloglu, N.; Dag, Y.; Celik, Y.[Abstract Not Available]
