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Öğe A 12 months course of interferon and lamivudine combination therapy versus interferon monotherapy for untreated chronic hepatitis B infection(Elsevier Science Bv, 2002) Yalcin, K; Yildiz, F; Degertekin, H; Celik, Y[Abstract Not Available]Öğe Comparison of 12-month courses of interferon-?-2b-lamivudine combination therapy and interferon-?-2b monotherapy among patients with untreated chronic hepatitis B(Oxford Univ Press Inc, 2003) Yalcin, K; Degertekin, H; Yildiz, F; Celik, YWe compared the use of prolonged synchronous combination therapy with interferon (IFN)-alpha-2b and lamivudine with the use of IFN-alpha-2b monotherapy in patients with untreated hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (HBV) infection. Thirty-three patients received therapy with lamivudine (100 mg daily) and IFN-alpha-2b (10 million U 3 times per week) for 12 months; 16 patients received IFN-alpha-2b alone (10 million U 3 times per week for 12 months). The primary end point was sustained suppression of HBV DNA and HBeAg seroconversion, which was observed in 15 (45%) of 33 patients treated with combination therapy and in 3 (19%) of 16 patients treated with monotherapy (P = .133). Both therapeutic regimens were well tolerated. Combination therapy increased the rate of sustained suppression of HBeAg and resulted in significant improvement in Knodell histologic activity index scores, compared with monotherapy. However, there was no significant difference in rates of sustained suppression between the 2 groups at the end of follow-up.Öğe Comparison of microsuturing to the use of tissue adhesives in anastomosing sciatic nerve cuts in rats(Walter De Gruyter & Co, 1997) Inaloz, SS; Ak, HE; Vayla, V; Akin, M; Aslan, A; Sari, I; Celik, YThe purpose of this study was to investigate and to compare the effects of microsuturing to that of tissue adhesives (Tissee(R)) on the healing of anastomosing peripheral nerve incisions. Forty-five Wistar-Albino rats were placed in special cages and separated into three groups (n = 15). In the control group, biliteral sciatic nerves were explored but no incision was made. In the first experimental group, bilateral sciatic nerves were incised and end-to-end anastomosing was performed by microsuturing the epineurium. In the second experimental group, tissue adhesive (Tisseel(R)) was used alone in anastomosing the sciatic nerve cuts. Assessments of the healing processes were demonstrated by 1. electromyography (EMG), 2. measuring the electrical responses of the anastomosed nerves after electrical stimuli, 3. histopathological examination. Statistical analysis of the EMG findings showed that the Tisseel group was the closest in the healing process to the control group. After applying electrical stimuli to the dissected nerves, the resistance value of the Tisseel group was nearest to those of the control group. The histopathological examinations showed highly degenerative nerve bundles and prominent foreign body granuloma at the anastomosed sites of the microsutured group. The granulomatous inflammation was observed to be much less in the Tisseel group. We conclude that the healing effect of Tisseel was found to be superior to that of microsuturing as demonstrated by the findings of EMG, electrical responses of the anastomosed nerves, and histopathological examination.Öğe Impression cytology, tear film break up, and Schirmer test in patients with inactive trachoma(Elsevier Science Inc, 1997) Aksunger, A; Unlu, K; Karakas, N; Nergiz, Y; Celik, YSchirmer I and tear film break up time (BUT) tests were used to determine cytological changes and conjunctival surface epithelial morphology was investigated using impression cytology in patients with inactive trachoma; patients with mild and severe scarring, and control subjects, were compared. Schirmer I, BUT, and goblet cell populations were significantly lower whereas the grade of squamous metaplasia was significantly higher in patients with inactive trachoma. There was a close correlation between our findings and the clinical severity of trachoma. (C) 1997 Japanese Ophthalmological Society.Öğe Markers of disease activity in chronic hepatitis B virus infection(Canadian Medical Association, 2003) Yalcin, K; Degertekin, H; Yildiz, F; Celik, YBackground: Assessment of disease activity is important in the management of chronic hepatitis B virus (HBV) infection. Our objective was to study the correlation between serum HBV DNA levels and HBV e antigen (HBeAg) status, alanine aminotransferase (ALT) levels, histologic activity, age and sex in patients who had chronic HBV, with emphasis on those who were HBeAg negative with high replication but had normal or below-normal liver enzyme levels and mild liver disease. Method: At our university-affiliated tertiary care medical centre in Turkey, we studied prospectively 179 consecutive patients who were long-term hepatitis B surface antigen carriers. These patients were first separated into 2 groups according to HBeAg positivity and then subdivided into 4 groups according to the presence of HBV DNA, HBeAg status and ALT levels. The clinical, virologic and histologic differences in these patients were evaluated with respect to the HBeAg status. Results: Of the 179 patients, 120 (67%) were HBeAg positive and 59 (33%) were HBeAg negative. The mean (and standard deviation) age in the former group was 24.8 (7.60) and in the latter group was 32.2 (11.2) years (p < 0.001). HBeAg-negative patients had significantly more severe liver disease, more male predominance and lower serum HBV DNA levels than HBeAg-positive patients (p < 0.05). HBeAg status had a close correlation with age. There was a significant correlation between age and serum HBV DNA levels but not between HBV DNA levels and disease activity in study groups. We found that some of anti-HBe-positive patients had below-normal ALT levels with minimal or absent histologic changes despite high viral replication. Conclusions: Monitoring of ALT is of value in assessing hepatocellular damage in patients with chronic hepatitis B virus infection. HBeAg-negative patients with elevated ALT levels and some with normal ALT levels should be considered highly infectious in the course of chronic HBV infection.Öğe On the proper use of statistics(Churchill Livingstone, 2005) Celik, Y; Celik, F[Abstract Not Available]Öğe Sodium depletion and hemoconcentration: Overlooked complications in patients with anorexia nervosa?(Elsevier Science Inc, 2005) Celik, Y; Celik, F[Abstract Not Available]
