Yazar "Celik, M. Salih" seçeneğine göre listele

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    The effect of extremely low frequency magnetic field on the conjunctiva and goblet cells
    (Taylor & Francis Inc, 2008) Keklikci, Ugur; Akpolat, Veysi; Ozekinci, Selver; Unlu, Kaan; Celik, M. Salih
    Purpose: The aim of this study was to examine the effects of extremely low frequency magnetic field (ELF MF) on the conjunctiva and goblet cells density. Methods: Thirty adult female Spraque Dawley rats were assigned to one of two groups, each containing 15 rats. The experimental group received magnetic field 4 hr/day for 7 days. The second group received standard laboratory care and served as a control. The specimens were evaluated by light microscopy for goblet cell density, conjunctival edema, inflammation, and fibroblast proliferation. Results: In ELF MF exposure group rats, the number of goblet cells was less than the control group. We also observed a significant difference between ELF MF exposure group and control group in terms of goblet cell density (p = 0.010). The ELF MF exposure group manifested conjunctival edema and inflammation compared to the control group (p < 0.001 and p = 0.003). There was no statistical difference between the groups for fibroblast proliferation (p = 0.422). Conclusion: This study suggests that ELF MF exposure leads to morphological alterations of the conjunctiva and reductions in the number of goblet cells. We believe that ELF MF may cause dry eye symptoms.
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    Effects of Extremely Low Frequency Magnetic Field on Pulp Tissue of Rats
    (Medwell Online, 2011) Kaya, Sadullah; Celik, M. Salih; Akdag, Mehmet Zulkuf; Adiguzel, Ozkan; Yavuz, Izzet; Nergiz, Yusuf; Ayaz, Ercan
    This study aims to investigate the effect of Extremely Low Frequency Magnetic Field (ELF-ME) on dental pulp of ovariectomized rats. About 75 female Wistar-albino rats were randomly divided into 5 groups: cage-control, ovariectomy, ELF-MF exposure, ELF-MF exposure with strontium ranelate treatments and ovariectomy application, ELF-MF exposure with ovariectomy application. All groups except cage-control and ovariectomy groups were exposed to 1.5 mT ELF-MF exposure throughout 6 months, 4 h a day. After all applications, pulp tissues of rat teeth were investigated under light microscope. Between the groups, histological differences in collagen fibrils, fibroblasts, blood vessels and odontoblasts that create the pulp were found. We concluded that osteoporosis affected the odontoblasts and fibroblasts in rat dental pulp, ELF-MF exposure did not resolve the histopathological effect due to osteoporosis but enhanced this pathological effect, strontium ranelate was more efficient to eliminate the effects of osteoporosis than ELF-MF application.
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    Effects of Pulsed and Sinusoidal Electromagnetic Fields on MMP-2, MMP-9, Collagen Type IV and E-cadherin Expression Levels in the Rat Kidney An Immunohistochemical Study
    (Sci Printers & Publ Inc, 2013) Tunik, Selcuk; Ayaz, Ercan; Akpolat, Veysi; Nergiz, Yusuf; Isen, Kenan; Celik, M. Salih; Seker, Ugur
    OBJECTIVE: To investigate the role of extremely low frequency pulsed and sinusoidal electromagnetic fields on kidney tissues. STUDY DESIGN: Twenty-seven male Wistar albino rats were used. The rats were divided into 3 groups (n = 9): control group, sinusoidal electromagnetic field (SEMF) group, and pulsed electromagnetic field (PEMF) group. The SEMF and PEMF groups (pulse time 25 mu sn, pulse frequency 50 Hz) were subjected to 1.5 mT, 50 Hz, exposure 6 hours a day, 5 days a week for 28 days in methacrylate boxes. Formalin-fixed, paraffin-embedded kidney tissue sections were stained with hematoxylin-eosin, Gomori and periodic acid-Schiff. In addition, matrix metalloproteinase-2 (MMP-2) and 9 (MMP-9), E-cadherin and collagen type IV expression levels were examined immunohistochemically. RESULTS: Thickening of glomerular basement membranes was evident in electromagnetic fields, especially in the SEMF group. In addition, expression levels of E-cadherin were decreased with electromagnetic field (EMF) exposure. The expression level of MMP-9 increased, and MMP-2 and collagen type IV expression levels were not altered with EMF exposure. CONCLUSION: Both EMFs changed the molecular component of the kidney adversely.
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    Effects of Pulsed and Sinusoidal Electromagnetic Fields on Rat Testes
    (Sci Printers & Publ Inc, 2020) Tunik, Selcuk; Baran, Ozlem Pamukcu; Akpolat, Veysi; Ayaz, Ercan; Nergiz, Yusuf; Celik, M. Salih; Yumusak, Ozkan
    OBJECTIVE: To investigate the role of 50-Hz extremely low frequency pulsed (PEMF) and sinusoidal (SEMF) electromagnetic fields on the testis using a rat model. STUDY DESIGN: Twenty-seven male Wistar albino rats were used. The rats were divided into three groups (n=9 each): sham group, SEMF group, and PEMF group. The SEMF and PEMF groups (pulse time: 20 milliseconds, pulse frequence: 50 Hz) were subjected to 1.5 mT, 50 Hz exposure 6 hours a day, 5 days a week for 28 days in methacrylate boxes. Formalin-fixed, paraffin-embedded tissue sections were stained with H-E and PAS. In addition, E-cadherin and type IV collagen expressions were examined immunohistochemically. RESULTS: Seminiferous tubule basement membranes decreased with EMFs, especially those treated with SEMF. In addition, expression levels of E-cadherin on seminiferous epithelium decreased in PEMF and SEMF groups. The expression level of type IV collagen was also decreased in perivascular and seminiferous tubule basement membrane as compared to that in the sham group. CONCLUSION: PEMF and SEMF have adverse effects on the testis at a histopathological level. EMF leads to a decrease in E-cadherin and type IV collagen expression levels.