Yazar "Celen, M. K." seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • [ X ]
    Öğe
    Comparison of snakebite cases in children and adults
    (Verduci Publisher, 2015) Tekin, R.; Sula, B.; Cakir, G.; Aktar, F.; Deveci, O.; Yolbas, I.; Celen, M. K.
    OBJECTIVE: There are very few studies that compare the snakebite cases in children and adults. The present study aimed to compare the demographic characteristics, clinical presentations, laboratory findings, and developed complications in pediatric and adult patients due to snakebites. PATIENTS AND METHODS: This study included the patients admitted to the hospital and monitored due to snakebite between July 1999 and December 2012. The condition of each patient who had been bitten was admitted to the hospital was monitored from the time of admission to the end of their hospital stay. The fact that a snakebite occurred was recorded if the subjects saw the snake or if the appearance of the puncture sites was convincingly a snakebite. RESULTS: The present work included 290 patients, of whom 123 were children and 167 were adults. The most common location of the bites was the lower extremity with 78.9% (n=97) and 63.5% (n=106) in pediatric and adult patients, respectively. All of the pediatric patients received prophylactic treatment with antibiotics, whereas 62 (37.1%) adult patients received antimicrobial treatments due to the soft tissue infection. The most common complication developed was pulmonary edema in children at a rate of 33.3% (n=41) and compartment syndrome in adult patients at a rate of 3% (n=5). CONCLUSIONS: Patients admitted to the hospital due to snakebite should be monitored for at least 12 hours, even if there is no sign of clinical envenomation. Antivenom treatment should be administered to the patients requiring clinical staging. Patients should be kept under close monitoring to prevent the development of serious complications such as cellulitis, pulmonary edema, compartment syndrome, and disseminated intravascular coagulation.
  • [ X ]
    Öğe
    Effects of entecavir, tenofovir and telbivudine treatment on renal functions in chronic hepatitis B patients
    (Univ Catholique Louvain-Ucl, 2019) Kara, A., V; Yildirim, Y.; Ozcicek, F.; Aldemir, M. N.; Arslan, Y.; Bayan, K.; Celen, M. K.
    Background and study aims : The aim of this study was to enlighten the controversy about the renal safety of entecavir, tenofovir, and telbivudine treatments in chronic hepatitis B (CHB) patients by comparing these treatments in real-world conditions. Patients and methods: We retrospectively enrolled 104 treatment-naive patients with CHB monoinfection into our study. Patients were treated with entecavir monotherapy (n=38), tenuflivir monotherapy (n=35), or telbivudine monotherapy (n=31). We then compared and statistically analyzed the effects of these drugs on the estimated glomerular filtration rate (eGFR) over a 24-month follow-up period. Results : In the entecavir group, time-dependent change in eGFR was not statistically significant (p = 0.357). There was a statistically significant increase in eGFR in the telbivudine group at 12 months (p < 0.001) and at 24 months (p < 0.001) and, in contrast, a statistically significant decrease in the tenofovir group at 12 months (p < 0.001) and at 24 months (p < 0.001). There was no significant relationship between entecavir and eGFR change (p = 0.763). We found that tenofovir and telbivudine were independent predictors of eGFR change (decrease in eGFR, p < 0.001 and increase in eGFR, p = 0.001, respectively) Conclusions : We recommend close follow-up of renal functions, especially for patients treated with tenofovir. Telbivudine was superior to the other drugs in terms of renal function. We conclude that an individualized therapy program considering treatment efficacy and side effects is the best option for patients.
  • [ X ]
    Öğe
  • [ X ]
    Öğe
    An Investigation of the Effects of the Mean Platelet Volume, Platelet Distribution Width, Platelet/Lymphocyte Ratio, and Platelet Counts on Mortality in Patents with Sepsis who applied to the Emergency Department
    (Medknow Publications & Media Pvt Ltd, 2018) Orak, M.; Karakoc, Y.; Ustundag, M.; Yildirim, Y.; Celen, M. K.; Guloglu, C.
    Aim: The aim of this study is to examine the role of the mean platelet volume (MPV), platelet distribution width (PDW), platelet/lymphocyte ratio (PLR), and platelet values for predicting mortality in patients with sepsis. Materials and Methods: This is a retrospective study, involving patients 18 years and above who were diagnosed with sepsis. Blood samples were analyzed for platelets characteristics (counts, MPV, PDW, and PLR). The patients were separated into two groups namely the survivors and deceased. The two groups' MPV, PDW, PLR, and platelet counts which were considered to have an effect on mortality, were compared. Results: Three hundred and thirty patients who were diagnosed with sepsis in our emergency department and complying with the study participation criteria were studied retrospectively. Comparison of the MPV, PDW, PLR, and platelet counts of the deceased and survivors showed that the MPV, PDW, and PLR were higher in the deceased while the platelet counts were higher in the survivors. Conclusion: The low number of platelets in patients with sepsis at the moment of application and the high PDW and PLR values are valuable for predicting a high mortality.
  • [ X ]
    Öğe
    Risk factors for typhoid fever among adult patients in Diyarbakir, Turkey
    (Cambridge Univ Press, 2006) Hosoglu, S.; Celen, M. K.; Geyik, M. F.; Akalin, S.; Ayaz, C.; Acemoglu, H.; Loeb, Mark
    We conducted a case-control study to assess risk factors for typhoid fever in Diyarbakir, Turkey, a region where transmission of Salmonella typhi is endemic. We prospectively identified febrile patients from Diyarbakir and the surrounding area who were admitted to hospital. Cases were defined as patients who had S. typhi isolated from at least one blood culture. Sixty-four cases with blood culture-confirmed S. typhi were identified between May 2001 and May 2003. In total, 128 age- and sex-matched controls selected from neighbourhoods as cases were enrolled. We hypothesized that consumption of raw vegetables contaminated with sewage would be associated with an increased risk of typhoid fever. Conditional logistic regression modelling revealed that living in a crowded household (OR 3(.)31, 95 % CI 1(.)58-6(.)92, P= 0(.)002), eating cig kofte (a traditional raw food) (OR 5(.)29, 95 % CI 2(.)20-12(.)69, P= 0(.)000) and lettuce salad (OR 3(.)55, 95 % CI 1(.)52-8(.)28, P=0(.)003) in the 15 days prior to symptoms onset was independently associated with typhoid fever. We conclude that living in a crowded household and consumption of raw vegetables outside the home increase the risk of typhoid fever in this region.
  • [ X ]
    Öğe
    TELBIVUDINE VERSUS TENOFOVIR-BASED TREATMENT OPTIMISATION STRATEGY IN HBeAg-NEGATIVE CHRONIC HEPATITIS B PATIENTS
    (Elsevier Science Bv, 2015) Krastev, Z.; Kotzev, I.; Celen, M. K.; McNeeley, D.; Hamed, K.
    [Abstract Not Available]