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    Evaluation of serum inflammatory markers in treatment-resistant manic patients and adequate responder manic patients
    (Elsevier Ireland Ltd, 2019) Bulut, Mahmut; Cati, Songul; Gunes, Mehmet; Kaya, Mehmet Cemal; Kaplan, Ibrahim; Ozkan, Mustafa
    Mania is accompanied with immune activation as indicated by increased pro-inflammatory cytokines, acute phase proteins; and carcinoembryonic antigen (CEA) is known to accompany signs of immune-inflammatory responses in bipolar disorder (BD) and medical disorders. In this study, it was aimed to compare high sensitivity C-reactive protein (hsCRP), CEA levels and white blood cells (WBCs) counts in the treatment-resistant BD (Group 3), the treatment-responsive BD patients (Group 2), and the healthy control group (Group 1). The socio-demographic data form, the Young Mania Rating Scale (YMRS), the Hamilton Depression Rating Scale (HDRS), and the Clinical Global Impression Severity of Illness (CGI-S) Scale were applied to the patients. In Group 3, the WBCs counts, and CEA levels were significantly higher than the other two groups. There was a positive correlation between WBCs counts and YMRS and CGI-S scores in all manic patients. There was a positive correlation between CEA levels and YMRS, HDRS and CGI-S in manic patients. This study shows that there is an activation of the immune-inflammatory response system in treatment resistant manic patients; and, WBCs counts and CEA levels are associated with severity of disease in manic patients.
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    Öğe
    Infection risk in psychiatric patients: a catatonic case report
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Atli, Abdullah; Bulut, Mahmut; Kaya, Mehmet Cemal; Cati, Songul; Bez, Yasin
    Catatonia is occurring in some psychiatric disorders such as schizophrenia, bipolar disorder and depression. Catatonia is presented with catalepsy, catatonic excitation, negativism, mutism, posturing, stereotypic movements, mannerism, grimas, echolalia, and echopraksia. Hospital bacterial infections generally occur in patients whom longterm hospitalized and immune system weakened. Patients with psychiatric disorders, - especially immobilized and hospitalized ones-, patients who resist to drug-food intake, lack of self-care may have predisposition to infections. In case of a worsening in the clinical state of the patients with catatonia, which is a severe psychiatric condition, clinicians should keep in mind organic pathologies like sepsis. Herein we reported a case of sepsis, which was diagnosed as bipolar mood disorder depressive episode with catatonic features and had been hospitalized in our clinic for 67 days and resisted to food and drug intake.