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Öğe Elevated amniotic fluid amino acid levels in fetuses with gastroschisis(Blackwell Publishing, 2006) Kaplan, A.; Kale, A.; Kale, E.; Akdeniz, N.; Canoruc, N.[Abstract Not Available]Öğe Elevated amniotic fluid amino acid levels in fetuses with gastroschisis(Assoc Bras Divulg Cientifica, 2006) Kale, A.; Kale, E.; Akdeniz, N.; Canoruc, N.Our objective was to measure maternal plasma and amniotic fluid amino acid concentrations in pregnant women diagnosed as having fetuses with gastroschisis in the second trimester of pregnancy. Twenty-one pregnant women who had fetuses with gastroschisis detected by ultrasonography (gastroschisis group) in the second trimester and 32 women who had abnormal triple screenings indicating an increased risk for Down syndrome but had healthy fetuses (control group) were enrolled in the study. Amniotic fluid was obtained by amniocentesis, and maternal plasma samples were taken simultaneously. The chromosomal analysis of the study and control groups was normal. Levels of free amino acids and non-essential amino acids were measured in plasma and amniotic fluid samples using EZ:fast kits (EZ:fast GC/FID free (physiological) amino acid kit) by gas chromatography (Focus GC AI 3000 Thermo Finnigan analyzer). The mean levels of essential amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine) and non-essential amino acids (alanine, glycine, proline, and tyrosine) in amniotic fluid were found to be significantly higher in fetuses with gastroschisis than in the control group (P < 0.05). A significant positive correlation between maternal plasma and amniotic fluid concentrations of essential and nonessential amino acids was found only in the gastroschisis group (P < 0.05). The detection of significantly higher amino acid concentrations in the amniotic fluid of fetuses with a gastroschisis defect than in healthy fetuses suggests the occurrence of amino acid malabsorption or of amino acid leakage from the fetus into amniotic fluid.Öğe Proposal of a diagnostic test for the detection of preterm premature rupture of membranes based on the determination of thyroid hormones in vaginal washing fluid(Karger, 2007) Kale, Ahmet; Kale, Ebru; Akdeniz, Nurten; Kuyumcuoglu, U.; Canoruc, N.Objectives: To determine whether measurement of total T3 (triiodothyronine), total T4 (thyroxine), free T3 (free triiodothyronine) and free T4 (free thyroxine) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (PPROM). Study Design: The PPROM group and normal pregnancy group consisted of 30 and 30 pregnant patients between 26 and 36 weeks' gestation, respectively. Vaginal fluid total T4, free T4, total T3 and free T3 levels were measured in both groups. Results: Vaginal fluid total T3 and free T3 levels were not statistically significant in the PPROM group as compared with the control group (p = 0.087, p = 0.123, respectively). Vaginal fluid total T4 and free T4 levels were significantly higher in the PPROM group as compared with the control group (p = 0.002, p < 0.000, respectively). The optimal cut-off value for total T4 (0.866 mu g/dl) gave a sensitivity level of 83.3% (65.3-94.3, 95% CI) at a specificity of 60.0% (40.6-77.3, 95% CI) with positive and negative predictive values of 67.6 and 78.3%, respectively. The optimal cut-off value for free T4 ( 0.079 ng/dl) gave a sensitivity level of 90% (73.4-97.8, 95% CI) at a specificity of 70.0% (50.6-85.2, 95% CI) with positive and negative predictive values of 75.0 and 87.5%, respectively. Conclusions: Total and free T4 measurements from vaginal fluids appears to be a useful marker of PPROM. Copyright (c) 2007 S. Karger AG, Basel.Öğe Screening survey of beta thalassemia carriers in Diyarbakir province(Blackwell Publishing, 2006) Ekinci, S.; Erdinc, L.; Gunes, K.; Batun, S.; Kaplan, A.; Kale, E.; Canoruc, N.[Abstract Not Available]Öğe Serum IL-2R, IL-6, Ig G, Ig G subgroups (IgG 1, 2, 3, 4) levels in iron deficiency anemia and ?-thalassemia carriers(Blackwell Publishing, 2006) Demir, M.; Canoruc, N.; Batun, S.; Kale, E.; Erdinc, L.; Kaplan, A.[Abstract Not Available]
