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Öğe 5-fluorouracil-induced vasospastic angina(K Faisal Spec Hosp Res Centre, 2005) Ayyildiz, O; Karabulut, O; Isikdogan, A; Cakir, O; Dursun, M[Abstract Not Available]Öğe Cardiac hydatic cyst causing cerebral emboli in a child(Springer, 2002) Cakir, O; Eren, N; Kilinc, NCardiac hydatic cyst is rarely encountered. In this article, a case of hydatid cyst localized in the left ventricle causing cerebral emboli is reported.Öğe Copper etching with cupric chloride and regeneration of waste etchant(Elsevier Science Sa, 2006) Cakir, OCopper etching is considerably important process in electronics industry. particularly in the fabrication of printed circuit board. Various etchants can be used for this purpose, but nowadays cupric chloride is more accepted etchant, because of its high etch rate and easy regeneration properties. In the present study, copper etching process with cupric chloride etchant was investigated. In the etching of copper, the most important etching parameter is etch rate, therefore the investigation was based on the various effects on etch rate. The influence of etchant concentration, additives and etching temperature were examined. It is also important to regeneration/recycle of waste etchant from environmental point of view. Thus, various cupric chloride etchant regeneration processes were investigated. (c) 2005 Elsevier B.V. All rights reserved.Öğe Does sodium nitroprusside reduce lung injury under cardiopulmonary bypass?(Elsevier Science Bv, 2003) Cakir, O; Oruc, A; Eren, S; Buyukbayram, H; Erdinc, L; Eren, NObjective: We hypothesized that direct pulmonary arterial infusion of sodium nitroprusside (SNP) would ameliorate lung injury under cardiopulmonary bypass. Methods: Experiments were performed on 12 adult mongrel dogs of both sexes weighing 20-28 kg. The animals were randomly divided into two groups of six animals each. All animals were subjected to total cardiopulmonary bypass (CPB) and moderate hypothermia (28degreesC core temperature). During total CPB, the aorta was clamped together with the pulmonary artery to prevent any antegrade flow to the lungs. After cardioplegic arrest for 120 min, the animals were rewarmed, weaned from CPB, and their condition stabilized for another 90 min. After the release of the aortic cross-clamp, the dogs received either a 5% glucose solution as a placebo (group I) or SNP (0.5 mug/kg per min) (group II), both infused into the pulmonary arterial line. The infusion was stopped after 60 min. To measure lung tissue malondialdehyde (MDA), water content and polymorphonuclear leukocytes count, lung tissue samples were taken before CPB and after weaning from CPB. In addition, alveolar-arterial oxygen difference (AaDO(2)) for tissue oxygenation was calculated by obtaining arterial blood gas samples. Results: Values of MDA before CPB of 42.0 +/- 5.3 nmol/g of tissue rose to 67.6 +/- 5.7 nmol/g of tissue after weaning from CPB in group I (P = 0.028). In group II MDA values also increased from 43.1 +/- 4.3 to 52.4 +/- 5.7 nmol MDA/g of tissue after weaning from CPB (P = 0.046). The MDA increase in group II after CPB was found to be significantly lower than that for group I (P = 0.004). The wet-to-dry lung weight ratio in the sodium nitroprusside group was 5.1 +/- 0.2, significantly lower than in the control group (6.8 +/- 0.4), (P = 0.01). AaDO(2) increased significantly in group I (P = 0.028). There was no statistically significant difference (P = 0.065) between groups I and II. During histopathological examination it was observed that neutrophil counts in the lung parenchyma rose significantly after CPB in both groups. The increase in group I was significantly larger than that in group II (P < 0.001). Conclusions: The results represented in our study indicate that pulmonary arterial infusion of sodium nitroprusside during reperfusion can reduce lung injury under cardiopulmonary bypass. (C) 2003 Elsevier Science B.V. All rights reserved.Öğe The effect of aprotinin on ischemia-reperfusion injury in an in situ normothermic ischemic lung model(Elsevier Science Bv, 2003) Eren, S; Esme, H; Balci, AE; Cakir, O; Buyukbayram, H; Eren, MN; Erdinc, LObjectives: In the context of the physiopathology of damage due to ischemic preservation and reperfusion injury following preservation, we aimed to demonstrate the positive effects of the addition of aprotinin, a serine protease inhibitor, to low potassium dextran (LPD), used as a single-flush solution in normothermic ischemic animal models, on lung protection and the prevention of reperfusion injury. Methods: In the study, 21 New Zealand white rabbits were used as experimental subjects. The subjects were ventilated with the assistance of a manual mechanical ventilator at 30 breaths/min and 10 ml/kg tidal volume. Lung protection solution was supplied to the pulmonary artery via a catheter. After applying the solution, ischemia was carried out for 120 min. At the end of this period, reperfusion was carried out for 90 min. The subjects were divided into three groups of seven subjects each. In the control group, pulmonary perfusion solution was not employed, whereas in the second group LPD was employed, and in the third group LPD and aprotinin (LPD + A) were perfused. Blood gas analysis, bronchoalveolar lavage (BAL) fluid examination, tissue malondialdehyde (MDA) level analysis and morphological examinations were performed. Results: The LPD + A group showed the significantly highest levels of oxygenation at the 15th and 60th minutes of reperfusion (297 +/- 76.7 and 327 +/- 97.4 mmHg) in comparison to the LPD (157 +/- 20.6 and 170 +/- 53.6 mmHg) and control (64 +/- 8.4 and 59 +/- 7.2 mmHg) groups (P < 0.001). The LPD + A group showed the significantly lowest levels of alveolar-arterial oxygen difference at the 60th minute of reperfusion (389 +/- 15 mmHg) in comparison to the LPD (478 +/- 19 mmHg) and control (542 + 23) groups (P < 0.001). The BAL fluid neutrophil percentage was significantly lower in the LPD + A group (22 +/- 2.4%) compared to the LPD (31 +/- 6.1%) and control (38 2.4%) groups. MDA levels were significantly lower in the LPD + A group (119.8 +/- 5.3 nmol MDA/g) when compared to the LPD (145.06 +/- 9.5 nmol MDA/g) and control (147.3 +/- 3.9 nmol MDA/g) groups (P < 0.05). Morphological examinations revealed pathological lesions and alveolar hemorrhaging in all samples, with the LPD + A group having statistically more significant levels than the LPD and control groups (P < 0.005). The LPD + A group had a significantly lower percentage of pathological lesions and alveolar hemorrhage grade values than the LPD and control groups (P < 0.005). Conclusions: It was observed that the addition of aprotinin to LPD solution as a pulmonary flush solution in an in situ normothermic ischemic lung model prevents reperfusion injury by means of various mechanisms and also protects the morphological, functional and biochemical integrity of the lung. In our view, therefore, the addition of aprotinin to lung protection solution will provide positive results in lung transplantation protocols. (C) 2002 Elsevier Science B.V. All rights reserved.Öğe Extremity vascular trauma in civilian population: A 7-year review from North India(Elsevier Sci Ltd, 2006) Subasi, M; Cakir, O[Abstract Not Available]Öğe Free-floating ball thrombus in the left atrium(Springer, 2002) Cakir, O; Eren, N; Oruç, A; Buyukbayram, HFree-floating ball thrombi in the left atrium are rarely seen. They can cause sudden death by occluding the mitral valve. A 47-year-old female patient who showed signs of mitral stenosis during it physical examination and atrial fibrillation by electrocardiography was not administered anticoagulant therapy. On the transthoracic echocardiogram, a stenotic mitral valve and a floating mobile mass were seen inside the large left atrium. This mass was rounded (ball-like), had smooth contours, and occasionally occluded the stenotic mitral valve. The patient underwent emergency surgery to remove the mass, which was later proven to be a thrombus pathologically. Additionally, mitral valve replacement was performed. The importance of anticoagulant therapy for patients with rheumatic mitral stenosis has been emphasized by this case.Öğe Neuroprotective effect of N-acetylcysteine and hypothermia on the spinal cord ischemia-reperfusion injury(Elsevier Sci Ltd, 2003) Cakir, O; Erdem, K; Oruc, A; Kilinc, N; Eren, NThe purpose of this study was to investigate the effect of N-acetylcysteine (NAC) on spinal cord ischemia-reperfusion (I-R) in rabbits. Thirty rabbits were divided into five equal groups, group I (sham-operated, no I-R), group II (control, only I-R), group III (I-R + NAC), group IV (I-R + hypothermia), group V (I-R + NAC + hypothermia). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the aortic bifurcation. Forty-eight hours postoperatively, the motor function of the lower limbs was evaluated in each animal according to Tarlov Score. Spinal cord samples were taken to evaluate the histopathological changes. The sham-operated rabbits (group I) showed no neurologic deficit (Score = 4). Paraplegia (Score = 0) developed in all rabbits in the control group (group II). Administration of 50 mg/kg of NAC (group III) resulted in significant reduction of motor dysfunction (Score = 3.1 +/- 1.3, p = 0.002). Application of hypothermia alone (group IV) showed significant recovery of motor functions (Score = 3.0 +/- 1.1, p = 0.002), and combination of hypothermia and 50 mg/kg of NAC (group V) showed complete recovery of lower limb motor function (Score = 4, p = 0.001). Histologic examination of the spinal cord in rabbits with paraplegia revealed several injured neurons. The cords of animals with no motor function deficits showed only minimal cellular infiltrates in the gray matter, and there was good preservation of nerve cells. NAC showed protective effects of the spinal cord. Moderate hypothermia alone also showed protective effects. Combined use of NAC and hypothermia resulted in highly significant recovery of spinal cord function. (C) 2003 The International Society for Cardiovascular Surgery. Published by Elsevier Ltd. All rights reserved.Öğe Thoracic firearm injuries in children: management and analysis of prognostic factors(Oxford Univ Press Inc, 2003) Eren, S; Balci, AE; Ulku, R; Cakir, O; Eren, MNObjective: Thoracic firearm injuries (TFI) have become increasingly prevalent in children. Our purpose is to assess the injury pattern, Injury Severity Score (ISS), length of hospital stay (LOS), management and outcome of children with TFI with respect to the type of injury and to evaluate the value of ISS for predicting injury severity and the eventual need for thoracotomy, as well as the rate of morbidity and mortality. Methods: Between January 1987 and June 2002, 110 children (88 boys and 22 girls) less than or equal to 16 years of age with firearm injuries to the chest were evaluated. The children were divided in four groups according to cause of injury. An ISS was calculated for each child. Those children who died before admission were excluded from the study. The relationship between ISS and prognostic factors was analyzed in all four groups. Results: The mean age was 11.1 +/- 3.0 (range 3 - 16) years. Eighty-eight (80%) were male and 22 (20%) were female. The causes of firearm injuries were high-velocity gunshot wounds (HVGSW) in 52 (47.2%), low-velocity gunshot wounds (LVGSW) in 23 (20.9%), shotgun wounds (SGW) in 18 (16.3%), and explosives wounds (EW) in 17 (15.4%). Lung injury Occurred in 72 (65.5%) patients. Tube thoracostomy was sufficient in 76.3% (84 of 110) for thoracic injury. The morbidity rate was 16.3% (18/110) and the mortality rate was 4.5% (5/110). Mean ISS was 16.62 +/- 8.2 (range 4-48). Fifty-eight patients (52.7%) had an ISS : 16, while 31 (28.2%) had a score between 17 and 25, and 21 (19.1%) had a score greater than 25. The need for thoracotomy, as well as the rate of morbidity and mortality were significantly higher in children for those with an ISS >25. SGW and EW groups had a significantly higher ISS. The mean LOS was 10.84 +/- 4.7 days (range 4-42). The value of LOS was significantly higher in children with SGW and EW. Conclusion: The majority of TFI in children can be treated successfully by tube thoracostomy if there are no gross pulmonary lacerations and airway injuries. SGW and EW were commonly associated with higher ISS and LOS. The ISS was found to be an independent predictor of the need for thoracotomy, as well as for rates of morbidity and mortality. (C) 2003 Elsevier Science B.V. All rights reserved.Öğe Treatment of vascular injuries associated with limb fractures(Royal Coll Surgeons England, 2005) Cakir, O; Subasi, M; Erdem, K; Eren, NINTRODUCTION The goal of therapy in all patients with combined orthopaedic and vascular injuries of the extremities is salvage of a functional limb. In this study, we have evaluated our experience with a subset of patients who had a combination of vascular injury and limb fracture. PATIENTS AND METHODS The records of 192 patients with vascular injuries of the lower and upper limbs associated with bone fractures were reviewed. Of these, 168 were males and 24 were females; the mean age was 26 years. RESULTS The mechanism of injury was a penetrating wound in 97 (51%) patients and blunt trauma in 95 (49%) patients. Injured vessels included 6 subclavian/axillary, 39 brachial, 14 radial/ulnar, 11 radial, 8 ulnar, 36 femoral, 43 popliteal, 35 tibial arteries. Saphenous vein graft was the most common conduit of choice in arterial repair (55%). Amputations were needed for 20 patients. The limb salvage rate was 88%. Three patients died. CONCLUSIONS This study established that delay in surgery, blunt trauma and extensive soft tissue defect in combined orthopaedic and vascular injuries are associated with increased risk of amputation.Öğe Type III mixed cryoglobulinemia associated with digital necrotic ulcer successfully treated with intermittent intravenous pulse cyclophosphamide - A case report(Sage Publications Inc, 2005) Cakir, O; Ayyildiz, O; Isikdogan, ACryoglobulinemic vasculitis is an immune complex-mediated vasculitis predominantly affecting small vessels. The authors report an 18-year-old woman with painful digital necrotic ulcer due to type III cryoglobulinemic vasculitis on the basis of systemic lupus erythematosus. Serum protein electrophoresis and immunoelectrophoresis demonstrated a polyclonal peak of the immunoglobulin G lambda (IgG lambda) and IgM lambda type. The patient was successfully treated with intermittent intravenous pulse cyclophosphamide.Öğe Warfarin resistance: interaction between warfarin and Eruca sativa L.(E M H Swiss Medical Publishers Ltd, 2006) Goz, M; Goz, F; Cakir, O; Aydinol, B; Eren, N[Abstract Not Available]
