Yazar "Cakir, Fatih" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    Determination the Subtypes of Blastocystis sp. and Evaluate the Effect of These Subtypes on Pathogenicity
    (Springer International Publishing Ag, 2019) Cakir, Fatih; Cicek, Mutalip; Yildirim, Ibrahim Halil
    PurposeThe present study aimed to determine the frequency of subtypes of Blastocystis sp. in the immunosuppressed individuals, in patients with chronic urticaria, and in patients with GIS complaints to investigate the difference of Blastocystis sp. subtype distribution between patient and control groups.MethodsA total of 345 stool samples were collected from the patients and samples were studied by native-Lugol, trichrome staining, and Jones medium culture method. Positively detected samples were subjected to PCR to determine the subtypes. ResultsThis is the first study of nine subtypes of Blastocystis sp. investigated in our country and the most frequently found subtype was ST3, and then, the other subtypes were ST1, ST2, ST5, and ST6, respectively. Mix subtype was detected in the 11.6% and no subtype was detected in the 17.4% of the samples. The ST5 was detected first time in the control group and ST6, which is reported limitedly in our country, was found in patients with GIS complaints. ST1 and ST2 were found higher in the patient group.ConclusionThis study confirmed that the subtype (ST) differences are an important factor affecting the pathogenesis of Blastocystis sp.
  • [ X ]
    Öğe
    THE RELATIONSHIP BETWEEN TRACE ELEMENTS AND CERULOPLASMIN WITH SEVERITY OF FASCIOLIASIS PATIENTS
    (Carbone Editore, 2013) Basarali, Mustafa Kemal; Kaplan, Ibrahim; Cicek, Mutalip; Cakir, Fatih
    The aim of our study is to evaluate the relationship between trace elements, as zinc (Zn) and copper (Cu), and acute phase reactant ceruloplasmin (CP) levels during fascioliasis hepatic infection. 45 patients with fascioliasis and 38 healthy controls were enrolled in the study. Fascioliasis was diagnosed with ELISA IgG, stool examination and radiologic imaging. Number of females and males were determined as 34111 and 3018 in patient and control groups respectively. Mean age was 38.1 +/- 11.7 and 358 +/- 16.9 years in patient and control groups, respectively. Blood samples were collected to determine plasma Zn, Cu, and CP levels. As a result of the study serum Cu (from 1.4 to 1.8) and CP (from 26.7 to 33.4) levels were rised in while Zn (from 1.1 to 1.9) level was decreased in patient group. We determinated significant correlation (r: 0.781) of fasciola titers with ceruloplasmine that increased by acute phase in the patients with fascioliasis. In conclusion, an high correlation between CP and Cu levels in patients suffering from fascioliasis can be noted. On the other hand, low Zn levels, especially in endemic areas of disease, suggested that Zn can be given in addition to medical treatment, or as a dietary supplement. This situation may lead the way in terms of increasing the efficiency of treatment of fascioliasis.
  • [ X ]
    Öğe
    Viral and Parasitic Gastroenteritis Agents and Metronidazole Treatment in Diyarbakir Children's Hospital
    (Bilimsel Tip Yayinevi, 2019) Bacalan, Fatma; Cakir, Fatih; Demirkaya, Safinaz; Ozcan, Nida
    Introduction: Acute gastroenteritis (AGE) agents vary according to the hygiene and sanitation conditions of the regions and age groups of the patients. Rotavirus is the most commonly reported agent in all ages, whereas adenovirus is usually detected in sporadic cases. Giardia lamblia is a common gastroenteritis protozoa worldwide. The incidence of giardiasis approaches 40% in regions with insufficient sanitation and hygiene conditions. Amibic colitis is a parasitic infection caused by Entamoeba histolytica. Metronidazole is a synthetic 5-nitroimidazole affecting anaerobic bacteria and protozoa. Unnecessary usage of metronidazole, which is widely prescribed in the treatment of amebiasis and giardiasis, may lead to antibiotic resistance as well as intestinal dysbiosis. In this study, we investigated rotavirus, adenovirus, G. lamblia and E. histolytica in the stool samples and metronidazole presciption of AGE patients admitted to our hospital. Materials and Methods: The fecal samples of 8874 patients (6 months-16 years) admitted to Diyarbakir Pediatrics Hospital with the diagnosis of AGE were retrospectively analyzed. Rotavirus, adenovirus, G. lamblia and E. histolytica/dispar agents were investigated by Enzyme Immun Assay (EIA) method using RIDASCREEN (R) (R-biopharm AG, Germany) commercial kits. Fresh stool samples were also evaluated for G. lamblia and Entamoeba cyst and trophozoites by native-lugol (NL) method. Results: Among the 8874 samples, G. lamblia (1730 samples, 19.5%) was the most common agent followed by rotavirus (1083 samples, 12.2%). Adenovirus and E. histolytica/dispar were detected in 276 (3.1%) and 189 (2.2%) samples, respectively. Among the 3162 patients who were prescribed with metronidazole, G. lamblia, rotavirus, E. histolytica/dispar and adenovirus was found in 1730, 124, 194 and 35 patients, respectively. Metronidazole was prescribed in 1238 (17.8%) of the 6950 patients who were not diagnosed as giardiasis or amoebiasis by laboratory methods. Conclusion: Metronidazole prescription rate without laboratory findings of giardiasis or amoebiasis was high in our hospital. The proper use of laboratory methods in the diagnosis of acute gastroenteritis and the regulation of treatment after laboratory-based diagnosis will reduce unnecessary antibiotics usage.