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Öğe Effects of seasonal and physiological variations on the serum chemistry, vitamins and thyroid hormone concentrations in sheep(Wiley, 2006) Yokus, B.; Cakir, D. U.; Kanay, Z.; Gulten, T.; Uysal, E.The aim of this study was to investigate the possible effects of the reproductive status and seasonal variations on the serum chemistry and vitamin status and their relationships with the thyroid hormones in Sakiz-Awassi crossbreed sheep. The sheep (n = 34) were divided into two groups. The first group (n = 22) was mated; the second group (n = 12) was not mated. Their serum samples were collected four times a year at the each season and under reproductive status. The periods are 1, early pregnancy (October); 2, late pregnancy (January); 3, lactation (April); and 4, dry season (July). The results of this study indicated that (1) total protein (TP), globulin, cholesterol, creatinine, uric acid and T4/T3 vary with reproductive status but not seasonal variations; (2) alanine aminotransferase, T4, fT4 concentrations in serum vary only with reproductive status; (3) the urea, creatine kinase, lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase, amylase, albumin, triglyceride, VLDL, Vit A-E, T3 and fT3 concentration could vary with both reproductive status and seasonal variations; (4) the glucose, gamma-glutamyl transpeptidase, folate concentrations were altered neither season of the year nor the reproductive status; (5) a single reference interval for folate, gamma-glutamyl transpeptidase (GGT), glucose, TP, globulin, cholesterol, creatinine, uric acid and T4/T3 can be used for both mated and non-mated sheep because of no differences were found due to the reproductive status. Taking the results together suggests that reproductive status and seasonal variations have to be taken into consideration for a correct interpretation of the serum chemistry values of sheep. Nutritional supplements are required for sheep during certain periods to avoid a decline of their performance, which would then represent consequent economic, loses.Öğe P53 gene exon 4 RFLP polymorphism and relation with severity of disease in patients with coronary artery disease(Blackwell Publishing, 2006) Cakir, D. U.; Yokus, B.; Tekes, S.; Iltimur, K.; Mete, N.; Uysal, E.[Abstract Not Available]Öğe Prepartum and postpartum serum paraoxonase activity in dairy cattle and their associations with dystocia(Blackwell Publishing, 2006) Yokus, B.; Bademkiran, S.; Cakir, D. U.[Abstract Not Available]Öğe THE ROLE OF ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISM IN CLINICALLY CLASSIFIED PATIENTS WITH CORONARY ARTERY DISEASE(Taylor & Francis Ltd, 2010) Cakir, D. U.; Mete, N.The aim of the study was to investigate the relationship of eNOS (4 intron 27bp) polymorphism in clinically classified patients with coronary artery disease (CAD) in Turkish population PCR and restriction fragment length polymorphism analysis were used to detect the variant of the eNOS gene in 74 patients' with CAD and 20 healthy controls The CAD group was separated into 3 clinical groups depending on angiography criteria and clinical form designation 1st Group Myocardial infarction (MI) (n 20) 2nd Group Unstable Angina Pectoris (UAP) (n 18) 3rd Group Stable Angina Pectoris (SAP) (n 36) When a and b allele frequencies in the CAD and control groups we, e compared no statistically significant difference was found No significant difference was observed in the 4 intron 27 bp variants of the eNOS gene when CAD patients were compared without distinguishing them clinically from the control group When we assessed CAD patients classified according to their clinical form no significant difference was determined in allele frequencies and genotype distribution in the subgroups except for subgroup S4P When we compared SAP patients with the other subgroups and with the control group it was found that there was a significant increase in the ab genotype and the a allele frequency and a decrease in the bb genotype (p < 0 05) In conclusion CAD seemed to develop without any alterations in eNOS (4 intron 27bp) genotype frequency However the 27 bp repeat polymorphism of the eNOS gene in patients with SAP can be considered as SAP which may have a hereditary origin High eNOS gene polymorphism in patients with SAP can be related to the increased risk of possible coronary occurrence in future It was concluded that further studies of the relationship between eNOS gene polymorphism and CAD should take account of the clinical forms of CADÖğe The role of nitric oxide synthase (eNOS) gene polymorphism in coronary artery diseases and relation with severity of disease(Blackwell Publishing, 2006) Tekes, S.; Cakir, D. U.; Yokus, B.; Mete, N.; Iltimur, K.[Abstract Not Available]Öğe Total antioxidant response and oxidative stress index and relation with severity of disease in coronary artery disease(Blackwell Publishing, 2006) Mete, N.; Cakir, D. U.; Yokus, B.; Iltimur, K.[Abstract Not Available]
