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Öğe Age and sex distribution of colorectal carcinoma in the southeast of Turkey(1999) Degertekin H.; Sari Y.; Arslan A.; Akgul Y.; Buyukbayram H.In this study, the relationship between colorectal carcinoma and distribution of age and sex was investigated. We studied 102 cases from 1990- 1996 in the southeast of Turkey and compared the results with other similar studies. Fifty three percent of cases were female and 47% were male. The mean age of patients was 48 years F 47 yrs, M49 yrs. Of all cases, 30.3% of patients were under 40 years, 50.8% under 50 years and 80.2% under 60 years old. Carcinoma was seen most frequently at the 5th decade (29.4%) then 4th decade (20.5%) and 3rd decade (14.7%) respectively. The ratio of carcinoma over 60 years was 19.58%. These findings show that colorectal carcinoma was found equally in both sexes, the mean age was 48 yrs and at least half of the patients were under 50 years old. Although the mean age was lower our region, these results are roughly similar to other studies from our country, while in western countries 90% of colorectal carcinoma cases are known to occur at a mean age of over 50 years. Our findings were significantly different from these results. In conclusion, we can say that colorectal carcinoma has been considered in all suspected cases despite age of patient, and further epidemiological and etiological studies are needed in our region and country.Öğe Eosinophilic esophagitis frequency in gastroesophageal reflux disease(2010) Goral V.; Ozcaylak S.; Buyukbayram H.Objective This study compares the frequency of eosinophilic esophagitis in patients with gastroe sophageal reflux disease (GERD). Methods This study was conducted among the patients having gastroesophageal reflux complaints and accepting endoscopic procedure. The patients (50 men, 37 women) involved in the study be tween 16 and 70 years of ages and having GERD complaints were applied a questionnaire consisting of ten questions to define the level of GERD symptoms,and the endoscopic procedures were applied to the patients by the same gas troenterologist. Reflux esophagitis was evaluated according to the Los Angeles classification. The history of the pa tients was reviewed and the allergic histories were evaluated. Total serum Ig E level and eosinophilia count at the esophageal biopsies were calculated. Results There was no meaningful relationship when the patients were evalua ted in terms of their ages, genders, body mass index, habits (smoking, alcohol, tea, coffee, medicine), diarrhea, en doscopic appearance, total Ig E level, and hemogram study as well as number and percentage of eosinophil (P>0,05). When the endoscopic biopsies obtained from the patients were evaluated, no eosinophilic esophagitis has been observed. Conclusion According to the our study, there is no relationship with eosinophilic esophagitis and GERD. Eosinophilic esophagitis should be considered in the differential diagnosis of any cases with refractory reflux who complain of chronic unexplained dysphagia.with history of recurrent food impaction, and atopy or abnor mal endoscopic features.Öğe Giant-cell reparative granuloma of the tibia(2003) Subasi M.; Kapukaya A.; Buyukbayram H.; Bukte Y.Giant-cell reparative granuloma (GCRG) occurs in the jaw, temporal bone, and short tubular bones of the hands and feet. Although GCRG can affect long bones, only small numbers of such cases have been sporadically reported. This report describes a giant-cell reparative granuloma in the proximal tibia in a 60-year-old woman, describes features of GCRG in long bones and reviews the literature. A 60-year-old female patient was referred to us with complaints of moderately tender swelling of the right leg. Whole-body scintigraphic scanning was performed, which incidentally also disclosed a distal femoral lesion. The patient was admitted for surgery and incisional biopsies were performed on both lesions. Pathology analysis of the specimen from the tibia showed new bone lamellæ encircled by osteoblasts and multinucleated giant cells which were more numerous in the hæmorrhagic regions of the stroma; the latter displayed fibroblasts, histiocytes and inflammatory cells. The specimen from the femoral lesion showed typical features of a benign enchondroma. The patient was readmitted for surgery. The femoral enchondroma was curetted and the cavity was packed with bone graft. The tibial GCRG was treated with marginal resection, autogenous and allogenous bone grafting and intramedullary nailing. Follow-up examination after two years showed no clinical or radiological evidence of a recurrence. Although GCRG is uncommon, it should be considered whenever a lucent, expansile, and possibly destructive lesion of a long bone is encountered. It should be distinguished from true giant cell tumours occurring in the same locations because they have different biologic behaviours.Öğe Mast cells count and serum cytokine levels in patients with irritable bowel syndrome(2010) Goral V.; Kucukoner M.; Buyukbayram H.Background/Aims: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder. Psychological factors and subtle histopathological changes have been implicated in IBS. In some studies, mast cell infiltration has been determined in colon mucosa of the patients with IBS. The aim of this study was to investigate the relationship between mast cell counts and cytokine levels and IBS. Methodology: 72 consecutive IBS patients fulfilling the Rome III criteria and 50 asymptomatic healthy controls underwent colonoscopic biopsy. 15 patients in diarrhea-predominant IBS group which were performed colonoscopy were made a biopsy from caecum, other 25 patients in diarrhea-predominant IBS and 32 patients in constipation predominant IBS were performed a biopsy from rectum. Additionally, serum cytokines were analysed in the patients with IBS and in control group. Results: The results showed significantly increased mast cells in the IBS-diarrhea group compared to IBS-constipation and the control groups (p<0.0001). The statistical analysis of the inflammatory cytokine data obtained in the present study showed significantly higher levels for the sIL-2 receptor in the IBS-diarrhea group compared to other groups. Conclusions: Histopathologic and laboratory data demonstrate low-grade mucosal inflammation in a subset of patients with IBS. Mast cells and cytokines may be related to the pathophysiologic mechanism of IBS. © H.G.E. Update Medical Publishing S.A.Öğe Portal colopathy findings in patients with liver cirrhosis(1999) Goral V.; Kizilay E.; Yukselen V.; Dursun M.; Aras N.; Canoruc F.; Buyukbayram H.Portal hypertension diffusely affects the gastrointestinal (GI) tract. Portal colopathy is a new clinical entity with liver cirrhosis but the frequency and profile of distinct colonic mucosal lesions (portal colopathy) and rectal varices has been little studied in patients with liver cirrhosis. In this study, colonoscopic findings, upper GI endoscopy, portal system colored Doppler ultrasonographic results and the degree of liver dysfunction were prospectively investigated among 25 haemodynamically stable patients with postviral cirrhosis without a history of bleeding. We found the incidence of esophageal varices to be 96%, congestive gastropathy 20% and portal colopathy excluding anorectal varices and hemorrhoids 92% in our patients. Portal colopathic lesions were occasionally localized in the rectosigmoid area, ascending colon, anal canal and transverse colon. The degree of esophageal varices was associated with congestive colopathy but not with anorectal varices and hemorrhoids. While congestive gastropathy had no significant relationship with esophageal varices, congestive colopathy was present in all patients with congestive gastropathy. However, no association was evident between these lesions and the degree of disease severity. Additional studies are required not only to determine the frequency of this entity, but also to understand the pathophysiology of these lesions. Since the colonic lesions, although usually asymptomatic and clinically insignificant, are a potential source of acute or chronic lower GI bleeding, further investigation is needed to reduce the risk of bleeding and offer alternative treatment models.
