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Öğe CLASSIFICATION OF NON-HODGKIN LYMPHOMA IN SOUTHEAST TURKEY: A REVIEW OF 550 CASES(Pergamon-Elsevier Science Ltd, 2016) Ekmen, M.; Dal, M.; Karakus, A.; Buyukbayram, H.; Ayyildiz, O.[Abstract Not Available]Öğe EXPRESSION OF E-CADHERIN, COX-2, P53 AND BCL-2 IN PROSTATE CARCINOMAS: CORRELATION WITH TUMOR DIFFERENTIATION AND METASTATIC POTENTIAL(Taylor & Francis Ltd, 2010) Ozekinci, S.; Uzunlar, A. K.; Senturk, S.; Gedik, Abdullah; Buyukbayram, H.; Mizrak, B.Prognostic factors of prostate cancer such as PSA stage Gleason grade and surgical margins have limitations they are inable to indicate metastatic potential The aim of this study was to investigate expression of e-cadherin cox-2 p53 and bcl-2 in prostate carcinomas and to search association with tumor differentiation and metastatic potential Eighty-seven prostate cancer specimens were retreived from tissue blocks embedded in parafin and expression patterns of e-cadherin cox-2 p53 and bcl-2 were investigated by immunoperoxidase method Gleason scoring system was used for tumor grading and expression patterns of these antibodies were compared among different tumor grades Seven cases (8%) had well-differentiated 39(45%) had moderately differentiated and 41 (47%) had poorly differentiated tumors Metastases were present in 31 patients (35%) There was a statistically significant association between tumor differentiation and expression of e-cadherin or bcl-2 (p < 0 01) however no association was found between tumor differentiation and expression of cox-2 or p53 (p > 0 01) There was no association between expressions of e-cadherin cox-2 p53 or bcl-2 and metastasis E-cadherin expression is less frequent in poorly differentiated tumors whereas bcl-2 expression is more frequent However there is no relation with metastatic potential and expression of these markers Expression of cox-2 and p53 is neither related to the degree of differentiation nor to the metastatic potentialÖğe An increase of elastic tissue fibers in blood vessel walls of placental stem villi and differences in the thickness of blood vessel walls in third trimester pre-eclampsia pregnancies(Versita, 2010) Baran, Ozlem Pamukcu; Tuncer, Mehmet Cudi; Nergiz, Yusuf; Akkus, Murat; Erdemoglu, Mahmut; Buyukbayram, H.This study has goals of examining whether pre-eclampsia may lead to an increase of elastic tissue fibers in blood vessel walls of placental stem villi or whether there are differences in the thickness of blood vessel walls within these villi when compared to normotensive pregnant women. Non-infarcted placental tissue samples from 28 participants with uncomplicated pregnancies and 26 patients with pre-eclampsia were obtained. After routine histological procedures, the sections were processed either for conventional Verhoeff staining for the demonstration of elastic fiber system. Paraffine sections from placenta biopsies prepared for light microscopic examination were gathered. In uncomplicated pregnancies, terminal villi blood vessels were observed with no stained elastic tissue fibers in most areas. In the pre-eclampsia pregnancy of human placenta, the elastic fibers significiantly increased in terminal villi blood vessel walls which were dark in color, using Verhoeff's tissue stain, when comparing with the uncomplicated pregnancy group. Our results indicate that an increase of elastic tissue fibers in blood vessels of placental stem villus and terminal villi, and also an increase of wall thickness during pre-eclampsia.Öğe N-Acetylcysteine Prevents Deleterious Effects of Ischemia/Reperfusion Injury on Healing of Colonic Anastomosis in Rats(Karger, 2009) Kabali, B.; Girgin, S.; Gedik, E.; Ozturk, H.; Kale, E.; Buyukbayram, H.This study was designed to determine the effects of intraperitoneally or orally administered N-acetylcysteine (NAC) on wound healing following resection and anastomosis of a colon segment with ischemia/reperfusion injury. Forty female Spraque-Dawley rats were randomly allocated to one of four groups containing 10 rats each: (1) normal resection plus anastomosis; (2) ischemia/reperfusion plus resection plus anastomosis; (3) ischemia/reperfusion plus resection plus anastomosis plus intraperitoneal NAC; (4) ischemia/reperfusion plus resection plus anastomosis plus oral NAC. Group comparison showed that the anastomosis bursting pressure was significantly higher in group 3 than in the other groups. The mean tissue hydroxyproline concentration in the anastomotic tissue was significantly lower in group 2 than in the other groups. The collagen deposition was significantly increased on day 7 in groups 3 and 4 compared to the other groups. In conclusion, this study demonstrates that NAC significantly prevents the effects of reperfusion injury on colonic anastomoses in a rat model. Copyright (C) 2009 S. Karger AG, BaselÖğe The significance of tc 99m-mdp bone scintigraphy in the articular involvement of behcet's disease(Springer, 2006) Kaya, H.; Kesemenli, C.; Kaya, B.; Necmioglu, S.; Buyukbayram, H.[Abstract Not Available]
