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    A comparison of the effects of aggressive dose and conventional dose atorvastatin applications on IL-6 and NO levels in patients with acute myocardial infarction
    (Academic Journals, 2011) Basarali, Mustafa Kemal; Buyukbas, Sadik; Yazar, Hayrullah; Kiyici, Aysel; Kayrak, Mehmet; Ulgen, Siddik
    High dose statin medication in acute coronary syndrome cases is a therapy which lowers mortality and morbidity rates. Interleukin-6 (IL-6) is produced in higher amounts in acute myocardial infarction (MI) and facilitates myocardial damage. However, secretion of nitric oxide (NO) is depleted. We aimed to compare the effects of conventional dose (10-40 mg/day) and aggressive dose (80 mg/day) atorvastatin medications on IL-6 and NO levels in patients with primary percutaneous transluminal coronary angioplasty (PTCA) intervention after acute MI. 50 patients (8 females, 42 males) with the diagnosis of acute MI with ST segment elevation enrolled to the study. Primary PTCA intervention was performed on these patients and consequently either conventional dose (10 to 40 mg/day) or aggressive dose (80 mg/day) atorvastatin medications were given to the patients. Three months later, plasma IL-6 and NO levels were determined and alterations in the groups were evaluated. IL-6 levels decreased from 24.34 +/- 12.04 to 11.40 +/- 5.79 pg/ml and from 29.62 +/- 17.38 to 12.51 +/- 8.95 pg/ml in conventional dose and aggressive dose regimens respectively (p<0.001). However, NO concentrations increased from 22.90 +/- 8.24 to 31.70 +/- 7.56 mu M in conventional dose and from 19.37 +/- 5.60 mu M to 34.15 +/- 9.60 mu M in aggressive dose groups (p < 0.001). The effects of aggressive dose atorvastatin medication on IL-6 and NO levels were similar to conventional dose application in cases with ST segment elevation acute MI.
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    The Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Rats
    (Medwell Online, 2011) Alp, Harun; Aytekin, Ismail; Atakisi, Onur; Hatipoglu, Namik Kemal; Basarali, Kemal; Ogun, Metin; Buyukbas, Sadik
    The aim of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) and Ellagic Acid (EA) on acitivities of Malondialdehyde (MDA), reduced Glutathione (GSH) and Nitric Oxide (NO) in rat lung, liver and kidney tissues in acute Diazinon (DI) toxicity. Six groups of 6 Sprague Dawley rats were used comprising control, CAPE, EA, DI control, DI+CAPE and DI+EA. Tissue samples were analysed for GSH, MDA and NO levels in lung, liver and kidney tissues. Biochemical parameters were measured colormetrically by spectrophotometer. Control, CAPE and EA groups showed no statistically significant difference whereas DI+medication groups revealed that CAPE and EA increased the level of GSH in liver tissue by blocking the DI effect. NO levels in lung, liver and kidney tissues were significantly increased by DI but CAPE and EA attenuated those levels. In DI+medication groups, MDA levels showed no significant change in kidney and liver tissues but in lung tissues, CAPE and EA reduced the MDA level by blocking the DI effect. It was concluded that CAPE and EA which showed similar effects to each other could be used for protection and support against oxidative stress caused by acute DI intoxication.
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    Effects of exercise and caffeic acid phenethyl ester after chronic exercise rat model
    (Journal Sports Science & Medicine, 2011) Alp, Ayse; Buyukbas, Sadik; Alp, Harun; Gergerlioglu, H. Serdar; Oz, Mehmet; Basarali, M. Kemal; Kiyici, Aysel
    In order to understand whether exercise and caffeic acid phenethyl ester (CAPE) has an effect on obesity and weight control, we investigated the effects of CAPE, and exercise on lipid parameters (triglyceride, total cholesterol, HDL-C, LDLC), and adipokine substances such as leptin and resistin in rats. 40 male rat were randomly assigned into 4 groups. It was determined that CAPE does not have any significant effect on these parameters but that lipid parameters and leptin values in exercise groups decreased considerably, while no significant change occurred in resistin levels. In order to understand whether diet has an effect on exercise, body weights of all animal groups in pre and post-exercise were compared. A significant weight gain was observed (p = 0.005) in all groups. This study concluded that exercise has a considerable effect on leptin and lipid parameters; however, exercise alone was not sufficient for weight control and could be effective in weight control only when accompanied by a restricted diet.
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    Effects of Silybum marianum Extract on High-Fat Diet Induced Metabolic Disorders in Rats
    (Inst Animal Reproduction & Food Research Polish Acad Sciences Olsztyn, 2016) Sayin, Fatma Kubra; Buyukbas, Sadik; Basarali, M. Kemal; Alp, Harun; Toy, Hatice; Ugurcu, Veli
    Silybum marianum extract (SME) has been used for centuries as a natural remedy for diseases of liver and biliary tract. Lately, it has been promoted as a nutritional supplement for beneficial effects on some risk factors of diabetes and hyperlipidemia. In this study we aimed to determine the effects of SME on high-fat diet (HFD) induced metabolic disorders. Male Sprague Dawley rats were fed HFD for 11 weeks to induce obesity. SME was given to animals for two different durations, for 11 weeks or for 7 weeks. The results showed significant increase in plasma transaminases, total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), leptin, high sensitive C-reactive protein (hsCRP), glucose and insulin along with significant increase in body mass index (BMI) and liver weights in rats fed the HFD diet compared to rats fed with standard rat diet. SME supplementation for different durations raised improvement in the HFD-induced metabolic disorders such as insulin resistance, hyperlipidemia and hepatopathy at different degrees. Our study concludes that SME can be well considered as an effective supplement to improve insulin and leptin sensitivity and hyperlipidemia and to suppress body weight gain.
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    Serum resistin levels and metabolic changes in bipolar disorder
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Yumru, Mehmet; Gergerlioglu, H. Serdar; Savas, Haluk A.; Basarali, Kemal; Kalenderoglu, Aysun; Buyukbas, Sadik
    Aim: Metabolic changes in bipolar disorder appear to be among the cluster of disturbances that have insulin resistance as a common etiologic factor. Several recently discovered adipokines such as resistin and visfatin play a role in the pathogenesis of insulin resistance. In this study we aimed to evaluate the association between serum resistin levels and metabolic changes in bipolar disorder. Method: Sixty euthymic bipolar I disorder patients, of 29 on mood stabilizer (MS) (lithium, valproic acid, carbamazepine, and lamotrigine) treatment and of 31 on atypical antipsychotic (AA) (risperidone, quetiapine and olanzapine) treatment for at least 3 months, were enrolled. The control group consisted of 27 healthy members who have had similar distributions of age, sex, and BMI with the patients. Resistin, glucose, triglycerides, and high density lipoprotein (HDL) levels were measured in all groups. Results: Resistin levels were found to be significantly high in bipolar patients than that in the controls. However, when metabolic parameters were considered resistin levels were not significantly different between the patient and control groups (p>0.05). Conclusion: Despite serum resistin levels were high in bipolar patients, we did not find any association between metabolic disturbances and treatment modalities.