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    Effects of N-acetyl-cysteine and acetylsalicylic acid on the tonsil bacterial biofilm tissues by light and electron microscopy
    (Verduci Publisher, 2014) Bulut, F.; Meric, F.; Yorgancilar, E.; Nergiz, Y.; Akkus, M.; Nergiz, S.; Nasir, Y.
    OBJECTIVE: The present study aimed to investigate the effects of the bacterial biofilm formation on the tonsil surface exposed N-acetyl-cysteine (NAC) and acetylsalicylic acid (ASA) of patients undergoing tonsillectomy by light and electron microscopy. The general process of biofilm formation comprises adhesion of free-living or planktonic bacteria to a surface, which subsequently develop into microcolonies and form a biofilm. Based on studies that have shown the presence of biofilms in common sites of chronic infections, it has become clear that bacteria may persist on mucosal surfaces through formation of biofilms. PATIENTS AND METHODS: Ten patients between 4 and 39 years of age (mean, 11.9 +/- 11.2 years). In all cases, periodic acide Schiff (PAS) staining was found to be an accurate predictor of the presence or absence of biofilm using light microscopy as a control standard. Therapeutic doses of NAC and ASA were identificated as the effective on the tonsil bacterial biofilm using light and electron microscopy. RESULTS: Biofilm formation was detected on all samples. Tonsils removed from patients with ASA-10 had showed higher-grade inhibitory effect at the biofilm formation than the other group (p <= 0.0001). The correlation was found between drug dose and decrease at the biofilm formation. CONCLUSIONS: In chronic or recurrent tonsillitis patients, decrease on the tonsils surface biofilm formation may be associated with ASA dose. Whether effect on the tonsils surface biofilm formation of other agent have a role is not known.
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    Schwannoma of the nasal tip: case report and short review of literature
    (Galenos Yayincilik, 2009) Yildirim, M.; Yorgancilar, E.; Bulut, F.; Meric, F.; Topcu, I.
    A case of nasal tip Schwannoma is presented in this paper. Schwannoma is usually a benign neoplasm which is composed of Schwann cells. A 14-year-old boy had suffered from progressive swelling of the nasal tip over 4 months. Computed tomography showed a large soft tissue density in the nasal tip. The mass was resected using an external rhinoplasty approach, and the pathologic diagnosis was Schwannoma. Here, we present this case and discuss the clinical and pathological aspects of Schwannoma arising in the nasal tip.